Control over Stress, But Not Stress Per Se Increases Prefrontal Cortical Pyramidal Neuron Excitability
Open accessAbstract
Behavioral control over a stressful event reduces the negative consequences of not only that event, but also future stressful events. Plasticity in the prelimbic (PL) medial prefrontal cortex is critical to this process, but the nature of the changes induced is unknown. We used patch-clamp recording to measure the intrinsic excitability of PL pyramidal neurons in acute slices from rats exposed to either escapable stress (ES), for which rats had behavioral control over tail-shock termination, or inescapable stress (IS) without control. Shortly after exposure (2 h) to tail-shock stress, neurons in the ES group had larger action potential (AP) amplitude and faster AP rise rate, larger postspike afterdepolarization, and reduced membrane time constant. No significant effects of IS were observed. We developed a conductance-based computer model using the simulation tool NEURON. The computer model simulated the observed changes in the ES group with increases in Na+conductance (g Na) and T-type Ca 2+conductance (g Ca T). The empirical and computational results indicate that behavioral control over stress, but not stress itself, increases PL pyramidal neuron excitability by increasing intrinsic membrane excitability. It is proposed that plasticity of excitability is important to the behavioral effects of controllable stressor exposure.
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Direct electrophysiological measurement indicates escapable shock but not inescapable shock increases excitability of projecting prelimbic neurons.
“Direct electrophysiological measurement of projecting prelimbic neurons indicates that escapable shock, but not inescapable shock increases their excitability (Varela, Wang, Christianson, Maier, & Cooper, 2012).”
From Learned helplessness at fifty: Insights from neuroscience. (2016) · cites this paper as Varela, Wang, Christianson, Maier, & Cooper, 2012
V1a receptor binding is not evident in adult male rat insula.
“V1a receptor binding is not evident in adult male rat insula61.”
From Insular cortex mediates approach and avoidance responses to social affective stimuli (2018) · cites this paper as [61]
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- Authors
- Varela, J. A., Wang, J., Christianson, J. P., Maier, S. F., & Cooper, D. C.
- Affiliations
- University of Colorado Boulder (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-09-12
- Volume
- 32
- Issue
- 37
- Pages
- 12848-12853
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3732060
- OpenAlex
- W2064336860
- Cited by
- 56
- References
- 20
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 9
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (K99MH093412, MH050479, R00MH093412, MH093412, R37MH050479, R01MH050479)
- National Institute on Drug Abuse (DA024040, R01DA024040, K01DA017750)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- inescapable stress, action potential amplitude, afterdepolarizations, membrane time constant, sodium conductance, conductance-based neuron model, stress-induced plasticity
- MeSH terms
- Action Potentials, Adaptation, Psychological, Animals, Escape Reaction, Male, Stress, Psychological, Rats, Sprague-Dawley, Prefrontal Cortex, Pyramidal Cells, Rats
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