Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function

Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

Mangiarini, L., Sathasivam, K., Seller, M., Cozens, B., Harper, A., Hetherington, C., Lawton, M., Trottier, Y., Lehrach, H., Davies, S. W., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81369-0 · Cited by 3,073

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

Barres, B. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.013 · Cited by 1,352

Diversity of astrocyte functions and phenotypes in neural circuits

Khakh, B. S., & Sofroniew, M. V. (2015) · Nature Neuroscience · doi:10.1038/nn.4043 · Cited by 1,239

Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data

Tabrizi, S. J., Langbehn, D. R., Leavitt, B. R., Roos, R. A., Durr, A., Craufurd, D., Kennard, C., Hicks, S. L., Fox, N. C., Scahill, R. I., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70170-x · Cited by 984

An optimized fluorescent probe for visualizing glutamate neurotransmission

Marvin, J., Borghuis, B., Tian, L., Cichon, J., Harnett, M. T., Akerboom, J., Gordus, A., Renninger, S., Chen, T.-W., Bargmann, C., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2333 · Cited by 965

Potassium buffering in the central nervous system

Kofuji, P., & Newman, E. A. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.008 · Cited by 847

Mechanisms of Disease: astrocytes in neurodegenerative disease

Maragakis, N. J., & Rothstein, J. D. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0355 · Cited by 836

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

Kuchibhotla, K. V., Lattarulo, C. R., Hyman, B. T., & Bacskai, B. J. (2009) · Science · doi:10.1126/science.1169096 · Cited by 729

Astrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses

Panatier, A., Vallée, J., Haber, M., Murai, K. K., Lacaille, J.-C., & Robitaille, R. (2011) · Cell · doi:10.1016/j.cell.2011.07.022 · Cited by 650

Astrocytes: From the Physiology to the Disease

Trujillo‐Estrada, L., Gómez-Arboledas, Á., Forner, S., Martini, A. C., Gutiérrez, A., Baglietto‐Vargas, D., & LaFerla, F. M. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190830110152 · Cited by 30

Astrocytes in Huntington’s Disease

Gray, M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9913-8_14 · Cited by 27

Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits

Reyes-Ortiz, A. M., Abud, E. M., Burns, M. S., Wu, J., Hernandez, S. J., McClure, N. R., Wang, K. Q., Schulz, C. J., Miramontes, R., Lau, A., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105732 · Cited by 30

Neurodegenerative Disease: From Molecular Basis to Therapy

Ricci, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020967 · Cited by 28

Diversity of Evoked Astrocyte Ca2+ Dynamics Quantified through Experimental Measurements and Mathematical Modeling

Taheri, M., Handy, G., Borisyuk, A., & White, J. A. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00079 · Cited by 28

Astrocytes as Drivers and Disruptors of Behavior: New Advances in Basic Mechanisms and Therapeutic Targeting

Barnett, D., Bohmbach, K., Grelot, V., Charlet, A., Dallérac, G. M., Ju, Y. H., Nagai, J., & Orr, A. G. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1376-23.2023 · Cited by 27

Pathway-Specific Control of Striatal Neuron Vulnerability by Corticostriatal Cannabinoid CB1 Receptors

Ruiz-Calvo, A., Maroto, I. B., Bajo‐Grañeras, R., Chiarlone, A., Gaudioso, Á., Ferrero, J. J., Resel, E., Sánchez‐Prieto, J., Rodríguez‐Navarro, J. A., Marsicano, G., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx285 · Cited by 28

Single Synapse Indicators of Impaired Glutamate Clearance Derived from Fast iGlu u Imaging of Cortical Afferents in the Striatum of Normal and Huntington (Q175) Mice

Dvorzhak, A., Helassa, N., Török, K., Schmitz, D., & Grantyn, R. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2865-18.2019 · Cited by 27

Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis

Lisbôa, B. C. G., Oliveira, K. C., Tahira, A. C., Barbosa, A. D. L., Feltrin, A. S., Gouveia, G. R., Lima, L. C., dos Santos, A. C. F., Martins, D., Puga, R., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-38965-1 · Cited by 29

The Paradox of Astroglial Ca2 + Signals at the Interface of Excitation and Inhibition

Caudal, L. C., Gobbo, D., Scheller, A., & Kirchhoff, F. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.609947 · Cited by 28

Human iPSC‐derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model

Park, H. J., Jeon, J., Choi, J., Kim, J. Y., Kim, H. S., Huh, J. Y., Goldman, S. A., & Song, J. (2021) · Cell Proliferation · doi:10.1111/cpr.13082 · Cited by 28

Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons

Ruiz-Calvo, A., Bajo‐Grañeras, R., Maroto, I. B., Zian, D., Grabner, G. F., García-Taboada, E., Resel, E., Zechner, R., Zimmermann, R., Ortega‐Gutiérrez, S., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.027 · Cited by 27

Revisiting astrocytic calcium signaling in the brain

Bai, Y., Zhou, Z., Han, B., Xiang, X., Huang, W., & Yao, H. (2024) · Fundamental Research · doi:10.1016/j.fmre.2023.11.021 · Cited by 29

Morphine Protects Spinal Cord Astrocytes from Glutamate-Induced Apoptosis via Reducing Endoplasmic Reticulum Stress

Zhang, C., Wang, C., Ren, J., Guo, X., & Yun, K. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101523 · Cited by 26

Miniaturized Electrochemical Sensing Platforms for Quantitative Monitoring of Glutamate Dynamics in the Central Nervous System

Wang, Q., Yang, C., Chen, S., & Li, J. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202406867 · Cited by 26

Progress of Astrocyte-Neuron Crosstalk in Central Nervous System Diseases

Zhang, Y., Wang, Z., Xu, F., Liu, Z., Zhao, Y., Yang, L. Z., & Fang, W. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04241-6 · Cited by 28

The Emerging Landscape of Small-Molecule Therapeutics for the Treatment of Huntington’s Disease

Ahamad, S., & Bhat, S. A. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00799 · Cited by 26

Dysregulation of astrocytic Ca2+ signaling and gliotransmitter release in mouse models of α-synucleinopathies

Nanclares, C., Poynter, J., Martell-Martinez, H. A., Vermilyea, S., Araque, A., Kofuji, P., Lee, M. K., & Covelo, A. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02547-3 · Cited by 24

Astrocyte Dysfunctions in Obsessive Compulsive Disorder: Rethinking Neurobiology and Therapeutic Targets

Gonzalez, L., & Bezzi, P. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70092 · Cited by 24

SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington’s disease

Park, H. J., Han, A., Kim, J. Y., Choi, J., Bae, H. S., Cho, G., Shin, H., Shin, E. J., Lee, K.-I., Kim, S., et al. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-021-00198-0 · Cited by 24

The function of astrocytes and their role in neurological diseases

Yuan, W., Huang, W., Jiang, Y., Xu, H., Duan, C., Chen, N., Liu, Y., & Fu, X. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16160 · Cited by 26

Mapping astrocyte activity domains by light sheet imaging and spatio-temporal correlation screening

Pham, C., Chao, D. H. M., Mouffle, C., Didienne, S., Hepp, R., Pfrieger, F. W., Mangin, J., Legendre, P., Martin, C., Luquet, S. H., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117069 · Cited by 23

A spatial threshold for astrocyte calcium surgePreprint

Lines, J., Baraibar, A. M., Nanclares, C., Martín, E. D., Aguilar, J., Kofuji, P., Navarrete, M., & Araque, A. (2023) · eLife · doi:10.7554/elife.90046 · Cited by 24

On astrocyte-neuron interactions: broad insights from the striatum

Khakh, B. S. (2025) · Neuron · doi:10.1016/j.neuron.2025.08.009 · Cited by 23

The Astrocyte–Neuron Interface: An Overview on Molecular and Cellular Dynamics Controlling Formation and Maintenance of the Tripartite Synapse

Hasan, U., & Singh, S. K. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9068-9_1 · Cited by 23

PolyQ length-dependent metabolic alterations and DNA damage drive human astrocyte dysfunction in Huntington’s disease

Lange, J., Gillham, O., Flower, M. D., Ging, H., Eaton, S. D., Kapadia, S., Neueder, A., Duchen, M. R., Ferretti, P., & Tabrizi, S. J. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102448 · Cited by 23

Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the HdhQ150/Q150 Mouse Model of Huntington’s Disease

Rattray, I., Smith, E. J., Crum, W. R., Walker, T. A., Gale, R., Bates, G. P., & Modo, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0168556 · Cited by 21

Astrocyte aquaporin mediates a tonic water efflux maintaining brain homeostasisPreprint

Pham, C., Komaki, Y., Deàs-Just, A., Gac, B. L., Mouffle, C., Franco, C., Chaperon, A., Vialou, V., Tsurugizawa, T., Cauli, B., et al. (2024) · eLife · doi:10.7554/elife.95873 · Cited by 23

Purinergic-associated immune responses in neurodegenerative diseases

Carracedo, S., Launay, A., Déchelle-Marquet, P.-A., Faivre, É., Blum, D. L., Delarasse, C., & Boué‐Grabot, É. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102693 · Cited by 20

Astrocyte-neuron interaction in the dorsal striatum-pallidal circuits and alcohol-seeking behaviors

Hong, S., Kang, S., Baker, M. R., & Choi, D. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108759 · Cited by 20

Seeing glutamate at central synapses

Hao, Y., & Plested, A. J. R. (2022) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2022.109531 · Cited by 18

Autoimmune inflammation triggers aberrant astrocytic calcium signaling to impair synaptic plasticity

Baraibar, A. M., Colomer, T., Moreno‐García, A., Bernal‐Chico, A., Sánchez-Martín, E., Utrilla, C., Serrat, R., Gómez, E. S., Rodríguez-Antigüedad, A., Araque, A., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.07.010 · Cited by 18

Dysregulated cholesterol metabolism, aberrant excitability and altered cell cycle of astrocytes in fragile X syndrome.

Ren, B., Burkovetskaya, M., Jung, Y., Bergdolt, L., Totusek, S., Martinez‐Cerdeno, V., Stauch, K., Korade, Z., & Dunaevsky, A. (2023) · Glia · doi:10.1002/glia.24331 · Cited by 18

Glia Signaling and Brain Microenvironment in Migraine

Amani, H., Khaboushan, A. S., Terwindt, G. M., & Tafakhori, A. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03300-3 · Cited by 19

Studying Axon-Astrocyte Functional Interactions by 3D Two-Photon Ca2+ Imaging: A Practical Guide to Experiments and “Big Data” Analysis

Savtchouk, I., Carriero, G., & Volterra, A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00098 · Cited by 17

Mechanisms of altered skeletal muscle action potentials in the R6/2 mouse model of Huntington’s disease

Miranda, D. R., Reed, E. J., Jama, A., Bottomley, M. A., Ren, H., Rich, M. M., & Voss, A. A. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00153.2020 · Cited by 16

VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels

McClenahan, S. J., Kent, C. N., Kharade, S. V., Isaeva, E., Williams, J. C., Han, C., Terker, A. S., Gresham, R. M., Lazarenko, R. M., Days, E., et al. (2022) · Molecular Pharmacology · doi:10.1124/molpharm.121.000464 · Cited by 16

Astrocyte transduction is required for rescue of behavioral phenotypes in the YAC128 mouse model with AAV-RNAi mediated HTT lowering therapeutics

Stanek, L. M., Bu, J., & Shihabuddin, L. S. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.04.015 · Cited by 15

Mitochondrial organization and structure are compromised in fibroblasts from patients with Huntington’s disease

Vanišová, M., Štufková, H., Kohoutová, M., Daňhelovská, T., Křížová, J., Klempíř, J., Ryšánková, I., Roth, J., Zeman, J., & Hansíková, H. (2022) · Ultrastructural Pathology · doi:10.1080/01913123.2022.2100951 · Cited by 15

Astrocytes and presynaptic plasticity in the striatum: Evidence and unanswered questions

Dvorzhak, A., Melnick, I. V., & Grantyn, R. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.01.001 · Cited by 16

Enhanced Na+‐K+‐2Cl‐ cotransporter 1 underlies motor dysfunction in huntington's disease

Hsu, Y., Chang, Y., Liu, Y., Wang, K., Chen, H., Lee, D., Yang, S., Tsai, C., Lien, C., & Chern, Y. (2019) · Movement Disorders · doi:10.1002/mds.27651 · Cited by 15

NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes

Pereira, C. A. S., Medaglia, N. D. C., Ureshino, R. P., Bincoletto, C., Antonioli, M., Fimia, G. M., Piacentini, M., Pereira, G. J. S., Erustes, A. G., & Smaili, S. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065593 · Cited by 14

Electrophysiological In Vitro Study of Long‐Range Signal Transmission by Astrocytic Networks

Hastings, N., Yu, Y., Huang, B., Middya, S., Inaoka, M., Erkamp, N. A., Mason, R. J., Carnicer‐Lombarte, A., Rahman, S. M. J., Knowles, T. P. J., et al. (2023) · Advanced Science · doi:10.1002/advs.202301756 · Cited by 13

Ezrin-mediated astrocyte-synapse signaling regulates cognitive function via astrocyte morphological changes in fine processes in male mice

Chen, L., Jiao, J., Fan, L., Zhou, B., Li, H., Liao, P. S., Li, X., Kang, Y., Liu, J., & Jiang, R. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.11.022 · Cited by 15

Friends Turn Foe—Astrocytes Contribute to Neuronal Damage in NeuroAIDS

Pandey, H. S., & Seth, P. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01357-1 · Cited by 13

Two-photon calcium imaging of neuronal and astrocytic responses: the influence of electrical stimulus parameters and calcium signaling mechanisms

Ma, Z., Wei, L., Du, X., Hou, S., Chen, F., Jiao, Q., Liu, A., Liu, S., Wang, J., & Shen, H. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac0b50 · Cited by 14

Diminished LC3-Associated Phagocytosis by Huntington’s Disease Striatal Astrocytes

Wakida, N. M., Lau, A., Nguyen, J., Cruz, G. M. S., Fote, G., Steffan, J. S., Thompson, L. M., & Berns, M. W. (2022) · Journal of Huntington s Disease · doi:10.3233/jhd-210502 · Cited by 17

Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease

Novati, A., Hentrich, T., Wassouf, Z., Weber, J. J., Yu-Taeger, L., Déglon, N., Nguyen, H. P., & Schulze-Hentrich, J. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-24243-z · Cited by 16

When the Stars Misfire: Astrocytic Dysfunctions in Major Depressive Disorder

González-Arias, C., & Perea, G. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04483-y · Cited by 14

Astrocytes and Microglia Exhibit Cell-Specific Ca2+ Signaling Dynamics in the Murine Spinal Cord

Rieder, P., Gobbo, D., Stopper, G., Welle, A., Damo, E., Kirchhoff, F., & Scheller, A. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.840948 · Cited by 11

Orai2 channel regulates prostaglandin E2 production in TNFα / IL1α ‐stimulated astrocytes

Nakajima, H., Fujita, S., Kakae, M., Nagayasu, K., Oh‐hora, M., Shirakawa, H., & Kaneko, S. (2022) · Glia · doi:10.1002/glia.24188 · Cited by 12

Contribution of Glial Cells to Polyglutamine Diseases: Observations from Patients and Mouse Models

Cvetanović, M., & Gray, M. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01357-5 · Cited by 12

Control of feeding by a bottom-up midbrain-subthalamic pathway

Reis, F. M., Maesta‐Pereira, S., Ollivier, M., Schuette, P. J., Sethi, E., Miranda, B. A., Iniguez, E., Chakerian, M., Vaughn, E., Sehgal, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46430-5 · Cited by 14

Shared patterns of glial transcriptional dysregulation link Huntington’s disease and schizophrenia

Huynh, N. P. T., Osipovitch, M., Foti, R., Bates, J., Mansky, B., Cano, J. C., Benraiss, A., Zhao, C., Lu, Q. R., & Goldman, S. A. (2024) · Brain · doi:10.1093/brain/awae166 · Cited by 10

Non-Cell Autonomous and Epigenetic Mechanisms of Huntington’s Disease

Kim, C., Yousefian-Jazi, A., Choi, S.-H., Chang, I., Lee, J.-H., & Ryu, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212499 · Cited by 13

Abnormal Ca2+ Signals in Reactive Astrocytes as a Common Cause of Brain Diseases

Koizumi, S., Shigetomi, E., Sano, F., Saito, K., Kim, S. K., & Nabekura, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010149 · Cited by 12

Manipulations of Glutathione Metabolism Modulate IP3-Mediated Store-Operated Ca2+ Entry on Astroglioma Cell Line

Mokrane, N., Snabi, Y., Cens, T., Guiramand, J., Charnet, P., Bertaud, A., Ménard, C., Rousset, M., Ferreira, M. D. J., Thibaud, J., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.785727 · Cited by 11

Sex-dependent impaired locomotion and motor coordination in the HdhQ200/200 mouse model of Huntington's Disease

Cao, J. K., Viray, K., Zweifel, L. S., & Stella, N. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104607 · Cited by 11

Dysfunctional astrocyte glutamate uptake in the hypothalamic paraventricular nucleus contributes to visceral pain and anxiety‐like behavior in mice with chronic pancreatitis

Luo, R., Hu, X., Li, X., Fan, L., Liao, P. S., Yi, L., Zhang, X., Zhou, B., & Jiang, R. (2024) · Glia · doi:10.1002/glia.24595 · Cited by 10

Astrocyte Heterogeneity in Regulation of Synaptic Activity

Kruyer, A. (2022) · Cells · doi:10.3390/cells11193135 · Cited by 10

Astrocytes Control Cocaine-Induced Synaptic Plasticity and Reward Through the Matricellular Protein Hevin

Mongrédien, R., Anésio, A., Fernandes, G. J. D., Eagle, A. L., Maldera, S., Pham, C., Robert, S., Bezerra, F. R., Vilette, A., Bianchi, P. C., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.02.904 · Cited by 11

Neurodegenerative diseases

Verkhratsky, A., & Butt, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821565-4.00012-2 · Cited by 10

Altered calcium signaling in Bergmann glia contributes to spinocerebellar ataxia type-1 in a mouse model of SCA1

Nanclares, C., Noriega‐Prieto, J. A., Labrada-Moncada, F. E., Cvetanović, M., Araque, A., & Kofuji, P. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106318 · Cited by 12

Mechanisms of astrocyte development

Sardar, D., Cheng, Y.-T., Szewczyk, Ł. M., Deneen, B., & Molofsky, A. V. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00032-1 · Cited by 8

Neurochemical changes in the progression of Huntington's disease: A meta-analysis of in vivo 1H-MRS studies

Jing, Y., Dogan, I., Reetz, K., & Romanzetti, S. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106574 · Cited by 7

Calcium imaging: A versatile tool to examine Huntington’s disease mechanisms and progression

Barry, J., Peng, A., Levine, M. S., & Cepeda, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1040113 · Cited by 7

Glial Cells as Key Mediators in the Pathophysiology of Neurodegenerative Diseases

Bogus, K., Marchesi, N., Campagnoli, L. I. M., Pascale, A., & Pałasz, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020884 · Cited by 10

Role of dysregulated calcium homeostasis in astrocytes in neurodegenerative disorders

Sanchez-Mico, M. V., Calvo-Rodríguez, M., & Bacskai, B. J. (2026) · Nature reviews. Neuroscience · doi:10.1038/s41583-026-01032-6 · Cited by 9

An event-based paradigm for analyzing fluorescent astrocyte activity uncovers novel single-cell and population-level physiologyPreprint

Wang, Y., DelRosso, N. V., Vaidyanathan, T. V., Reitman, M. E., Cahill, M. K., Mi, X., Yu, G., & Poskanzer, K. E. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/504217 · Cited by 6

Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy

Schneider, Y., Gauer, C., Andert, M., Hoffmann, A., Riemenschneider, M. J., Krebs, W., Chalmers, N., Lötzsch, C., Naumann, U. J., Xiang, W., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01699-3 · Cited by 7

Functional contribution of astrocytic Kir4.1 channels to spasticity after spinal cord injury

Barbay, T., Pecchi, É., Ramírez‐Franco, J., Ivanov, A., Brocard, F., Rouach, N., & Bos, R. (2025) · Brain · doi:10.1093/brain/awaf147 · Cited by 5

Human glial progenitors transplanted into Huntington disease mice normalize neuronal gene expression, dendritic structure, and behavior

Villanueva, C. B., Huynh, N. P. T., Mariani, J. N., Mansky, B., Tate, A., Lorenzen, S. S., Chandler-Militello, D., Benraiss, A., & Goldman, S. A. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115762 · Cited by 6

Kir 4.1 inward rectifier potassium channel is upregulated in astrocytes in a murine multiple sclerosis model

Mercado, F., Almanza, A., Rubio, N., & Soto, E. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.04.052 · Cited by 5

Microglia Mediate Early Corticostriatal Synapse Loss and Cognitive Dysfunction in Huntington’s Disease Through Complement-Dependent MechanismsPreprint

Wilton, D. K., Mastro, K. J., Heller, M. D., Gergits, F. W., Willing, C. R., Frouin, A., Daggett, A., Gu, X., Kim, A. Y., Faull, R. L. M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.03.471180 · Cited by 5

A Systematic Review of Delta-9-Tetrahydrocannabinol (∆9-THC) in Astrocytic Markers

Ramos-Jiménez, C., Petkau, S., & Mizrahi, R. (2024) · Cells · doi:10.3390/cells13191628 · Cited by 4

Presence of Astrocytic S1R/5-HT1A Heterocomplex in the mPFC: A Putative Link to S1R Activation Mediated Faster Antidepressant-Like Effects

Ren, P., Wang, J.-Y., Xu, M., Ni, H., Zhang, S., Yue, C.-X., Yang, D., & Li, Y. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05568-z · Cited by 4

Curing the brain: in search for new astrocyte-specific therapies

Verkhratsky, A., Lee, C. J., Chun, H., Göritz, C., Harkany, T., Lee, J., Lee, S., Lindskog, M., Koh, W., Mulder, J., et al. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01712-4 · Cited by 8

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Sulejczak, D., Taraszewska, A., Chrapusta, S. J., Dziewulska, D., Nakielski, P., & Rafałowska, J. (2016) · Folia Neuropathologica · doi:10.5114/fn.2016.64818 · Cited by 4

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Brown, T. G., & Chen, L. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.106664 · Cited by 4

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Lines, J., Baraibar, A. M., Nanclares, C., Martín, E. D., Aguilar, J., Kofuji, P., Navarrete, M., & Araque, A. (2024) · eLife · doi:10.7554/elife.90046.2 · Cited by 4

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Nijhuis, P. J. H., Romijn, M., Honing, R., van Zon, G., Huitinga, I., de Winter, F., & Verhaagen, J. (2025) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2025.101504 · Cited by 2

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Yu, C., Nguyen, D. L., Gyimesi, M., Peall, I. W., Pham, S. H., Griffiths, L. R., Okolicsanyi, R. K., & Haupt, L. M. (2025) · Cells · doi:10.3390/cells14151158 · Cited by 3

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Lopes, A. R., da Costa-Silva, D. G., Rodrigues, N. R., Martins, I. K., Leandro, L. P., Nunes, M. E. M., Posser, T., & Franco, J. L. (2024) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2024.2337366 · Cited by 2

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Weiss, S., Clamon, L. C., Manoim, J. E., Ormerod, K. G., Parnas, M., & Littleton, J. T. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.16.285841 · Cited by 2

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Villanueva, C. B., Stephensen, H. J. T., Mokso, R., Benraiss, A., Jon Sporring, A., & Goldman, S. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.06.519168 · Cited by 2

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Villanueva, C. B., Stephensen, H. J. T., Mokso, R., Benraiss, A., Jon Sporring, A., & Goldman, S. A. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210719120 · Cited by 22

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Khakh, B. S., Beaumont, V., Cachope, R., Muñoz-Sanjuán, I., Goldman, S. A., & Grantyn, R. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.05.002 · Cited by 238

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