The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.
Nicotinic Acetylcholine Receptors in the Mesolimbic Pathway: Primary Role of Ventral Tegmental Area α6β2* Receptors in Mediating Systemic Nicotine Effects on Dopamine Release, Locomotion, and Reinforcement
Open accessAbstract
α6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by mesostriatal dopamine (DA) neurons. These neurons are thought to mediate several behavioral effects of nicotine, including locomotion, habit learning, and reinforcement. Yet the functional role of α6* nAChRs in midbrain DA neurons is mostly unknown. The aim of this study was to determine the composition and in vivo functional role of α6* nAChR in mesolimbic DA neurons of male rats. Immunoprecipitation and immunopurification techniques coupled with cell-specific lesions showed that the composition of α6* nAChR in the mesostriatal system is heterogeneous, with (non-α4)α6β2* being predominant in the mesolimbic pathway and α4α6β2* in the nigrostriatal pathway. We verified whether α6* receptors mediate the systemic effects of nicotine on the mesolimbic DA pathway by perfusing the selective antagonists α-conotoxin MII (CntxMII) (α3/α6β2* selective) or α-conotoxin PIA (CntxPIA) (α6β2* selective) into ventral tegmental area (VTA). The intra-VTA perfusion of CntxMII or CntxPIA markedly decreased systemic nicotine-elicited DA release in the nucleus accumbens and habituated locomotion; the intra-VTA perfusion of CntxMII also decreased the rate of nicotine infusion in the maintenance phase of nicotine, but not of food, self-administration. Overall, the results of these experiments show that the α6β2* nAChRs expressed in the VTA are necessary for the effects of systemic nicotine on DA neuron activity and DA-dependent behaviors such as locomotion and reinforcement, and suggest that α6β2*-selective compounds capable of crossing the blood–brain barrier may affect the addictive properties of nicotine and therefore be useful in the treatment of tobacco dependence.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Similarly, conotoxins selective for α6/β2 Ã nAChRs disrupt nicotine self-administration in the rat when infused into the VTA (Gotti et al. 2010) and following selfadministration training, these conotoxins decrease the motivation to lever press for nicotine on a progressive ratio schedule (Brunzell et al. 2010).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Gotti et al. 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
LIGAND: A versatile computerized approach for characterization of ligand-binding systems
Munson, P. J., & Rodbard, D. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90515-1 · Cited by 8,373
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501
Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320
Self-citationBrain nicotinic acetylcholine receptors: native subtypes and their relevance
Gotti, C., Zoli, M., & Clementi, F. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.07.004 · Cited by 882
Self-citationWise, R. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00965-0 · Cited by 881
Nicotinic Receptors at the Amino Acid Level
Corringer, P., Novère, N. G. L., & Changeux, J. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.431 · Cited by 832
Corrigall, W. A., Coen, K. M., & Adamson, K. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)90401-4 · Cited by 740
Role of dopamine in the behavioural actions of nicotine related to addiction
Chiara, G. D. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00122-9 · Cited by 698
Cited by
Sorted by citations
Items 101–200 of 228
Hauser, S. R., Bracken, A. L., Deehan, G. A., Toalston, J. E., Ding, Z., Truitt, W. A., Bell, R. L., McBride, W. J., & Rodd, Z. A. (2013) · Addiction Biology · doi:10.1111/adb.12048 · Cited by 29
The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers
Robinson, J. D., Versace, F., Lam, C. Y., Minnix, J. A., Engelmann, J. M., Cui, Y., Karam‐Hage, M., Shete, S. S., Tomlinson, G. E., Chen, T. T.-L., et al. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00114 · Cited by 30
Sagheddu, C., Scherma, M., Congiu, M., Fadda, P., Carta, G., Banni, S., Wood, J. T., Makriyannis, A., Malamas, M. S., & Pistis, M. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.013 · Cited by 27
Levamisole enhances the rewarding and locomotor-activating effects of cocaine in rats
Tallarida, C. S., Tallarida, R. J., & Rawls, S. M. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.01.035 · Cited by 28
Lian, M., Hueffer, K., & Weltzin, M. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e10434 · Cited by 26
Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking Cessation
Mohamed, T. S., Jayakar, S. S., & Hamouda, A. K. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00071 · Cited by 27
Melis, M., & Pistis, M. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.03.009 · Cited by 27
Perez, X. A., McIntosh, J. M., & Quik, M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12442 · Cited by 28
Pharmacologic Characterization of a Nicotine-Discriminative Stimulus in Rhesus Monkeys
Cunningham, C. S., Javors, M. A., & McMahon, L. R. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.193078 · Cited by 26
Morganstern, I., Lukatskaya, O., Moon, S.-H., Guo, W.-R., Shaji, J., Karatayev, O., & LEIBOWITZ, S. F. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3178-6 · Cited by 26
Bracken, A. L., Chambers, R. A., Berg, S. A., Rodd, Z. A., & McBride, W. J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.04.008 · Cited by 23
“Neuronal nAChRs have recently been directly linked to mediation of nicotine-stimulated locomotor activity (Gotti et al. 2010).”
BackgroundBordia, T., McIntosh, J. M., & Quik, M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12179 · Cited by 23
Tobey, K. M., Walentiny, D. M., Wiley, J. L., Carroll, F. I., Damaj, M. I., Azar, M. R., Koob, G. F., George, O., Harris, L. S., & Vann, R. E. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2703-3 · Cited by 23
Hauser, S. R., Deehan, G. A. J., Toalston, J. E., Bell, R., Mcbride, W., & Rodd, Z. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3508-3 · Cited by 18
Peng, C., Stokes, C. A., Mineur, Y. S., Picciotto, M. R., Tian, C., Eibl, C., Tomassoli, I., Guendisch, D., & Papke, R. L. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.206904 · Cited by 21
Cameli, C., Bacchelli, E., Paola, M. D., Giucastro, G., Cifiello, S., Collo, G., Cainazzo, M. M., Pini, L. A., Maestrini, E., & Zoli, M. (2018) · European Journal of Human Genetics · doi:10.1038/s41431-018-0223-2 · Cited by 23
Self-citationNicotinic acetylcholine receptor mutations
Steinlein, O. K., Kaneko, S., & Hirose, S. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02851.x · Cited by 21
Endogenous Cholinergic Neurotransmission Contributes to Behavioral Sensitization to Morphine
Bajic, D., Soiza‐Reilly, M., Spalding, A. L., Berde, C. B., & Commons, K. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117601 · Cited by 20
Expression of cloned α6* nicotinic acetylcholine receptors
Wang, J., Kuryatov, A., & Lindstrom, J. M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.009 · Cited by 21
The potential of nicotinic enhancement of cognitive remediation training in schizophrenia
Hahn, B., Gold, J. M., & Buchanan, R. W. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.050 · Cited by 18
Filippis, S. D., Martinotti, G., Nicoletti, F., Mastrostefano, A., Trovini, G., Pugliese, A., & Nicola, M. D. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666240827165327 · Cited by 22
Cunningham, C. S., & McMahon, L. R. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3037-5 · Cited by 19
Differential behavioral profiling of stimulant substances in the rat using the LABORAS™ system
Castagné, V., Wolinsky, T. D., Quinn, L. P., & Virley, D. J. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.03.001 · Cited by 19
The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein
O'Brien, B. C. V., Thao, S., Weber, L., Danielson, H. L., Boldt, A. D., Hueffer, K., & Weltzin, M. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1394713 · Cited by 15
The novel hybrid agonist HyNDA-1 targets the D3R-nAChR heteromeric complex in dopaminergic neurons
Matera, C., Bono, F., Pelucchi, S., Collo, G., Bontempi, L., Gotti, C., Zoli, M., Amici, M. D., Missale, C., Fiorentini, C., et al. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.02.019 · Cited by 18
Self-citationSteffensen, S. C., Shin, S. I., Nelson, A. C., Pistorius, S. S., Williams, S. B., Woodward, T. J., Park, H.-J., Friend, L. N., Gao, M., Gao, F., et al. (2017) · Addiction Biology · doi:10.1111/adb.12559 · Cited by 18
Beckmann, J. S., Meyer, A. C., Pivavarchyk, M., Horton, D. B., Zheng, G., Smith, A. M., Wooters, T. E., McIntosh, J. M., Crooks, P. A., Bardo, M. T., et al. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1680-4 · Cited by 18
Marusich, J. A., Darna, M., Wilson, A. G., Denehy, E. D., Ebben, A., Deaciuc, A. G., Dwoskin, L. P., Bardo, M. T., Lefever, T. W., Wiley, J. L., et al. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.08.029 · Cited by 16
Corrie, L. W.-C., Stokes, C. A., Wilkerson, J. L., Carroll, F. I., McMahon, L. R., & Papke, R. L. (2020) · Molecular Pharmacology · doi:10.1124/molpharm.120.000037 · Cited by 19
Teodoro, R., Scheunemann, M., Deuther‐Conrad, W., Wenzel, B., Fasoli, F., Gotti, C., Kranz, M., Donat, C. K., Patt, M., Hillmer, A. T., et al. (2015) · Molecules · doi:10.3390/molecules201018387 · Cited by 16
Self-citationKim, M. N., Jutkiewicz, E. M., Zhang, M., & Gnegy, M. E. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.10.003 · Cited by 15
Modulation of Gain-of-function α6*-Nicotinic Acetylcholine Receptor by β3 Subunits
Dash, B., & Lukas, R. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.322610 · Cited by 15
Zhu, X.-P., Wang, S., Kaas, Q., Yu, J.-P., Wu, Y., Harvey, P., Zhangsun, D.-T., Craik, D., & Luo, S.-L. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01786 · Cited by 14
Hoestgaard-Jensen, K., Hoestgaard-Jensen, K., & Jensen, A. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.509356 · Cited by 15
Dash, B., Li, M. D., & Lukas, R. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.566018 · Cited by 15
A role for α4(non-α6)* nicotinic acetylcholine receptors in motor behavior
Soll, L. G., Grady, S. R., Salminen, O., Marks, M. J., & Tapper, A. R. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.001 · Cited by 15
Guildford, M. J., Sacino, A. V., & Tapper, A. R. (2016) · Alcohol · doi:10.1016/j.alcohol.2016.08.006 · Cited by 14
Gene editing vectors for studying nicotinic acetylcholine receptors in cholinergic transmission
Peng, C., Yan, Y., Kim, V. J., Engle, S. E., Berry, J. N., McIntosh, J. M., Neve, R. L., & Drenan, R. M. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13957 · Cited by 15
Eibl, C., Tomassoli, I., Munoz, L., Stokes, C. A., Papke, R. L., & Gündisch, D. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.09.059 · Cited by 14
Nicotinic Acetylcholine Receptors of PC12 Cells
Mussina, K., Toktarkhanova, D., & Filchakova, O. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00846-x · Cited by 15
Kucinski, A., Wersinger, S., Stachowiak, E., Corso, T. D., Parry, M., Zhang, J., Jordan, K., Letchworth, S., Bencherif, M., & Stachowiak, M. (2013) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2013.07.005 · Cited by 13
Chiamulera, C., Padovani, L., & Corsi, M. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.08.009 · Cited by 14
Self-citationDeletion of lynx1 reduces the function of α6* nicotinic receptors
Parker, R. L., O’Neill, H. C., Henley, B. M., Wageman, C. R., Drenan, R. M., Marks, M. J., Miwa, J. M., Grady, S. R., & Lester, H. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188715 · Cited by 14
Matera, C., Pucci, L., Fiorentini, C., Fucile, S., Missale, C., Grazioso, G., Clementi, F., Zoli, M., Amici, M. D., Gotti, C., et al. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.06.039 · Cited by 13
Self-citationAllen, M. I., Johnson, B., Kumar, A., Su, Y., Singh, S., Deep, G., & Nader, M. A. (2024) · Addiction Neuroscience · doi:10.1016/j.addicn.2024.100151 · Cited by 12
The interpeduncular nucleus blunts the rewarding effect of nicotine
Jehl, J., Ciscato, M., Vicq, É., Guyon, N., de la Bâtie, G. D., Mondoloni, S., Frangieh, J., Mohayyaei, M., Nguyen, C., Pons, S., et al. (2023) · Neuron · doi:10.1016/j.neuron.2025.03.035 · Cited by 12
Madsen, H. B., Koghar, H. S., Pooters, T., Massalas, J. S., Drago, J., & Lawrence, A. J. (2014) · Addiction Biology · doi:10.1111/adb.12148 · Cited by 15
Farquhar, M. J., Latimer, M. P., & Winn, P. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2452-8 · Cited by 12
Yu, J., Zhu, X., Yang, Y., Luo, S., & Zhangsun, D. (2017) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13104 · Cited by 12
Moen, J. K., DeBaker, M. C., Myjak, J. E., Wickman, K., & Lee, A. M. (2020) · Addiction Biology · doi:10.1111/adb.12954 · Cited by 13
New medications development for smoking cessation
Lengel, D., & Kenny, P. J. (2023) · Addiction Neuroscience · doi:10.1016/j.addicn.2023.100103 · Cited by 14
Gao, R., Schneider, A. M., Mulloy, S., & Lee, A. M. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16109 · Cited by 12
Ley, C. K.-K., Kuryatov, A., Wang, J., & Lindstrom, J. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103244 · Cited by 11
Karimani, F., Delphi, L., & Rezayof, A. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.04.013 · Cited by 11
Cardenas, A. M., Bai, Y., Heydary, Y. H., Li, J., Leslie, F. M., & Lotfipour, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063145 · Cited by 12
Rose, J. E., & Dehkordi, O. (2016) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.1000274 · Cited by 10
Collo, G., Cavalleri, L., Zoli, M., Maskos, U., Ratti, E., & Pich, E. M. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00572 · Cited by 10
Self-citationMore than Smoke and Patches: The Quest for Pharmacotherapies to Treat Tobacco Use Disorder
Moerke, M. J., McMahon, L. R., & Wilkerson, J. L. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018028 · Cited by 11
Carroll, F. I., Navarro, H. A., Mascarella, S. W., Castro, A. H., Luetje, C. W., Wageman, C. R., Marks, M. J., Jackson, A. B., & Damaj, M. I. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00077 · Cited by 10
Papke, R. L. (2023) · Advances in pharmacology · doi:10.1016/bs.apha.2023.08.001 · Cited by 9
Moerke, M. J., Zhu, A. Z. X., Tyndale, R. F., Javors, M. A., & McMahon, L. R. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.12.003 · Cited by 9
Peterson, D. J., Gill, W. D., Dose, J. M., Hoover, D. B., Pauly, J. R., Cummins, E. D., Burgess, K. C., & Brown, R. W. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.029 · Cited by 9
Dash, B., & Li, M. D. (2014) · Molecular Brain · doi:10.1186/1756-6606-7-35 · Cited by 8
Cocaine and Nicotine Research Illustrates a Range of Hypocretin Mechanisms in Addiction
Baimel, C., Borgland, S. L., & Corrigall, W. A. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-394623-2.00016-0 · Cited by 8
Reyes-Parada, M. I., & Iturriaga‐Vásquez, P. (2016) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2016.1227317 · Cited by 8
Li, M. D., Yang, Z., Guo, H., & Dash, B. (2016) · Neuromethods · doi:10.1007/978-1-4939-3768-4_12 · Cited by 8
Seipel, A. T., & Yakel, J. L. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06883.x · Cited by 8
Elucidating the reinforcing effects of nicotine: a tribute to Nadia Chaudhri
Sved, A. F., Caggiula, A. R., & Donny, E. C. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06266-7 · Cited by 7
Scientific overview: 2013 BBC plenary symposium on tobacco addiction
Biasi, M. D., McLaughlin, I., Perez, E. E., Crooks, P. A., Dwoskin, L. P., Bardo, M. T., Pentel, P. R., & Hatsukami, D. K. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.05.013 · Cited by 7
Miszkiel, J., Kruk, M., McCreary, A. C., Przegaliński, E., Biała, G., & Filip, M. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70720-4 · Cited by 7
van Hout, M., Klein, J. L., Ahring, P. K., Brown, D. T., Thaneshwaran, S., dos Santos, A. B., Jensen, A. A., Kohlmeier, K. A., Christophersen, P., & Dyhring, T. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113788 · Cited by 7
Genetic susceptibility to nicotine and/or alcohol addiction: a systematic review
Legáz, I., Pérez-Cárceles, M. D., de la Calle, I., Arjona, F., Roca, M., Cejudo, P., Maldonado, A. L., & Osuna, E. (2019) · Toxin Reviews · doi:10.1080/15569543.2019.1619085 · Cited by 7
Unraveling the Role of CHRNA6, the Neuronal α6 Nicotinic Acetylcholine Receptor Subunit
Heydary, Y. H., Castro, E. M., Lotfipour, S., & Leslie, F. M. (2025) · Receptors · doi:10.3390/receptors4010001 · Cited by 8
Specificity of a rodent alpha(α)6 nicotinic acetylcholine receptor subunit antibody
Cardenas, A. M., Elabd, M., & Lotfipour, S. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05413-x · Cited by 6
Carreño, D., & Lotfipour, S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1064211 · Cited by 9
Rapid nicotine tolerance and cross-tolerance to varenicline in rhesus monkeys: Drug discrimination.
Moerke, M. J., & McMahon, L. R. (2018) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000226 · Cited by 6
Kruk, M., Miszkiel, J., McCreary, A. C., Przegaliński, E., Filip, M., & Biała, G. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70929-5 · Cited by 6
Kucinski, A. J., Wersinger, S. R., Stachowiak, E. K., Radell, M. L., Hesse, R. A., Corso, T. D., Parry, M. J., Bencherif, M., Green-Jordan, K., Letchworth, S. R., et al. (2012) · Health · doi:10.4236/health.2012.431176 · Cited by 5
Leri, F., & Vaccarino, F. J. (2016) · Brain Research · doi:10.1016/j.brainres.2015.12.064 · Cited by 5
Cannabinoid-Nicotine Interactions
Auber, A., Justinová, Z., Scherma, M., Goldberg, S. R., & Panlilio, L. V. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_13 · Cited by 4
Dutra-Tavares, A. C., Ribeiro‐Carvalho, A., Nunes, F., Araújo, U. C., Bruno, V., Marcourakis, T., Filgueiras, C. C., Manhães, A. C., & Abreu‐Villaça, Y. (2023) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174423000077 · Cited by 4
Taylor, D. H. (2013) · Biochemistry & Pharmacology Open Access · doi:10.4172/2167-0501.s1-002 · Cited by 5
Baladi, M. G., Nielsen, S. M., McIntosh, J. M., Hanson, G. R., & Fleckenstein, A. E. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000215 · Cited by 4
González-Gutiérrez, J. P., Pessoa-Mahana, H. A., Iturriaga‐Vásquez, P., Reyes-Parada, M. I., Guerra-Díaz, N., Hödar-Salazar, M., Viscarra, F., Paillali, P., Núñez, G., Lorca, M., et al. (2019) · Molecules · doi:10.3390/molecules24203808 · Cited by 4
Nicotinic Acetylcholine Receptor Mutations
Steinlein, O. K., Kaneko, S., & Hirose, S. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780199746545.003.0058 · Cited by 4
α6 nicotinic acetylcholine receptors: A pharmacological challenge with untapped therapeutic promise
Zhang, B., Mao, K., Ma, L., Chen, Y.-S., Ren, M., Xiong, Y., Zhangsun, D., Dong, S., Luo, S., & Gao, B. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118300 · Cited by 3
Nicotine-related beliefs induce dose-dependent responses in the human brain
Perl, O., Shuster, A., Heflin, M., Na, S., Kidwai, A., Booker, N., Putnam, W. C., Fiore, V. G., & Gu, X. (2024) · Nature Mental Health · doi:10.1038/s44220-023-00188-9 · Cited by 3
Simulations of Promising Indolizidine—α6-β2 Nicotinic Acetylcholine Receptor Complexes
Acquah, F. A., Paramel, M., Kuta, A., Hussaini, S. R., Wallace, D. R., & Mooers, B. H. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157934 · Cited by 3
Barloscio, D., Cerri, E., Domenici, L., Longhi, R., Dallanoce, C., Moretti, M., Vilella, A., Zoli, M., Gotti, C., & Origlia, N. (2016) · The FASEB Journal · doi:10.1096/fj.201600855r · Cited by 3
Self-citationTrigo, J. M., & Foll, B. L. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9554-7_11 · Cited by 3
Costas‐Ferreira, C., Barreiro-Chapela, M., Durán, R., & Faro, L. R. F. (2024) · Biomedicines · doi:10.3390/biomedicines12112591 · Cited by 2
Kohlmeier, K. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813035-3.00007-1 · Cited by 2
Critical Role of Cannabinoid CB1 Receptors in Nicotine Reward and Addiction
Rezayof, A., & Hashemizadeh, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00015-8 · Cited by 2
Smoking Effects in the Human Nervous System
Schuman‐Olivier, Z., Stoeckel, L. E., Weisz, E., & Evins, A. E. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418679-8.00011-3 · Cited by 2
Evolutionary Relations of Genes Encoding Nicotinic Acetylcholine Receptor Subunits
Li, M. D. (2018) · Springer eBooks · doi:10.1007/978-981-10-7530-8_18 · Cited by 2
Pathology of oral nicotine pouches and their addiction mechanisms
Zou, H., Lyu, Q., & Hu, S. (2025) · Journal of Dentistry · doi:10.1016/j.jdent.2025.106272 · Cited by 4
Presynaptic Nicotinic Acetylcholine Receptors: Subtypes and Functions
Marks, M. J., Grady, S. R., McClure‐Begley, T. D., O’Neill, H. C., & Zambrano, C. A. (2014) · The Receptors · doi:10.1007/978-1-4939-1167-7_4 · Cited by 1
Neuronal Nicotinic Acetylcholine Receptors in Reward and Addiction
Hendrickson, L. M., & Tapper, A. R. (2014) · The Receptors · doi:10.1007/978-1-4939-1167-7_15 · Cited by 2
Evaluación de la Nicotina como Estímulo Aversivo
Sánchez-Castillo, H., Olivares, G. L. F., Reyes, A. K. R., Paz-Trejo, D. B., & Herrera, F. M. (2013) · Acta de Investigación Psicológica · doi:10.1016/s2007-4719(13)70943-8 · Cited by 1
Conopeptides in Addiction Disorders Treatment
Russo, P., & Bufalo, A. D. (2015) · International journal of advanced research in chemical sciences · Cited by 1
Metadata
- Authors
- Gotti, C., Guiducci, S., Tedesco, V., Corbioli, S., Zanetti, L., Moretti, M., Zanardi, A., Rimondini, R., Mugnaini, M., Clementi, F., Chiamulera, C., & Zoli, M.
- Affiliations
- University of Milan (IT)
- University of Modena and Reggio Emilia (IT)
- University of Verona (IT)
- GlaxoSmithKline (Italy) (IT)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-04-14
- Volume
- 30
- Issue
- 15
- Pages
- 5311-5325
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6632743
- OpenAlex
- W2051648601
- Cited by
- 226
- References
- 64
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 3 · 2020: 9 · 2019: 12 · 2018: 10 · 2017: 9 · 2016: 15 · 2015: 21 · 2014: 26 · 2013: 30 · 2012: 29
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by-nc-sa)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Funders
- GlaxoSmithKline
- Compagnia di San Paolo
- Fondazione Cariplo
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotinic acetylcholine receptors, ventral tegmental area, mesolimbic dopamine system, nicotine, dopamine release, nucleus accumbens, locomotion, nicotine self-administration, nicotine reinforcement, alpha-conotoxin MII, receptor heterogeneity, nicotine dependence, tobacco dependence
- MeSH terms
- Animals, Corpus Striatum, Dopamine, Feeding Behavior, Male, Mesencephalon, Motor Activity, Neural Pathways, Neurons, Nicotine, Nucleus Accumbens, Receptors, Nicotinic, Reinforcement, Psychology, Self Administration, Rats, Sprague-Dawley, Ventral Tegmental Area, Nicotinic Agonists, Nicotinic Antagonists, Conotoxins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review