Allothetic orientation and sequential ordering of places is impaired in early stages of Alzheimer's disease: corresponding results in real space tests and computer tests
Abstract
Spatial disorientation and learning problems belong to the integral symptoms of Alzheimer's disease (AD). A circular arena for human subjects (2.9 m diameter, 3 m high) was equipped with a computerized tracking system, similar to that used in animals. We studied navigation in 11 subjects diagnosed with early stages of Alzheimer's disease (AD), 27 subjects with subjective problems with memory or concentration, and 10 controls. The task was to locate one or several unmarked goals using the arena geometry, starting position and/or cues on the arena wall. Navigation in a real version and a computer map view version of the tests yielded similar results. The AD group was severely impaired relative to controls in navigation to one hidden goal in eight rotated positions. The impairment was largest when only the cues on the wall could be used for orientation. Also, the AD group recalled worse than controls the order of six sequentially presented locations, though they recalled similarly to controls the positions of the locations. The group with subjective problems was not impaired in any of the tests. Our results document the spatial navigation and non-verbal episodic memory impairment in the AD. Similar results in real and map view computer tests support the use of computer tests in diagnosis of cognitive disturbances.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The most specific domains for VR diagnostic and training purposes in AD patients include attention, executive functions, memory, orientation, and ADL.
“The most specific domains for VR diagnostic and training purposes in AD patients include attention (322), executive functions (323–326), memory (327–333), orientation (322, 327, 334–336), and ADL (337, 338).”
From The Multidisciplinary Approach to Alzheimer’s Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment (2018) · cites this paper as [322]
Cites
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010 · see citing works
The Mini‐Mental State Examination: A Comprehensive Review
Tombaugh, T. N., & McIntyre, N. J. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb01992.x · Cited by 5,152 · see citing works
The hippocampus as a cognitive map
Passingham, R. E. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90015-0 · Cited by 5,128 · see citing works
(2007) · Cognitive Psychology · doi:10.4135/9781446212967.n15 · Cited by 3,749 · see citing works
Spatial localization does not require the presence of local cues
Morris, R. G. M. (1981) · Learning and Motivation · doi:10.1016/0023-9690(81)90020-5 · Cited by 2,699 · see citing works
Gallistel, C. R. (1990) · Cited by 2,571 · see citing works
Battig, W. F., Tulving, E., & Donaldson, W. (1973) · The American Journal of Psychology · doi:10.2307/1421962 · Cited by 1,428 · see citing works
Statistical Methods and Scientific Inference.
Bartlett, M. S., & Fisher, R. A. (1957) · Biometrika · doi:10.2307/2333276 · Cited by 1,288 · see citing works
Critical role of the hippocampus in memory for sequences of events
Fortin, N. J., Agster, K. L., & Eichenbaum, H. B. (2002) · Nature Neuroscience · doi:10.1038/nn834 · Cited by 881 · see citing works
Schenk, F. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90036-t · Cited by 790 · see citing works
Homing by path integration in a mammal
Mittelstaedt, M.-L., & Mittelstaedt, H. (1980) · Die Naturwissenschaften · doi:10.1007/bf00450672 · Cited by 728 · see citing works
Astur, R., Ortiz, M. L., & Sutherland, R. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00019-9 · Cited by 586 · see citing works
Spatial knowledge acquisition from maps and from navigation in real and virtual environments
Richardson, A. E., Montello, D. R., & Hegarty, M. (1999) · Memory & Cognition · doi:10.3758/bf03211566 · Cited by 570 · see citing works
Associations across time: The hippocampus as a temporary memory store
Rawlins, J. N. P. (1985) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00001291 · Cited by 561 · see citing works
Bohbot, V. D., Kalina, M., Stepankova, K., Spackova, N., Petrides, M., & Nadel, L. (1998) · Neuropsychologia · doi:10.1016/s0028-3932(97)00161-9 · Cited by 516 · see citing works
Males and females use different distal cues in a virtual environment navigation task
Sandstrom, N. J., Kaufman, J., & Huettel, S. A. (1998) · Cognitive Brain Research · doi:10.1016/s0926-6410(98)00002-0 · Cited by 510 · see citing works
The Transfer of Spatial Knowledge in Virtual Environment Training
Waller, D. A., Hunt, E. B., & Knapp, D. (1998) · PRESENCE Virtual and Augmented Reality · doi:10.1162/105474698565631 · Cited by 477 · see citing works
Virtual spaces and real world places: transfer of route knowledge
Witmer, B. G., Bailey, J. H., Knerr, B. W., & Parsons, K. C. (1996) · International Journal of Human-Computer Studies · doi:10.1006/ijhc.1996.0060 · Cited by 405 · see citing works
Astur, R. S., Taylor, L. B., Mamelak, A. N., Philpott, L. M., & Sutherland, R. J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00399-0 · Cited by 400 · see citing works
Ruddle, R. A., Payne, S. J., & Jones, D. M. (1997) · Journal of Experimental Psychology Applied · doi:10.1037/1076-898x.3.2.143 · Cited by 399 · see citing works
Age differences in spatial memory in a virtual environment navigation task
Moffat, S. D., Zonderman, A. B., & Resnick, S. M. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00251-2 · Cited by 367 · see citing works
Human spatial navigation: cognitive maps, sexual dimorphism, and neural substrates
Maguire, E. A., Burgess, N., & O'Keefe, J. M. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80023-3 · Cited by 332 · see citing works
Serial Position Curve in Rats: Role of the Dorsal Hippocampus
Kesner, R. P., & Novak, J. M. (1982) · Science · doi:10.1126/science.7123228 · Cited by 310 · see citing works
The Hippocampal and Parietal Foundations of Spatial Cognition
Burgess, N., Jeffery, K. J., & O'Keefe, J. M. (1999) · Cited by 249 · see citing works
The Role of Global and Local Landmarks in Virtual Environment Navigation
Steck, S. D., & Mallot, H. A. (2000) · PRESENCE Virtual and Augmented Reality · doi:10.1162/105474600566628 · Cited by 246 · see citing works
Effects of age on virtual environment place navigation and allocentric cognitive mapping.
Moffat, S. D., & Resnick, S. M. (2002) · Behavioral Neuroscience · doi:10.1037/0735-7044.116.5.851 · Cited by 243 · see citing works
Chiba, A. A., Kesner, R. P., & Reynolds, A. M. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80065-2 · Cited by 241 · see citing works
Effects of age on virtual environment place navigation and allocentric cognitive mapping.
Moffat, S. D., & Resnick, S. M. (2002) · Behavioral Neuroscience · doi:10.1037//0735-7044.116.5.851 · Cited by 231 · see citing works
Overman, W., Pate, B. J., Moore, K., & Peuster, A. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1205 · Cited by 227 · see citing works
Spatial disorientation in Alzheimer’s disease
Monacelli, A., Cushman, L. A., Kavcic, V., & Duffy, C. J. (2003) · Neurology · doi:10.1212/wnl.61.11.1491 · Cited by 202 · see citing works
The Hippocampal and Parietal Foundations of Spatial Cognition
Beninger, R. J. (1998) · doi:10.1093/oso/9780198524533.001.0001 · Cited by 194 · see citing works
Standardized Mini-Mental State Examination. Use and interpretation.
Vertesi, A., Lever, J. A., Molloy, D. W., Sanderson, B., Tuttle, I., Pokoradi, L., & Principi, E. (2001) · PubMed Central · Cited by 194 · see citing works
Memory deficits in Alzheimer's patients: A comprehensive review
Carlesimo, G. A., & Oscar‐Berman, M. (1992) · Neuropsychology Review · doi:10.1007/bf01108841 · Cited by 184 · see citing works
A visuospatial variant of mild cognitive impairment
Mapstone, M. E., Steffenella, T. M., & Duffy, C. J. (2003) · Neurology · doi:10.1212/01.wnl.0000049471.76799.de · Cited by 181 · see citing works
The Neurobiology of Spatial Behaviour
Jeffery, K. J. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198515241.001.0001 · Cited by 177 · see citing works
Transfer of Spatial Information from a Virtual to a Real Environment
Wilson, P. N., Foreman, N., & Tlauka, M. (1997) · Human Factors The Journal of the Human Factors and Ergonomics Society · doi:10.1518/001872097778667988 · Cited by 132 · see citing works
Place Learning in Virtual Space I: Acquisition, Overshadowing, and Transfer
Jacobs, W. J., Laurance, H. E., & Thomas, K. G. F. (1997) · Learning and Motivation · doi:10.1006/lmot.1997.0977 · Cited by 131 · see citing works
Freksa, C., Habel, C., Brauer, W., & Wender, K. (2000) · Lecture Notes in Computer Science · doi:10.1007/3-540-45460-8 · Cited by 108 · see citing works
Route learning performance in Alzheimer disease patients.
Cherrier, M. M., Mendez, M. F., & Perryman, K. M. (2002) · PubMed · Cited by 106 · see citing works
Object–location memory impairment in patients with thermal lesions to the right or left hippocampus
Štěpánková, K., Fenton, A. A., Pastalkova, E., Kalina, M., & Bohbot, V. D. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.01.002 · Cited by 93 · see citing works
Bureš, J., Fenton, A. A., Kaminsky, Y., Rossier, J., Sacchetti, B., & Zinyuk, L. E. (1997) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1997.0138 · Cited by 88 · see citing works
Self-citationPath integration following temporal lobectomy in humans
Worsley, C. L. (2001) · Neuropsychologia · doi:10.1016/s0028-3932(00)00140-8 · Cited by 86 · see citing works
Spatial information transfer from virtual to real versions of the Kiel locomotor maze
Foreman, N., Stirk, J. A., Pohl, J., Mandelkow, L., Lehnung, M., Herzog, A., & Leplow, B. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00159-5 · Cited by 56 · see citing works
Fraser, D. S., Foreman, N. K., & Wilson, P. N. (1998) · PubMed · Cited by 55 · see citing works
Rodent navigation after dissociation of the allocentric and idiothetic representations of space
Bureš, J., Fenton, A. A., Kaminsky, Y., Wesierska, M., & Zahálka, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00031-8 · Cited by 55 · see citing works
Self-citationThe Neural Basis of Navigation
Sharp, P. E. (2002) · Springer eBooks · doi:10.1007/978-1-4615-0887-8 · Cited by 50 · see citing works
Rossier, J., Kaminsky, Y., Schenk, F., & Bureš, J. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.2.273 · Cited by 50 · see citing works
Self-citationThe Neurobiology of Spatial Behaviour
Smulders, T. V. (2004) · Animal Behaviour · doi:10.1016/j.anbehav.2004.04.002 · Cited by 48 · see citing works
The hippocampus and spatial memory in humans
Morris, R. G., Nunn, J. A., Abrahams, S., Feigenbaum, J., & Recce, M. L. (1998) · Cited by 24 · see citing works
Spatial Orientation and Spatial Memory Within a ‘Locomotor Maze’ for Humans
Leplow, B., Höll, D., Zeng, L., et al. (1998) · Lecture notes in computer science · doi:10.1007/3-540-69342-4_20 · Cited by 20 · see citing works
Štěpánková, K., Pastalkova, E., Kalová, E., Kalina, M., & Bureš, J. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00141-4 · Cited by 19 · see citing works
Self-citationKaminsky, Y., & Krekule, I. (1997) · PubMed · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Effect of probiotics on central nervous system functions in animals and humans: a systematic review
Wang, H., Lee, I.-S., Braun, C., & Enck, P. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16018 · Cited by 334 · see citing works
Zucchella, C., Sinforiani, E., Tamburin, S., Federico, A., Mantovani, E., Bernini, S., Casale, R., & Bartolo, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01058 · Cited by 297 · see citing works
“The most specific domains for VR diagnostic and training purposes in AD patients include attention (322), executive functions (323–326), memory (327–333), orientation (322, 327, 334–336), and ADL (337, 338).”
BackgroundWeniger, G., Ruhleder, M., Lange, C., Wolf, S., & Irle, E. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.12.031 · Cited by 204 · see citing works
Visual short-term memory binding in Alzheimer's disease and depression
Parra, M. A., Abrahams, S., Logie, R. H., & Della Sala, S. (2010) · Journal of Neurology · doi:10.1007/s00415-010-5484-9 · Cited by 115 · see citing works
Bellassen, V., Iglói, K., de Souza, L. C., Dubois, B., & Rondi-Reig, L. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4556-11.2012 · Cited by 93 · see citing works
Ladyka‐Wojcik, N., & Barense, M. D. (2021) · WIREs Cognitive Science · doi:10.1002/wcs.1549 · Cited by 18 · see citing works
- Authors
- Kalová, E., Vlček, K., Jarolímová, E., & Bureš, J.
- Affiliations
- Na Homolce Hospital (CZ)
- Czech Academy of Sciences (CZ)
- Gerontologické Centrum (CZ)
- Corresponding author
- Vlček, Kamil
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 159
- Issue
- 2
- Pages
- 175-186
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2063654543
- Cited by
- 131
- References
- 52
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 14 · 2022: 12 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 10 · 2017: 10 · 2016: 11 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 8
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Grantová Agentura České Republiky
- Topics
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Alzheimer's disease, early Alzheimer's disease, spatial disorientation, spatial navigation, place learning, environmental cues, cognitive impairment diagnosis
- MeSH terms
- Aged, Alzheimer Disease, Attention, Computer Graphics, Exploratory Behavior, Female, Humans, Male, Memory, Memory Disorders, Middle Aged, Orientation, Serial Learning, Severity of Illness Index, Space Perception, Spatial Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
