Cited by 165Pain Mechanisms and TreatmentsPain Management and Placebo EffectPain Management and Treatment

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Uncertainty Increases Pain: Evidence for a Novel Mechanism of Pain Modulation Involving the Periaqueductal Gray

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Yoshida, Wako, Seymour, Ben, Koltzenburg, Martin, Dolan, Raymond J.·2013·The Journal of Neuroscience

DOI 10.1523/jneurosci.4984-12.2013PMC PMC3701089

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Abstract

Predictions about sensory input exert a dominant effect on what we perceive, and this is particularly true for the experience of pain. However, it remains unclear what component of prediction, from an information-theoretic perspective, controls this effect. We used a vicarious pain observation paradigm to study how the underlying statistics of predictive information modulate experience. Subjects observed judgments that a group of people made to a painful thermal stimulus, before receiving the same stimulus themselves. We show that the mean observed rating exerted a strong assimilative effect on subjective pain. In addition, we show that observed uncertainty had a specific and potent hyperalgesic effect. Using computational functional magnetic resonance imaging, we found that this effect correlated with activity in the periaqueductal gray. Our results provide evidence for a novel form of cognitive hyperalgesia relating to perceptual uncertainty, induced here by vicarious observation, with control mediated by the brainstem pain modulatory system.

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Self-citation
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Price, D. D., McGrath, P. A., Rafii, A., & Buckingham, B. (1983) · Pain · doi:10.1016/0304-3959(83)90126-4 · Cited by 3,921
Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry
Basbaum, A. I., & Fields, H. L. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001521 · Cited by 2,687
Psychological and neural mechanisms of the affective dimension of pain
Price, D. D. (2000) · Science · doi:10.1126/science.288.5472.1769 · Cited by 2,092
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992
Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation
Reynolds, D. V. (1969) · Science · doi:10.1126/science.164.3878.444 · Cited by 1,380
Dissociating pain from its anticipation in the human brain
Ploghaus, A., Tracey, I., Gati, J. S., Clare, S., Menon, R. S., Matthews, P. M., & Rawlins, J. N. P. (1999) · Science · doi:10.1126/science.284.5422.1979 · Cited by 1,151
Thermosensory activation of insular cortex
Craig, A. D., Chen, K., Bandy, D., & Reiman, E. M. (2000) · Nature Neuroscience · doi:10.1038/72131 · Cited by 1,004

Show all 74 references

Research works printed but not linked: 1

Fields HL (2006) Proceedings of the 11th World Congress on Pain A motivation-decision model of pain: the role of opioids, eds Flor H Kalso E Dostrovsky JO (IASP, Seattle), pp 449–459.

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Self-citation

Authors: Yoshida, W., Seymour, B., Koltzenburg, M., & Dolan, R. J.
Affiliations: Wellcome Centre for Human Neuroimaging (GB)
UCL Queen Square Institute of Neurology (GB)
ORCID: Yoshida, Wako
Seymour, Ben
Koltzenburg, Martin
Dolan, Raymond J.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2013-03-27
Volume: 33
Issue: 13
Pages: 5638-5646
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.4984-12.2013
PMC: PMC3701089
OpenAlex: W2085014216
Cited by: 165
References: 74
Citations by year: 2026: 11 · 2025: 13 · 2024: 23 · 2023: 25 · 2022: 12 · 2021: 7 · 2020: 7 · 2019: 14 · 2018: 10 · 2017: 14 · 2016: 7 · 2015: 11 · 2014: 9 · 2013: 2
FWCI: 6.66
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Max Planck Digital Library (submittedVersion, other-oa)
Cambridge University Engineering Department Publications Database (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders: Wellcome Trust (091593, 078865/Z/05/Z, 078865, 098362, 098362/Z/12/Z, 091593/Z/10/Z)
Ministry of Internal Affairs and Communications
Medical Research Council (MR/K000608/1, MR/K015222/1)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: pain perception, uncertainty, periaqueductal gray, predictive information, assimilation, thermal pain
MeSH terms: Brain Mapping, Computer Simulation, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Models, Biological, Oxygen, Pain, Pain Measurement, Periaqueductal Gray, Physical Stimulation, Pain Threshold, Uncertainty, Pain Perception

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Uncertainty Increases Pain: Evidence for a Novel Mechanism of Pain Modulation Involving the Periaqueductal Gray

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