Newborn neurons in the olfactory bulb selected for long-term survival through olfactory learning are prematurely suppressed when the olfactory memory is erased
Open accessAbstract
A role for newborn neurons in olfactory memory has been proposed based on learning-dependent modulation of olfactory bulb neurogenesis in adults. We hypothesized that if newborn neurons support memory, then they should be suppressed by memory erasure. Using an ecological approach in mice, we showed that behaviorally breaking a previously learned odor-reward association prematurely suppressed newborn neurons selected to survive during initial learning. Furthermore, intrabulbar infusions of the caspase pan-inhibitor ZVAD (benzyloxycarbonyl-Val-Ala-Asp) during the behavioral odor-reward extinction prevented newborn neurons death and erasure of the odor-reward association. Newborn neurons thus contribute to the bulbar network plasticity underlying long-term memory.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adult-born granule cells support flexible olfactory behaviors in adulthood.
“while adult-born GCs are well-known to support flexible olfactory behaviors in adulthood [19,50–52]”
From Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system (2026) · cites this paper as [52]
The Results and Discussion link adult-born neurons in the olfactory bulb’s granule cell layer to learned odor processing and long-term odor–reward memory in adult mice. That supports a role in an olfactory behavior, but the study does not establish that these cells support flexible olfactory behaviors generally. Passage-level page numbers are not available in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Adult neurogenesis and functional plasticity in neuronal circuits
Lledo, P., Alonso, M., & Grubb, M. S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1867 · Cited by 1,364 · see citing works
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., & Kageyama, R. (2008) · Nature Neuroscience · doi:10.1038/nn.2185 · Cited by 1,054 · see citing works
Becoming a new neuron in the adult olfactory bulb
Carleton, A., Petreanu, L., Lansford, R. D., Álvarez-Buylla, A., & Lledo, P. (2003) · Nature Neuroscience · doi:10.1038/nn1048 · Cited by 808 · see citing works
Olfactory perceptual learning requires adult neurogenesis
Moreno, M., Linster, C., Escanilla, O., Sacquet, J., Didier, A., & Mandairon, N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907063106 · Cited by 265 · see citing works
Self-citationBreton‐Provencher, V., Lemasson, M., Peralta, M. R., & Saghatelyan, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3606-09.2009 · Cited by 263 · see citing works
Olfactory Discrimination Learning Increases the Survival of Adult-Born Neurons in the Olfactory Bulb
Alonso, M., Viollet, C., Gabellec, M., Meas‐Yedid, V., Olivo‐Marín, J., & Lledo, P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2633-06.2006 · Cited by 263 · see citing works
Magavi, S. S. P., Mitchell, B. D., Szentirmai, O., Carter, B. S., & Macklis, J. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2250-05.2005 · Cited by 215 · see citing works
Cellular and Behavioral Effects of Cranial Irradiation of the Subventricular Zone in Adult Mice
Lazarini, F., Mouthon, M., Gheusi, G., de Chaumont, F., Olivo‐Marín, J., Lamarque, S., Abrous, D. N., Boussin, F. D., & Lledo, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007017 · Cited by 204 · see citing works
Learning and survival of newly generated neurons: when time matters
Mouret, A., Gheusi, G., Gabellec, M.-M., de Chaumont, F., Olivo-Marin, J.-C., & Lledo, P.-M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2954-08.2008 · Cited by 180 · see citing works
Learning‐dependent neurogenesis in the olfactory bulb determines long‐term olfactory memory
Sultan, S., Mandairon, N., Kermen, F., Garcia, S., Sacquet, J., & Didier, A. (2010) · The FASEB Journal · doi:10.1096/fj.09-151456 · Cited by 159 · see citing works
Self-citationMandairon, N., Sacquet, J., Jourdan, F., & Didier, A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.066 · Cited by 121 · see citing works
Self-citationNeurogenic correlates of an olfactory discrimination task in the adult olfactory bulb
Mandairon, N., Sacquet, J., Garcia, S., Ravel, N., Jourdan, F., & Didier, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05235.x · Cited by 113 · see citing works
Self-citationMandairon, N., Sultan, S., Nouvian, M., Sacquet, J., & Didier, A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2919-11.2011 · Cited by 55 · see citing works
Self-citationA computer-assisted odorized hole-board for testing olfactory perception in mice
Mandairon, N., Sultan, S., Rey, N. L., Kermen, F., Moreno, M., Busto, G. U., Farget, V., Messaoudi, B., Thévenet, M., & Didier, A. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.04.008 · Cited by 42 · see citing works
Self-citationSultan, S., Lefort, J. M., Sacquet, J., et al. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00052 · Cited by 25 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Topographical representation of odor hedonics in the olfactory bulb
Kermen, F., Midroit, M., Kuczewski, N., Forest, J., Thévenet, M., Sacquet, J., Benetollo, C., Richard, M., Didier, A., & Mandairon, N. (2016) · Nature Neuroscience · doi:10.1038/nn.4317 · Cited by 55 · see citing works
Self-citationNeural processing of the reward value of pleasant odorants
Midroit, M., Chalençon, L., Renier, N., Milton, A., Thevenet, M., Sacquet, J., Breton, M., Forest, J., Noury, N., Richard, M., et al. (2021) · Current Biology · doi:10.1016/j.cub.2021.01.066 · Cited by 55 · see citing works
Self-citationShort-term availability of adult-born neurons for memory encoding
Forest, J., Moreno, M., Cavelius, M., Chalençon, L., Ziessel, A., Sacquet, J., Richard, M., Didier, A., & Mandairon, N. (2019) · Nature Communications · doi:10.1038/s41467-019-13521-7 · Cited by 24 · see citing works
Self-citationDejou, J., Athanassi, A., Brunel, T., Thevenet, M., Didier, A., & Mandairon, N. (2026) · PLOS Biology · doi:10.1371/journal.pbio.3003845 · Cited by 1 · see citing works
“At the neuronal level, while adult-born GCs are well-known to support flexible olfactory behaviors in adulthood [19,50–52], neonatal-born GCs have been primarily associated with innate olfactory responses [14,20,21,53,54].”
Self-citation
- Authors
- Sultan, S., Rey, N., Sacquet, J., Mandairon, N., & Didier, A.
- Affiliations
- Lyon 1 Université (FR)
- Université de Lyon (FR)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-10-19
- Volume
- 31
- Issue
- 42
- Pages
- 14893-14898
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6623563
- OpenAlex
- W2013219165
- Cited by
- 39
- References
- 15
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2021: 2 · 2019: 6 · 2018: 5 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 5
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- olfactory bulb, adult neurogenesis, newborn neurons, olfactory memory, memory erasure, caspase inhibition, zVAD, neuronal survival, network plasticity, long-term memory
- MeSH terms
- Analysis of Variance, Animals, Behavior, Animal, Bromodeoxyuridine, Cell Count, Conditioning, Psychological, Cues, Enzyme Inhibitors, Male, Mice, Inbred C57BL, Neurons, Odorants, Olfactory Bulb, Oligopeptides, Phosphopyruvate Hydratase, Photic Stimulation, Reaction Time, Retention, Psychology, Reward, Smell, Time Factors, Proto-Oncogene Proteins c-fos, Mice, Early Growth Response Protein 1, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
