A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain
Open accessAbstract
Active adult neurogenesis occurs in discrete brain regions of all mammals and is widely regarded as a neuronal replacement mechanism. Whether adult-born neurons make unique contributions to brain functions is largely unknown. Here we systematically characterized synaptic plasticity of retrovirally labeled adult-born dentate granule cells at different stages during their neuronal maturation. We identified a critical period between 1 and 1.5 months of the cell age when adult-born neurons exhibit enhanced long-term potentiation with increased potentiation amplitude and decreased induction threshold. Furthermore, such enhanced plasticity in adult-born neurons depends on developmentally regulated synaptic expression of NR2B-containing NMDA receptors. Our study demonstrates that adult-born neurons exhibit the same classic critical period plasticity as neurons in the developing nervous system. The transient nature of such enhanced plasticity may provide a fundamental mechanism allowing adult-born neurons within the critical period to serve as major mediators of experience-induced plasticity while maintaining stability of the mature circuitry.
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An aberrant increase in the generation of newborn neurons increases depolarization in response to GABA-ergic inputs.
“and depolarization in response to GABA-ergic inputs.34”
From Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression (2017) · cites this paper as [34]
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- Authors
- Ge, S., Yang, C.-H., Hsu, K.-S., Ming, G.-L., & Song, H.
- Affiliations
- Johns Hopkins University (US)
- National Cheng Kung University (TW)
- Corresponding author
- Song, Hongjun
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 54
- Issue
- 4
- Pages
- 559-566
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2040308
- OpenAlex
- W2120811265
- Cited by
- 927
- References
- 45
- Citations by year
- 2026: 20 · 2025: 35 · 2024: 25 · 2023: 27 · 2022: 36 · 2021: 49 · 2020: 47 · 2019: 52 · 2018: 47 · 2017: 64 · 2016: 63 · 2015: 63 · 2014: 60 · 2013: 66 · 2012: 60
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2305 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG 024984, R01AG024984)
- National Institute of Neurological Disorders and Stroke (R01NS047344, NS 047344, R37NS047344, R56NS047344)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adult neurogenesis, synaptic plasticity, critical period, long-term potentiation, dentate gyrus granule cells, neuronal maturation, experience-dependent plasticity, adult-born neurons, hippocampus
- MeSH terms
- Animals, Critical Period, Psychological, Female, Gene Expression Regulation, Mice, Inbred C57BL, Neurons, Piperidines, Synapses, Time Factors, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, Dentate Gyrus, Excitatory Postsynaptic Potentials, Green Fluorescent Proteins, Mice, In Vitro Techniques
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