Yanagisawa, Masashi

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell

Regulation of Appetite and ObesitySleep and Wakefulness Research

Cited by 5,501

Narcolepsy in orexin Knockout Mice

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell

Sleep and Wakefulness ResearchNeuroscience of respiration and sleep

Cited by 3,095

Differential expression of orexin receptors 1 and 2 in the rat brain

Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology

Sleep and Wakefulness ResearchRegulation of Appetite and Obesity

Cited by 1,659

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences

Gut microbiota and healthRegulation of Appetite and Obesity

Cited by 1,564

Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo

Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J.-I., Williams, S. C., Richardson, J. A., & Yanagisawa, M. (2001) · Developmental Biology

Congenital heart defects researchDevelopmental Biology and Gene Regulation

Cited by 1,241

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L.-X., Rey, F., Wang, T., et al. (2013) · Proceedings of the National Academy of Sciences

Renin-Angiotensin System StudiesGut microbiota and health

Cited by 1,191

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

Kim, M. H., Kang, S. G., Park, J. H., Yanagisawa, M., & Kim, C. H. (2013) · Gastroenterology

Gut microbiota and healthInflammatory Bowel Disease

Cited by 1,127

Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

Tanaka, T., Yamamoto, J., Iwasaki, S., Asaba, H., Hamura, H., Ikeda, Y., Watanabe, M., Magoori, K., Ioka, R. X., Tachibana, K., et al. (2003) · Proceedings of the National Academy of Sciences

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 832

Fos Expression in Orexin Neurons Varies with Behavioral State

Estabrooke, I. V., McCarthy, M. T., Ko, E., Chou, T. C., Chemelli, R. M., Yanagisawa, M., Saper, C. B., & Scammell, T. E. (2001) · The Journal of Neuroscience

Sleep and Wakefulness ResearchNeuroscience of respiration and sleep

Cited by 654

Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice

Willie, J. T., Chemelli, R. M., Sinton, C. M., Tokita, S., Williams, S. C., Kisanuki, Y. Y., Marcus, J. N., Lee, C., Elmquist, J. K., Kohlmeier, K. A., et al. (2003) · Neuron

Sleep and Wakefulness ResearchNeuroscience of respiration and sleep

Cited by 645

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S. A., Anderson, J. G., Jung, S., Birnbaum, S., Yanagisawa, M., Elmquist, J. K., Nestler, E. J., et al. (2008) · Nature Neuroscience

Regulation of Appetite and ObesityNeuropeptides and Animal Physiology

Cited by 644

Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal

Georgescu, D., Zachariou, V., Barrot, M., Mieda, M., Willie, J. T., Eisch, A. J., Yanagisawa, M., Nestler, E. J., & DiLeone, R. J. (2003) · The Journal of Neuroscience

Neuropeptides and Animal PhysiologySleep and Wakefulness Research

Cited by 373

An essential role for orexins in emergence from general anesthesia

Kelz, M. B., Sun, Y., Chen, J., Cheng Meng, Q., Moore, J. T., Veasey, S. C., Dixon, S., Thornton, M., Funato, H., & Yanagisawa, M. (2008) · Proceedings of the National Academy of Sciences

Sleep and Wakefulness ResearchAnesthesia and Sedative Agents

Cited by 341

The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker

Mieda, M., Williams, S. C., Richardson, J. A., Tanaka, K., & Yanagisawa, M. (2006) · Proceedings of the National Academy of Sciences

Circadian rhythm and melatoninSleep and Wakefulness Research

Cited by 290

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

Roh, J. H., Jiang, H., Finn, M. B., Stewart, F. R., Mahan, T. E., Cirrito, J. R., Heda, A., Snider, B. J., Li, M., Yanagisawa, M., et al. (2014) · Journal of Experimental Medicine

Sleep and Wakefulness ResearchAlzheimer's disease research and treatments

Cited by 237

Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo

Omori, S., Wang, T.-W., Johmura, Y., Kanai, T., Nakano, Y., Kido, T., Susaki, E. A., Nakajima, T., Shichino, S., Ueha, S., et al. (2020) · Cell Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 194

Neuromedin S-Producing Neurons Act as Essential Pacemakers in the Suprachiasmatic Nucleus to Couple Clock Neurons and Dictate Circadian Rhythms

Lee, I. T., Chang, A. S., Manandhar, M., Shan, Y., Fan, J., Izumo, M., Ikeda, Y., Motoike, T., Dixon, S., Seinfeld, J. E., et al. (2015) · Neuron

Circadian rhythm and melatoninSleep and Wakefulness Research

Cited by 180

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney

Sato, Y., Mii, A., Hamazaki, Y., Fujita, H., Nakata, H., Masuda, K., Nishiyama, S., Shibuya, S., Haga, H., Ogawa, O., et al. (2016) · JCI Insight

Acute Kidney Injury ResearchChronic Kidney Disease and Diabetes

Cited by 148

Role of tyrosine kinase pathways in ETB receptor activation of NHE3

Chu, T. S., Tsuganezawa, H., Peng, Y., Cano, A., Yanagisawa, M., & Alpern, R. J. (1996) · American Journal of Physiology-Cell Physiology

Nitric Oxide and Endothelin EffectsIon Transport and Channel Regulation

Cited by 99

Hypothalamic Orexin Prevents Hepatic Insulin Resistance via Daily Bidirectional Regulation of Autonomic Nervous System in Mice

Tsuneki, H., Tokai, E., Nakamura, Y., Takahashi, K., Fujita, M., Asaoka, T., Kon, K., Anzawa, Y., Wada, T., Takasaki, I., et al. (2015) · Diabetes

Circadian rhythm and melatoninSleep and Wakefulness Research

Cited by 73

Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis

Hyter, S., Coleman, D. J., Ganguli‐Indra, G., Merrill, G. F., Ma, S., Yanagisawa, M., & Indra, A. K. (2013) · Pigment Cell & Melanoma Research

melanin and skin pigmentationMelanoma and MAPK Pathways

Cited by 61

Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors

Tsai, C.-J., Nagata, T., Liu, C.-Y., Suganuma, T., Kanda, T., Miyazaki, T., Liu, K., Saitoh, T., Nagase, H., Lazarus, M., et al. (2021) · Cell Reports

Sleep and Wakefulness ResearchTraumatic Brain Injury and Neurovascular Disturbances

Cited by 48

Subacute ingestion of caffeine and oolong tea increases fat oxidation without affecting energy expenditure and sleep architecture: a randomized, placebo-controlled, double-blinded cross-over trial

Zhang, S., Takano, J., Murayama, N., Tominaga, M., Abe, T., Park, I., Seol, J., Ishihara, A., Tanaka, Y., Yajima, K., et al. (2020) · Nutrients

Coffee research and impactsTea Polyphenols and Effects

Cited by 34

Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity

Tsuneki, H., Maeda, T., Takata, S., Sugiyama, M., Otsuka, K., Ishizuka, H., Onogi, Y., Tokai, E., Koshida, C., Kon, K., et al. (2022) · Cell Reports

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 21