Cited by 94Dementia and Cognitive Impairment ResearchCognitive Functions and MemoryAlzheimer's disease research and treatments

Temporal order memory assessed during spatiotemporal navigation as a behavioral cognitive marker for differential Alzheimer's disease diagnosis

Open access
Bellassen, Virginie, Iglói, Kinga, de Souza, Leonardo Cruz, Dubois, Bruno, Rondi-Reig, Laure·2012·The Journal of Neuroscience

Abstract

Episodic memory impairment is a hallmark for early diagnosis of Alzheimer's disease. Most actual tests used to diagnose Alzheimer's disease do not assess the spatiotemporal properties of episodic memory and lead to false-positive or -negative diagnosis. We used a newly developed, nonverbal navigation test for Human, based on the objective experimental testing of a spatiotemporal experience, to differentially Alzheimer's disease at the mild stage (N = 16 patients) from frontotemporal lobar degeneration (N = 11 patients) and normal aging (N = 24 subjects). Comparing navigation parameters and standard neuropsychological tests, temporal order memory appeared to have the highest predictive power for mild Alzheimer's disease diagnosis versus frontotemporal lobar degeneration and normal aging. This test was also nonredundant with classical neuropsychological tests. As a conclusion, our results suggest that temporal order memory tested in a spatial navigation task may provide a selective behavioral marker of Alzheimer's disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1523/jneurosci.4556-11.2012

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Lezak MD (1983) Neuropsychological assessment, Ed 2. New York: Oxford UP.

Cited by

Sorted by citations

Authors
Bellassen, V., Iglói, K., de Souza, L. C., Dubois, B., & Rondi-Reig, L.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Université Pierre-et-Marie-Curie (FR)
  • Inserm (FR)
Venue
The Journal of Neuroscience
Published
2012-02-08
Volume
32
Issue
6
Pages
1942-1952
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2095306411
Cited by
93
References
71
Citations by year
2026: 1 · 2025: 9 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 2 · 2019: 6 · 2018: 6 · 2017: 10 · 2016: 7 · 2015: 9 · 2014: 7 · 2013: 4 · 2012: 3
FWCI
5.23
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Agence Nationale de la Recherche (ANR-07-JCJC-0108)
  • Centre National de la Recherche Scientifique
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, temporal order memory, episodic memory, frontotemporal lobar degeneration, mild cognitive impairment, differential diagnosis, normal aging
MeSH terms
Adult, Aged, Aged, 80 and over, Alzheimer Disease, Cognition Disorders, Diagnosis, Differential, Female, Humans, Male, Memory, Memory Disorders, Middle Aged, Neuropsychological Tests, Photic Stimulation, Psychomotor Performance, Spatial Behavior, Time Factors, Frontotemporal Lobar Degeneration

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review