Egocentric versus allocentric spatial memory in behavioral variant frontotemporal dementia and Alzheimer's disease
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Background: Diagnosis of behavioral variant frontotemporal dementia (bvFTD) can be challenging, in particular when patients present with significant memory problems, which can increase the chance of a misdiagnosis of Alzheimer’s disease (AD). Growing evidence suggests spatial orientation is a reliable cognitive marker able to differentiate these two clinical syndromes. Objective: Assess the integrity of egocentric and allocentric heading orientation and memory in bvFTD and AD, and their clinical implications. Method: A cohort of 22 patients with dementia (11 bvFTD; 11 AD) and 14 healthy controls were assessed on the virtual supermarket task of spatial orientation and a battery of standardized neuropsychological measures of visual and verbal memory performance. Results: Judgements of egocentric and allocentric heading direction were differentially impaired in bvFTD and AD, with AD performing significantly worse on egocentric heading judgements than bvFTD. Both patient cohorts, however, showed similar degree of impaired allocentric spatial representation, and associated hippocampal pathology. Conclusions: The findings suggest egocentric heading judgements offer a more sensitive discriminant of bvFTD and AD than allocentric map-based measures of spatial memory.
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Spatial memory, drawing and spatial orientation, and praxis are typically intact in behavioural variant frontotemporal dementia and can assist with differential diagnosis from Alzheimer's disease.
“Conversely, spatial memory, 38 drawing and spatial orientation, 39 and praxis 40 are typically intact and can assist with differential diagnosis from Alzheimer's disease.”
From Advances and controversies in frontotemporal dementia: diagnosis, biomarkers, and therapeutic considerations (2022) · cites this paper as [38]
The Discussion (page not provided) reports that heading orientation was preserved in bvFTD and could aid differential diagnosis from Alzheimer’s disease. But it also reports impaired allocentric spatial memory in bvFTD, so the blanket claim that spatial memory is typically intact overstates this source. Drawing and praxis have separate citations in the citing sentence and are not assessed here. (LLM, conf=0.89)
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Spatial orientation – a stable marker for vascular cognitive impairment?
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- Authors
- Tu, S., Spiers, H. J., Hodges, J. R., Piguet, O., & Hornberger, M.
- Affiliations
- The University of Sydney (AU)
- University College London (GB)
- University of East Anglia (GB)
- Corresponding author
- Hornberger, Michael
- Venue
- Journal of Alzheimer’s Disease
- Publisher
- SAGE Publications
- Published
- 2017-07-01
- Volume
- 59
- Issue
- 3
- Pages
- 883-892
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2729059723
- Cited by
- 70
- References
- 45
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 12 · 2019: 7 · 2018: 8 · 2017: 1
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- green
- ueaeprints.uea.ac.uk
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Isaac Newton Trust
- Medical Research Council
- Australian Research Council (DP1093279)
- National Health and Medical Research Council (1022684, 1037746)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- behavioral variant frontotemporal dementia, Alzheimer's disease
- MeSH terms
- Aged, Alzheimer Disease, Female, Humans, Judgment, Magnetic Resonance Imaging, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Orientation, Space Perception, Cohort Studies, Case-Control Studies, Statistics, Nonparametric, Frontotemporal Dementia, Spatial Memory
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