The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Role of Fabp7 , a Downstream Gene of Pax6, in the Maintenance of Neuroepithelial Cells during Early Embryonic Development of the Rat Cortex
Open accessAbstract
Pax6 is a transcription factor with key functional roles in the developing brain. Pax6 promotes neuronal differentiation via transcriptional regulation of the Neurogenin2 ( Ngn2 ) gene, although Pax6 expression appears in proliferating neuroepithelial cells before the onset of neurogenesis. Here, we identified Fabp7 ( BLBP/B-FABP ), a member of the fatty acid-binding protein (FABP) family, as a downregulated gene in the embryonic brain of Pax6 mutant rat ( rSey 2 /rSey 2 ) by microarray analysis. Marked reduction of Fabp7 expression was confirmed by quantitative PCR. Spatiotemporal expression patterns of Fabp7 in the wild-type rat embryos from embryonic day 10.5 (E10.5) to E14.5 were similar to those of Pax6 , and expression of Fabp7 was undetectable in the rSey 2 /rSey 2 cortex. The expression pattern of Fabp7 in the wild-type mouse embryo at E10.5 (corresponding to E12.5 rat) was different from that in the rat embryo, and no change of expression was observed in the Sey/Sey mouse embryo. Overexpression of exogenous Pax6 mainly induced ectopic expression of Fabp7 , rather than of Ngn2 , in the early cortical primordium. Interestingly, knocking-down FABP7 function by electroporation of Fabp7 small interfering RNA severely curtailed cell proliferation but promoted neuronal differentiation. We conclude that Fabp7 is a downstream gene of Pax6 transcription factor in the developing rat cortex and essential for maintenance of neuroepithelial cells during early cortical development.
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Englund, C., Fink, A., Lau, C., Pham, D., Daza, R. A. M., Bulfone, A., Kowalczyk, T., & Hevner, R. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2899-04.2005 · Cited by 1,261
The Wnt/β-catenin pathway directs neuronal differentiation of cortical neural precursor cells
Hirabayashi, Y., Itoh, Y., Tabata, H., Nakajima, K., Akiyama, T., Masuyama, N., & Gotoh, Y. (2004) · Development · doi:10.1242/dev.01165 · Cited by 600
Calegari, F., Haubensak, W., Haffner, C., & Huttner, W. B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0778-05.2005 · Cited by 396
Cited by
Taverna, E., Götz, M., & Huttner, W. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155801 · Cited by 759
Molecular characterization of retinal stem cells and their niches in adult zebrafish
Raymond, P. A., Barthel, L. K., Bernardos, R. L., & Perkowski, J. J. (2006) · BMC Developmental Biology · doi:10.1186/1471-213x-6-36 · Cited by 504
Osumi, N., Shinohara, H., Numayama-Tsuruta, K., & Maekawa, M. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0884 · Cited by 344
Self-citationPankratz, M. T., Li, X.-J., LaVaute, T. M., Lyons, E. A., Chen, X., & Zhang, S.-C. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0707 · Cited by 317
Radial glial cell heterogeneity—The source of diverse progeny in the CNS
PINTO, L., & GOTZ, M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.02.010 · Cited by 260
Metadata
- Authors
- Arai, Y., Funatsu, N., Numayama-Tsuruta, K., Nomura, T., Nakamura, S., & Osumi, N.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-10-19
- Volume
- 25
- Issue
- 42
- Pages
- 9752-9761
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2035040472
- Cited by
- 174
- References
- 3
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Arai, Y., Funatsu, N., Numayama-Tsuruta, K., Nomura, T., Nakamura, S., & Osumi, N. (2005). Role of Fabp7 , a Downstream Gene of Pax6, in the Maintenance of Neuroepithelial Cells during Early Embryonic Development of the Rat Cortex. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2512-05.2005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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