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Firing and Cellular Properties of V2a Interneurons in the Rodent Spinal Cord
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Previous studies have shown that a group of ventrally located neurons, designated V2a interneurons, play a key role in maintaining locomotor rhythmicity and in ensuring appropriate left–right alternation during locomotion (Crone et al., 2008, 2009). These V2a interneurons express the transcription factor Chx10. The aim of the present study was to characterize the locomotor-related activity of individual V2a interneurons, their cellular properties, and their detailed anatomical attributes in Chx10-GFP mice. A dorsal horn-removed preparation was developed to allow for visual whole-cell patch recordings from V2a interneurons along the entire lumbar spinal cord while at the same time leaving enough of the spinal cord intact to generate fictive locomotion. During drug-evoked locomotor-like activity, a large proportion of Chx10 cells showed rhythmic firing or membrane potential fluctuations related to either flexor or extensor activity in every lumbar segment. Chx10 cells received predominantly rhythmic excitatory input. Chx10 neurons displayed a wide variety of firing and potential rhythmogenic properties. However, none of these properties was obviously related to the observed rhythmicity during locomotor-like activity. In dual recordings, we found no evidence of Chx10 neuron interconnectivity. Intracellular fills revealed diverse projection patterns with most Chx10 interneurons being local with projections to the central pattern generator and motor neuron regions of the spinal cord and others with long ascending and/or descending branches. These data are compatible with V2a neurons having a role in regulating segmental left–right alternation and ipsilateral motor neuron firing with little effect on rhythm generation.
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“Specific subpopulations of V2a neurons in the brainstem, cervical spinal cord and lumbar spinal cord have been implicated in different aspects of motor control35,41–45.”
From The neurons that restore walking after paralysis (2022) · cites this paper as [43]
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“These neurons originate from a subset of developmentally defined V2a neurons35,41–45, which describe a family of neuronal subpopulations distributed along the neuraxis35,41–45.”
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Metadata
- Authors
- Dougherty, K. J., & Kiehn, O.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Kiehn, Ole
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-01-06
- Volume
- 30
- Issue
- 1
- Pages
- 24-37
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3842458
- OpenAlex
- W2166837618
- Cited by
- 138
- References
- 105
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 8 · 2023: 6 · 2022: 13 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 12 · 2017: 7 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 7 · 2012: 8
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0701166)
- European Commission
- Hjärnfonden
- Karolinska Institutet
- National Institutes of Health (5r01ns040795-09)
- Medical Research Council
- National Institute of Neurological Disorders and Stroke (R01 NS040795, R01NS040795-08)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Physical Sciences › Engineering › Control and Systems Engineering › Robotic Locomotion and Control
- Keywords
- V2a interneurons, Chx10, spinal cord, locomotor rhythm, fictive locomotion, left-right alternation, central pattern generator, neuronal firing patterns, membrane potential fluctuations, interneuron connectivity, axonal projections, lumbar spinal cord
- MeSH terms
- Action Potentials, Animals, Animals, Newborn, Anterior Horn Cells, Interneurons, Mice, Transgenic, Periodicity, Spinal Cord, Transcription Factors, Homeodomain Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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