Involvement of the Lateral Hypothalamic Peptide Orexin in Morphine Dependence and Withdrawal

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501

Neurons containing hypocretin (orexin) project to multiple neuronal systems

Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466

Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain.

Olds, J., & Milner, P. (1954) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0058775 · Cited by 3,176

Narcolepsy in orexin Knockout Mice

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095

Molecular basis of long-term plasticity underlying addiction

Nestler, E. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053570 · Cited by 1,893

Orexin A activates locus coeruleus cell firing and increases arousal in the rat

Hagan, J. J., Leslie, R. A., Patel, S., Evans, M. L., Wattam, T. A., Holmes, S., Benham, C. D., Taylor, S. G., Routledge, C., Hemmati, P., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10911 · Cited by 1,234

Hypothalamic control of food intake in rats and cats.

Anand, B. K., & Brobeck, J. R. (1951) · PubMed · Cited by 1,197

Mice lacking melanin-concentrating hormone are hypophagic and lean

Shimada, M., Tritos, N. A., Lowell, B. B., Flier, J. S., & Maratos–Flier, E. (1998) · Nature · doi:10.1038/25341 · Cited by 1,152

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB

Sheng, M., McFadden, G., & Greenberg, M. E. (1990) · Neuron · doi:10.1016/0896-6273(90)90115-v · Cited by 1,076

Autoradiographic differentiation of mu, delta and kappa opioid receptors in the rat forebrain and midbrain

Mansour, A., Khachaturian, H., Lewis, M. E. S., Akil, H., & Watson, S. J. (1988) · Pain · doi:10.1016/0304-3959(88)90103-0 · Cited by 973

Reduced emotional signs of opiate withdrawal in rats selectively bred for low (LoS) versus high (HiS) saccharin intake

Radke, A. K., Holtz, N. A., Gewirtz, J. C., & Carroll, M. E. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2945-0 · Cited by 26

Assesment of orexin receptor 1 in stress attenuated nociceptive behaviours in formalin test

Sofiabad, M., Heidari-Oranjaghi, N., Ghasemi, E., Esmaeili, M. H., Haghdoost-Yazdi, H., Erami, E., & Zarmehri, H. A. (2011) · Cited by 26

Central antagonism of orexin type-1 receptors attenuates the development of morphine dependence in rat locus coeruleus neurons

Fakhari, M., Azizi, H., & Semnanian, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.054 · Cited by 26

Intra-ventral tegmental area or intracerebroventricular orexin-A increases the intra-cranial self-stimulation threshold via activation of the corticotropin-releasing factor system in rats: Brain reward system inhibition by orexin-A and CRF

Hata, T., Chen, J., Ebihara, K., Date, Y., Ishida, Y., & Nakahara, D. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07808.x · Cited by 25

Targeting the Orexin System for Prescription Opioid Use Disorder

Matzeu, A., & Martin‐Fardon, R. (2020) · Brain Sciences · doi:10.3390/brainsci10040226 · Cited by 25

Suppression of Hypothalamic–Pituitary–Adrenal Axis by Acute Heroin Challenge in Rats During Acute and Chronic Withdrawal from Chronic Heroin Administration

Zhou, Y., Leri, F., Ho, A., & Kreek, M. J. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1091-3 · Cited by 27

Hypocretin/Orexin Involvement in Reward and Reinforcement

España, R. A. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-394623-2.00010-x · Cited by 26

Modulatory Effects of Food Restriction on Brain and Behavioral Effects of Abused Drugs

Carr, K. D. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200204141057 · Cited by 23

The blockade of GABAA receptors attenuates the inhibitory effect of orexin type 1 receptors antagonist on morphine withdrawal syndrome in rats

Davoudi, M., Azizi, H., Mirnajafi‐Zadeh, J., & Semnanian, S. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.02.022 · Cited by 24

Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment

Posa, L., Accarie, A., Noble, F., & Marie, N. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv108 · Cited by 24

Enhancement of μ-opioid receptor desensitization by orexin-A in rat locus coeruleus neurons

Ahmadi‐Soleimani, S. M., Azizi, H., Pachenari, N., Mirnajafi‐Zadeh, J., & Semnanian, S. (2017) · Neuropeptides · doi:10.1016/j.npep.2017.03.004 · Cited by 24

Persistent effects of the orexin-1 receptor antagonist SB-334867 on naloxone precipitated morphine withdrawal symptoms and nociceptive behaviors in morphine dependent rats

Kourosh‐Arami, M., Joghataei, M. T., Komaki‬, A., Gholami, M., Najafi, Z., & Lavaie, M. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1802266 · Cited by 23

Role of orexin-1 and orexin-2 receptors in the CA1 region of hippocampus in the forced swim stress- and food deprivation-induced reinstatement of morphine seeking behaviors in rats

Edalat, P., Kavianpour, M., Zarrabian, S., & Haghparast, A. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.06.016 · Cited by 24

Hypocretin/Orexin Interactions with Norepinephrine Contribute to the Opiate Withdrawal Syndrome

McGregor, R., Wu, M., Holmes, B., Lam, H. A., Maidment, N. T., Gera, J., Yamanaka, A., & Siegel, J. M. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1557-21.2021 · Cited by 20

Suvorexant, an FDA-approved dual orexin receptor antagonist, reduces oxycodone self-administration and conditioned reinstatement in male and female rats

Illenberger, J. M., Flores‐Ramirez, F. J., Matzeu, A., Mason, B. J., & Martin‐Fardon, R. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1127735 · Cited by 21

Location, location, location: the CNS sites of leptin action dictate its regulation of homeostatic and hedonic pathways

Leinninger, G. M. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.66 · Cited by 23

Insights for Developing Pharmacological Treatments for Psychostimulant Relapse Targeting Hypothalamic Peptide Systems

James, M. H., Yeoh, J. W., Graham, B. A., & Dayas, C. V. (2012) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.s4-008 · Cited by 22

Yokukansan (Kampo medicinal formula) prevents the development of morphine tolerance by inhibiting the secretion of orexin A

Katayama, A., Kanada, Y., Tsukada, M., Akanuma, Y., Takemura, H., Ono, T., Suga, H., Mera, H., Hisamitsu, T., & Sunagawa, M. (2018) · Integrative Medicine Research · doi:10.1016/j.imr.2018.02.005 · Cited by 21

Orexin type-1 receptor inhibition in the rat lateral paragigantocellularis nucleus attenuates development of morphine dependence

Rezaei, Z., Kourosh‐Arami, M., Azizi, H., & Semnanian, S. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.134875 · Cited by 21

Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats

Li, Y., Zhong, F., Yu, P., Han, J., Cui, C., & Wu, L. (2009) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nep133 · Cited by 21

The role of leptin in the regulation of neuroendocrine function and CNS development

Louis, G. W., & Myers, M. G. (2007) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-007-9043-3 · Cited by 21

Non-Opioid Treatments for Opioid Use Disorder: Rationales and Data to Date

Chalhoub, R., & Kalivas, P. W. (2020) · Drugs · doi:10.1007/s40265-020-01373-1 · Cited by 20

Similar role of mPFC orexin-1 receptors in the acquisition and expression of morphine- and food-induced conditioned place preference in male rats

Jamali, S., Zarrabian, S., & Haghparast, A. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108764 · Cited by 22

Cross-talk between the HPA axis and addiction-related regions in stressful situations

Nikbakhtzadeh, M., Ranjbar, H., Moradbeygi, K., Zahedi, E., Bayat, M., Soti, M., & Shabani, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15525 · Cited by 24

Concentration‐dependent activation of dopamine receptors differentially modulates GABA release onto orexin neurons

Linehan, V., Trask, R. B., Briggs, C., Rowe, T. M., & Hirasawa, M. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12967 · Cited by 20

Role of melanin-concentrating hormone in drug use disorders

Morganstern, I., Gulati, G., & LEIBOWITZ, S. F. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146872 · Cited by 20

Advances in Narcolepsy

Cao, M. T. (2010) · Medical Clinics of North America · doi:10.1016/j.mcna.2010.02.008 · Cited by 19

Opioids in the perifornical lateral hypothalamus suppress ethanol drinking

Chen, Y., Barson, J. R., Chen, A., Hoebel, B. G., & LEIBOWITZ, S. F. (2012) · Alcohol · doi:10.1016/j.alcohol.2012.11.001 · Cited by 19

Contribution of hypothalamic orexin (hypocretin) circuits to pathologies of motivation

Mohammadkhani, A., Mitchell, C. S., James, M. H., Borgland, S. L., & Dayas, C. V. (2024) · British Journal of Pharmacology · doi:10.1111/bph.17325 · Cited by 21

Potentiation of rewarding properties of morphine by concurrent chemical stimulation of lateral hypothalamus in rats

Zarepour, L., Komaki‬, A., Shahidi, ‬., Sarihi, A., & Haghparast, A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.03.018 · Cited by 18

OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy

Yamamoto, H., Nagumo, Y., Ishikawa, Y., Irukayama‐Tomobe, Y., Namekawa, Y., Nemoto, T., Tanaka, H., Takahashi, G., Tokuda, A., Saitoh, T., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0271901 · Cited by 19

Orexin and natural reward

Sebastiano, A. R. D., & Coolen, L. M. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59489-1.00006-9 · Cited by 19

Update on narcolepsy

Reading, P. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09310-3 · Cited by 17

Narp regulates long-term aversive effects of morphine withdrawal.

Reti, I. M., Crombag, H. S., Takamiya, K., Sutton, J. M., Guo, N., Dinenna, M. L., Huganir, R. L., Holland, P. C., & Baraban, J. M. (2008) · Behavioral Neuroscience · doi:10.1037/a0012514 · Cited by 17

Regulation of morphine reward and feeding by CREB in the lateral hypothalamus

Olson, V. G., Green, T. A., Neve, R. L., & Nestler, E. J. (2006) · Synapse · doi:10.1002/syn.20344 · Cited by 18

From Molecule to Behavior: Hypocretin/orexin Revisited From a Sex-dependent Perspective

Gao, X., & Horváth, T. L. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab042 · Cited by 18

Intra-LC microinjection of orexin type-1 receptor antagonist SB-334867 attenuates the expression of glutamate-induced opiate withdrawal like signs during the active phase in rats

Hooshmand, B., Azizi, H., Javan, M., & Semnanian, S. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.10.051 · Cited by 16

Inhibition of orexin receptor 1 contributes to the development of morphine dependence via attenuation of cAMP response element-binding protein and phospholipase Cβ3

Kourosh‐Arami, M., Javan, M., & Semnanian, S. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101801 · Cited by 16

Orexin/hypocretin and major psychiatric disorders

Lin, C.-C., & Huang, T. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2022.03.006 · Cited by 16

Antagonism of orexin type-1 receptors (OX1Rs) attenuates naloxone-precipitated morphine withdrawal syndrome in rat dorsal hippocampus

Hooshmandi, M., Hosseinmardi, N., Janahmadi, M., Khakpai, F., Rohampour, K., & Doostmohammadi, J. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.06.001 · Cited by 16

Tail flick modification of orexin-a induced changes of electrophysiological parameters in the rostral ventromedial medulla.

Azhdari‐Zarmehri, H., Semnanian, S., Fathollahi, Y., & Pakdel, F. G. (2014) · Europe PMC (PubMed Central) · Cited by 16

Physiological Role of Orexin/Hypocretin in the Human Body in Motivated Behavior: A Comprehensive Review

Singh, R. P., & Biswas, D. A. (2023) · Cureus · doi:10.7759/cureus.34009 · Cited by 15

Comparing the analgesic effects of periaqueductal gray matter injection of orexin A and morphine on formalin- induced nociceptive behaviors.

Zarmehri, H. A., Semnanian, S., & Fathollahi, Y. (2008) · Cited by 15

Hypocretin/Orexin and Plastic Adaptations Associated with Drug Abuse

Baimel, C., & Borgland, S. L. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_44 · Cited by 15

Pleasure, addiction, and hypocretin (orexin)

McGregor, R., Thannickal, T. C., & Siegel, J. M. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820107-7.00022-7 · Cited by 18

Higher plasma orexin A levels in children with Prader–Willi syndrome compared with healthy unrelated sibling controls

Manzardo, A. M., Johnson, L., Miller, J. L., Driscoll, D. J., & Butler, M. G. (2016) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.37749 · Cited by 14

The dual orexin/hypocretin receptor antagonist suvorexant reduces addiction-like behaviors for the opioid fentanylPreprint

O’Connor, S. L., Fragale, J. E. C., James, M. H., & Aston‐Jones, G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.25.061887 · Cited by 15

Deep Brain Stimulation of the Lateral Hypothalamus Facilitates Extinction and Prevents Reinstatement of Morphine Place Preference in Rats

Moeini, M. M., Sadr, S. S., & Riahi, E. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13320 · Cited by 13

Pharmacology of Opioid Drugs

Cox, B. M. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-993-2_3 · Cited by 14

Central blockade of orexin type 1 receptors reduces naloxone induced activation of locus coeruleus neurons in morphine dependent rats

Aghajani, N., Pourhamzeh, M., Azizi, H., & Semnanian, S. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135909 · Cited by 13

Opioid-induced neuroanatomical, microglial and behavioral changes are blocked by suvorexant without diminishing opioid analgesia

McGregor, R., Wu, M.-F., Thannickal, T. C., Li, S., & Siegel, J. M. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00278-2 · Cited by 13

An emerging multi-omic understanding of the genetics of opioid addiction

Johnson, E. O., Fisher, H. S., Sullivan, K. A., Corradin, O., Sanchez‐Roige, S., Gaddis, N., Sami, Y. N., Townsend, A., Prates, E. T., Pavicic, M., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172886 · Cited by 14

Decrease of inhibitory synaptic currents of locus coeruleus neurons via orexin type 1 receptors in the context of naloxone-induced morphine withdrawal

Davoudi, M., Azizi, H., Mirnajafi‐Zadeh, J., & Semnanian, S. (2018) · The Journal of Physiological Sciences · doi:10.1007/s12576-018-0645-1 · Cited by 13

Median Nerve Stimulation as a Nonpharmacological Approach to Bypass Analgesic Tolerance to Morphine: A Proof-of-Concept Study in Mice

Lee, M. T., Chen, Y., Mackie, K., & Chiou, L. (2020) · Journal of Pain · doi:10.1016/j.jpain.2020.09.003 · Cited by 15

K+ channels stimulated by glucose: a new energy-sensing pathway

Burdakov, D. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0189-8 · Cited by 13

A sensitizing d-amphetamine dose regimen induces long-lasting spinophilin and VGLUT1 protein upregulation in the rat diencephalon

Boikess, S. R., O’Dell, S. J., & Marshall, J. F. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.042 · Cited by 13

Blockade of orexin receptor type-1 by SB-334867 and activation of orexin receptor type-2 attenuate morphine tolerance in rats

Özdemir, E., Baser, T., & Taşkıran, A. Ş. (2022) · Physiology International · doi:10.1556/2060.2022.00078 · Cited by 12

Modulation of histone deacetylase attenuates naloxone-precipitated opioid withdrawal syndrome

Rehni, A. K., Singh, N., Rachamalla, M., & Tikoo, K. (2012) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-012-0739-x · Cited by 12

Higher plasma orexin a levels in children with Prader–Willi syndrome compared with healthy unrelated sibling controls

Manzardo, A. M., Johnson, L., Miller, J. L., Driscoll, D. J., & Butler, M. G. (2016) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.37777 · Cited by 13

The Molecular Mechanisms of Reward

Winstanley, C. A., & Nestler, E. J. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00004-8 · Cited by 11

Forced ethanol ingestion by Wistar rats from a juvenile age increased voluntary alcohol consumption in adulthood, with the involvement of orexin-A

Mendoza-Ruiz, L. G., Vázquez-León, P., Martínez-Mota, L., Juan, E. R., & Miranda-Páez, A. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.01.008 · Cited by 11

Immunohistochemical localization of mu opioid receptor in the marginal division with comparison to patches in the neostriatum of the rat brain

Wang, C., Shu, S., Guo, Z., Cai, Y. F., Bao, X., Zeng, C., Wu, B., Hu, Z., & Liu, X. (2011) · Journal of Biomedical Science · doi:10.1186/1423-0127-18-34 · Cited by 11

Differential effect of amphetamine over the corticotropin-releasing factor CRF2 receptor, the orexin OX1 receptor and the CRF2-OX1 heteroreceptor complex

Navarro, G., Medrano, M., Aguinaga, D., Vega‐Quiroga, I., Lillo, A., Jiménez, J., Casanovas, M., Canela, E. I., Mallol, J., Gysling, K., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.014 · Cited by 11

Alteration of orexin-A and PKCα in the postmortem brain of pure-opioid and multi-drug abusers

Sadat‐Shirazi, M., Soltani, H., Nikpour, N., Haghshenas, M., Khalifeh, S., Mokri, A., & Zarrindast, M. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102074 · Cited by 11

Orexin-a modulates firing of rat rostral ventromedial medulla neurons: an in vitro study.

Azhdari‐Zarmehri, H., Semnanian, S., & Fathollahi, Y. (2015) · PubMed Central · doi:10.22074/cellj.2015.524 · Cited by 11

Orexin-mediated motivated arousal and reward seeking

Bjorness, T. E., & Greene, R. W. (2024) · Peptides · doi:10.1016/j.peptides.2024.171280 · Cited by 10

Daily treatment with the dual orexin receptor antagonist DORA-12 during oxycodone abstinence decreases oxycodone conditioned reinstatement

Illenberger, J. M., Flores‐Ramirez, F. J., Pascasio, G., Matzeu, A., & Martin‐Fardon, R. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109685 · Cited by 10

Pharmacological modulation of geranylgeranyltransferase and farnesyltransferase attenuates opioid withdrawal in vivo and in vitro

Rehni, A. K., & Singh, T. G. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.01.022 · Cited by 10

Orexin‐mediated restoration of hippocampal synaptic potentiation in mice with established cocaine‐conditioned place preference

Lu, G., Lee, M. T., & Chiou, L. (2018) · Addiction Biology · doi:10.1111/adb.12672 · Cited by 10

Reward-Seeking Behavior and Addiction: Cause or Cog?

Arias-Carrión, Ó., & Salama, M. (2012) · Current Drug Abuse Reviews · doi:10.2174/1874473711205030178 · Cited by 10

Interaction Between Orexins and the Mesolimbic System for Overriding Satiety

Hirasawa, M., Parsons, M. P., & Alberto, C. O. (2007) · Reviews in the Neurosciences · doi:10.1515/revneuro.2007.18.5.383 · Cited by 10

Neuroimaging reveals distinct brain glucose metabolism patterns associated with morphine consumption in Lewis and Fischer 344 rat strains

Soto‐Montenegro, M. L., García‐Vázquez, V., Lamanna‐Rama, N., Montoya, G. L., Desco, M., & Ambrosio, E. (2022) · Scientific Reports · doi:10.1038/s41598-022-08698-9 · Cited by 9

Yiguanjian cataplasm attenuates opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome

Shuai, G., Hong, G., Fan, Y., Zhang, G., Fengkai, S., Jing, Z., Li, F., Yang, Y., & Wang, K. (2016) · 中医杂志：英文版 · doi:10.1016/s0254-6272(16)30063-2 · Cited by 9

Activation of orexin-1 receptors in the amygdala enhances feeding in the diet-induced obesity rats: Blockade with μ-opioid antagonist

Wang, M., Sun, X., Guo, F., Luan, X., Wang, C., & Luo, X. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.08.120 · Cited by 9

Potential therapeutic targets for the treatment of opioid abuse and pain

Kiguchi, N., & Ko, M. (2022) · Advances in pharmacology · doi:10.1016/bs.apha.2021.09.002 · Cited by 9

Treatment-like steady-state methadone in rats interferes with incubation of cocaine sensitization and associated alterations in gene expression

Leri, F., Zhou, Y., Carmichael, B., Cummins, E., & Kreek, M. J. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.06.003 · Cited by 9

Pharmacological modulation of leukotriene D4 attenuates the development of opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome

Rehni, A. K., Singh, I., Singh, N., Bansal, N., Bansal, S., & Kumar, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.09.025 · Cited by 9

Chemical stimulation of the lateral hypothalamus potentiated the sensitization to morphine in rats

Razavi, Y., Karimi, S., Bani-Ardalan, M., & Haghparast, A. (2014) · Europe PMC (PubMed Central) · doi:10.17877/de290r-7236 · Cited by 9

Synergistic effect of orexin-glutamate co-administration on spontaneous discharge rate of locus coeruleus neurons in morphine-dependent rats

Hooshmand, B., Azizi, H., Ahmadi‐Soleimani, S. M., & Semnanian, S. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.04.060 · Cited by 9

Drug addiction co-morbidity with alcohol: Neurobiological insights

McGinn, M. A., Pantazis, C. B., Tunstall, B. J., Marchette, R. C. N., Carlson, E. R., Said, N., Koob, G. F., & Vendruscolo, L. F. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2020.11.002 · Cited by 11

Involvement of Corticotrophin-Releasing Factor and Orexin-A in Chronic Migraine and Medication Overuse Headache: Findings From Cerebrospinal Fluid

Holland, P. R., & Bartsch, T. (2008) · Cephalalgia · doi:10.1111/j.1468-2982.2008.01585.x · Cited by 9

Sleep deprivation engages the orexin/hypocretin system to regulate food reward seeking

Rojo, A. L. A., Barnhardt, T. R., Pham, T. Q., Heim, B., Cai, L., Tseng, G. C., & Huang, Y. H. (2025) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaf047 · Cited by 10

Current understanding on the neurobiology of sleep and wakefulness

Kutty, B. M., SATHIAMMA, S., & Sasidharan, A. (2014) · International Journal of Clinical and Experimental Physiology · doi:10.4103/2348-8093.129720 · Cited by 8

Ammonium pyrrolidine dithiocarbamate and RS 102895 attenuate opioid withdrawal in vivo and in vitro

Rehni, A. K., & Singh, N. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2489-8 · Cited by 8

Neural correlates and potential targets for the contribution of orexin to addiction in cortical and subcortical areas

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