Role of the ventral medial prefrontal cortex in mediating behavioral control-induced reduction of later conditioned fear
Open accessAbstract
A prior experience of behavioral control over a stressor interferes with subsequent Pavlovian fear conditioning, and this effect is dependent on the activation of the ventral medial prefrontal cortex (mPFCv) at the time of the initial experience with control. It is unknown whether mPFCv activity is necessary during fear learning and/or testing for this interference to occur. One week following controllable stress, the infralimbic cortex (IL) was temporarily inactivated either before fear learning or later testing. Inactivation of the IL before the test for conditioned fear, but not before conditioning, blocked the fear reducing effects of prior controllable stress. This suggests that the experience with control interferes with the expression of fear behavior and not the learning of the association, and that the mPFCv is needed to regulate conditioned fear behavior.
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Effects of prior control on fear conditioning depend on vmPFC.
“Moreover, these effects of prior control depended on the ventromedial prefrontal cortex (Baratta, Lucero, Amat, Watkins, & Maier, 2008)”
From Learned helplessness at fifty: Insights from neuroscience. (2016) · cites this paper as Baratta, Lucero, Amat, Watkins, & Maier, 2008
Previous history with escapable shock results in a lasting reduction of the conditioned response, and this effect is eliminated with IL inactivation.
“Mirroring these findings, studies have shown that previous history with escapable shock results in a lasting reduction of the conditioned response, and this effect is eliminated with IL inactivation [113].”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [113]
vmPFC inactivation abolishes all these benefits of control without affecting the learning of escape responses per se.
“vmPFC inactivation abolishes all these benefits of control without affecting the learning of escape responses per se.”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [41]
Control over shock speeds subsequent escape learning, slows subsequent fear conditioning, reduces threat-related serotonin responses in the dorsal raphe to novel contexts, and buffers animals against later adverse effects of inescapable shock.
“Control speeds subsequent escape learning [40] and slows subsequent fear conditioning [41], reduces threat-related serotonin responses in the dorsal raphe to novel contexts [40], and buffers the animals against later adverse effects of inescapable shock [42].”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [41]
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- Authors
- Baratta, M. V., Lucero, T. R., Amat, J., Watkins, L. R., & Maier, S. F.
- Affiliations
- University of Colorado Boulder (US)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-01-29
- Volume
- 15
- Issue
- 2
- Pages
- 84-87
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC12599004
- OpenAlex
- W2097388044
- Cited by
- 58
- References
- 24
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 4
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institute of Mental Health (F31MH075213, R01MH050479)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- ventromedial prefrontal cortex, infralimbic cortex, fear conditioning, behavioral control, fear expression, fear learning, neural inactivation
- MeSH terms
- Acoustic Stimulation, Animals, Behavior, Animal, Conditioning, Classical, Cues, Electroshock, Fear, Limbic System, Male, Stress, Physiological, Rats, Sprague-Dawley, Prefrontal Cortex, Rats
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