Neural processing of the reward value of pleasant odorants
Open accessAbstract
Pleasant odorants are represented in the posterior olfactory bulb (pOB) in mice. How does this hedonic information generate odor-motivated behaviors? Using optogenetics, we report here that stimulating the representation of pleasant odorants in a sensory structure, the pOB, can be rewarding, self-motivating, and is accompanied by ventral tegmental area activation. To explore the underlying neural circuitry downstream of the olfactory bulb (OB), we use 3D high-resolution imaging and optogenetics and determine that the pOB preferentially projects to the olfactory tubercle, whose increased activity is related to odorant attraction. We further show that attractive odorants act as reinforcers in dopamine-dependent place preference learning. Finally, we extend those findings to humans, who exhibit place preference learning and an increase BOLD signal in the olfactory tubercle in response to attractive odorants. Thus, strong and persistent attraction induced by some odorants is due to a direct gateway from the pOB to the reward system.
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The odorants (+)-limonene, β-citronellol, and camphor are attractive to mice.
“an attractive odorant (either (+)-limonene (5989-27-5, Sigma-Aldrich), β-citronellol (106-22-9, Sigma-Aldrich), or camphor (76-22-2, Sigma-Aldrich)) [34,35]”
From Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system (2026) · cites this paper as [35]
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FUNCTIONAL MAGNETIC RESONANCE IMAGING OF HUMAN OLFACTION
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Non-imaged based method for matching brains in a common anatomical space for cellular imagery
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Self-citation
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The human olfactory bulb processes odor valence representation and cues motor avoidance behavior
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Common principles for odour coding across vertebrates and invertebrates
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Olfaction in the context of obesity and diabetes: Insights from animal models to humans
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Odour hedonics and the ubiquitous appeal of vanilla
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Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior
Johnson, N. L., Cotelo-Larrea, A., Stetzik, L. A., Akkaya, U. M., Zhang, Z., Gadziola, M. A., Varga, A. G., Ma, M., & Wesson, D. W. (2025) · Nature Communications · doi:10.1038/s41467-024-55644-6 · Cited by 17 · see citing works
Self-citationMaegawa, A., Murata, K., Kuroda, K., Fujieda, S., & Fukazawa, Y. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.908964 · Cited by 17 · see citing works
Chronic unpredictable mild stress alters odor hedonics and adult olfactory neurogenesis in mice
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Reinert, J. K., & Fukunaga, I. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102623 · Cited by 17 · see citing works
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Neural Circuitry for Stress Information of Environmental and Internal Odor Worlds
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Altered neural representation of olfactory food reward in the nucleus accumbens after acute stress
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Endogenous opioids in the olfactory tubercle and their roles in olfaction and quality of life
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Diet and odor hedonic ratings: comparative study between vegetarians, flexitarians, and omnivores
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Chalençon, L., Thévenet, M., Noury, N., Bensafi, M., & Mandairon, N. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109422 · Cited by 9 · see citing works
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Good scents: A short road from olfaction to satisfaction
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Cai, J., Wang, X., Zhou, J., di, Y., Shen, Z., An, S., Long, B., Wang, Y., Li, Z., Li, Y., et al. (2025) · NeuroImage · doi:10.1016/j.neuroimage.2025.121569 · Cited by 7 · see citing works
Ping, Z., Tian, Y., Chen, Y., Chen, W., Wang, P., Du, L., & Wu, C. (2021) · Biosensors · doi:10.3390/bios11090309 · Cited by 7 · see citing works
Pardo‐Bellver, C., Vila-Martín, M. E., Martínez‐Bellver, S., Villafranca-Faus, M., Teruel-Sanchis, A., Savarelli-Balsamo, C., Drabik, S., Martínez‐Ricós, J., Cervera‐Ferri, A., Martínez‐Garciá, F., et al. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.988015 · Cited by 7 · see citing works
Dopamine Modulates the Processing of Food Odour in the Ventral Striatum
Rampin, O., Deliot, A. S.-A., Ouali, C., Burguet, J., Gry, E., Champeil‐Potokar, G., Jérôme, N., Davidenko, O., Darcel, N., Bombail, V., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10051126 · Cited by 6 · see citing works
Age-related differences in perception and coding of attractive odorants in mice
Chalençon, L., Midroit, M., Athanassi, A., Thévenet, M., Breton, M., Forest, J., Richard, M. B., Didier, A., & Mandairon, N. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.02.003 · Cited by 6 · see citing works
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Tarrida, J., Moreno, M., Vidal, J., Panyella, D., Marco‐Pallarés, J., & Fuentemilla, L. (2025) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.a.77 · Cited by 3 · see citing works
Wang, W., Zhong, Y., Tan, R., Wang, M., Liu, J., Wang, D., Wang, H., Li, Y., Li, G., Yang, J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2514847122 · Cited by 3 · see citing works
Neige, C., Imbert, L., Beynel, L., Fivel, L., Mondino, M., & Brunelin, J. (2024) · Medical Hypotheses · doi:10.1016/j.mehy.2024.111403 · Cited by 3 · see citing works
Control of Innate Olfactory Valence by Segregated Cortical Amygdala CircuitsPreprint
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Imbert, L., Neige, C., Dumas, M., Bensafi, M., Mandairon, N., & Brunelin, J. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1451096 · Cited by 2 · see citing works
Self-citationJeffs, Q. L., Prather, J. F., & Todd, W. D. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1295998 · Cited by 2 · see citing works
A Short Glance at the Role of Olfactory Tubercle in Odour Processing
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Dejou, J., Athanassi, A., Brunel, T., Thevenet, M., Didier, A., & Mandairon, N. (2026) · PLOS Biology · doi:10.1371/journal.pbio.3003845 · Cited by 1 · see citing works
“At P24, mice were exposed to an attractive odorant (either (+)-limonene (5989-27-5, Sigma-Aldrich), β -citronellol (106-22-9, Sigma-Aldrich), or camphor (76-22-2, Sigma-Aldrich)) [34,35] in their regular housing for 1 h to prevent olfactory neophobia in later sessions.”
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Athanassi, A., François, A., Bourinet, E., Thévenet, M., & Mandairon, N. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1601127 · Cited by 1 · see citing works
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Wright, K. N., Johnson, N. L., Dossat, A., Wilson, J., & Wesson, D. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105122 · Cited by 1 · see citing works
Self-citationMeasuring Hedonic Behaviors to Food Odors in Children
Dantec, M., Chalençon, L., Thévenet, M., Adrar, I., Baudino, S., Mandairon, N., & Bensafi, M. (2023) · Methods and protocols in food science · doi:10.1007/978-1-0716-2934-5_11 · Cited by 1 · see citing works
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Distributed representations of chemosensory valence in a naïve vertebrate brainPreprint
Jenkins, B., & Frank, T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.17.732810 · Cited by 2 · see citing works
The how, when, and what of odor valence communication between the olfactory bulb and piriform cortexPreprint
Nordén, F., Iravani, B., Schaefer, M., Winter, A. L., Lundqvist, M., Arshamian, A., & Lundström, J. N. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.02.564696
Odor-induced persistent neural activity in associative encoding in humansPreprint
Tarrida, J., Moreno, M., Vidal, J., Panyella, D., Marco‐Pallarés, J., & Fuentemilla, L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.23.581728
Sniffing can be initiated by dopamine’s actions on ventral striatum neuronsPreprint
Johnson, N. L., Cotelo-Larrea, A., Stetzik, L. A., Akkaya, U. M., Zhang, Z., Gadziola, M. A., Varga, A. G., Ma, M., & Wesson, D. W. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.19.581052
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Familiarity with social partners influences affiliative interactions but not spatial associationsPreprint
O’Connell, C. L., van der Marel, A., & Hobson, E. A. (2024) · doi:10.32942/x2vs56
Biljman, K., Gozes, I., Lam, J. C. K., & Li, V. O. K. (2024) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823241307617
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Neurobiology of the Sense of Smell
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Beyond breathing: multimodal pathways connecting olfaction to autonomic nervous system modulation
Walter, M., Puech, A., Aliyari, F., Courtiol, E., & Buonviso, N. (2026) · Trends in Neurosciences · doi:10.1016/j.tins.2026.08.004
- Authors
- Midroit, M., Chalençon, L., Renier, N., Milton, A., Thevenet, M., Sacquet, J., Breton, M., Forest, J., Noury, N., Richard, M., Raineteau, O., Ferdenzi, C., Fournel, A., Wesson, D. W., Bensafi, M., Didier, A., & Mandairon, N.
- Affiliations
- Lyon 1 Université (FR)
- Centre National de la Recherche Scientifique (FR)
- Case Western Reserve University (US)
- University of Florida (US)
- Corresponding author
- Mandairon, Nathalie
- ORCID
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 31
- Issue
- 8
- Pages
- 1592-1605.e9
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC9291255
- OpenAlex
- W3129836667
- Cited by
- 55
- References
- 108
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 20 · 2023: 5 · 2022: 11 · 2021: 5
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 390 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- Funders
- CNRS
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- olfactory bulb, olfactory tubercle, ventral tegmental area, dopamine, hedonic value, olfactory attraction, reward systems
- MeSH terms
- Animals, Emotions, Male, Mice, Inbred C57BL, Motivation, Odorants, Olfactory Bulb, Reward, Smell, Mice, Olfactory Perception, Optogenetics
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