The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis
Open accessAbstract
Theiler's virus infection of the CNS induces an immune-mediated demyelinating disease in susceptible mouse strains and serves as a relevant infection model for human multiple sclerosis (MS). Cannabinoids may act as immunosuppressive compounds that have shown therapeutic potential in chronic inflammatory disorders. Using the Theiler's murine encephalomyelitis virus model, we report here that treatment with the synthetic cannabinoids WIN 55,212–2, ACEA, and JWH-015 during established disease significantly improved the neurological deficits in a long-lasting way. At a histological level, cannabinoids reduced microglial activation, abrogated major histocompatibility complex class II antigen expression, and decreased the number of CD4+ infiltrating T cells in the spinal cord. Both recovery of motor function and diminution of inflammation paralleled extensive remyelination. Overall, the data presented may have potential therapeutic implications in demyelinating pathologies such as MS; in particular, the possible involvement of cannabinoid receptor CB2 would enable nonpsychoactive therapy suitable for long-term use.
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Cited by
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Metadata
- Authors
- Arévalo-Martı́n, Á., Vela, J. M., Molina-Holgado, E., Borrell, J., & Guaza, C.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-04-01
- Volume
- 23
- Issue
- 7
- Pages
- 2511-2516
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1956139961
- Cited by
- 314
- References
- 39
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Arévalo-Martı́n, Á., Vela, J. M., Molina-Holgado, E., Borrell, J., & Guaza, C. (2003). Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.23-07-02511.2003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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