Cited by 319Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Embracing diversity in the 5-HT neuronal system

Okaty, Benjamin W., Commons, Kathryn G., Dymecki, Susan M.·2019·Nature Reviews Neuroscience

Abstract

Neurons that synthesize and release 5-hydroxytryptamine (5-HT; serotonin) express a core set of genes that establish and maintain this neurotransmitter phenotype and distinguish these neurons from other brain cells. Beyond a shared 5-HTergic phenotype, these neurons display divergent cellular properties in relation to anatomy, morphology, hodology, electrophysiology and gene expression, including differential expression of molecules supporting co-transmission of additional neurotransmitters. This diversity suggests that functionally heterogeneous subtypes of 5-HT neurons exist, but linking subsets of these neurons to particular functions has been technically challenging. We discuss recent data from molecular genetic, genomic and functional methods that, when coupled with classical findings, yield a reframing of the 5-HT neuronal system as a conglomeration of diverse subsystems with potential to inspire novel, more targeted therapies for clinically distinct 5-HT-related disorders.

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Crossref · 10.1038/s41583-019-0151-3

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Authors
Okaty, B. W., Commons, K. G., & Dymecki, S. M.
Affiliations
  • Harvard University (US)
  • Boston Children's Hospital (US)
Corresponding author
  • Okaty, Benjamin W.
  • Dymecki, Susan M.
Venue
Nature Reviews Neuroscience
Published
2019-04-04
Volume
20
Issue
7
Pages
397-424
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2930394955
Cited by
319
References
331
Citations by year
2026: 47 · 2025: 57 · 2024: 47 · 2023: 54 · 2022: 49 · 2021: 32 · 2020: 25 · 2019: 8
FWCI
3.79
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Drug Abuse (R21DA023643, R01DA021801)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD036379)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
serotonin, serotonergic neurons, neuronal heterogeneity, co-transmission, neuronal morphology, neuronal electrophysiology, neuronal cell types, targeted therapy
MeSH terms
Animals, Brain, Humans, Serotonin, Serotonergic Neurons, Transcriptome

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