Cited by 148Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNicotinic Acetylcholine Receptors Study

Basal forebrain cholinergic signalling: development, connectivity and roles in cognition

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Ananth, Mala R., Rajebhosale, Prithviraj, Kim, Ronald, Talmage, David A., Role, Lorna W.·2023·Nature Reviews Neuroscience

Abstract

Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have mapped the activity and functional connectivity of cholinergic neurons have shown that the axons of basal forebrain cholinergic neurons innervate the pallium with far more topographical and functional organization than was historically appreciated. Together with the results of studies using new probes that allow release of acetylcholine to be detected with high spatial and temporal resolution, these findings have implicated cholinergic networks in 'binding' diverse behaviours that contribute to cognition. Here, we review recent findings on the developmental origins, connectivity and function of cholinergic neurons, and explore the participation of cholinergic signalling in the encoding of cognition-related behaviours.

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  • ACh signaling is essential for neuronal development, where it plays a trophic role in establishing and maintaining neuronal connectivity.

    “ACh signaling is essential for neuronal development, where it plays a trophic role in establishing and maintaining neuronal connectivity [111, 112].”

    From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [111]

    The Introduction describes ACh as a neurotransmitter that modulates synaptic activity. The 'Development of cholinergic neurons' section instead describes trophic factors acting on cholinergic neurons during differentiation; it does not say that ACh itself has a trophic role in establishing or maintaining neuronal connectivity. Searches for ACh-mediated neuronal development and connectivity found no passage supporting that attribution. (LLM, conf=0.72)

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Authors
Ananth, M. R., Rajebhosale, P., Kim, R., Talmage, D. A., & Role, L. W.
Affiliations
National Institutes of Health (US)
Corresponding author
  • Ananth, Mala R.
  • Role, Lorna W.
Venue
Nature Reviews Neuroscience
Published
2023-02-23
Volume
24
Issue
4
Pages
233-251
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W4321610346
Cited by
148
References
268
Citations by year
2026: 44 · 2025: 63 · 2024: 36 · 2023: 5
FWCI
5.70
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (1zians009424-02, ZIA NS009424)
  • National Institute of Neurological Disorders and Stroke
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
basal forebrain cholinergic neurons, acetylcholine, cholinergic neurotransmission, cognitive behavior
MeSH terms
Acetylcholine, Cognition, Humans, Signal Transduction, Cholinergic Agents, Basal Forebrain

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