Impaired Attention and Synaptic Senescence of the Prefrontal Cortex Involves Redox Regulation of NMDA Receptors

The Rat Brain in Stereotaxic Coordinates

Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works

AChE-stained horizontal sections of the rat brain in stereotaxic coordinates

Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793 · see citing works

Medial Frontal Cortex Mediates Perceptual Attentional Set Shifting in the Rat

Birrell, J. M., & Brown, V. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04320.2000 · Cited by 1,421 · see citing works

The ageing cortical synapse: hallmarks and implications for cognitive decline

Morrison, J. H., & Baxter, M. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3200 · Cited by 965 · see citing works

Top-down suppression deficit underlies working memory impairment in normal aging

Gazzaley, A., Cooney, J. W., Rissman, J., & D'Esposito, M. (2005) · Nature Neuroscience · doi:10.1038/nn1543 · Cited by 934 · see citing works

Do thin spines learn to be mushroom spines that remember?

Bourne, J., & Harris, K. M. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.009 · Cited by 843 · see citing works

Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal

Carli, M., Robbins, T. W., Evenden, J. L., & Everitt, B. J. (1983) · Behavioural Brain Research · doi:10.1016/0166-4328(83)90138-9 · Cited by 736 · see citing works

A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: Implications for theories of executive functioning and cognitive aging

Robbins, T. W., James-Galton, M., Owen, A. M., Sahakian, B. J., Lawrence, A. D., McInnes, L., & Rabbitt, P. (1998) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617798455073 · Cited by 607 · see citing works

Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses

Arnsten, A. F. T., Wang, M. J., & Paspalas, C. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.038 · Cited by 538 · see citing works

Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity

Chudasama, Y., Passetti, F., Rhodes, S. E. V., Lopian, D., Desai, A., & Robbins, T. W. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.020 · Cited by 518 · see citing works

The Cerebral Cortex of the Rat and Visual Attentional Function: Dissociable Effects of Mediofrontal, Cingulate, Anterior Dorsolateral, and Parietal Cortex Lesions on a Five-Choice Serial Reaction Time Task

Muir, J. L., Everitt, B. J., & Robbins, T. W. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.3.470 · Cited by 503 · see citing works

NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex

Wang, M., Yang, Y., Wang, C.-J., Gamo, N. J., Jin, L. E., Mazer, J. A., Morrison, J. H., Wang, X.-J., & Arnsten, A. F. T. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.032 · Cited by 489 · see citing works

NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex

Jackson, M. E., Homayoun, H., & Moghaddam, B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308455101 · Cited by 430 · see citing works

Time-Dependent Relationship between the Dorsal Hippocampus and the Prefrontal Cortex in Spatial Memory

Lee, I., & Kesner, R. P. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01517.2003 · Cited by 287 · see citing works

Distinct Changes in Cortical Acetylcholine and Noradrenaline Efflux during Contingent and Noncontingent Performance of a Visual Attentional Task

Dalley, J. W., McGaughy, J., O'Connell, M. T., Cardinal, R. N., Levita, L., & Robbins, T. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04908.2001 · Cited by 277 · see citing works

NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia

Snyder, M. A., & Gao, W. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00031 · Cited by 237 · see citing works

Multiple Forms of Short-Term Plasticity at Excitatory Synapses in Rat Medial Prefrontal Cortex

Hempel, C. M., Hartman, K. H., Wang, X.-J., Turrigiano, G. G., & Nelson, S. B. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.5.3031 · Cited by 229 · see citing works

Effects of increased processing demands on age differences in working memory.

Babcock, R. L., & Salthouse, T. A. (1990) · Psychology and Aging · doi:10.1037//0882-7974.5.3.421 · Cited by 224 · see citing works

The Frontal Cortex of the Rat and Visual Attentional Performance: Dissociable Functions of Distinct Medial Prefrontal Subregions

Passetti, F. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.12.1254 · Cited by 223 · see citing works

Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex

Bloss, E. B., Janssen, W. G., Ohm, D. T., Yuk, F. J., Wadsworth, S., Saardi, K. M., McEwen, B. S., & Morrison, J. H. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0839-11.2011 · Cited by 219 · see citing works

Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG–saporin-induced lesions of the medial prefrontal cortex

Dalley, J. W. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh052 · Cited by 191 · see citing works

Impact of aging brain circuits on cognition

Samson, R. D., & Barnes, C. A. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12183 · Cited by 184 · see citing works

Aged Rats Are Impaired on an Attentional Set-Shifting Task Sensitive to Medial Frontal Cortex Damage in Young RatsPreprint

Barense, M. D., Fox, M. T., & Baxter, M. G. (2002) · Learning & Memory · doi:10.1101/lm.48602 · Cited by 183 · see citing works

Characterizing cognitive aging of working memory and executive function in animal models

Bizon, J. L., Foster, T. C., Alexander, G. E., & Glisky, E. L. (2012) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2012.00019 · Cited by 179 · see citing works

Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: Relevance to schizophrenia

Steullet, P., Neijt, H. C., Cuénod, M., & Do, K. Q. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.014 · Cited by 173 · see citing works

Effects of increased processing demands on age differences in working memory.

Babcock, R. L., & Salthouse, T. A. (1990) · Psychology and Aging · doi:10.1037/0882-7974.5.3.421 · Cited by 166 · see citing works

Glutamate receptors in the rat medial prefrontal cortex regulate set-shifting ability

Stefani, M. R., Groth, K., & Moghaddam, B. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.4.728 · Cited by 164 · see citing works

Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity

Foster, T. C. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.01.007 · Cited by 160 · see citing works

Intracellular Redox State Alters NMDA Receptor Response during Aging through Ca²⁺/Calmodulin-Dependent Protein Kinase II

Bodhinathan, K., Kumar, A., & Foster, T. C. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5485-09.2010 · Cited by 153 · see citing works

Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex

Luebke, J. I., Chang, Y., Moore, T. L., & Rosene, D. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.035 · Cited by 142 · see citing works

The modulation of N‐methyl‐D‐aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro.

Tang, L. H., & Aizenman, E. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019678 · Cited by 133 · see citing works

Prefrontal Cortical GABAergic Dysfunction Contributes to Age-Related Working Memory Impairment

Bañuelos, C., Beas, B. S., McQuail, J. A., Gilbert, R. J., Frazier, C. J., Setlow, B., & Bizon, J. L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5192-13.2014 · Cited by 133 · see citing works

Characterizing cognitive aging in humans with links to animal models

Alexander, G. E., Ryan, L., Bowers, D., Foster, T. C., Bizon, J. L., Geldmacher, D., & Glisky, E. L. (2012) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2012.00021 · Cited by 132 · see citing works

Forebrain NR2B Overexpression Facilitating the Prefrontal Cortex Long-Term Potentiation and Enhancing Working Memory Function in Mice

Cui, Y., Jin, J., Zhang, X., Xu, H., Yang, L., Du, D., Zeng, Q., Tsien, J. Z., Yu, H., & Cao, X. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020312 · Cited by 132 · see citing works

The effects of aging on N-methyl-d-aspartate receptor subunits in the synaptic membrane and relationships to long-term spatial memory

Zhao, X., Rosenke, R., Kronemann, D., Brim, B. C., Das, S. R., Dunah, A. W., & Magnusson, K. R. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.018 · Cited by 115 · see citing works

Systemic and Prefrontal Cortical NMDA Receptor Blockade Differentially Affect Discrimination Learning and Set-Shift Ability in Rats.

Stefani, M. R., & Moghaddam, B. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.2.420 · Cited by 106 · see citing works

Distinct forms of short-term plasticity at excitatory synapses of hippocampus and neocortex.

Castro-Alamancos, M., & Connors, B. W. (1997) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.94.8.4161 · Cited by 104 · see citing works

Age-associated impairments in a test of attention: evidence for involvement of cholinergic systems

Jones, D., Barnes, J., Kirkby, D. L., & Higgins, G. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07282.1995 · Cited by 98 · see citing works

[3H]MK-801 binding to the NMDA receptor complex, and its modulation in human frontal cortex during development and aging

Piggott, M. A., Perry, E. K., Perry, R. H., & COURT, J. A. (1992) · Brain Research · doi:10.1016/0006-8993(92)91586-4 · Cited by 97 · see citing works

Attention and memory in aged rats: Impact of lifelong environmental enrichment.

Harati, H., Majchrzak, M., Cosquer, B., Galani, R., Kelche, C., Cassel, J., & Barbelivien, A. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.012 · Cited by 94 · see citing works

Redox Sensitive Calcium Stores Underlie Enhanced After Hyperpolarization of Aged Neurons: Role for Ryanodine Receptor Mediated Calcium Signaling

Bodhinathan, K., Kumar, A., & Foster, T. C. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00577.2010 · Cited by 86 · see citing works

Assessing a vigilance decrement in aged rats: effects of pre-feeding, task manipulation, and psychostimulants

Grottick, A. J., & Higgins, G. A. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1174-3 · Cited by 82 · see citing works

When the mind wanders: Age-related differences between young and older adults

Zavagnin, M., Borella, E., & Béni, R. D. (2013) · Acta Psychologica · doi:10.1016/j.actpsy.2013.10.016 · Cited by 80 · see citing works

In vitro autoradiography of hippocampal excitatory amino acid binding in aged Fischer 344 rats: Relationship to performance on the Morris water maze.

Clark, A. S., Magnusson, K. R., & Cotman, C. W. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.2.324 · Cited by 79 · see citing works

Linking Redox Regulation of NMDAR Synaptic Function to Cognitive Decline during Aging

Kumar, A., & Foster, T. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2176-13.2013 · Cited by 78 · see citing works

Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task

Carli, M., & Invernizzi, R. W. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00058 · Cited by 74 · see citing works

Distinct manifestations of executive dysfunction in aged rats

Beas, B. S., Setlow, B., & Bizon, J. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.019 · Cited by 73 · see citing works

Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning

Dalton, G. L., Ma, L., Phillips, A. G., & Floresco, S. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2246-z · Cited by 71 · see citing works

Glutamate receptor binding in the frontal cortex and dorsal striatum of aged rats with impaired attentional set‐shifting

Nicolle, M. M., & Baxter, M. G. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03077.x · Cited by 71 · see citing works

In vitro autoradiography of hippocampal excitatory amino acid binding in aged Fischer 344 rats: Relationship to performance on the Morris water maze.

Clark, A. S., Magnusson, K. R., & Cotman, C. W. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.324 · Cited by 69 · see citing works

Decline in visual attention and spatial memory in aged rats

Muir, J. L., Fischer, W., & Björklund, A. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00098-6 · Cited by 65 · see citing works

Glutamate receptor subunits expression in memory‐associated brain structures: Regional variations and effects of aging

Liu, P., Smith, P. F., & Darlington, C. L. (2008) · Synapse · doi:10.1002/syn.20563 · Cited by 63 · see citing works

Tonic NMDA receptor-mediated current in prefrontal cortical pyramidal cells and fast-spiking interneurons

Povysheva, N. V., & Johnson, J. W. (2012) · Journal of Neurophysiology · doi:10.1152/jn.01017.2011 · Cited by 62 · see citing works

Changes in the expression of the NR2B subunit during aging in macaque monkeys

Bai, L., Hof, P. R., Standaert, D. G., Xing, Y., Nelson, S. E., Young, A. B., & Magnusson, K. R. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00091-5 · Cited by 59 · see citing works

Age-related decline of functional inhibition in rat cortex

Schmidt, S., Redecker, C., Bruehl, C., & Witte, O. W. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.006 · Cited by 58 · see citing works

Toward modeling age-related changes of attentional abilities in rats: Simple and choice reaction time tasks and vigilance

Moore, H., Dudchenko, P. A., Bruno, J. P., & Sarter, M. F. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90100-c · Cited by 55 · see citing works

Differential Balance of Prefrontal Synaptic Activity in Successful versus Unsuccessful Cognitive Aging

Bories, C., Husson, Z., Guitton, M. J., & Koninck, Y. D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3258-12.2013 · Cited by 53 · see citing works

Investigating sustained attention ability in the elderly by using two different approaches: Inhibiting ongoing behavior versus responding on rare occasions

Staub, B., Doignon‐Camus, N., Bacon, É., & Bonnefond, A. (2014) · Acta Psychologica · doi:10.1016/j.actpsy.2013.12.003 · Cited by 51 · see citing works

Age-Related Changes in [3H]MK-801 Binding in the Fischer 344 Rat Brain

Mitchell, J. J., & Anderson, K. J. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00058-x · Cited by 47 · see citing works

How Nox2-Containing NADPH Oxidase Affects Cortical Circuits in the NMDA Receptor Antagonist Model of Schizophrenia

Wang, X., Pinto-Duarte, A., Sejnowski, T. J., & Behrens, M. M. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4907 · Cited by 46 · see citing works

Role of antioxidant enzymes in redox regulation of N-methyl-D-aspartate receptor function and memory in middle-aged rats

Russell, W. L., Kumar, A., Rani, A., & Foster, T. C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.12.002 · Cited by 36 · see citing works

Influence of Viral Vector–Mediated Delivery of Superoxide Dismutase and Catalase to the Hippocampus on Spatial Learning and Memory During Aging

Russell, W. L., Kumar, A., Rani, A., Herrera, J., Xu, J., Someya, S., & Foster, T. C. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4054 · Cited by 35 · see citing works

Effects of Aging on Paired-Pulse Behavior of Rat Somatosensory Cortical Neurons

David-Jürgens, M., & Dinse, H. R. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp185 · Cited by 35 · see citing works

Variations in excitatory and inhibitory postsynaptic protein content in rat cerebral cortex with respect to aging and cognitive status

Majdi, M., Ribeiro‐da‐Silva, A., & Cuello, A. C. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.034 · Cited by 32 · see citing works

Long-lasting modification of the N-methyl-D-aspartate receptor channel by a voltage-dependent sulfhydryl redox process.

Tang, L. H., & Aizenman, E. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13211-2 · Cited by 31 · see citing works

GABAB receptor-mediated heterosynaptic depression of excitatory synaptic transmission in rat frontal neocortex

Chu, Z., & Hablitz, J. J. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03720-4 · Cited by 22 · see citing works

Interaction of DHPG‐LTD and synaptic‐LTD at senescent CA3‐CA1 hippocampal synapses

Kumar, A., & Foster, T. C. (2014) · Hippocampus · doi:10.1002/hipo.22240 · Cited by 18 · see citing works

Challenges and opportunities for characterizing cognitive aging across species

Roberson, E. D., DeFazio, R. A., Barnes, C. A., Alexander, G. E., Bizon, J. L., Bowers, D., Foster, T. C., Glisky, E. L., Levin, B. E., Ryan, L., et al. (2012) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2012.00006 · Cited by 18 · see citing works

Decrease of immunoreactive catalase protein in specific areas of ageing rat brain

Ciriolo, M. R., Marasco, M. R., Iannone, M., Nisticò, G., & Rotilio, G. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00344-3 · Cited by 17 · see citing works

Age in High-Functioning Healthy Men Is Associated with Nonlinear Decline in Some ‘Executive’ Functions in Late Middle Age

Silver, H., Goodman, C., & Bilker, W. B. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000204916 · Cited by 14 · see citing works

Excitatory amino acid receptors in the prefrontal cortex of aging mice

Migani, P., Magnone, M. C., Rossolini, G., & PIANTANELLI, L. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00146-9 · Cited by 8 · see citing works

Challenges and opportunities in characterizing cognitive aging across species

Foster, T. C. (2012) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2012.00033 · Cited by 6 · see citing works

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis

Hardingham, G. E., & Do, K. Q. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.19 · Cited by 304 · see citing works

NMDA Receptor Function During Senescence: Implication on Cognitive Performance

Kumar, A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00473 · Cited by 121 · see citing works

Redox Signaling in Neurotransmission and Cognition During Aging

Kumar, A., Yegla, B., & Foster, T. C. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7111 · Cited by 104 · see citing works

Central role for NMDA receptors in redox mediated impairment of synaptic function during aging and Alzheimer’s disease

Foster, T. C., Kyritsopoulos, C., & Kumar, A. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.012 · Cited by 92 · see citing works

Early Identification and Intervention of Schizophrenia: Insight From Hypotheses of Glutamate Dysfunction and Oxidative Stress

Lin, C., & Lane, H. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00093 · Cited by 80 · see citing works

NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline

McQuail, J. A., Beas, B. S., Kelly, K. B., Simpson, K. L., Frazier, C. J., Setlow, B., & Bizon, J. L. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2332-16.2016 · Cited by 80 · see citing works

Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia

Esteras, N., Kopach, O., Maiolino, M., Lariccia, V., Amoroso, S., Qamar, S., Wray, S., Rusakov, D. A., Jaganjac, M., & Abramov, A. Y. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12394 · Cited by 68 · see citing works

A HIF1a-Dependent Pro-Oxidant State Disrupts Synaptic Plasticity and Impairs Spatial Memory in Response to Intermittent Hypoxia

Arias‐Cavieres, A., Khuu, M. A., Nwakudu, C. U., Barnard, J. E., Dalgin, G., & Garcia, A. J. (2020) · eNeuro · doi:10.1523/eneuro.0024-20.2020 · Cited by 67 · see citing works

Effect of peripheral cellular senescence on brain aging and cognitive decline

Budamagunta, V., Kumar, A., Rani, A., Bean, L. A., Manohar‐Sindhu, S., Yang, Y., Zhou, D., & Foster, T. C. (2023) · Aging Cell · doi:10.1111/acel.13817 · Cited by 65 · see citing works

Depressive-Like Behaviors Are Regulated by NOX1/NADPH Oxidase by Redox Modification of NMDA Receptor 1

Ibi, M., Liu, J., Arakawa, N., Kitaoka, S., Kawaji, A., Matsuda, K., Iwata, K., Matsumoto, M., Katsuyama, M., Zhu, K., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2988-16.2017 · Cited by 66 · see citing works

Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex

Ianov, L., Rani, A., Beas, B. S., Kumar, A., & Foster, T. C. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00113 · Cited by 54 · see citing works

Cystine/Glutamate Antiporter in Schizophrenia: From Molecular Mechanism to Novel Biomarker and Treatment

Hung, C.-C., Lin, C., & Lane, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189718 · Cited by 52 · see citing works

Redox signaling and metabolism in Alzheimer's disease

Holubiec, M. I., Gellert, M., & Hanschmann, E.-M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1003721 · Cited by 52 · see citing works

Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-β-Induced Neurotoxicity

Huang, Y. Y., Shen, W., Su, J., Cheng, B., Li, D., Liu, G., Zhou, W., & Zhang, Y. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161186 · Cited by 50 · see citing works

Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators

Yao, L., & Zhou, Q. (2017) · Neural Plasticity · doi:10.1155/2017/2875904 · Cited by 48 · see citing works

Increased Plasma Kynurenic Acid Levels are Associated with Impaired Attention/Vigilance and Social Cognition in Patients with Schizophrenia

Huang, X., Ding, W., Wu, F., Zhou, S., Deng, S., & Ning, Y. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s239763 · Cited by 43 · see citing works

The Role of N-Methyl-D-Aspartate Receptor Neurotransmission and Precision Medicine in Behavioral and Psychological Symptoms of Dementia

Lin, C.-H., & Lane, H.-Y. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00540 · Cited by 37 · see citing works

Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging

Kumar, A., Thinschmidt, J. S., & Foster, T. C. (2019) · Aging · doi:10.18632/aging.102108 · Cited by 39 · see citing works

Precision Medicine of Sodium Benzoate for the Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD)

Lin, C., Yang, H.-T., Chen, P.-K., Wang, S., & Lane, H. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s234371 · Cited by 39 · see citing works

Allosteric Modulators of Metabotropic Glutamate Receptors as Novel Therapeutics for Neuropsychiatric Disease

Luessen, D. J., & Conn, P. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000540 · Cited by 33 · see citing works

Regulation of neuronal excitability by reactive oxygen species and calcium signaling: Insights into brain aging

Doser, R. L., & Hoerndli, F. J. (2021) · Current Research in Neurobiology · doi:10.1016/j.crneur.2021.100012 · Cited by 35 · see citing works

Senolytic treatment alleviates doxorubicin‐induced chemobrain

Budamagunta, V., Kumar, A., Rani, A., Sindhu, S. M., Yang, Y., Zhou, D., & Foster, T. C. (2024) · Aging Cell · doi:10.1111/acel.14037 · Cited by 35 · see citing works

Nonsteroidal anti-inflammatory drug, indomethacin improves spatial memory and NMDA receptor function in aged animals

Kumar, A., Rani, A., Scheinert, R. B., Ormerod, B. K., & Foster, T. C. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.06.026 · Cited by 30 · see citing works

Adulthood systemic inflammation accelerates the trajectory of age-related cognitive decline

Barter, J., Kumar, A., Bean, L. A., Ciesla, M. R., & Foster, T. C. (2021) · Aging · doi:10.18632/aging.203588 · Cited by 29 · see citing works

DNA damage and repair in neuropsychiatric disorders. What do we know and what are the future perspectives?

Czarny, P. L., Białek, K. I., Ziółkowska, S., Strycharz, J., & Śliwiński, T. (2019) · Mutagenesis · doi:10.1093/mutage/gez035 · Cited by 30 · see citing works

Effect of Systemic Inflammation on Rat Attentional Function and Neuroinflammation: Possible Protective Role for Food Restriction

Yegla, B., & Foster, T. C. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00296 · Cited by 28 · see citing works

Preclinical Magnetic Resonance Imaging and Spectroscopy Studies of Memory, Aging, and Cognitive Decline

Febo, M., & Foster, T. C. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00158 · Cited by 27 · see citing works

Contribution of N-methyl-D-aspartate receptors to attention and episodic spatial memory during senescence

Guidi, M., Rani, A., Karic, S., Severance, B., Kumar, A., & Foster, T. C. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.07.015 · Cited by 27 · see citing works

Molecular Mechanisms Underlying NMDARs Dysfunction and Their Role in ADHD Pathogenesis

Kuś, J., Saramowicz, K., Czerniawska, M., Wiese, W., Siwecka, N., Rozpędek‐Kamińska, W., Kucharska-Lusina, A., Strzelecki, D., & Majsterek, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612983 · Cited by 26 · see citing works

Effects of β-hydroxy-β-methyl butyrate on working memory and cognitive flexibility in an animal model of aging

Hankosky, E. R., Sherrill, L. K., Ruvola, L. A., Haake, R. M., Kim, T., Hammerslag, L. R., Kougias, D. G., Juraska, J. M., & Gulley, J. M. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2016.1145376 · Cited by 23 · see citing works

Sex-dependent effects of chronic intermittent voluntary alcohol consumption on attentional, not motivational, measures during probabilistic learning and reversal

Aguirre, C. G., Stolyarova, A., Das, K., Kolli, S., Marty, V. N., Ray, L. A., Spigelman, I., & Izquierdo, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234729 · Cited by 22 · see citing works

Superoxide dismutase activity and risk of cognitive decline in older adults: Findings from the Chinese Longitudinal Healthy Longevity Survey

Sun, D., Sun, X., Xu, Y. Y., Wu, T., & Tao, L. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.01.010 · Cited by 21 · see citing works

Age-related deficits in synaptic plasticity rescued by activating PKA or PKC in sensory neurons of Aplysia californica

Kempsell, A. T., & Fieber, L. A. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00173 · Cited by 20 · see citing works

Age-Dependent, Subunit Specific Action of Hydrogen Sulfide on GluN1/2A and GluN1/2B NMDA Receptors

Yakovlev, A. V., Kurmasheva, E. D., Ishchenko, Y., Giniatullin, R. A., & Ситдикова, Г. Ф. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00375 · Cited by 20 · see citing works

Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex

Salman, T., Afroz, R., Nawaz, S., Mahmood, K., Haleem, D. J., & Zarina, S. (2021) · Biochimie · doi:10.1016/j.biochi.2021.08.009 · Cited by 18 · see citing works

Loss of Catecholaminergic Neuromodulation of Persistent Forms of Hippocampal Synaptic Plasticity with Increasing Age

Twarkowski, H., & Manahan‐Vaughan, D. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00030 · Cited by 19 · see citing works

Age-related memory deficits are associated with changes in protein degradation in brain regions critical for trace fear conditioning

Dulka, B. N., Pullins, S. E., Cullen, P. K., Moyer, J. R., & Helmstetter, F. J. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.03.001 · Cited by 19 · see citing works

A comprehensive review on schizophrenia: epidemiology, pathogenesis, diagnosis, conventional treatments, and proposed natural compounds used for management

Anwar, A., Mustafa, A. M., Abdou, K., Rabie, M. A., El‐Shiekh, R. A., & El‐Dessouki, A. M. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04351-0 · Cited by 17 · see citing works

Failure of senolytic treatment to prevent cognitive decline in a female rodent model of aging

Rani, A., Bean, L. A., Budamagunta, V., Kumar, A., & Foster, T. C. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1384554 · Cited by 16 · see citing works

Senescent neurophysiology: Ca2+ signaling from the membrane to the nucleus

Foster, T. C. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107064 · Cited by 16 · see citing works

Left DLPFC activity is associated with plasma kynurenine levels and can predict treatment response to escitalopram in major depressive disorder

Kamishikiryo, T., Okada, G., Itai, E., Masuda, Y., Yokoyama, S., Takamura, M., Fuchikami, M., Yoshino, A., Mawatari, K., Numata, S., et al. (2022) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13373 · Cited by 15 · see citing works

Potential synergistic action of 19 schizophrenia risk genes in the thalamus

Richard, E. A., Khlestova, E., Nanu, R., & Lisman, J. E. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.09.008 · Cited by 15 · see citing works

Animal models for studies of alcohol effects on the trajectory of age-related cognitive decline

Foster, T. C. (2022) · Alcohol · doi:10.1016/j.alcohol.2022.04.005 · Cited by 12 · see citing works

Animal models of cognitive aging and circuit-specific vulnerability

Burke, S. N., & Foster, T. C. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00002-9 · Cited by 11 · see citing works

Cellular and Molecular Mechanisms for Age-Related Cognitive Decline

Barter, J., & Foster, T. C. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108554350.003 · Cited by 10 · see citing works

Age, but not severity of injury, mediates decline in executive function: Validation of the rodent touchscreen paradigm for preclinical models of traumatic brain injury

Arulsamy, A., Corrigan, F., & Collins‐Praino, L. E. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111912 · Cited by 9 · see citing works

TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models

Nakashima, M., Suzuki, N., Shiraishi, E., & Iwashita, H. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112192 · Cited by 9 · see citing works

Acute psychosocial stress in mid-aged male rats causes hyperthermia, cognitive decline, and increased deep sleep power, but does not alter deep sleep duration

Hargis, K., Buechel, H. M., Popović, J., & Blalock, E. M. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.06.009 · Cited by 9 · see citing works

Acanthoscurria gomesiana spider‐derived Mygalin in the prelimbic prefrontal cortex modulates neuropathic pain and depression comorbid

Medeiros, A. C., de Medeiros, P. S., Ruggiero, R. N., Gregorio, D. D., Gobbi, G., Júnior, P. I. S., dos Santos, W. F., Coimbra, N. C., & de Freitas, R. L. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23353 · Cited by 8 · see citing works

The Application of the Neuroprotective and Potential Antioxidant Effect of Ergotamine Mediated by Targeting N-Methyl-D-Aspartate Receptors

Lee, S., Eom, S., Nguyen, K. V. A., Lee, J., Park, Y., Yeom, H. D., & Lee, J. (2022) · Antioxidants · doi:10.3390/antiox11081471 · Cited by 7 · see citing works

Superoxide Dismutase Modified the Association of Serum Malondialdehyde Levels with Cognitive Decline Among Older Adults: Findings from the Chinese Longitudinal Healthy Longevity Survey

Liu, J., Sun, S., & Chen, Y. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231278 · Cited by 6 · see citing works

Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia

Hayes, J., Laursen, B., Eneberg, E., Kehler, J., Rasmussen, L. K., Langgård, M., Bastlund, J. F., & Gerdjikov, T. V. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108454 · Cited by 6 · see citing works

Aging in nucleus accumbens and its impact on alcohol use disorders

Konar-Nié, M., Guzmán-Castillo, A., Armijo‐Weingart, L., & Aguayo, L. G. (2022) · Alcohol · doi:10.1016/j.alcohol.2022.08.004 · Cited by 5 · see citing works

Conditioning learning in an attentional task relates to age and ventricular expansion in a nonhuman primate (Microcebus murinus)

Wittkowski, J., Fritz, R. G., Meier, M., & Schmidtke, D. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113053 · Cited by 4 · see citing works

Serine racemase expression profile in the prefrontal cortex and hippocampal subregions during aging in male and female rats

Bean, L. A., Bose, P., Rani, A., & Kumar, A. (2024) · Aging · doi:10.18632/aging.205841 · Cited by 2 · see citing works

CaMKIIα‐TARPγ8 signaling mediates hippocampal synaptic impairment in aging

JianHua, Z., Li, M., Hu, Q., Donoghue, P. S., Jiang, S., Li, J., Li, S.-J., Ren, X., Zhang, Z., Du, J.-Z., et al. (2024) · Aging Cell · doi:10.1111/acel.14349 · Cited by 2 · see citing works

Sex-dependent effects of chronic intermittent voluntary alcohol consumption on attentional, not motivational, measures during probabilistic learning and reversalPreprint

Aguirre, C. G., Stolyarova, A., Das, K., Kolli, S., Marty, V. N., Ray, L. A., Spigelman, I., & Izquierdo, A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.01.071092 · Cited by 2 · see citing works

Strain- and age-dependent divergence in mouse appetitive spatial learning and decision strategies

Liu, J., Manahan‐Vaughan, D., & Haubrich, J. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1858691 · Cited by 1 · see citing works

Viral vector-mediated upregulation of serine racemase expression in medial prefrontal cortex improves learning and synaptic function in middle age rats

Yegla, B., Rani, A., & Kumar, A. (2023) · Aging · doi:10.18632/aging.204652 · Cited by 1 · see citing works

Spatiotemporal terahertz modulation enhances NMDAR-mediated miniature EPSCs

Jiang, S., Zhong, Y., Chen, P., Wang, A., Zhu, J., Li, Y., & Zhu, Z. H. (2025) · Scientific Reports · doi:10.1038/s41598-025-08207-8 · Cited by 1 · see citing works

Plasma Kynurenine Level is Associated With Left DLPFC Activity and Can Predict Treatment Response in Major Depressive DisorderPreprint

Kamishikiryo, T., Okada, G., Itai, E., Masuda, Y., Yokoyama, S., Takamura, M., Fuchikami, M., Yoshino, A., Mawatari, K., Numata, S., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-911537/v1

Changes in the Properties of Ethanol-Sensitive Molecular Targets During Maturation and Aging

Aguayo, L. G., Armijo‐Weingart, L., Martín, L. S., Guzmán-Castillo, A., Konar-Nié, M., & Gallegos, S. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-81908-7_13

Age-related electrophysiological changes in layer 5 pyramidal cells and interneurons of the rat medial prefrontal cortex

Martínez-Rojas, V. A., Rosas-García, D. A., Rocha-Botello, G., Márquez, L. A., Herrera‐López, G., Sollozo-Dupont, I., Moreno‐Castilla, P., & Galván, E. J. (2026) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2026.112254

Linking Redox Regulation of NMDAR Synaptic Function to Cognitive Decline during Aging

Kumar, A., & Foster, T. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2176-13.2013 · Cited by 78 · see citing works

Central role for NMDA receptors in redox mediated impairment of synaptic function during aging and Alzheimer’s disease

Foster, T. C., Kyritsopoulos, C., & Kumar, A. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.012 · Cited by 92 · see citing works

Intracellular Redox State Alters NMDA Receptor Response during Aging through Ca²⁺/Calmodulin-Dependent Protein Kinase II

Bodhinathan, K., Kumar, A., & Foster, T. C. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5485-09.2010 · Cited by 153 · see citing works

Role of antioxidant enzymes in redox regulation of N-methyl-D-aspartate receptor function and memory in middle-aged rats

Russell, W. L., Kumar, A., Rani, A., & Foster, T. C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.12.002 · Cited by 36 · see citing works

Viral vector-mediated upregulation of serine racemase expression in medial prefrontal cortex improves learning and synaptic function in middle age rats

Yegla, B., Rani, A., & Kumar, A. (2023) · Aging · doi:10.18632/aging.204652 · Cited by 1 · see citing works