The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Reelin Regulates Neuronal Progenitor Migration in Intact and Epileptic Hippocampus
Open accessAbstract
Dentate granule cell (DGC) neurogenesis persists throughout life in the mammalian hippocampal dentate gyrus and increases after epileptogenic insults. The DGC layer in human and experimental mesial temporal lobe epilepsy (mTLE) often shows abnormal dispersion and the appearance of hilar-ectopic DGCs. In the pilocarpine mTLE model, hilar-ectopic DGCs arise as a result of an aberrant chain migration of neural progenitors. Reelin is a secreted migration guidance cue that persists in the adult rodent and human hippocampus. We tested the hypothesis that loss of Reelin in the epileptic dentate gyrus leads to aberrant chain migration of DGC precursors. We found that interneuron subsets typically lost in human and experimental mTLE express Reelin, and DGC progenitors express the downstream Reelin signaling molecule Disabled 1 (Dab1). Prolonged seizures decreased Reelin immunoreactivity in the adult rat dentate gyrus and increased Dab1 expression in hilar-ectopic neuroblasts. Exogenous Reelin increased detachment of chain-migrating neuroblasts in dentate gyrus explants, and blockade of Reelin signaling increased chain migration. These findings suggest that Reelin modulates DGC progenitor migration to maintain normal DGC integration in the neonatal and adult mammalian dentate gyrus. Loss of Reelin expression in the epileptic adult hippocampus, moreover, likely contributes to ectopic chain migration and aberrant integration of newborn DGCs.
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Cites
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
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“…upregulated subgranular zone (SGZ) cell proliferation or DGC neurogenesis (Bengzon et al., 1997; Parent et al., 1997, 1998; Gray and Sundstrom, 1998; Scott et al., 1998; Nakagawa et al., 2000; Hattiangady et al., 2004; Mohapel et al., 2004; Jessberger et al., 2005; Overstreet-Wadiche et al., 2006).”
BackgroundReelin Is a Ligand for Lipoprotein Receptors
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“Reelin binds to the apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) expressed on neurons or radial glia (D’Arcangelo et al., 1999; Hiesberger et al., 1999; Trommsdorff et al., 1999; Luque et al., 2003).”
BackgroundRole of the Reelin Signaling Pathway in Central Nervous System Development
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Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice
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Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway
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Seizures accelerate functional integration of adult-generated granule cells
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Cited by
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
The role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719
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Signaling in Adult Neurogenesis
Suh, H., Deng, W., & Gage, F. H. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113256 · Cited by 375
Metadata
- Authors
- Gong, C., Wang, T.-W., Huang, H. S., & Parent, J. M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-02-21
- Volume
- 27
- Issue
- 8
- Pages
- 1803-1811
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1980349152
- Cited by
- 233
- References
- 11
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gong, C., Wang, T.-W., Huang, H. S., & Parent, J. M. (2007). Reelin Regulates Neuronal Progenitor Migration in Intact and Epileptic Hippocampus. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.3111-06.2007
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