Cell Adhesion Molecules in Synapse Formation: Figure 1.
Open accessAbstract
Neuronal transmission relies on signals transmitted through a vast array of excitatory and inhibitory neuronal synaptic connections. How do axons communicate with dendrites to build synapses, and what molecules regulate this interaction? There is a wealth of evidence suggesting that cell adhesion molecules (CAMs) provide much of the information required for synapse formation. This review highlights the molecular mechanisms used by CAMs to regulate presynaptic and postsynaptic differentiation.
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How different cell adhesion molecules differentially modulate synaptic specificity and whether all of them act in concert to produce a variety of synaptic connections and strengths needs further investigation.
“Furthermore, how different cell adhesion molecules differentially modulate synaptic specificity and whether all of them act in concert to produce a variety of synaptic connections and strengths needs further investigation [1,89].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [89]
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Yamagata, M., Sanes, J. R., & Weiner, J. A. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00107-8 · Cited by 374 · see citing works
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- Dityatev A, Dityateva G, Sytnyk V, Delling M, Toni N, Nikonenko I, Muller D, Schachner M (2004) Polysialylated neural cell adhesion molecule PSA- NCAM promotes formation and remodeling of hippocampal synapses. J Neurosci, in press.
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Molecular Physiology of the Neuronal Synapse
Ramírez-Expósito, M. J., Cueto-Ureña, C., & Martínez-Martos, J. M. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48010088 · Cited by 6 · see citing works
“Furthermore, how different cell adhesion molecules differentially modulate synaptic specificity and whether all of them act in concert to produce a variety of synaptic connections and strengths needs further investigation [1,89].”
- Authors
- Washbourne, P., Dityatev, A., Scheiffele, P., Biederer, T., Weiner, J. A., Christopherson, K. S., & El-Husseini, A.
- Affiliations
- University of Oregon (US)
- Universität Hamburg (DE)
- Columbia University (US)
- Yale University (US)
- University of Iowa (US)
- University of British Columbia (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-10-20
- Volume
- 24
- Issue
- 42
- Pages
- 9244-9249
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6730099
- OpenAlex
- W2013027206
- Cited by
- 191
- References
- 1
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 9 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 9 · 2014: 9 · 2013: 8 · 2012: 14
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- adhesion molecules, synaptogenesis, presynaptic differentiation, postsynaptic differentiation, neural transmission, synaptic connectivity
- MeSH terms
- Animals, Axons, Dendrites, Humans, Synapses, Cell Adhesion Molecules
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