Temporal order memory assessed during spatiotemporal navigation as a behavioral cognitive marker for differential Alzheimer's disease diagnosis
Open accessAbstract
Episodic memory impairment is a hallmark for early diagnosis of Alzheimer's disease. Most actual tests used to diagnose Alzheimer's disease do not assess the spatiotemporal properties of episodic memory and lead to false-positive or -negative diagnosis. We used a newly developed, nonverbal navigation test for Human, based on the objective experimental testing of a spatiotemporal experience, to differentially Alzheimer's disease at the mild stage (N = 16 patients) from frontotemporal lobar degeneration (N = 11 patients) and normal aging (N = 24 subjects). Comparing navigation parameters and standard neuropsychological tests, temporal order memory appeared to have the highest predictive power for mild Alzheimer's disease diagnosis versus frontotemporal lobar degeneration and normal aging. This test was also nonredundant with classical neuropsychological tests. As a conclusion, our results suggest that temporal order memory tested in a spatial navigation task may provide a selective behavioral marker of Alzheimer's disease.
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The most specific domains for VR diagnostic and training purposes in AD patients include attention, executive functions, memory, orientation, and ADL.
“The most specific domains for VR diagnostic and training purposes in AD patients include attention (322), executive functions (323–326), memory (327–333), orientation (322, 327, 334–336), and ADL (337, 338).”
From The Multidisciplinary Approach to Alzheimer’s Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment (2018) · cites this paper as [330]
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Additional file 1 of Age-related impairment of navigation and strategy in virtual star maze
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D-sérine : un maillon central de la physiopathologie amyloïde ?
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- Authors
- Bellassen, V., Iglói, K., de Souza, L. C., Dubois, B., & Rondi-Reig, L.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Université Pierre-et-Marie-Curie (FR)
- Inserm (FR)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-02-08
- Volume
- 32
- Issue
- 6
- Pages
- 1942-1952
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6621707
- OpenAlex
- W2095306411
- Cited by
- 93
- References
- 71
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 2 · 2019: 6 · 2018: 6 · 2017: 10 · 2016: 7 · 2015: 9 · 2014: 7 · 2013: 4 · 2012: 3
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-07-JCJC-0108)
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, temporal order memory, episodic memory, frontotemporal lobar degeneration, mild cognitive impairment, differential diagnosis, normal aging
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Cognition Disorders, Diagnosis, Differential, Female, Humans, Male, Memory, Memory Disorders, Middle Aged, Neuropsychological Tests, Photic Stimulation, Psychomotor Performance, Spatial Behavior, Time Factors, Frontotemporal Lobar Degeneration
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