Optogenetic stimulation of prefrontal glutamatergic neurons enhances recognition memory
Open accessAbstract
UNLABELLED: Finding effective cognitive enhancers is a major health challenge; however, modulating glutamatergic neurotransmission has the potential to enhance performance in recognition memory tasks. Previous studies using glutamate receptor antagonists have revealed that the medial prefrontal cortex (mPFC) plays a central role in associative recognition memory. The present study investigates short-term recognition memory using optogenetics to target glutamatergic neurons within the rodent mPFC specifically. Selective stimulation of glutamatergic neurons during the online maintenance of information enhanced associative recognition memory in normal animals. This cognitive enhancing effect was replicated by local infusions of the AMPAkine CX516, but not CX546, which differ in their effects on EPSPs. This suggests that enhancing the amplitude, but not the duration, of excitatory synaptic currents improves memory performance. Increasing glutamate release through infusions of the mGluR7 presynaptic receptor antagonist MMPIP had no effect on performance. SIGNIFICANCE STATEMENT: These results provide new mechanistic information that could guide the targeting of future cognitive enhancers. Our work suggests that improved associative-recognition memory can be achieved by enhancing endogenous glutamatergic neuronal activity selectively using an optogenetic approach. We build on these observations to recapitulate this effect using drug treatments that enhance the amplitude of EPSPs; however, drugs that alter the duration of the EPSP or increase glutamate release lack efficacy. This suggests that both neural and temporal specificity are needed to achieve cognitive enhancement.
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Optogenetic stimulation of mPFC glutamatergic neurons does not affect memory for NOP and OPP, but facilitates OiP memory.
“Optogenetic stimulation of the mPFC glutamatergic neurons did not affect memory for NOP and OPP, but facilitated OiP memory, which is involved in object association information by switching inter-object locations (Benn et al., 2016).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Benn et al., 2016
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Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,831 · see citing works
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
Neurodegenerative Disorders: Parkinson's Disease and Huntington's Disease
Hague, S., Klaffke, S., & Bandmann, O. (2006) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781860948961_0007 · Cited by 2,767 · see citing works
Aravanis, A. M., Wang, L., Zhang, F., Meltzer, L. A., Mogri, M., Schneider, M. B., & Deisseroth, K. A. (2007) · Journal of Neural Engineering · doi:10.1088/1741-2560/4/3/s02 · Cited by 960 · see citing works
When Is the Hippocampus Involved in Recognition Memory?
Barker, G. R. I., & Warburton, E. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6413-10.2011 · Cited by 818 · see citing works
D1 receptors in prefrontal cells and circuits
Goldman-Rakic, P. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00045-4 · Cited by 807 · see citing works
Barker, G. R. I., Bird, F., Alexander, V., & Warburton, E. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5289-06.2007 · Cited by 691 · see citing works
Channelrhodopsin-2 and optical control of excitable cells
Zhang, F., Wang, L., Boyden, E. S., & Deisseroth, K. A. (2006) · Nature Methods · doi:10.1038/nmeth936 · Cited by 683 · see citing works
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex
Covington, H. E., Lobo, M. K., Maze, I., Vialou, V., Hyman, J. M., Zaman, S., LaPlant, Q., Mouzon, E., Ghose, S., Tamminga, C. A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-10.2010 · Cited by 621 · see citing works
Winters, B. D., Forwood, S., Cowell, R. A., Saksida, L. M., & Bussey, T. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1346-04.2004 · Cited by 588 · see citing works
Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K. A., Tsai, L., & Moore, C. I. (2010) · Nature Protocols · doi:10.1038/nprot.2009.228 · Cited by 542 · see citing works
Jung, M. W., Qin, Y. F., McNaughton, B. L., & Barnes, C. A. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.5.437 · Cited by 306 · see citing works
Optogenetic tools for analyzing the neural circuits of behavior
Bernstein, J. G., & Boyden, E. S. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.10.003 · Cited by 269 · see citing works
ANOVA for the Behavioral Sciences Researcher
Cardinal, R. N., & Aitken, M. R. F. (2013) · Psychology Press eBooks · doi:10.4324/9780203763933 · Cited by 249 · see citing works
Hannesson, D. K., Howland, J. G., & Phillips, A. G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5517-03.2004 · Cited by 231 · see citing works
Behavioural pharmacology: 40+ years of progress, with a focus on glutamate receptors and cognition
Robbins, T., & Murphy, E. R. (2006) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.01.009 · Cited by 198 · see citing works
Stress-induced activation of nitric oxide-producing neurons in the rat brain
Krukoff, T. L., & Khalili, P. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970127)377:4 · Cited by 167 · see citing works
Christie, I. N., Wells, J. A., Southern, P., Marina, N., Kasparov, S., Gourine, A. V., & Lythgoe, M. F. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.10.074 · Cited by 136 · see citing works
Suzuki, G., Tsukamoto, N., Fushiki, H., Kawagishi, A., Nakamura, M., Kurihara, H., Mitsuya, M., Ohkubo, M., & Ohta, H. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.124701 · Cited by 132 · see citing works
Modulation of medial prefrontal cortical activity using in vivo recordings and optogenetics
Ji, G., & Neugebauer, V. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-36 · Cited by 130 · see citing works
Barker, G. R. I., & Warburton, E. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4447-07.2008 · Cited by 118 · see citing works
Hampson, R. E., Rogers, G. A., LYNCH, G. S., & Deadwyler, S. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02748.1998 · Cited by 117 · see citing works
Pirot, S., Jay, T. M., Glowinski, J., & Thierry, A. M. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00621.x · Cited by 116 · see citing works
Benzamide-Type AMPA Receptor Modulators Form Two Subfamilies with Distinct Modes of Action
Arai, A., Xia, Y., Rogers, G. A., LYNCH, G. S., & Kessler, M. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.040360 · Cited by 113 · see citing works
Cross, L., Brown, M. W., Aggleton, J. P., & Warburton, E. C. (2013) · Learning & Memory · doi:10.1101/lm.028266.112 · Cited by 106 · see citing works
GABAC Receptors as Drug Targets
Johnston, G. A. R., Chebib, M., Hanrahan, J. R., & Mewett, K. N. (2003) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007033482805 · Cited by 89 · see citing works
Jy, C., Chen, L., Luo, F., L.-H., S., & Woodward, D. J. (2002) · Experimental Brain Research · doi:10.1007/s00221-001-0918-3 · Cited by 78 · see citing works
Audet, M. A., Doucet, G., Oleskevich, S., & Descarries, L. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902740302 · Cited by 77 · see citing works
Hampson, R. E., España, R. A., Rogers, G. A., Porrino, L. J., & Deadwyler, S. A. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1360-z · Cited by 54 · see citing works
Damgaard, T. D., Larsen, D. B., Hansen, S. L., Grayson, B., Neill, J. C., & Plath, N. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.09.048 · Cited by 47 · see citing works
Benn, A., & Robinson, E. S. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115374 · Cited by 44 · see citing works
A profile of the behavioral changes produced by facilitation of AMPA-type glutamate receptors
Davis, C. M., Moskovitz, B., Nguyen, M. A., Tran, M. B., Arai, A., LYNCH, G. S., & Granger, R. (1997) · Psychopharmacology · doi:10.1007/s002130050386 · Cited by 39 · see citing works
AMPA receptor modulators have different impact on hippocampal pyramidal cells and interneurons
Xia, Y.-F., & Arai, A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.031 · Cited by 17 · see citing works
du Plessis, I., Mitchell, D., Niesler, C. U., & Laburn, H. P. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.062 · Cited by 12 · see citing works
Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse
Van Pett, K., Viau, V., Bittencourt, J. C., Chan, R. K. W., Li, H.-Y., Arias, C., Prins, G. S., Perrin, M., Vale, W., & Sawchenko, P. E. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001211)428:2
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Chao, O. Y.-H., Nikolaus, S., Yang, Y., & Huston, J. P. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104855 · Cited by 157 · see citing works
Sampath, D., Sathyanesan, M., & Newton, S. S. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s136122 · Cited by 139 · see citing works
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Miyamoto, H., Shimohata, A., Abe, M., Abe, T., Mazaki, E., Amano, K., Suzuki, T., Tatsukawa, T., Itohara, S., Sakimura, K., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx379 · Cited by 35 · see citing works
Villaruel, F. R., Lacroix, F., Sanio, C., Sparks, D. W., Chapman, C. A., & Chaudhri, N. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx275 · Cited by 36 · see citing works
Kim, S., Nam, Y., Jeong, Y.-O., Park, H. H., Lee, S.-K., Shin, S. J., Jung, H., Kim, B., Hong, S. B., Park, Y., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163992 · Cited by 29 · see citing works
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Landin, J. D., Palac, M., Carter, J. M., Dzumaga, Y., Santerre, J. L., Fernandez, G. M., Savage, L. M., Varlinskaya, E. I., SPEAR, L. P., Moore, S. D., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.022 · Cited by 23 · see citing works
Papp, M., Gruca, P., Łasoń, M., Litwa, E., Solecki, W., & Willner, P. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120967857 · Cited by 21 · see citing works
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Wu, Z., Kavanova, M., Hickman, L., Lin, F., Boschin, E., Galeazzi, J. M., Verhagen, L., & Buckley, M. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.16.909812
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Saleh, A. Y., Saputra, D. A. Y., Valentina, R., & Susanto, T. D. (2025) · F1000Research · doi:10.12688/f1000research.160416.1 · Cited by 1 · see citing works
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- Authors
- Benn, A., Barker, G. R. I., Stuart, S. A., Roloff, E. V. L., Teschemacher, A. G., Warburton, E. C., & Robinson, E. S. J.
- Affiliations
- University of Bristol (GB)
- Corresponding author
- Benn, Abigail
- Robinson, Emma S. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2016-05-04
- Volume
- 36
- Issue
- 18
- Pages
- 4930-4939
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4854963
- OpenAlex
- W2345524922
- Cited by
- 42
- References
- 35
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 1
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Explore Bristol Research (submittedVersion, cc-by)
- Funders
- Wellcome Trust (084621/Z/08/Z)
- Research Councils UK
- Biotechnology and Biological Sciences Research Council (BB/I00310X/1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- optogenetic stimulation, medial prefrontal cortex, glutamatergic neurons, recognition memory, associative memory, cognitive enhancement, AMPA receptor agonists, excitatory postsynaptic potentials, mGluR7, glutamate release, synaptic transmission
- MeSH terms
- Animals, Dioxoles, Glutamates, Male, Memory, Memory, Short-Term, Neurons, Piperidines, Psychomotor Performance, Pyridones, Proto-Oncogene Proteins c-fos, Prefrontal Cortex, Receptors, Metabotropic Glutamate, Excitatory Postsynaptic Potentials, Recognition, Psychology, Rats, Optogenetics
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