C-Phycocyanin and Phycocyanobilin as Remyelination Therapies for Enhancing Recovery in Multiple Sclerosis and Ischemic Stroke: A Preclinical Perspective
Open accessAbstract
Myelin loss has a crucial impact on behavior disabilities associated to Multiple Sclerosis (MS) and Ischemic Stroke (IS). Although several MS therapies are approved, none of them promote remyelination in patients, limiting their ability for chronic recovery. With no available therapeutic options, enhanced demyelination in stroke survivors is correlated with a poorer behavioral recovery. Here, we show the experimental findings of our group and others supporting the remyelinating effects of C-Phycocyanin (C-PC), the main biliprotein of Spirulina platensis and its linked tetrapyrrole Phycocyanobilin (PCB), in models of these illnesses. C-PC promoted white matter regeneration in rats and mice affected by experimental autoimmune encephalomyelitis. Electron microscopy analysis in cerebral cortex from ischemic rats revealed a potent remyelinating action of PCB treatment after stroke. Among others biological processes, we discussed the role of regulatory T cell induction, the control of oxidative stress and pro-inflammatory mediators, gene expression modulation and COX-2 inhibition as potential mechanisms involved in the C-PC and PCB effects on the recruitment, differentiation and maturation of oligodendrocyte precursor cells in demyelinated lesions. The assembled evidence supports the implementation of clinical trials to demonstrate the recovery effects of C-PC and PCB in these diseases.
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Astrocyte-derived BDNF supports OPC maturation under hypoxic conditions in vitro and oligodendrogenesis after white matter damage in vivo.
“It was seen that astrocyte-derived BDNF supports OPC maturation under hypoxic conditions in vitro and oligodendrogenesis after white matter damage in vivo, also indicating a positive role of C-PC in myelin regeneration [101].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [101]
C-PC has a positive role in myelin regeneration.
“also indicating a positive role of C-PC in myelin regeneration [101].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [101]
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Marín‐Prida, J., Pentón‐Rol, G., Rodrigues, F. P., Alberici, L. C., Padovani, K. S., Leopoldino, A. M., Naal, Z., Polizello, A. C. M., Llopiz, A., Rosa, M. N., et al. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.08.011 · Cited by 48 · see citing works
Self-citationZhou, J., Zhuang, J., Li, J., Ooi, E., Bloom, J., Poon, C., Lax, D. N., Rosenbaum, D. M., & Barone, F. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057503 · Cited by 46 · see citing works
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Pentón-Rol, G., Lagumersindez-Denis, N., Muzio, L., Bergami, A., Furlan, R., Fernández-Massó, J. R., Nazabal-Galvez, M., Llópiz-Arzuaga, A., Herrera-Rolo, T., Veliz-Rodriguez, T., et al. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9642-9 · Cited by 36 · see citing works
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Functional Expression of Electron Transport Chain and FoF1-ATP Synthase in Optic Nerve Myelin Sheath
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Involvement of nitric oxide on kainate-induced toxicity in oligodendrocyte precursors
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Westad, A., Venugopal, A., & Snyder, E. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.107 · Cited by 15 · see citing works
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Setting new standards in multiple sclerosis care and research
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Flagged first, then by citations
Research works printed but not linked: 1
- [97]Marín-Prida J. Neuroprotective Effects and Molecular Mechanisms Associated to C-Phycocyanin and Phycocyanobilin in Experimental Models of Cerebral Ischemia Ph.D. Thesis University of Medical Sciences of Havana Havana, Cuba 2015 Open Access Repository of Ph.D. Thesis of the Virtual Library of Health, Cuba Available online: http://tesis.repo.sld.cu/901/ (accessed on 12 May 2015) (In Spanish)
Cited by
Sorted by citations
Beneficial Effects of Spirulina Consumption on Brain Health
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Phycocyanobilin reduces brain injury after endothelin-1- induced focal cerebral ischaemia
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Retracted
- Authors
- Pentón-Rol, G., Marín-Prida, J., & Falcón-Cama, V.
- Affiliations
- Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/158 y 190, Cubanacan, P.O. Box 6162, Playa, Havana 10600, Cuba
- Center for Research and Biological Evaluations (CEIEB), Institute of Pharmacy and Food, University of Havana, Ave. 23 e/214 y 222, La Lisa, PO Box 430, Havana 13600, Cuba
- Venue
- Behavioral Sciences
- Publisher
- MDPI AG
- Published
- 2018-01-18
- Volume
- 8
- Issue
- 1
- Pages
- 15
- ISSN
- 2076-328X (ISSN-L)
- PMC
- PMC5791033
- OpenAlex
- W2789995443
- Cited by
- 50
- References
- 108
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 3 · 2018: 2
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Behavioral Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- C-phycocyanin, phycocyanobilin, remyelination, multiple sclerosis, ischemic stroke, demyelination, experimental autoimmune encephalomyelitis, oligodendrocyte precursor cells, regulatory T cells, oxidative stress, pro-inflammatory mediators, COX-2 inhibition, Spirulina platensis, tetrapyrroles, functional recovery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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