VGLUT3 (Vesicular Glutamate Transporter Type 3) Contribution to the Regulation of Serotonergic Transmission and Anxiety

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Norepinephrine and serotonin are required for vagus nerve stimulation directed cortical plasticity

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Basal forebrain cholinergic signalling: development, connectivity and roles in cognition

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Interplay between VGLUT Isoforms and Endophilin A1 Regulates Neurotransmitter Release and Short-Term Plasticity

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Distribution of vesicular glutamate transporters in the human brain

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Cholinergic modulation of striatal microcircuits

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Lateral habenula and the rostromedial tegmental nucleus innervate neurochemically distinct subdivisions of the dorsal raphe nucleus in the rat

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Maternal high-fat intake alters presynaptic regulation of dopamine in the nucleus accumbens and increases motivation for fat rewards in the offspring

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Expanding the repertoire of L-DOPA’s actions: A comprehensive review of its functional neurochemistry

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A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

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A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory

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Serotonin neuron development: shaping molecular and structural identities

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Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons

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Chronic L-DOPA therapy alters central serotonergic function and L-DOPA-induced dopamine release in a region-dependent manner in a rat model of Parkinson's disease

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Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain

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Glutamatergic drive of the dorsal raphe nucleus

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Distribution of VGLUT3 in Highly Collateralized Axons from the Rat Dorsal Raphe Nucleus as Revealed by Single-Neuron Reconstructions

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Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and Commonalities

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Extrasynaptic Neurotransmission in the Modulation of Brain Function. Focus on the Striatal Neuronal–Glial Networks

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Rewiring of the Serotonin System in Major Depression

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Development of Serotonergic Fibers in the Post-Natal Mouse Brain

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The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes

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The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens

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Distinct features of neurotransmitter systems in the human brain with focus on the galanin system in locus coeruleus and dorsal raphe

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Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells

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Modulation of firing and synaptic transmission of serotonergic neurons by intrinsic G protein-coupled receptors and ion channels

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Investigation of a central nucleus of the amygdala/dorsal raphe nucleus serotonergic circuit implicated in fear-potentiated startle

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Dorsal Raphe Serotonin Neurons in Mice: Immature Hyperexcitability Transitions to Adult State during First Three Postnatal Weeks Suggesting Sensitive Period for Environmental Perturbation

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Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease

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Cellular architecture and transmitter phenotypes of neurons of the mouse median raphe region

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Synaptic and circuit functions of multitransmitter neurons in the mammalian brain

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Octopamine neuron dependent aggression requires dVGLUT from dual-transmitting neurons

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Molecular, Structural, Functional, and Pharmacological Sites for Vesicular Glutamate Transporter Regulation

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Disruption of the grid cell network in a mouse model of early Alzheimer’s disease

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Lack of serotonin reuptake during brain development alters rostral raphe-prefrontal network formation

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Multisite Intracerebral Microdialysis to Study the Mechanism of L-DOPA Induced Dopamine and Serotonin Release in the Parkinsonian Brain

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The ascending median raphe projections are mainly glutamatergic in the mouse forebrain

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Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits

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Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity

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Monoaminergic control of brain states and sensory processing: Existing knowledge and recent insights obtained with optogenetics

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Roles of dopamine and glutamate co‐release in the nucleus accumbens in mediating the actions of drugs of abuse

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Localization of glutamatergic, GABAergic, and cholinergic neurons in the brain of the African cichlid fish,Astatotilapia burtoni

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Mixed neurotransmission in the hippocampal mossy fibers

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Imbalanced Dopaminergic Transmission Mediated by Serotonergic Neurons in L-DOPA-Induced Dyskinesia

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Paradoxical network excitation by glutamate release from VGluT3+ GABAergic interneurons

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Serotonergic regulation of the dopaminergic system: Implications for reward-related functions

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Dopamine Neurons That Cotransmit Glutamate, From Synapses to Circuits to Behavior

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Cannabinoid type-1 receptor signaling in central serotonergic neurons regulates anxiety-like behavior and sociability

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SLC10A4 Is a Vesicular Amine-Associated Transporter Modulating Dopamine Homeostasis

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Dual serotonergic signals: a key to understanding paradoxical effects?

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Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis

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Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus

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Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3

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Cholinergic/glutamatergic co‐transmission in striatal cholinergic interneurons: new mechanisms regulating striatal computation

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Contribution of Serotonergic Transmission to the Motor and Cognitive Effects of High-Frequency Stimulation of the Subthalamic Nucleus or Levodopa in Parkinson’s Disease

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Correlative analysis of dopaminergic and serotonergic metabolism across the brain to study monoaminergic function and interaction

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Advances and challenges in adeno-associated viral inner-ear gene therapy for sensorineural hearing loss

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Serotonin/dopamine interaction: Electrophysiological and neurochemical evidence

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Simultaneous serotonin and dopamine monitoring across timescales by rapid pulse voltammetry with partial least squares regression

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Co-existence of Functionally Different Vesicular Neurotransmitter Transporters

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Axonal Segregation and Role of the Vesicular Glutamate Transporter VGLUT3 in Serotonin Neurons

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Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe

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Morphological and physiological properties of CCK/CB1R-expressing interneurons in the basal amygdala

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Role of the atypical vesicular glutamate transporter VGLUT3 in l-DOPA-induced dyskinesia

Gangarossa, G., Guzmán, M. S., Prado, V. F., Prado, M. A. M., Daumas, S., Mestikawy, S. E., & Valjent, E. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.12.010 · Cited by 35

Sensorimotor gating, working and social memory deficits in mice with reduced expression of the vesicular glutamate transporter VGLUT1

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Region-specific expression of vesicular glutamate and GABA transporters under various ischaemic conditions in mouse forebrain and retina

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Effects of environmental manipulations in genetically targeted animal models of affective disorders

Renoir, T., Pang, T. Y., & Hannan, A. J. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.04.003 · Cited by 32

Roads Less Traveled: Sexual Dimorphism and Mast Cell Contributions to Migraine Pathology

Loewendorf, A. I., Matynia, A., Saribekyan, H., Gross, N. B., CSETE, M. E., & Harrington, M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00140 · Cited by 29

Neurotransmitter phenotype plasticity: An unexpected mechanism in the toolbox of network activity homeostasis

Demarque, M., & Spitzer, N. C. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20909 · Cited by 30

GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior

Aizawa, F., Nishinaka, T., Yamashita, T., Nakamoto, K., Kurihara, T., Hirasawa, A., Kasuya, F., Miyata, A., & Tokuyama, S. (2016) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2016.09.007 · Cited by 29

Differential Expression of VGLUT2 in Mouse Mesopontine Cholinergic Neurons

Steinkellner, T., Yoo, J. H., & Hnasko, T. S. (2019) · eNeuro · doi:10.1523/eneuro.0161-19.2019 · Cited by 32

Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors

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Enhanced innate fear and altered stress axis regulation in VGluT3 knockout mice

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Divergent in vivo activity of non‐serotonergic and serotonergic VGluT3–neurones in the median raphe region

Domonkos, A., Nikitidou Ledri, L., Laszlovszky, T., Cserép, C., Borhegyi, Z., Papp, E., Nyiri, G., Freund, T. F., & Varga, V. (2016) · The Journal of Physiology · doi:10.1113/jp272036 · Cited by 25

Neurochemical differences between target-specific populations of rat dorsal raphe projection neurons

Prouty, E. W., Chandler, D. J., & Waterhouse, B. D. (2017) · Brain Research · doi:10.1016/j.brainres.2017.08.031 · Cited by 25

Dorsal raphe organization

Commons, K. G. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101868 · Cited by 25

Targeting Vesicular Glutamate Transporter Machinery: Implications on Metabotropic Glutamate Receptor 5 Signaling and Behavior

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Neurotransmitter segregation: Functional and plastic implications

Sámano, C., Cifuentes, F., & Morales, M. A. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.04.004 · Cited by 23

Ethanol affects limbic and striatal presynaptic glutamatergic and DNA methylation gene expression in outbred rats exposed to early‐life stress

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Sucrose Consumption Alters Serotonin/Glutamate Co-localisation Within the Prefrontal Cortex and Hippocampus of Mice

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Inhibition of vesicular glutamate transporters contributes to attenuate methamphetamine-induced conditioned place preference in rats

He, Z., Chen, Y., Dong, H., Su, R., Gong, Z., & Yan, L. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.047 · Cited by 22

Glutamatergic input is selectively increased in dorsal raphe subfield 5‐HT neurons: role of morphology, topography and selective innervation

Crawford, L. K., Craige, C. P., & Beck, S. G. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07882.x · Cited by 21

Axonal Non-segregation of the Vesicular Glutamate Transporter VGLUT3 Within Serotonergic Projections in the Mouse Forebrain

Belmer, A., Beecher, K., Jacques, A., Patkar, O. L., Sicherre, F., & Bartlett, S. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00193 · Cited by 21

Neurochemically and Hodologically Distinct Ascending VGLUT3 versus Serotonin Subsystems Comprise the r2-Pet1Median Raphe

Senft, R. A., Freret, M. E., Sturrock, N., & Dymecki, S. M. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1667-20.2021 · Cited by 26

Axonal Segregation and Role of the Vesicular Glutamate Transporter VGLUT3 in Serotonin Neurons

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Phenotypic Behavioural Effects of Genetic Deletion of the Vesicular Glutamate Transporter 3 in 5‐Hydroxytryptamine Neurons

Gullino, L. S., Chabbah, N., Jayaram, S., Pinacho, R., Mestikawy, S. E., Daumas, S., Bannerman, D. M., & Sharp, T. (2026) · Genes Brain & Behavior · doi:10.1111/gbb.70063

CRISPR/CAS9-MEDIATED LOSS OF VESICULAR GLUTAMATE TRANSPORTER IN SEROTONIN NEURONS OF THE DORSAL RAPHE NUCLEUS LEADS TO SYNAPTIC CHANGES AND ANXIETY-LIKE BEHAVIORSPreprint

Saidi, L., Rioux, V., Wallman, M., Rajan, S. S., Metzakopian, E., Lévesque, M., Proulx, C. D., & Parent, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.23.707446

Enhanced anxiety, depressive‐like behaviour and impaired recognition memory in mice with reduced expression of the vesicular glutamate transporter 1 (VGLUT1)

Tordera, R. M., Totterdell, S., Wojcik, S. M., Brose, N., Elizalde, N., Lasheras, B., & del Rı́o, J. A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05259.x · Cited by 169

Modulation intra-synaptique des neurotransmissions cholinergique et sérotoninergique par le glutamate via VGLUT3 (transporteur vésiculaire du glutamate de type 3)

Amilhon, B. (2009)