The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool
Open accessAbstract
The proapoptotic Bcl-2 family members Bak and Bax play central and redundant roles in the regulation of apoptosis. In this study, we investigated the effect of loss of Bax and Bak in the CNS. The adult bax-/-bak-/- mice display masses of densely staining cells in the proliferative zones of the brain. These cells are shown to be a mix of neural progenitor cells and postmitotic cells at different stages of neural and glial differentiation. Both neural progenitor cells and mature neurons derived from bax-/-bak-/- mice were resistant to various apoptotic stimuli. Despite this resistance, postmitotic mature bax-/-bak-/- neurons remain as sensitive to excitoxic death as wild-type neurons. Thus, Bax and Bak play a critical role in regulating the number of neural progenitor cells in the adult brain but are not absolutely required for the initiation of neuronal cell death after neurotoxic injury.
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Cites
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Wei, M. C., Zong, W.-X., Cheng, E. H.-Y., Lindsten, T., Panoutsakopoulou, V., Ross, A. J., Roth, K. A., MacGregor, G. R., Thompson, C. B., & Korsmeyer, S. J. (2001) · Science · doi:10.1126/science.1059108 · Cited by 3,988 · see citing works
Self-citationCNS stem cells express a new class of intermediate filament protein
Lendahl, U., Zimmerman, L. B., & McKay, R. D. G. (1990) · Cell · doi:10.1016/0092-8674(90)90662-x · Cited by 3,164 · see citing works
Cell death during development of the nervous system
Oppenheim, R. W. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002321 · Cited by 3,084 · see citing works
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904 · see citing works
Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A., & Nicotera, P. (1995) · Neuron · doi:10.1016/0896-6273(95)90186-8 · Cited by 1,884 · see citing works
Lindsten, T., Ross, A. J., King, A., Zong, W.-X., Rathmell, J. C., Shiels, H. A., Ulrich, E., Waymire, K. G., Mahar, P., Frauwirth, K., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00136-2 · Cited by 1,489 · see citing works
Self-citationMassive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice
Motoyama, N., Wang, F., Roth, K. A., Sawa, H., Nakayama, K., Nakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S., et al. (1995) · Science · doi:10.1126/science.7878471 · Cited by 1,164 · see citing works
Sommer, I., & Schachner, M. (1981) · Developmental Biology · doi:10.1016/0012-1606(81)90477-2 · Cited by 1,136 · see citing works
The Adult Rat Hippocampus Contains Primordial Neural Stem Cells
Palmer, T. D., TAKAHASHI, J. C., & Gage, F. H. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0595 · Cited by 1,090 · see citing works
BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development
Deckwerth, T. L., Elliott, J. L., Knudson, C. M., Johnson, E. M., Snider, W. D., & Korsmeyer, S. J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80173-7 · Cited by 749 · see citing works
Molecular Mechanisms of Glutamate Receptor-Mediated Excitotoxic Neuronal Cell Death
Sattler, R., & Tymianski, M. (2001) · Molecular Neurobiology · doi:10.1385/mn:24:1-3:107 · Cited by 537 · see citing works
Proliferation, differentiation, and long-term culture of primary hippocampal neurons.
Ray, J., Peterson, D. A., Schinstine, M., & Gage, F. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3602 · Cited by 457 · see citing works
p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons
Ghatan, S., Larner, S. F., Kinoshita, Y., Hetman, M., Patel, L. S., Xia, Z., Youle, R. J., & Morrison, R. S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.2.335 · Cited by 390 · see citing works
Miller, T. M., Moulder, K. L., Knudson, C. M., Creedon, D. J., Deshmukh, M., Korsmeyer, S. J., & Johnson, E. M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.1.205 · Cited by 383 · see citing works
Nitric oxide: NO apoptosis or turning it ON?
Brüne, B. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401261 · Cited by 361 · see citing works
Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system
Purves, D., Snider, W. D., & Voyvodic, J. T. (1988) · Nature · doi:10.1038/336123a0 · Cited by 338 · see citing works
Bax Involvement in p53-Mediated Neuronal Cell Death
Xiang, H., Kinoshita, Y., Knudson, C. M., Korsmeyer, S. J., Schwartzkroin, P. A., & Morrison, R. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01363.1998 · Cited by 331 · see citing works
Metabolic and Genetic Analyses of Apoptosis in Potassium/Serum-Deprived Rat Cerebellar Granule Cells
Miller, T. M., & Johnson Jr., E. M. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07487.1996 · Cited by 228 · see citing works
bax Deficiency Prevents the Increased Cell Death of Immature Neurons in bcl-x -Deficient Mice
Shindler, K. S., Latham, C. B., & Roth, K. A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03112.1997 · Cited by 177 · see citing works
Nilsen, J., Mor, G., & Naftolin, F. N. (2000) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(200004)43:1 · Cited by 143 · see citing works
Fannjiang, Y., Kim, C., Huganir, R. L., et al. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00091-1 · Cited by 120 · see citing works
BCL-2 family members in the development and degenerative pathologies of the nervous system
Sadoul, R. (1998) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400438 · Cited by 96 · see citing works
The proapoptotic proteins Bax and Bak are not involved in Wallerian degeneration
Whitmore, A. V., Lindsten, T., RAFF, M. C., & Thompson, C. B. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401147 · Cited by 82 · see citing works
Self-citationThe role of Bax in glutamate‐induced nerve cell death
Dargusch, R., Piasecki, D. P., Tan, S., et al. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00035.x · Cited by 43 · see citing works
Kendler, A., & Golden, J. A. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199612000-00009 · Cited by 31 · see citing works
Self-citationHeuer, G. G., Skorupa, A. F., Alur, R., Jiang, K., & Wolfe, J. H. N. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0917 · Cited by 20 · see citing works
β‐amyloid binds to p75NTR and activates NFκB in human neuroblastoma cells
Kuner, P., Schubenel, R., & Hertel, C. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19981215)54:6 · Cited by 1 · see citing works
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- Authors
- Lindsten, T., Golden, J. A., Zong, W.-X., Minarcik, J., Harris, M. H., & Thompson, C. B.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-12-03
- Volume
- 23
- Issue
- 35
- Pages
- 11112-11119
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6741039
- OpenAlex
- W1953301620
- Cited by
- 107
- References
- 27
- Citations by year
- 2025: 1 · 2024: 3 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2017: 3 · 2016: 7 · 2015: 5 · 2014: 2 · 2013: 3 · 2012: 10
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research Institute
- National Institutes of Health (HD 26979)
- Directorate for Biological Sciences
- National Cancer Institute
- National Institute of Child Health and Human Development (HD26979)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD026979, HD 26979)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Bax, Bak, Bcl-2 family proteins, apoptosis, neural stem cells, neural progenitor cells, excitotoxicity, neuronal cell death, glial differentiation, brain development
- MeSH terms
- Animals, Antigens, Differentiation, Cell Count, Cell Division, Cells, Cultured, Cerebellum, Flow Cytometry, Membrane Proteins, Neurons, Proto-Oncogene Proteins, Stem Cells, Apoptosis, Mice, Knockout, Proto-Oncogene Proteins c-bcl-2, Lateral Ventricles, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein, Mice
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