The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.
Locus Ceruleus Degeneration Promotes Alzheimer Pathogenesis in Amyloid Precursor Protein 23 Transgenic Mice
Open accessAbstract
Locus ceruleus (LC) degeneration and loss of cortical noradrenergic innervation occur early in Alzheimer’s disease (AD). Although this has been known for several decades, the contribution of LC degeneration to AD pathogenesis remains unclear. We induced LC degeneration with N-(2-chloroethyl)-N-ethyl-bromo-benzylamine (dsp4) in amyloid precursor protein 23 (APP23) transgenic mice with a low amyloid load. Then 6 months later the LC projection areas showed a robust elevation of glial inflammation along with augmented amyloid plaque deposits. Moreover, neurodegeneration and neuronal loss significantly increased. Importantly, the paraventricular thalamus, a nonprojection area, remained unaffected. Radial arm maze and social partner recognition tests revealed increased memory deficits while high-resolution magnetic resonance imaging-guided micro-positron emission tomography demonstrated reduced cerebral glucose metabolism, disturbed neuronal integrity, and attenuated acetylcholinesterase activity. Nontransgenic mice with LC degeneration were devoid of these alterations. Our data demonstrate that the degeneration of LC affects morphology, metabolism, and function of amyloid plaque-containing higher brain regions in APP23 mice. We postulate that LC degeneration substantially contributes to AD development.
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“In contrast, lesioning of another projection pathway, that from the locus coeruleus, was reported to increase plaque pathology in terminal fields of the cerebral cortex [72].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [72]
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Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
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Self-citationWidespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
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Vautheny, A. (2019) · theses.fr (ABES) · doi:10.70675/1812d71aze8d9z48d6z87d1z5a23a4e81953
Rôle du récepteur 5-HT2B dans la motilité des cellules microgliales
Etienne, F. (2020) · theses.fr (ABES) · doi:10.70675/525a2c9ez9415z45f8z8838z1155f108aaf2
Scotto, M., Galgani, A., Boido, M., Mohammady, N., Vercelli, A., & Giorgi, F. S. (2026) · Methods and Protocols · doi:10.3390/mps9020064
Advances in Transcutaneous Auricular Vagus Nerve Stimulation for Alzheimer’s Disease
廖, 若. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.16103465
Metadata
- Authors
- Heneka, M. T., Ramanathan, M., Jacobs, A. H., Dumitrescu-Ozimek, L., Bilkei-Gorzo, A., Debeir, T., Sastre, M., Galldiks, N., Zimmer, A., Hoehn, M., Heiss, W.-D., Klockgether, T., & Staufenbiel, M.
- Affiliations
- University of Bonn (DE)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-02-01
- Volume
- 26
- Issue
- 5
- Pages
- 1343-1354
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6675491
- OpenAlex
- W2118414216
- Cited by
- 305
- References
- 54
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 18 · 2023: 21 · 2022: 23 · 2021: 18 · 2020: 16 · 2019: 16 · 2018: 12 · 2017: 20 · 2016: 9 · 2015: 17 · 2014: 11 · 2013: 17 · 2012: 19
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB400)
- International Brain Research Organization
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease pathogenesis, glial inflammation, amyloid plaques, neurodegeneration, memory impairment, brain glucose metabolism, acetylcholinesterase activity, paraventricular thalamus, cholinergic hypothesis
- MeSH terms
- Alzheimer Disease, Animals, Astrocytes, Brain, Cognition Disorders, Female, Locus Coeruleus, Mice, Transgenic, Nerve Degeneration, Norepinephrine, Amyloid beta-Protein Precursor, Microglia, Peroxynitrous Acid, Positron-Emission Tomography, Vesicular Acetylcholine Transport Proteins, Mice, Nitric Oxide Synthase Type II, Plaque, Amyloid
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