The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?: Figure 1.
Open accessAbstract
Psychiatric and neurologic disorders take an enormous toll on society. Alleviating the devastating symptoms and consequences of neuropsychiatric disorders such as addiction, depression, epilepsy, and schizophrenia is a main force driving clinical and basic researchers alike. By elucidating these disease neuromechanisms, researchers hope to better define treatments and preventive therapies. Research suggests that regulation of adult hippocampal neurogenesis represents a promising approach to treating and perhaps preventing mental illness. Here we appraise the role of adult hippocampal neurogenesis in major psychiatric and neurologic disorders within the essential framework of recent progress made in understanding “normal” adult neurogenesis. Topics addressed include the following: the life cycle of an adult hippocampal stem cell and the implications for aging; links between learning and hippocampal neurogenesis; the reciprocal relationship between cocaine self-administration and adult hippocampal neurogenesis; the role of adult neurogenesis in an animal model of depression and response to antidepressant exposure; the impact of neonatal seizures on dentate gyrus neurogenesis; and the contribution of a schizophrenia-susceptibility gene to adult hippocampal neurogenesis. These topics are discussed in light of the regulation of adult neurogenesis, the relationship to normal neurogenesis in adulthood and aging, and, importantly, the manipulation of neurogenesis to promote mental health and treat mental illness.
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Cites
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
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“For example, a number of antidepressant-related stimuli, including fluoxetine, deep brain stimulation, and running, all enhance SGZ proliferation of the Type 2 cell (Kronenberg et al., 2003; Encinas et al., 2006; Toda et al., 2008).”
BackgroundFluoxetine targets early progenitor cells in the adult brain
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Self-citationTrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
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Cited by
Beneficial effects of physical exercise on neuroplasticity and cognition
Hötting, K., & Röder, B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.005 · Cited by 991
Antidepressants recruit new neurons to improve stress response regulation
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Structural Plasticity and Hippocampal Function
Leuner, B., & Gould, E. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100359 · Cited by 455
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Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells
Ables, J. L., DeCarolis, N. A., Johnson, M. A., Rivera, P. D., Gao, Z., Cooper, D. C., Radtke, F., Hsieh, J., & Eisch, A. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4721-09.2010 · Cited by 292
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Metadata
- Authors
- Eisch, A. J., Cameron, H. A., Encinas, J. M., Meltzer, L. A., Ming, G.-L., & Overstreet-Wadiche, L. S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-11-12
- Volume
- 28
- Issue
- 46
- Pages
- 11785-11791
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1994348124
- Cited by
- 247
- References
- 17
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Eisch, A. J., Cameron, H. A., Encinas, J. M., Meltzer, L. A., Ming, G.-L., & Overstreet-Wadiche, L. S. (2008). Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?: Figure 1. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.3798-08.2008
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