The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Accelerated Hippocampal Spreading Depression and Enhanced Locomotory Activity in Mice with Astrocyte-Directed Inactivation of Connexin43
Open accessAbstract
Using a human glial fibrillary acidic protein (hGFAP) promoter-driven cre transgene, we have achieved efficient inactivation of a floxed connexin43(Cx43) gene in astrocytes of adult mice. The loss of Cx43 expression was monitored in a cell-autonomous manner via conditional replacement of the Cx43-coding region by a lacZ reporter gene. In this way, we bypassed the early postnatal lethality previously reported for Cx43 null mice and characterized the phenotypic consequences of Cx43 deficiency in the CNS. Mice lacking Cx43 in astrocytes were viable and showed no evidence of either neurodegeneration or astrogliosis. Spreading depression (SD) is a pathophysiological phenomenon observed in the CNS that is characterized by a propagating wave of depolarization followed by neuronal inactivation. Inhibitors of gap junctional communication have previously been shown to block initiation and propagation of SD. In contrast, we observed an increase in the velocity of hippocampal SD in the stratum radiatum of mice lacking Cx43 in astrocytes. In the same brain subregion, dye-coupling experiments revealed a reduction in overall astrocytic intercellular communication by ∼50%. This strongly suggests separate and different neuronal and glial contributions of gap junctional intercellular communication to SD. Concomitant with increased velocity of spreading depression, we observed enhanced locomotory activity in mice lacking Cx43 in astrocytes.
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Cites
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Cited by
Reactive astrocyte nomenclature, definitions, and future directions
Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,513
Self-citationVerkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Heterogeneity of astrocytic form and function.
Oberheim, N. A., Goldman, S. A., & Nedergaard, M. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-452-0_3 · Cited by 638
The Impact of Astrocytic Gap Junctional Coupling on Potassium Buffering in the Hippocampus
Wallraff, A., Köhling, R., Heinemann, U., Theis, M., Willecke, K., & Steinhäuser, C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0037-06.2006 · Cited by 586
Self-citationMori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R., & Götz, M. (2006) · Glia · doi:10.1002/glia.20350 · Cited by 398
Metadata
- Authors
- Theis, M., Jauch, R., Zhuo, L., Speidel, D., Wallraff, A., Döring, B., Frisch, C., Söhl, G., Teubner, B., Euwens, C., Huston, J., Steinhäuser, C., Messing, A., Heinemann, U., & Willecke, K.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-02-01
- Volume
- 23
- Issue
- 3
- Pages
- 766-776
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1959780907
- Cited by
- 274
- References
- 53
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Theis, M., Jauch, R., Zhuo, L., Speidel, D., Wallraff, A., Döring, B., Frisch, C., Söhl, G., Teubner, B., Euwens, C., Huston, J., Steinhäuser, C., Messing, A., Heinemann, U., & Willecke, K. (2003). Accelerated Hippocampal Spreading Depression and Enhanced Locomotory Activity in Mice with Astrocyte-Directed Inactivation of Connexin43. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.23-03-00766.2003
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