Topographical representation of odor hedonics in the olfactory bulb
Open accessAbstract
Hedonic value is a dominant aspect of olfactory perception. Using optogenetic manipulation in freely behaving mice paired with immediate early gene mapping, we demonstrate that hedonic information is represented along the antero-posterior axis of the ventral olfactory bulb. Using this representation, we show that the degree of attractiveness of odors can be bidirectionally modulated by local manipulation of the olfactory bulb's neural networks in freely behaving mice.
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The odorants (+)-limonene, β-citronellol, and camphor are attractive to mice.
“an attractive odorant (either (+)-limonene (5989-27-5, Sigma-Aldrich), β-citronellol (106-22-9, Sigma-Aldrich), or camphor (76-22-2, Sigma-Aldrich)) [34,35]”
From Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system (2026) · cites this paper as [34]
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- Authors
- Kermen, F., Midroit, M., Kuczewski, N., Forest, J., Thévenet, M., Sacquet, J., Benetollo, C., Richard, M., Didier, A., & Mandairon, N.
- Affiliations
- Lyon 1 Université (FR)
- Corresponding author
- Mandairon, Nathalie
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2016-06-06
- Volume
- 19
- Issue
- 7
- Pages
- 876-878
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2409294965
- Cited by
- 55
- References
- 25
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 9 · 2020: 9 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 2
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- olfactory bulb, anterior-posterior axis, immediate early genes, optogenetics, olfactory perception, odor-guided behavior
- MeSH terms
- Animals, Behavior, Animal, Male, Mice, Inbred C57BL, Nerve Net, Odorants, Olfactory Bulb, Smell, Olfactory Perception
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