Cited by 138Neuroscience and Neuropharmacology ResearchMotor Control and AdaptationRobotic Locomotion and Control

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Firing and Cellular Properties of V2a Interneurons in the Rodent Spinal Cord

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Dougherty, Kimberly J., Kiehn, Ole·2010·The Journal of Neuroscience

DOI 10.1523/jneurosci.4821-09.2010PMC PMC3842458

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Abstract

Previous studies have shown that a group of ventrally located neurons, designated V2a interneurons, play a key role in maintaining locomotor rhythmicity and in ensuring appropriate left–right alternation during locomotion (Crone et al., 2008, 2009). These V2a interneurons express the transcription factor Chx10. The aim of the present study was to characterize the locomotor-related activity of individual V2a interneurons, their cellular properties, and their detailed anatomical attributes in Chx10-GFP mice. A dorsal horn-removed preparation was developed to allow for visual whole-cell patch recordings from V2a interneurons along the entire lumbar spinal cord while at the same time leaving enough of the spinal cord intact to generate fictive locomotion. During drug-evoked locomotor-like activity, a large proportion of Chx10 cells showed rhythmic firing or membrane potential fluctuations related to either flexor or extensor activity in every lumbar segment. Chx10 cells received predominantly rhythmic excitatory input. Chx10 neurons displayed a wide variety of firing and potential rhythmogenic properties. However, none of these properties was obviously related to the observed rhythmicity during locomotor-like activity. In dual recordings, we found no evidence of Chx10 neuron interconnectivity. Intracellular fills revealed diverse projection patterns with most Chx10 interneurons being local with projections to the central pattern generator and motor neuron regions of the spinal cord and others with long ascending and/or descending branches. These data are compatible with V2a neurons having a role in regulating segmental left–right alternation and ipsilateral motor neuron firing with little effect on rhythm generation.

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Authors: Dougherty, K. J., & Kiehn, O.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Kiehn, Ole
ORCID: Dougherty, Kimberly J.
Kiehn, Ole
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2010-01-06
Volume: 30
Issue: 1
Pages: 24-37
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.4821-09.2010
PMC: PMC3842458
OpenAlex: W2166837618
Cited by: 138
References: 105
Citations by year: 2026: 5 · 2025: 7 · 2024: 8 · 2023: 6 · 2022: 13 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 12 · 2017: 7 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 7 · 2012: 8
FWCI: 4.91
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (0701166)
European Commission
Hjärnfonden
Karolinska Institutet
National Institutes of Health (5r01ns040795-09)
Medical Research Council
National Institute of Neurological Disorders and Stroke (R01 NS040795, R01NS040795-08)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Physical Sciences › Engineering › Control and Systems Engineering › Robotic Locomotion and Control
Keywords: V2a interneurons, Chx10, spinal cord, locomotor rhythm, fictive locomotion, left-right alternation, central pattern generator, neuronal firing patterns, membrane potential fluctuations, interneuron connectivity, axonal projections, lumbar spinal cord
MeSH terms: Action Potentials, Animals, Animals, Newborn, Anterior Horn Cells, Interneurons, Mice, Transgenic, Periodicity, Spinal Cord, Transcription Factors, Homeodomain Proteins, Mice

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Firing and Cellular Properties of V2a Interneurons in the Rodent Spinal Cord

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