Cited by 927Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain

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Ge, Shaoyu, Yang, Chih-hao, Hsu, Kuei-sen, Ming, Guo-li, Song, Hongjun·2007·Neuron

Abstract

Active adult neurogenesis occurs in discrete brain regions of all mammals and is widely regarded as a neuronal replacement mechanism. Whether adult-born neurons make unique contributions to brain functions is largely unknown. Here we systematically characterized synaptic plasticity of retrovirally labeled adult-born dentate granule cells at different stages during their neuronal maturation. We identified a critical period between 1 and 1.5 months of the cell age when adult-born neurons exhibit enhanced long-term potentiation with increased potentiation amplitude and decreased induction threshold. Furthermore, such enhanced plasticity in adult-born neurons depends on developmentally regulated synaptic expression of NR2B-containing NMDA receptors. Our study demonstrates that adult-born neurons exhibit the same classic critical period plasticity as neurons in the developing nervous system. The transient nature of such enhanced plasticity may provide a fundamental mechanism allowing adult-born neurons within the critical period to serve as major mediators of experience-induced plasticity while maintaining stability of the mature circuitry.

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Crossref · 10.1016/j.neuron.2007.05.002

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Authors
Ge, S., Yang, C.-H., Hsu, K.-S., Ming, G.-L., & Song, H.
Affiliations
  • Johns Hopkins University (US)
  • National Cheng Kung University (TW)
Corresponding author
Song, Hongjun
Venue
Neuron
Publisher
Elsevier BV
Published
2007-05
Volume
54
Issue
4
Pages
559-566
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2120811265
Cited by
927
References
45
Citations by year
2026: 20 · 2025: 35 · 2024: 25 · 2023: 27 · 2022: 36 · 2021: 49 · 2020: 47 · 2019: 52 · 2018: 47 · 2017: 64 · 2016: 63 · 2015: 63 · 2014: 60 · 2013: 66 · 2012: 60
FWCI
14.97
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (AG 024984, R01AG024984)
  • National Institute of Neurological Disorders and Stroke (R01NS047344, NS 047344, R37NS047344, R56NS047344)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
adult neurogenesis, synaptic plasticity, critical period, long-term potentiation, dentate gyrus granule cells, neuronal maturation, experience-dependent plasticity, adult-born neurons, hippocampus
MeSH terms
Animals, Critical Period, Psychological, Female, Gene Expression Regulation, Mice, Inbred C57BL, Neurons, Piperidines, Synapses, Time Factors, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, Dentate Gyrus, Excitatory Postsynaptic Potentials, Green Fluorescent Proteins, Mice, In Vitro Techniques

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