The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
The Transmembrane Semaphorin Sema4D/CD100, an Inhibitor of Axonal Growth, Is Expressed on Oligodendrocytes and Upregulated after CNS Lesion
Open accessAbstract
Semaphorins are a family of secreted and membrane-bound proteins, known to regulate axonal pathfinding. Sema4D, also called CD100, was first isolated in the immune system where it is involved in B and T cell activation. We found that in the mouse, Sema4D is expressed in cells throughout the CNS white matter, with a peak during the myelination period. Double-labeling experiments with different markers of oligodendrocyte lineage such as olig1, olig2, platelet-derived growth factor receptor α, and proteolipid protein showed that Sema4D was expressed selectively by oligodendrocytes and myelin. The presence of Sema4D in myelin was confirmed using Western blot. Sema4D expression in myelinating oligodendrocytes was further observed using neuron-oligodendrocyte cocultures. Moreover, using stripe assay, we found that Sema4D is strongly inhibitory for postnatal sensory and cerebellar granule cell axons. This prompted us to examine whether Sema4D expression is modified after CNS injury. At 8 d after spinal cord lesions, Sema4D expression was strongly upregulated in oligodendrocytes at the periphery of the lesion. Sema4D-positive cells were not colabeled with the astrocyte marker GFAP, with the microglial and macrophagic marker isolectin B4, or with NG2, a marker of oligodendrocyte precursors. This upregulation was transient because from 1 month after the lesion, Sema4D expression was back to its normal level. These results indicate that Sema4D is a novel inhibitory factor for axonal regeneration expressed in myelin.
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Vargas, M. E., & Barres, B. A. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094354 · Cited by 510
Regulation of axonal regeneration after mammalian spinal cord injury
Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328
Signals to promote myelin formation and repair
Taveggia, C., Feltri, M. L., & Wrabetz, L. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.37 · Cited by 286
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Metadata
- Authors
- Moreau-Fauvarque, C., Kumanogoh, A., Camand, E., Jaillard, C., Barbin, G., Boquet, I., Love, C., Jones, E. Y., Kikutani, H., Lubetzki, C., Dusart, I., & Chédotal, A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-10-08
- Volume
- 23
- Issue
- 27
- Pages
- 9229-9239
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2141793003
- Cited by
- 293
- References
- 85
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Moreau-Fauvarque, C., Kumanogoh, A., Camand, E., Jaillard, C., Barbin, G., Boquet, I., Love, C., Jones, E. Y., Kikutani, H., Lubetzki, C., Dusart, I., & Chédotal, A. (2003). The Transmembrane Semaphorin Sema4D/CD100, an Inhibitor of Axonal Growth, Is Expressed on Oligodendrocytes and Upregulated after CNS Lesion. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.23-27-09229.2003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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