The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Single-Cell Microarray Analysis in Hippocampus CA1: Demonstration and Validation of Cellular Heterogeneity
Open accessAbstract
Laser capture microdissection in combination with microarrays allows for the expression analysis of thousands of genes in selected cells. Here we describe single-cell gene expression profiling of CA1 neurons in the rat hippocampus using a combination of laser capture, T7 RNA amplification, and cDNA microarray analysis. Subsequent cluster analysis of the microarray data identified two different cell types: pyramidal neurons and an interneuron. Cluster analysis also revealed differences among the pyramidal neurons, indicating that even a single cell type in vivo is not a homogeneous population of cells at the gene expression level. Microarray data were confirmed by quantitative RT-PCR and in situ hybridization. We also report on the reproducibility and sensitivity of this combination of methods. Single-cell gene expression profiling offers a powerful tool to tackle the complexity of the mammalian brain.
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Cites
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Cited by
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
The Petilla Interneuron Nomenclature Group (PING) (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2402 · Cited by 1,491
The Technology and Biology of Single-Cell RNA Sequencing
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Variability, compensation and homeostasis in neuron and network function
Marder, E., & Goaillard, J.-M. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1949 · Cited by 1,212
Neuronal Subtype-Specific Genes that Control Corticospinal Motor Neuron Development In Vivo
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Metadata
- Authors
- Kamme, F., Salunga, R., Yu, J., Tran, D.-T., Zhu, J., Luo, L., Bittner, A., Guo, H.-Q., Miller, N., Wan, J., & Erlander, M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-05-01
- Volume
- 23
- Issue
- 9
- Pages
- 3607-3615
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2145899551
- Cited by
- 291
- References
- 6
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Kamme, F., Salunga, R., Yu, J., Tran, D.-T., Zhu, J., Luo, L., Bittner, A., Guo, H.-Q., Miller, N., Wan, J., & Erlander, M. (2003). Single-Cell Microarray Analysis in Hippocampus CA1: Demonstration and Validation of Cellular Heterogeneity. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.23-09-03607.2003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
