The DOI matches its Crossref record; 172 of the 172 references it cites were found in a registry or an index.
Signals to promote myelin formation and repair
Open accessAbstract
The myelin sheath wraps large axons in both the CNS and the PNS, and is a key determinant of efficient axonal function and health. Myelin is targeted in a series of diseases, notably multiple sclerosis (MS). In MS, demyelination is associated with progressive axonal damage, which determines the level of patient disability. The few treatments that are available for combating myelin damage in MS and related disorders, which largely comprise anti-inflammatory drugs, only show limited efficacy in subsets of patients. More-effective treatment of myelin disorders will probably be accomplished by early intervention with combinatorial therapies that target inflammation and other processes—for example, signaling pathways that promote remyelination. Indeed, evidence suggests that such pathways might be impaired in pathology and, hence, contribute to the failure of remyelination in such diseases. In this article, we review the molecular basis of signaling pathways that regulate myelination in the CNS and PNS, with a focus on signals that affect differentiation of myelinating glia. We also discuss factors such as extracellular molecules that act as modulators of these pathways. Finally, we consider the few preclinical and clinical trials of agents that augment this signaling.
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Cites
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Cited by
Plasticity in gray and white: neuroimaging changes in brain structure during learning
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Distinct Profiles of Myelin Distribution Along Single Axons of Pyramidal Neurons in the Neocortex
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A regenerative approach to the treatment of multiple sclerosis
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Metadata
- Authors
- Taveggia, C., Feltri, M. L., & Wrabetz, L.
- Venue
- Nature Reviews Neurology
- Published
- 2010-04-20
- Volume
- 6
- Issue
- 5
- Pages
- 276-287
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- OpenAlex
- W2083229277
- Cited by
- 286
- References
- 172
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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