Basal forebrain cholinergic signalling: development, connectivity and roles in cognition
Open accessAbstract
Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have mapped the activity and functional connectivity of cholinergic neurons have shown that the axons of basal forebrain cholinergic neurons innervate the pallium with far more topographical and functional organization than was historically appreciated. Together with the results of studies using new probes that allow release of acetylcholine to be detected with high spatial and temporal resolution, these findings have implicated cholinergic networks in 'binding' diverse behaviours that contribute to cognition. Here, we review recent findings on the developmental origins, connectivity and function of cholinergic neurons, and explore the participation of cholinergic signalling in the encoding of cognition-related behaviours.
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ACh signaling is essential for neuronal development, where it plays a trophic role in establishing and maintaining neuronal connectivity.
“ACh signaling is essential for neuronal development, where it plays a trophic role in establishing and maintaining neuronal connectivity [111, 112].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [111]
The Introduction describes ACh as a neurotransmitter that modulates synaptic activity. The 'Development of cholinergic neurons' section instead describes trophic factors acting on cholinergic neurons during differentiation; it does not say that ACh itself has a trophic role in establishing or maintaining neuronal connectivity. Searches for ACh-mediated neuronal development and connectivity found no passage supporting that attribution. (LLM, conf=0.72)
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The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545 · see citing works
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627 · see citing works
Theta oscillations in the hippocampus
Buzsáki, G. (2002) · Neuron · doi:10.1016/s0896-6273(02)00586-x · Cited by 3,332 · see citing works
Mesulam, M. ‐., Mufson, E. J., Levey, A. I., & Wainer, B. H. (1983) · Journal of Comparative Neurology · doi:10.1002/cne.902140206 · Cited by 1,962 · see citing works
Molecular diversity and specializations among the cells of the adult mouse brain
Saunders, A., Macosko, E. Z., Wysoker, A., Goldman, M., Krienen, F. M., de Rivera, H., Bien, E., Baum, M., Bortolin, L., Wang, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.028 · Cited by 1,847 · see citing works
The role of acetylcholine in learning and memory
Hasselmo, M. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.002 · Cited by 1,693 · see citing works
Alzheimer's disease: Targeting the Cholinergic System
H. Ferreira-Vieira, T., M. Guimaraes, I., R. Silva, F., & M. Ribeiro, F. (2016) · Current Neuropharmacology · doi:10.2174/1570159x13666150716165726 · Cited by 1,551 · see citing works
Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404 · see citing works
Human Memory and the Cholinergic System
Drachman, D. A. (1974) · Archives of Neurology · doi:10.1001/archneur.1974.00490320001001 · Cited by 1,398 · see citing works
Swanson, L. W., & Petrovich, G. D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01265-x · Cited by 1,351 · see citing works
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
Dani, J. A., & Bertrand, D. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105214 · Cited by 1,197 · see citing works
A long, remarkable journey: Tangential migration in the telencephalon
Marín, Ó., & Rubenstein, J. L. R. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097509 · Cited by 1,050 · see citing works
Cholinergic systems in mammalian brain and spinal cord
WOOLF, N. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90006-m · Cited by 948 · see citing works
Brain nicotinic acetylcholine receptors: native subtypes and their relevance
Gotti, C., Zoli, M., & Clementi, F. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.07.004 · Cited by 882 · see citing works
Sussel, L., Marin, O., Kimura, S., & Rubenstein, J. L. R. (1999) · Development · doi:10.1242/dev.126.15.3359 · Cited by 873 · see citing works
Single-cell transcriptomic profiling of the aging mouse brain
Ximerakis, M., Lipnick, S. L., Innes, B. T., Simmons, S. K., Adiconis, X., Dionne, D., Mayweather, B. A., Nguyen, L., Niziolek, Z., Ozek, C., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0491-3 · Cited by 736 · see citing works
Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline
Ballinger, E. C., Ananth, M. R., Talmage, D. A., & Role, L. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.006 · Cited by 735 · see citing works
Self-citationDiversity and Pattern in the Developing Spinal Cord
Tanabe, Y., & Jessell, T. M. (1996) · Science · doi:10.1126/science.274.5290.1115 · Cited by 718 · see citing works
Organization of cerebral cortical afferent systems in the rat. II. Magnocellular basal nucleus
Saper, C. B. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902220302 · Cited by 703 · see citing works
Nicotinic acetylcholine involvement in cognitive function in animals
Levin, E. D., & Simon, B. B. (1998) · Psychopharmacology · doi:10.1007/s002130050667 · Cited by 675 · see citing works
THE ACTION OF CERTAIN ESTERS AND ETHERS OF CHOLINE, AND THEIR RELATION TO MUSCARINE
Dale, H. H. (1914) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)08268-0 · Cited by 658 · see citing works
A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons
Gras, C., Herzog, E., Bellenchi, G. C., Bernard, V., Ravassard, P., Pohl, M., Gasnier, B., Giros, B., & El Mestikawy, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05442.2002 · Cited by 639 · see citing works
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
Wess, J., Eglen, R. M., & Gautam, D. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2379 · Cited by 637 · see citing works
Prefrontal Acetylcholine Release Controls Cue Detection on Multiple Timescales
Parikh, V., Kozak, R., Martinez, V., & Sarter, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.025 · Cited by 623 · see citing works
Katz, B., & Miledi, R. (1965) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1965.0016 · Cited by 611 · see citing works
Molecular architecture of the developing mouse brain
La Manno, G., Siletti, K., Furlan, A., Gyllborg, D., Vinsland, E., Mossi Albiach, A., Mattsson Langseth, C., Khven, I., Lederer, A. R., Dratva, L. M., et al. (2021) · Nature · doi:10.1038/s41586-021-03775-x · Cited by 563 · see citing works
Flames, N., Pla, R., Gelman, D. M., Rubenstein, J. L. R., Puelles, L., & Marín, O. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2750-07.2007 · Cited by 560 · see citing works
Fast modulation of visual perception by basal forebrain cholinergic neurons
Pinto, L., Goard, M. J., Estandian, D., Xu, M., Kwan, A. C., Lee, S.-H., Harrison, T. C., Feng, G., & Dan, Y. (2013) · Nature Neuroscience · doi:10.1038/nn.3552 · Cited by 529 · see citing works
Hippocampal theta activity following selective lesion of the septal cholinergic systeM
Lee, M., Chrobak, J. J., Attila Gabor, S. I. K., Wiley, R. G., & Buzsáki, G. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90341-7 · Cited by 501 · see citing works
Developmental diversification of cortical inhibitory interneurons
Mayer, C., Hafemeister, C., Bandler, R. C., Machold, R., Batista Brito, R., Jaglin, X., Allaway, K., Butler, A., Fishell, G., & Satija, R. (2018) · Nature · doi:10.1038/nature25999 · Cited by 492 · see citing works
Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease
Leng, K., Li, E., Eser, R., Piergies, A., Sit, R., Tan, M., Neff, N., Li, S. H., Rodriguez, R. D., Suemoto, C. K., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00764-7 · Cited by 485 · see citing works
Improved CUT&RUN chromatin profiling tools
Meers, M. P., Bryson, T. D., Henikoff, J. G., & Henikoff, S. (2019) · eLife · doi:10.7554/elife.46314 · Cited by 474 · see citing works
The hippocampal sharp wave-ripple in memory retrieval for immediate use and consolidation
Joo, H. R., & Frank, L. M. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0077-1 · Cited by 430 · see citing works
The ins and outs of the striatum: Role in drug addiction
Yager, L. M., Garcia, A. F., Wunsch, A. M., & Ferguson, S. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.06.033 · Cited by 421 · see citing works
Kosaka, T., Tauchi, M., & Dahl, J. L. (1988) · Experimental Brain Research · doi:10.1007/bf00247609 · Cited by 417 · see citing works
Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR
Marvin, J. S., Scholl, B., Wilson, D. E., Podgorski, K., Kazemipour, A., Müller, J. A., Schoch, S., Quiroz, F. J. U., Rebola, N., Bao, H., et al. (2018) · Nature Methods · doi:10.1038/s41592-018-0171-3 · Cited by 412 · see citing works
Vandecasteele, M., Varga, V., Berényi, A., Papp, E., Barthó, P., Venance, L., Freund, T. F., & Buzsáki, G. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411233111 · Cited by 409 · see citing works
An optimized acetylcholine sensor for monitoring in vivo cholinergic activity
Jing, M., Li, Y., Zeng, J., Huang, P., Skirzewski, M., Kljakic, O., Peng, W., Qian, T., Tan, K., Zou, J., et al. (2020) · Nature Methods · doi:10.1038/s41592-020-0953-2 · Cited by 408 · see citing works
Central Cholinergic Neurons Are Rapidly Recruited by Reinforcement Feedback
Hangya, B., Ranade, S. P., Lorenc, M., & Kepecs, A. (2015) · Cell · doi:10.1016/j.cell.2015.07.057 · Cited by 399 · see citing works
Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer's disease
Mesulam, M. M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23415 · Cited by 378 · see citing works
A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies
Jing, M., Zhang, P., Wang, G., Feng, J., Mesik, L., Zeng, J., Jiang, H., Wang, S., Looby, J. C., Guagliardo, N. A., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4184 · Cited by 378 · see citing works
Self-citationMineur, Y. S., Obayemi, A., Wigestrand, M. B., Fote, G. M., Calarco, C. A., Li, A. M., & Picciotto, M. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219731110 · Cited by 375 · see citing works
Liu, A. K. L., Chang, R. C., Pearce, R. K. B., & Gentleman, S. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1392-5 · Cited by 365 · see citing works
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
Storm, E. E., Garel, S., Borello, U., Hébert, J. M., Martı́nez, S., McConnell, S. K., Martin, G. R., & Rubenstein, J. L. R. (2006) · Development · doi:10.1242/dev.02324 · Cited by 361 · see citing works
Eckenstein, F., & Baughman, R. W. (1984) · Nature · doi:10.1038/309153a0 · Cited by 356 · see citing works
Thiele, A., & Bellgrove, M. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.008 · Cited by 350 · see citing works
A genetically encoded fluorescent sensor for in vivo imaging of GABA
Marvin, J. S., Shimoda, Y., Magloire, V., Leite, M., Kawashima, T., Jensen, T. P., Kolb, I., Knott, E. L., Novák, O., Podgorski, K., et al. (2019) · Nature Methods · doi:10.1038/s41592-019-0471-2 · Cited by 350 · see citing works
The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors
Root, D. H., Meléndez, R. I., Záborszky, L., & Napier, T. C. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.03.005 · Cited by 343 · see citing works
Phasic acetylcholine release and the volume transmission hypothesis: time to move on
Sarter, M. F., Parikh, V., & Howe, W. M. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2635 · Cited by 340 · see citing works
Klinkenberg, I., Sambeth, A., & Blokland, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.033 · Cited by 335 · see citing works
Extended Amygdala and Basal Forebrain
Alheid, G. F. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07082.x · Cited by 334 · see citing works
Preissl, S., Fang, R., Huang, H., Zhao, Y., Raviram, R., Gorkin, D. U., Zhang, Y., Sos, B. C., Afzal, V., Dickel, D. E., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0079-3 · Cited by 332 · see citing works
Large-scale two-photon calcium imaging in freely moving mice
Zong, W., Obenhaus, H. A., Skytøen, E. R., Eneqvist, H., de Jong, N. L., do Vale, R. D., Jorge, M., Moser, M., & Moser, E. I. (2022) · Cell · doi:10.1016/j.cell.2022.02.017 · Cited by 325 · see citing works
Ren, J., Qin, C., Hu, F., Tan, J., Qiu, L., Zhao, S., Feng, G., & Luo, M. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.038 · Cited by 315 · see citing works
Intravenous nicotine in Alzheimer's disease: a pilot study
NEWHOUSE, P. A., Sunderland, T., Tariot, P. N., Blumhardt, C. L., Weingartner, H., Mellow, A. M., & Murphy, D. L. (1988) · Psychopharmacology · doi:10.1007/bf00174504 · Cited by 308 · see citing works
Motor neurons and the generation of spinal motor neuron diversity
Stifani, N. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00293 · Cited by 306 · see citing works
Functional consequences of neuropeptide and small-molecule co-transmission
Nusbaum, M. P., Blitz, D. M., & Marder, E. E. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.56 · Cited by 304 · see citing works
Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction
Mufson, E. J., Ginsberg, S. D., Ikonomović, M. D., & DeKosky, S. T. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(03)00068-1 · Cited by 295 · see citing works
DNA methylation atlas of the mouse brain at single-cell resolution
Liu, H., Zhou, J., Tian, W., Luo, C., Bartlett, A., Aldridge, A., Lucero, J., Osteen, J. K., Nery, J. R., Chen, H., et al. (2021) · Nature · doi:10.1038/s41586-020-03182-8 · Cited by 289 · see citing works
Záborszky, L., Csordás, A., Mosca, K., Kim, J., Gielow, M. R., Vadász, C., & Nádasdy, Z. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht210 · Cited by 284 · see citing works
Dalley, J. W., McGaughy, J., O'Connell, M. T., Cardinal, R. N., Levita, L., & Robbins, T. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04908.2001 · Cited by 277 · see citing works
Energy matters: presynaptic metabolism and the maintenance of synaptic transmission
Li, S., & Sheng, Z. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00535-8 · Cited by 273 · see citing works
Jones, B. E. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0444-2 · Cited by 265 · see citing works
Increases in cortical acetylcholine release during sustained attention performance in rats
Himmelheber, A. M., Sarter, M., & Bruno, J. P. (2000) · Cognitive Brain Research · doi:10.1016/s0926-6410(00)00012-4 · Cited by 261 · see citing works
Mechanisms and functions of GABA co-release
Tritsch, N. X., Granger, A. J., & Sabatini, B. L. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2015.21 · Cited by 261 · see citing works
Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors
Zoli, M., Pucci, S., Vilella, A., & Gotti, C. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170912110450 · Cited by 260 · see citing works
Early emergence of cortical interneuron diversity in the mouse embryo
Mi, D., Li, Z., Lim, L., Li, M., Moissidis, M., Yang, Y., Gao, T., Hu, T. X., Pratt, T., Price, D. J., et al. (2018) · Science · doi:10.1126/science.aar6821 · Cited by 259 · see citing works
Entorhinal cortex dysfunction in Alzheimer's disease
Igarashi, K. M. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.11.006 · Cited by 259 · see citing works
Ginsberg, S. D., Che, S., Wuu, J., Counts, S., & Mufson, E. J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03764.x · Cited by 253 · see citing works
Rethinking the Pedunculopontine Nucleus: From Cellular Organization to Function
Mena‐Segovia, J., & Bolam, J. P. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.027 · Cited by 249 · see citing works
Neural Circuit Motifs in Valence Processing
Tye, K. M. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.001 · Cited by 247 · see citing works
Mufson, E. J., Bothwell, M. A., Hersh, L. B., & Kordower, J. H. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902850204 · Cited by 245 · see citing works
Umbriaco, D., Watkins, K. C., Descarries, L., Cozzari, C., & Hartman, B. K. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903480304 · Cited by 237 · see citing works
The Input-Output Relationship of the Cholinergic Basal Forebrain
Gielow, M. R., & Záborszky, L. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.060 · Cited by 230 · see citing works
Jones, C. K., Byun, N. E., & Bubser, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.199 · Cited by 228 · see citing works
Zhao, Y., Marín, O., Hermesz, E., Powell, A., Flames, N., Palkovits, M., Rubenstein, J. L. R., & Westphal, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1537759100 · Cited by 227 · see citing works
Dual-transmitter neurons: functional implications of co-release and co-transmission
Vaaga, C. E., Borisovska, M., & Westbrook, G. L. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.04.010 · Cited by 221 · see citing works
Aghourian, M., Legault-Denis, C., Soucy, J.-P., Rosa-Neto, P., Gauthier, S., Kostikov, A., Gravel, P., & Bédard, M.-A. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.183 · Cited by 220 · see citing works
An action potential initiation mechanism in distal axons for the control of dopamine release
Liu, C., Cai, X., Ritzau-Jost, A., Kramer, P. F., Li, Y., Khaliq, Z. M., Hallermann, S., & Kaeser, P. S. (2022) · Science · doi:10.1126/science.abn0532 · Cited by 213 · see citing works
Eiden, L. E. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70062227.x · Cited by 209 · see citing works
Cholinergic modulation of hippocampal network function
Ruivo, L. M. T.-G., & Mellor, J. R. (2013) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2013.00002 · Cited by 205 · see citing works
Systematic Regional Variations in the Loss of Cortical Cholinergic Fibers in Alzheimer's Disease
Geula, C., & Mesulam, M.-M. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.2.165 · Cited by 202 · see citing works
Cortical cholinergic fibers in aging and Alzheimer's disease: A morphometric study
Geula, C., & Mesulam, M. M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90399-0 · Cited by 202 · see citing works
Specific basal forebrain-cortical cholinergic circuits coordinate cognitive operations
Záborszky, L., Gombkoto, P., Varsanyi, P., Gielow, M. R., Poe, G., Role, L. W., Ananth, M., Rajebhosale, P., Talmage, D. A., Hasselmo, M. E., et al. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1676-18.2018 · Cited by 202 · see citing works
Self-citationCorelease of acetylcholine and GABA from cholinergic forebrain neurons
Saunders, A., Granger, A. J., & Sabatini, B. L. (2015) · eLife · doi:10.7554/elife.06412 · Cited by 200 · see citing works
Co-release of acetylcholine and GABA by the starburst amacrine cells
O'Malley, D., Sandell, J. H., & Masland, R. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-04-01394.1992 · Cited by 195 · see citing works
Cortical cholinergic signaling controls the detection of cues
Gritton, H. J., Howe, W. M., Mallory, C. S., Hetrick, V. L., Berke, J. D., & Sarter, M. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516134113 · Cited by 191 · see citing works
Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics
Dulawa, S. C., & Janowsky, D. S. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0219-x · Cited by 187 · see citing works
Amilhon, B., Lepicard, È., Renoir, T., Mongeau, R., Popa, D., Poirel, O., Miot, S., Gras, C., Gardier, A. M., Gallego, J., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5196-09.2010 · Cited by 186 · see citing works
Jiang, L., Kundu, S., Lederman, J., López‐Hernández, G. Y., Ballinger, E. C., Wang, S., Talmage, D. A., & Role, L. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.028 · Cited by 186 · see citing works
Self-citationMolecular basis of muscarinic receptor function
Wess, J. (1993) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90049-p · Cited by 182 · see citing works
Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors
McKay, B. E., Placzek, A. N., & Dani, J. A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.001 · Cited by 181 · see citing works
Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum
Higley, M. J., Gittis, A. H., Oldenburg, I. A., Balthasar, N., Seal, R. P., Edwards, R. H., Lowell, B. B., Kreitzer, A. C., & Sabatini, B. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019155 · Cited by 175 · see citing works
Ruivo, L. M. T.-G., Baker, K. L., Conway, M. W., Kinsley, P. J., Gilmour, G., Phillips, K. G., Isaac, J. T. R., Lowry, J. P., & Mellor, J. R. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.085 · Cited by 175 · see citing works
Co-transmission of acetylcholine and GABA regulates hippocampal states
Takács, V. T., Cserép, C., Schlingloff, D., Pósfai, B., Szőnyi, A., Sos, K. E., Környei, Z., Dénes, Á., Gulyás, A. I., Freund, T. F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05136-1 · Cited by 169 · see citing works
Complete morphologies of basal forebrain cholinergic neurons in the mouse
Wu, H., Williams, J., & Nathans, J. (2014) · eLife · doi:10.7554/elife.02444 · Cited by 167 · see citing works
Cell type-specific long-range connections of basal forebrain circuit
Do, J. P. H., Xu, M., Lee, S., Chang, W.-C., Zhang, S., Chung, S., Yung, T. J., Fan, J. L., Miyamichi, K., Luo, L., et al. (2016) · eLife · doi:10.7554/elife.13214 · Cited by 167 · see citing works
The Basal Forebrain Cholinergic Projection System in Mice
Záborszky, L., van den Pol, A. N., & Gyengési, E. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-369497-3.10028-7 · Cited by 166 · see citing works
Berse, B., & Blusztajn, J. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.38.22101 · Cited by 164 · see citing works
The acetylcholine receptor at the neuromuscular junction
Peper, K., Bradley, R. J., & Dreyer, F. (1982) · Physiological Reviews · doi:10.1152/physrev.1982.62.4.1271 · Cited by 164 · see citing works
Alkaslasi, M. R., Piccus, Z. E., Hareendran, S., Silberberg, H., Chen, L., Zhang, Y., Petros, T. J., & Le Pichon, C. E. (2021) · Nature Communications · doi:10.1038/s41467-021-22691-2 · Cited by 163 · see citing works
Flandin, P., Zhao, Y., Vogt, D., Jeong, J., Long, J., Potter, G., Westphal, H., & Rubenstein, J. L. R. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.020 · Cited by 155 · see citing works
Time of origin of cholinergic neurons in the rat basal forebrain
Semba, K., & Fibiger, H. C. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902690107 · Cited by 150 · see citing works
Co-release of acetylcholine and gamma-aminobutyric acid by a retinal neuron
O'Malley, D. M., & Masland, R. H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3414 · Cited by 150 · see citing works
Koh, S., & Loy, R. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-09-02999.1989 · Cited by 147 · see citing works
Howe, W. M., Gritton, H. J., Lusk, N. A., Roberts, E. A., Hetrick, V. L., Berke, J. D., & Sarter, M. F. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2737-16.2017 · Cited by 147 · see citing works
Diffuse Cortical Projection Systems: Anatomical Organization and Role in Cortical Function
Saper, C. B. (1987) · Comprehensive physiology · doi:10.1002/cphy.cp010506 · Cited by 146 · see citing works
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity
Lohani, S., Moberly, A. H., Benisty, H., Landa, B., Jing, M., Li, Y., Higley, M. J., & Cardin, J. A. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01202-6 · Cited by 146 · see citing works
Lawson, V. H., & Bland, B. H. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1047 · Cited by 144 · see citing works
Alifragis, P., Liapi, A., & Parnavelas, J. G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1245-04.2004 · Cited by 143 · see citing works
Petrou, M., Frey, K. A., Kilbourn, M. R., Scott, P. J. H., Raffel, D. M., Bohnen, N. I., Müller, M. L. T. M., Albin, R. L., & Koeppe, R. A. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.124792 · Cited by 142 · see citing works
Fisher, A. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07507.x · Cited by 140 · see citing works
Cholinergic modulation of spatial learning, memory and navigation
Solari, N., & Hangya, B. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14089 · Cited by 139 · see citing works
Muscarinic Signaling in the Brain
Thiele, A. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170433 · Cited by 136 · see citing works
Fragkouli, A., van Wijk, N. V., Lopes, R., Kessaris, N., & Pachnis, V. (2009) · Development · doi:10.1242/dev.038083 · Cited by 135 · see citing works
Turrini, P., Casu, M. A., Wong, T. P., De Koninck, Y., Ribeiro-da-Silva, A., & Cuello, A. C. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00172-5 · Cited by 135 · see citing works
Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex
Colangelo, C., Shichkova, P., Keller, D. X., Markram, H., & Ramaswamy, S. (2019) · Frontiers in Neural Circuits · doi:10.3389/fncir.2019.00024 · Cited by 134 · see citing works
Bloem, B., Schoppink, L., Rotaru, D. C., Faiz, A., Hendriks, P., Mansvelder, H. D., van de Berg, W. D. J., & Wouterlood, F. G. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3011-14.2014 · Cited by 133 · see citing works
Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation
Gamage, R. V., Wagnon, I. M., Rossetti, I., Childs, R., Niedermayer, G., Chesworth, R., & Gyengési, E. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.577912 · Cited by 133 · see citing works
Cholinergic modulation of striatal microcircuits
Abudukeyoumu, N., Hernández-Flores, T., Garcia-Munoz, M., & Arbuthnott, G. W. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13949 · Cited by 128 · see citing works
Impact of Basal Forebrain Cholinergic Inputs on Basolateral Amygdala Neurons
Ünal, Ç. T., Paré, D., & Záborszky, L. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2706-14.2015 · Cited by 124 · see citing works
Majdi, A., Sadigh‐Eteghad, S., Aghsan, S. R., Farajdokht, F., Vatandoust, S. M., Abbas-Abad, A. N., & Mahmoudi, J. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0089 · Cited by 124 · see citing works
Granger, A. J., Wang, W., Robertson, K., El-Rifai, M., Zanello, A. F., Bistrong, K., Saunders, A., Chow, B. W., Nuñez, V., Turrero García, M., et al. (2020) · eLife · doi:10.7554/elife.57749 · Cited by 124 · see citing works
Acetylcholine, a New Active Principle of Ergot
Ewins, A. J. (1914) · Biochemical Journal · doi:10.1042/bj0080044 · Cited by 122 · see citing works
A regulatory network to segregate the identity of neuronal subtypes.
Lee, S., Lee, B., Joshi, K., Pfaff, S. L., Lee, J. W., & Lee, S.-K. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.03.021 · Cited by 122 · see citing works
Pax6 influences the time and site of origin of glial precursors in the ventral neural tube.
Sun, T., Pringle, N., Hardy, A. P., Richardson, W., & Smith, H. (1998) · Molecular and cellular neurosciences · doi:10.1006/mcne.1998.0711 · Cited by 121 · see citing works
Cholinergic shaping of neural correlations
Minces, V. H., Pinto, L., Dan, Y., & Chiba, A. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1621493114 · Cited by 120 · see citing works
Cho, H.-H., Cargnin, F., Kim, Y., Lee, B., Kwon, R.-J., Nam, H., Shen, R., Barnes, A. P., Lee, J. W., Lee, S., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004280 · Cited by 116 · see citing works
Involvement of the cholinergic system in conditioning and perceptual memory
Robinson, L., Platt, B., & Riedel, G. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.01.055 · Cited by 115 · see citing works
Cholinergic Modulation of Neuroinflammation: Focus on α7 Nicotinic Receptor
Piovesana, R., Intriago, M. S. S., Dini, L., & Tata, A. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094912 · Cited by 115 · see citing works
Transcriptional mechanisms controlling motor neuron diversity and connectivity
di Sanguinetto, S. D. T., Dasen, J. S., & Arber, S. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.04.002 · Cited by 109 · see citing works
Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory
Zhang, Y., Cao, L., Varga, V., Jing, M., Karadas, M., Li, Y., & Buzsáki, G. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016432118 · Cited by 107 · see citing works
Retinoids control anterior and dorsal properties in the developing forebrain.
Halilagic, A., Ribes, V., Ghyselinck, N., Zile, M., Dollé, P., & Studer, M. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.11.021 · Cited by 106 · see citing works
Kramer, P. F., Brill-Weil, S. G., Cummins, A. C., Zhang, R., Camacho-Hernandez, G. A., Newman, A. H., Eldridge, M. A. G., Averbeck, B. B., & Khaliq, Z. M. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.011 · Cited by 104 · see citing works
Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance
Geula, C., Dunlop, S. R., Ayala, I., Kawles, A. S., Flanagan, M. E., Gefen, T., & Mesulam, M. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15471 · Cited by 102 · see citing works
Wang, Y., Wang, X., Lu, J.-J., Li, Q., Gao, C., Liu, X.-H., Sun, Y., Yang, M., Lim, Y. P., Evin, G. M., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2733-10.2011 · Cited by 99 · see citing works
Chandler, D. J., & Waterhouse, B. D. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00020 · Cited by 99 · see citing works
Mori, T., Yuxing, Z., Takaki, H., Takeuchi, M., Iseki, K., Hagino, S., Kitanaka, J., Takemura, M., Misawa, H., Ikawa, M., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03415.x · Cited by 99 · see citing works
Cotransmission of acetylcholine and GABA
Granger, A. J., Mulder, N., Saunders, A. B., & Sabatini, B. L. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.031 · Cited by 98 · see citing works
The nicotinic acetylcholine receptor: From molecular biology to cognition
Changeux, J., Corringer, P., & Maskos, U. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.03.024 · Cited by 98 · see citing works
An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence
Frahm, S., Antolin-Fontes, B., Görlich, A., Zander, J.-F., Ahnert-Hilger, G., & Ibañez-Tallon, I. (2015) · eLife · doi:10.7554/elife.11396 · Cited by 98 · see citing works
Cholinergic regulation of fear learning and extinction
Wilson, M. A., & Fadel, J. R. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23840 · Cited by 98 · see citing works
Schmitz, T. W., Mur, M., Aghourian, M., Bédard, M., & Spreng, R. N. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.001 · Cited by 98 · see citing works
Díaz‐García, C. M., Lahmann, C., Martínez‐François, J. R., Li, B., Koveal, D., Nathwani, N., Rahman, M., Keller, J. P., Marvin, J. S., Looger, L. L., et al. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24433 · Cited by 97 · see citing works
TrkAGene Ablation in Basal Forebrain Results in Dysfunction of the Cholinergic Circuitry
Sanchez‐Ortiz, E., Yui, D., Song, D., Li, Y., Rubenstein, J. L. R., Reichardt, L. F., & Parada, L. F. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6314-11.2012 · Cited by 94 · see citing works
Borden, P. M., Zhang, P., Shivange, A. V., Marvin, J. S., Cichon, J., Dan, C., Podgorski, K., Figueiredo, A. M. P. D., Novák, O., Tanimoto, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.07.939504 · Cited by 94 · see citing works
Crouse, R. B., Kim, K. K. O., Batchelor, H. M., Girardi, E., Kamaletdinova, R., Chan, J., Rajebhosale, P., Pittenger, S. T., Role, L. W., Talmage, D. A., et al. (2020) · eLife · doi:10.7554/elife.57335 · Cited by 92 · see citing works
Self-citationLaszlovszky, T., Schlingloff, D., Hegedüs, P., Freund, T. F., Gulyás, A. I., Kepecs, Á., & Hangya, B. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0648-0 · Cited by 90 · see citing works
Intermediate targets in formation of topographic projections: inputs from the thalamocortical system
Garel, S., & Rubenstein, J. L. R. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.014 · Cited by 89 · see citing works
Regulation of neuronal nicotinic receptor traffic and expression
Gaimarri, A., Moretti, M., Riganti, L., Zanardi, A., Clementi, F., & Gotti, C. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.02.005 · Cited by 89 · see citing works
Poulin, A. N., Guerci, A., Mestikawy, S. E., & Semba, K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21081 · Cited by 87 · see citing works
A Central Role for Mixed Acetylcholine/GABA Transmission in Direction Coding in the Retina
Sethuramanujam, S., McLaughlin, A. J., deRosenroll, G., Hoggarth, A., Schwab, D. J., & Awatramani, G. B. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.041 · Cited by 86 · see citing works
Furusho, M., Ono, K., Takebayashi, H., Masahira, N., Kagawa, T., Ikeda, K., & Ikenaka, K. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.01.031 · Cited by 85 · see citing works
Obermayer, J., Luchicchi, A., Heistek, T. S., de Kloet, S. F., Terra, H., Bruinsma, B., Mnie-Filali, O., Kortleven, C., Galakhova, A. A., Khalil, A. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13244-9 · Cited by 83 · see citing works
Motor neurons and oligodendrocytes arise from distinct cell lineages by progenitor recruitmentPreprint
Ravanelli, A. M., & Appel, B. (2015) · Genes & Development · doi:10.1101/gad.271312.115 · Cited by 82 · see citing works
Isoform cell-type specificity in the mouse primary motor cortex
Booeshaghi, A. S., Yao, Z., van Velthoven, C. T. J., Smith, K. A., Tasic, B., Zeng, H., & Pachter, L. S. (2021) · Nature · doi:10.1038/s41586-021-03969-3 · Cited by 81 · see citing works
Elshatory, Y. M., & Gan, L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5730-07.2008 · Cited by 80 · see citing works
Endogenous FGF-2 Is Important for Cholinergic Sprouting in the Denervated Hippocampus
Fagan, A. M., Suhr, S. T., Lucidi‐Phillipi, C. A., Peterson, D. A., Holtzman, D. M., & Gage, F. H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02499.1997 · Cited by 79 · see citing works
The role of acetylcholine in negative encoding bias: Too much of a good thing?
Mineur, Y. S., & Picciotto, M. R. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14641 · Cited by 78 · see citing works
The role of basal forebrain cholinergic neurons in fear and extinction memory
Knox, D. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.06.001 · Cited by 76 · see citing works
Extensive and spatially variable within-cell-type heterogeneity across the basolateral amygdala
O’Leary, T. P., Sullivan, K. E., Wang, L., Clements, J., Lemire, A. L., & Cembrowski, M. S. (2020) · eLife · doi:10.7554/elife.59003 · Cited by 75 · see citing works
Aitta‐aho, T., Hay, Y. A., Phillips, B. U., Saksida, L. M., Bussey, T. J., Paulsen, O., & Apergis‐Schoute, J. (2018) · Current Biology · doi:10.1016/j.cub.2018.06.064 · Cited by 73 · see citing works
THE PROBLEMS OF NEURONS WITH LONG AXONS
Cavanagh, J. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92457-7 · Cited by 72 · see citing works
Fritz, H.-C., Ray, N. J., Dyrba, M., Sorg, C., Teipel, S. J., & Grothe, M. J. (2018) · Human Brain Mapping · doi:10.1002/hbm.24417 · Cited by 71 · see citing works
Diverse Spatiotemporal Scales of Cholinergic Signaling in the Neocortex
Disney, A. A., & Higley, M. J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1306-19.2019 · Cited by 71 · see citing works
Target selectivity of septal cholinergic neurons in the medial and lateral entorhinal cortex
Desikan, S., Koser, D. E., Neitz, A., & Monyer, H. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716531115 · Cited by 69 · see citing works
Upmanyu, N., Jin, J., Emde, H. V. D., Ganzella, M., Bösche, L., Malviya, V. N., Zhuleku, E., Politi, A. Z., Ninov, M., Silbern, I., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.02.008 · Cited by 69 · see citing works
Central cholinergic regulation of respiration: nicotinic receptors
Shao, X. M., & Feldman, J. L. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.88 · Cited by 68 · see citing works
NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory
Magno, L., Barry, C., Schmidt‐Hieber, C., Theodotou, P., Häusser, M., & Kessaris, N. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.053 · Cited by 68 · see citing works
Ma, X., Zhang, Y., Wang, L., Li, N., Barkai, E., Zhang, X., Lin, L., & Xu, J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1568-19.2020 · Cited by 68 · see citing works
Wong, D. F., Kuwabara, H., Horti, A. G., Roberts, J., Nandi, A., Cascella, N. G., Brašić, J. R., Weerts, E. M., Kitzmiller, K., Phan, J.-A., et al. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy021 · Cited by 65 · see citing works
Cantero, J. L., Atienza, M., Lage, C., Záborszky, L., Vilaplana, E., López‐García, S., Pozueta, A., Rodríguez‐Rodríguez, E., Blesa, R., Alcolea, D. A., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz224 · Cited by 65 · see citing works
Cholinergic double duty: cue detection and attentional control
Sarter, M., & Lustig, C. (2019) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2018.12.026 · Cited by 64 · see citing works
Robert, B., Kimchi, E. Y., Watanabe, Y., Chakoma, T. L., Jing, M., Li, Y., & Polley, D. B. (2021) · eLife · doi:10.7554/elife.69514 · Cited by 64 · see citing works
Silberberg, S. N., Taher, L., Lindtner, S., Sandberg, M., Nord, A. S., Vogt, D., Mckinsey, G. L., Hoch, R., Pattabiraman, K., Zhang, D., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.027 · Cited by 62 · see citing works
Interneuron Types and Their Circuits in the Basolateral Amygdala
Hájos, N. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.687257 · Cited by 61 · see citing works
PET Imaging of Cholinergic Neurotransmission in Neurodegenerative Disorders
Tiepolt, S., Meyer, P., Patt, M., Deuther‐Conrad, W., Hesse, S., Barthel, H., & Sabri, O. (2022) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.263198 · Cited by 61 · see citing works
Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons
G.‐Coviella, I. L., Follettie, M. T., Mellott, T. J., Kovacheva, V., Slack, B. E., Diesl, V., Berse, B., Thies, R. S., & Blusztajn, J. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502097102 · Cited by 60 · see citing works
Case, D. T., Burton, S. D., Gedeon, J. Y., Williams, S.-P. G., Urban, N. N., & Seal, R. P. (2017) · Nature Communications · doi:10.1038/s41467-017-00765-4 · Cited by 58 · see citing works
Molecularly defined and functionally distinct cholinergic subnetworks
Li, X., Yu, H., Zhang, B., Li, L., Chen, W., Yu, Q., Huang, X., Xiao, K., Wang, Y., Jing, W., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.08.025 · Cited by 58 · see citing works
Hollera, T., Berse, B., Cermak, J. M., Diebler, M., & Blusztajn, J. K. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12808-1 · Cited by 55 · see citing works
Nerve growth factor is primarily produced by GABAergic neurons of the adult rat cortex
Biane, J. S., Conner, J. M., & Tuszynski, M. H. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00220 · Cited by 55 · see citing works
Chen, L., Chatterjee, M., & Li, J. Y. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3742-10.2010 · Cited by 54 · see citing works
Kondo, H., & Záborszky, L. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.23967 · Cited by 54 · see citing works
Chavez, C. M., & Záborszky, L. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw091 · Cited by 54 · see citing works
Hillmer, A. T., Li, S., Zheng, M., Scheunemann, M., Lin, S.-F., Nabulsi, N., Holden, D., Pracitto, R., Labaree, D. C., Ropchan, J. R., et al. (2017) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-017-3621-8 · Cited by 54 · see citing works
A Review of the Cholinergic System and Therapeutic Approaches to Treat Brain Disorders
Bertrand, D., & Wallace, T. L. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_141 · Cited by 54 · see citing works
The homeobox genes Lhx7 and Gbx1 are expressed in the basal forebrain cholinergic system
Asbreuk, C. H. J., van Schaick, H. S. A., Cox, J. J., Kromkamp, M., Smidt, M. P., & Burbach, J. P. H. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00466-3 · Cited by 53 · see citing works
Nilbratt, M., Porras, O. H., Marutle, A., Hovatta, O., & Nordberg, A. K. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00916.x · Cited by 53 · see citing works
Lhx6 and Lhx8: cell fate regulators and beyond
Zhou, C., Yang, G., Chen, M., He, L., Xiang, L., Ricupero, C. L., Mao, J. J., & Ling, J. (2015) · The FASEB Journal · doi:10.1096/fj.14-267500 · Cited by 53 · see citing works
Nonomura, T., Nishio, C., Lindsay, R. M., & Hatanaka, H. (1995) · Brain Research · doi:10.1016/0006-8993(95)00357-v · Cited by 51 · see citing works
Slomianka, L., & Geneser, F. A. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903120404 · Cited by 51 · see citing works
Patterning, Regionalization, and Cell Differentiation in the Forebrain
Marín, Ó., & Rubenstein, J. L. R. (2002) · Elsevier eBooks · doi:10.1016/b978-012597951-1/50007-x · Cited by 50 · see citing works
Berse, B., López-Coviella, I., & Blusztajn, J. K. (1999) · Biochemical Journal · doi:10.1042/bj3420301 · Cited by 50 · see citing works
The Role of p75NTRin Cholinergic Basal Forebrain Structure and Function
Boskovic, Z., Alfonsi, F., Rumballe, B. A., Fonseka, S., Windels, F., & Coulson, E. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2364-14.2014 · Cited by 50 · see citing works
Kimes, A. S., Chefer, S. I., Matochik, J. A., Contoreggi, C. S., Vaupel, D. B., Stein, E. A., & Mukhin, A. G. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.09.015 · Cited by 49 · see citing works
Zhu, F., Elnozahy, S., Lawlor, J., & Kuchibhotla, K. V. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01289-5 · Cited by 49 · see citing works
Investigating striatal function through cell-type-specific manipulations
Kreitzer, A. C., & Berke, J. D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.018 · Cited by 48 · see citing works
Coppola, J. J., & Disney, A. A. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00008 · Cited by 48 · see citing works
Boskovic, Z., Meier, S., Wang, Y., Milne, M., Onraet, T., Tedoldi, A., & Coulson, E. J. (2019) · Neuronal Signaling · doi:10.1042/ns20180066 · Cited by 48 · see citing works
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
Cellular and organismal function of choline metabolism
Kenny, T. C., Scharenberg, S. G., Abu-Remaileh, M., & Birsoy, K. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01203-8 · Cited by 66 · see citing works
Lu, X., Xiong, W., Chen, Z., Li, Y.-M., Xu, F., Yang, X., Long, M., Guo, W., Wu, S., Sun, L. D., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01938-7 · Cited by 32 · see citing works
Huang, S., Yang, Z., Cheng, J., Li, H.-Y., Chen, S., Huang, Z.-H., Chen, J.-D., Xiong, R.-G., Yang, M.-T., Wang, C., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103578 · Cited by 33 · see citing works
Gargus, M., Ben‐Azu, B., Landwehr, A., Dunn, J., Errico, J. P., & Tremblay, M. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1527842 · Cited by 32 · see citing works
Rabah, Y., Berwick, J.-P., Sagar, N., Pasquer, L., Plaçais, P.-Y., & Préat, T. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01189-3 · Cited by 26 · see citing works
Reynolds, L. M., Faure, P., & Barik, J. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03110-0 · Cited by 26 · see citing works
“However, in addition to its functions in the mature brain, ACh signaling is essential for neuronal development, where it plays a trophic role in establishing and maintaining neuronal connectivity [111, 112].”
Zou, Y., Tong, C., Peng, W., Qiu, Y., Li, J., Xia, Y., Pei, M., Zhang, K., Li, W., Xu, M., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.017 · Cited by 24 · see citing works
Impaired cognition in narcolepsy: clinical and neurobiological perspectives
Cano, C. A., Harel, B. T., & Scammell, T. E. (2024) · SLEEP · doi:10.1093/sleep/zsae150 · Cited by 22 · see citing works
The basal forebrain cholinergic system as target for cell replacement therapy in Parkinson’s disease
Björklund, A., & Barker, R. A. (2024) · Brain · doi:10.1093/brain/awae026 · Cited by 21 · see citing works
Emerging Functions of Neuromodulation during Sleep
Sulaman, B. A., Zhang, Y., Matosevich, N., Kjærby, C., Foustoukos, G., Andersen, M., & Eban-Rothschild, A. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1277-24.2024 · Cited by 21 · see citing works
Mousavi, H., Rimaz, M., & Zeynizadeh, B. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00055 · Cited by 20 · see citing works
Rajebhosale, P., Ananth, M. R., Kim, R., Crouse, R. B., Jiang, L., López‐Hernández, G. Y., Zhong, C., Arty, C., Wang, S., Jone, A., et al. (2024) · eLife · doi:10.7554/elife.86581 · Cited by 17 · see citing works
Self-citationKim, R., Ananth, M. R., Desai, N. S., Role, L. W., & Talmage, D. A. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114009 · Cited by 16 · see citing works
Self-citationCholinergic signaling to CA1 astrocytes controls fear extinction
Li, Y., Li, L., Wang, Y., Li, X., Ding, X., Li, L., Fei, F., Zheng, Y., Li, C., Duan, S., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads7191 · Cited by 15 · see citing works
Cholinergic T cells revitalize the tumor immune microenvironment: TIME to ChAT
Zheng, C., Liu, S., Modares, N. F., Paul, M. S., & Mak, T. W. (2025) · Nature Immunology · doi:10.1038/s41590-025-02144-4 · Cited by 16 · see citing works
Updating functional brain units: Insights far beyond Luria.
Peña-Casanova, J., Sánchez-Benavides, G., & Sigg-Alonso, J. (2024) · Cortex; a journal devoted to the study of the nervous system and behavior · doi:10.1016/j.cortex.2024.02.004 · Cited by 12 · see citing works
Tian, S.-Y., Cao, X., Liu, G.-J., Zi, Y., Zhu, H., Jiang, Y., Lou, W.-W., Fang, X., Shan, L., Liu, Z., et al. (2025) · Current Neuropharmacology · doi:10.2174/011570159x368923250313045859 · Cited by 14 · see citing works
Mei, F., Zhao, C. F., Li, S., Xue, Z., Zhao, Y., Xu, Y., Ye, R., You, H., Yu, P., Han, X., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51707-w · Cited by 12 · see citing works
Li, H., Li, Y., Wang, T., Li, S., Liu, H., Ning, S., Shen, W., Zhao, Z., & Wu, H. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01296-x · Cited by 12 · see citing works
Iraji, A., Hariri, R., Hashempur, M. H., Ghasemi, M., Pourtaher, H., Saeedi, M., & Akbarzadeh, T. (2025) · BMC Chemistry · doi:10.1186/s13065-025-01475-5 · Cited by 12 · see citing works
Neuronal and Glial α7 Nicotinic Acetylcholine Receptors: Role in Alzheimer’s Disease Pathophysiology
Rennie, K. (2025) · Life · doi:10.3390/life15071032 · Cited by 11 · see citing works
Abdulla, Z. I., Mineur, Y. S., Crouse, R. B., Etherington, I. M., Yousuf, H., Na, J. J., & Picciotto, M. R. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-02003-0 · Cited by 11 · see citing works
Eisenstein, T., Groenewald, K., van Hillegondsberg, L., Alhajraf, F., Zerenner, T., Lawton, M., Ben‐Shlomo, Y., Griffanti, L., Hu, M. T., & Klein, J. C. (2025) · Brain · doi:10.1093/brain/awaf168 · Cited by 11 · see citing works
Huang, W., Sun, X., Zhang, X., Xu, R., Qian, Y., & Zhu, J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03962-7 · Cited by 10 · see citing works
The Modulation of Neuroimmune Responses in Peripheral Inflammation
Wang, J., Ji, D., Dai, N., Chang, Q., Gong, M., & Fu, B. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s533106 · Cited by 9 · see citing works
Acetylcholine chemotaxis in global bacterial plant pathogens
Gavira, J. A., Gilabert, M. J., Santamaría‐Hernando, S., Molina-Ollero, A., Rico‐Jiménez, M., Cabrera, J. J., López‐Solanilla, E., & Matilla, M. A. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128294 · Cited by 9 · see citing works
Unlocking the neuroprotective secrets of natural products: a focus on the gut-brain axis
Yang, X., Hu, D., Cheng, R., Bao, Q., Jiang, H., Zhao, B., & Zhang, Y. (2025) · Phytochemistry Reviews · doi:10.1007/s11101-025-10081-1 · Cited by 11 · see citing works
Chen, Z., Liu, Y., Yang, Y., Wang, L., Qin, M., Jiang, Z., Xu, M., & Zhang, S. (2025) · Science Advances · doi:10.1126/sciadv.adt1617 · Cited by 8 · see citing works
The cholinergic basal forebrain and its role in neurodegeneration
Cykowski, M. D., & Masdeu, J. C. (2025) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaf112 · Cited by 8 · see citing works
Huang, Y., Meng, K., Liu, G., Chen, Z., Han, Y., Yang, P., Zhang, R., & Cai, H. (2025) · Biology · doi:10.3390/biology14091167 · Cited by 7 · see citing works
Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways
Chen, J., Li, Q., Ji, B., Zhang, K., Ren, M., Li, A., Gong, H., Wang, J., Cao, G., Luo, Q., et al. (2025) · Brain · doi:10.1093/brain/awaf060 · Cited by 7 · see citing works
Abraham, S. M., Suresh, S., & Komal, P. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01586-6 · Cited by 8 · see citing works
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Antonioni, A. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106790 · Cited by 7 · see citing works
Zheng, F., Wess, J., & Alzheimer, C. (2023) · Cells · doi:10.3390/cells12141890 · Cited by 7 · see citing works
Li, C., Xiao, L., Lin, W., Li, M., Liu, J., Qiu, X., Li, M., Zheng, Y., Xu, C., Wang, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50042-4 · Cited by 6 · see citing works
Khan, N. (2025) · Environmental Reviews · doi:10.1139/er-2025-0081 · Cited by 6 · see citing works
Developing personalized treatment strategies for Parkinson’s disease based on disease subtypes
Hey, G. E., Eisinger, R. S., Guarín, D. L., Safarpour, D., Rodríguez‐Violante, M., & Ramirez‐Zamora, A. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2552784 · Cited by 6 · see citing works
Neuroscience in prostate cancer
Liu, Z., Peng, Q., Wang, Y., Chiu, P. K., Teoh, J. Y., Wang, R., Liu, X., Wu, D., & Ng, C. (2025) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-025-01042-y · Cited by 6 · see citing works
Distinct Neural Mechanisms Between Anesthesia Induction and Emergence: A Narrative Review
Zhang, D., & Wei, Y. (2024) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000007114 · Cited by 6 · see citing works
Long‐range inputome of prefrontal GABAergic interneurons in the Alzheimer's disease mouse
Ren, M., Li, Y., Jiang, T., Liu, B., Li, X., Jia, X., Li, A., Luo, Q., Gong, H., & Li, X. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14552 · Cited by 6 · see citing works
Ananth, M. R., Gardus, J. D., Huang, C., Palekar, N., Slifstein, M., Záborszky, L., Parsey, R. V., Talmage, D. A., DeLorenzo, C., & Role, L. W. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115249 · Cited by 6 · see citing works
Self-citationMolecular organization of central cholinergic synapses
Rosenthal, J., Zhang, D., Yin, J., Long, C., Yang, G., Li, Y., Lu, Z., Li, W., Yu, Z., Li, J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2422173122 · Cited by 6 · see citing works
Liang, Y., Jiang, K., Tu, J., Liu, Z., Hu, Y., Gong, W., Li, J., Dong, X., Hardiman, G., Guo, X., et al. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.144529 · Cited by 6 · see citing works
Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice
Manjila, S. B., Son, S., Parmaksiz, D., Kline, H. L., Betty, R., Wu, Y.-T., Pi, H.-J., Shin, D., Liwang, J. K., Kronman, F. N., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115827 · Cited by 6 · see citing works
Chen, Y., Wang, D., Liao, Y., Zuo, G., & Lu, X. (2024) · Discover Medicine · doi:10.1007/s44337-024-00135-2 · Cited by 5 · see citing works
The Central Cholinergic Synapse: A Primer
Klein, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199670 · Cited by 5 · see citing works
Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input
Xie, L., Wang, X., Lin, X., Wen, J., Ma, T., Leong, A. T. L., & Wu, E. X. (2025) · Nature Communications · doi:10.1038/s41467-025-66104-0 · Cited by 5 · see citing works
Adeyomoye, O., Adetunji, J. B., Olaniyan, O. T., Adetunji, C. O., & Ogunmiluyi, O. E. (2024) · Metabolism Open · doi:10.1016/j.metop.2024.100333 · Cited by 5 · see citing works
Garg, R., Qiu, Q., & Yu, C. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003374 · Cited by 5 · see citing works
Enhanced TrkA signaling impairs basal forebrain-dependent behavior
Calvo-Enrique, L., Lisa, S., Vicente‐García, C., Deogracias, R., & Arévalo, J. C. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1266983 · Cited by 4 · see citing works
Xu, X., Anayiti, X., Chen, P., Xie, Z., Tao, M., Xiang, Y., Tan, M., Liu, Y., Yue, L., Xiao, S., et al. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100298 · Cited by 4 · see citing works
Amygdala‐Dependent Signaling Pathways and Regulating Circuits in Fear Memory
Huang, M.-Q., Liang, X., Lin, X., Li, W., Jiang, Y., & Geng, F. (2025) · Synapse · doi:10.1002/syn.70026 · Cited by 4 · see citing works
Recent Advances and Future Directions in Alzheimer’s Disease Genetic Research
Stancheva, M., Toncheva, D. I., & Karachanak-Yankova, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167819 · Cited by 4 · see citing works
Wu, K., Yang, C., Zeng, J., Wu, Q., Zhao, Y., Hu, C., Zhao, Y., Wu, J., Wang, Z., Wang, Z., et al. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118273 · Cited by 4 · see citing works
Acetylcholine Neurons Become Cholinergic during Three Time Windows in the Developing Mouse Brain
Goral, R. O., Lamb, P. W., & Yakel, J. L. (2024) · eNeuro · doi:10.1523/eneuro.0542-23.2024 · Cited by 5 · see citing works
Cholinergic modulation of reinforcement learning and prefrontal value computations under uncertaintyPreprint
Kurtenbach, H., Froböse, M. I., Ort, E., Bahners, B. H., Butz, M., Schnitzler, A., Hirschmann, J., & Jocham, G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.20.614105 · Cited by 4 · see citing works
Luo, F., Jiang, L., Desai, N. S., Li, B., Watkins, G. V., Eldridge, M. A. G., Plotnikova, A. S., Mohanty, A., Cummins, A. C., Averbeck, B. B., et al. (2024) · The Journal of Comparative Neurology · doi:10.1002/cne.70001 · Cited by 3 · see citing works
Self-citationMcIntyre, R. S. (2025) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2025.2522885 · Cited by 3 · see citing works
Cholinergic white matter pathways integrity in prodromal and early manifest Lewy body disease
Eisenstein, T., Groenewald, K., van Hillegondsberg, L., Alhajraf, F., Zerenner, T., Lawton, M., Ben‐Shlomo, Y., Griffanti, L., Hu, M. T. M., & Klein, J. C. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf421 · Cited by 3 · see citing works
Cholinergic Phenotypes of Acetyl-CoA with ATP-Citrate Lyase Link
Gul‐Hinc, S., Jankowska-Kulawy, A., & Szutowicz, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020782 · Cited by 3 · see citing works
Subventricular zone radial glial cells maintain inhibitory neuron production in the human brain
Jia, L., Li, X., Yan, Y., Xu, L., Guo, J., Wang, W., Zhang, W., Li, L., Shang, B., Zhang, Y., et al. (2026) · Science · doi:10.1126/science.adw1803 · Cited by 4 · see citing works
Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex
Vattino, L. G., Clayton, K. K., Hackett, T. A., Polley, D. B., & Takesian, A. E. (2025) · Cerebral Cortex · doi:10.1093/cercor/bhaf338 · Cited by 3 · see citing works
Petrov, W., Ślebioda, D., Kozińska, R. B., Kukla, K., Petrov, P., Sroka, M., Tesyna, J., Puźniak, G., Kudliński, M., Rejda, T., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27135733 · Cited by 4 · see citing works
Nicotinic acetylcholine receptors in the brain
Barrantes, F. J. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19088-9.00004-4 · Cited by 3 · see citing works
Red-shifted GRAB acetylcholine sensors for multiplex imaging in vivo
Xie, S., Miao, X., Li, G., Zheng, Y. R., Li, M., Ji, E., Wang, J., Li, S., Cai, R., Geng, L., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02325-w · Cited by 4 · see citing works
Hashemi, M., Raouf, F. H., Dogani, M., Shahsavari, F., Abasnejad, M., Esmaeili‐Mahani, S., Khezri, A., Mirmohammadi, H., & Omid Dianat, A. (2025) · International Endodontic Journal · doi:10.1111/iej.14267 · Cited by 2 · see citing works
Ma, P., Zhang, K., Yi, L., Yang, C., Lang, H., Sun, J., Li, J., Bai, Q., He, Y., Dai, S., et al. (2025) · Advanced Science · doi:10.1002/advs.202500177 · Cited by 2 · see citing works
Improving Visual Working Memory with Cholinergic Deep Brain Stimulation
Bava, J., Wang, Z., Bick, S. K. B., Englot, D. J., & Constantinidis, C. (2023) · Brain Sciences · doi:10.3390/brainsci13060917 · Cited by 2 · see citing works
Pereira, P. A., Tavares, M., Laires, M., Mota, B., Madeira, M. D., Paula-Barbosa, M. M., & Cardoso, A. (2024) · Biology · doi:10.3390/biology13030155 · Cited by 2 · see citing works
Russell, J. K., Conley, A. C., Wilson, J. E., & NEWHOUSE, P. A. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_523 · Cited by 2 · see citing works
Goutal, S., Lancien, M., Rivier, F., Tournier, N., & Vaillend, C. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106771 · Cited by 2 · see citing works
Hierarchical organization of the forebrain cholinergic system in rats
Varsanyi, P., Alloway, K. D., Chavez, C. M., Gielow, M. R., Gombkötő, P., Kondo, H., Nádasdy, Z., & Záborszky, L. (2025) · iScience · doi:10.1016/j.isci.2025.112001 · Cited by 3 · see citing works
Mechanisms of the Pathogenesis of Alzheimer’s Disease: The Role of the Basal Forebrain
Kitchigina, V. F., Popova, I. Y., & Shubina, L. (2025) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-025-01784-1 · Cited by 2 · see citing works
Pavlov, V. A. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1593341 · Cited by 2 · see citing works
Shen, B., Jiang, L., Shi, Y., Guo, J., Chen, B., Qiu, Z., Wang, S., Yuan, Z., & Fang, J. (2025) · Brain and Behavior · doi:10.1002/brb3.71090 · Cited by 2 · see citing works
Brahmia, B., Naaldijk, Y., Sarkar, P., Parisiadou, L., & Hilfiker, S. (2024) · eLife · doi:10.7554/elife.101135.1 · Cited by 3 · see citing works
Cholinergic recruitment of Chandelier cells during arousalPreprint
Martinez-Marquez, E., Reyes-León, S., Garcia-San-Jose, F., López-Begines, S., Nieto-González, J. L., & García‐Junco‐Clemente, P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.18.633708 · Cited by 2 · see citing works
The Neural Basis of AgingPreprint
Jackson, B. (2025) · doi:10.33774/coe-2025-fcg76-v3 · Cited by 2 · see citing works
Feng, C.-H., Du, X., Wang, Z., Wu, T., & Zhang, L.-N. (2024) · Neuropeptides · doi:10.1016/j.npep.2024.102449 · Cited by 1 · see citing works
Doucette, L., Turnbill, V., Carlin, K., Cavanagh, A. S., Sollinger, B. I., Kuter, N., Flock, D. L., Robinson, S., Chavez‐Valdez, R., Jantzie, L. L., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106629 · Cited by 1 · see citing works
Auricular neuromodulation may act through interoception modulation
Canini, F., Claverie, D., Weill, F., Pailler, C., Paquier, B., Michel-Cherqui, M., Sonia Pellissier, A., Trousselard, M., & Sagui, E. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149736 · Cited by 1 · see citing works
Gong, X.-T., Li, Z.-S., Chen, Z.-L., Wu, X., Shangguan, L.-Y., Xu, Z., Chen, L., Yu, C., & Cai, P. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0007-25.2025 · Cited by 1 · see citing works
A disinhibitory microcircuit in the temporal association cortex for fear retrieval to pure tones
Cheng, R., Zhong, W., Yan, Y., Yao, L., Yin, P., Xu, Z., Qin, X., Tan, J., Zeng, Y., Liu, J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-05566-0 · Cited by 1 · see citing works
Ross, H., Adelman, M., Castillo, J., Walker, A., Latham, J. D., Qin, L., Macht, V. A., Crews, F. T., & Vetreno, R. P. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100779 · Cited by 1 · see citing works
Mesoscopic analysis of GABAergic marker expression in acetylcholine neurons in the whole mouse brain
Goral, R. O., Roy, S., Co, C. A., Wine, R. N., Lamb, P. W., Turner, P. M., McBride, S. J., Usdin, T. B., & Yakel, J. L. (2025) · iScience · doi:10.1016/j.isci.2025.114531 · Cited by 1 · see citing works
Chin, P.-S., Ding, Z., Kochukov, M. Y., Srivastava, S., Moss, E. H., Tong, Q., & Arenkiel, B. R. (2026) · Nature Communications · doi:10.1038/s41467-026-68313-7 · Cited by 1 · see citing works
Ebdah, W., Thomas, S. D., Eissa, N., Jayaprakash, P., Łażewska, D., Kieć‐Kononowicz, K., & Sadek, B. S. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1722019 · Cited by 1 · see citing works
The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis
Wearn, A. R., Onuska, K. M., Schmitz, T. W., Turner, G. R., & Spreng, R. N. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71249 · Cited by 1 · see citing works
Sensory-to-Motor Transformations: From Serial Pipelines to Dynamic, Distributed Processes
Lam, A., Kabbara, S., Carstens, K., Mol, W., Goel, A., Yang, H.-D., & Zagha, E. (2026) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106692 · Cited by 3 · see citing works
Malvankar, A., Raut, M., Singh, S. K., Singh, R., Mahindroo, N., & Bajad, N. G. (2026) · Future Medicinal Chemistry · doi:10.1080/17568919.2026.2684615 · Cited by 1 · see citing works
Long-term memory formation depends on an astrocyte-to-neuron H 2 O 2 signalingPreprint
Rabah, Y., Sagar, N., Pasquer, L., Plaçais, P.-Y., & Préat, T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.11.548505 · Cited by 1 · see citing works
Functional architecture of the forebrain cholinergic system in rodentsPreprint
Záborszky, L., Varsanyi, P., Alloway, K. D., Chavez, C. M., Gielow, M. R., Gombkötő, P., Kondo, H., & Nádasdy, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-4504727/v1 · Cited by 1 · see citing works
The Neural Basis of AgingPreprint
Jackson, B. (2025) · doi:10.33774/coe-2025-fcg76-v2 · Cited by 1 · see citing works
Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain modelPreprint
Porta, L. D., Fousek, J., Alain Destexhe, A., & Sanchez-Vives, M. V. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.28.685048 · Cited by 1 · see citing works
Dopaminergic Dependency of Cholinergic Pallidal Neurons
López-Niño, J., Padilla‐Orozco, M., Ortega, A., Cáceres-Chávez, V. A., Tapia, D., Laville, A., Galarraga, E., & Bargas, J. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.07.023
Ananth, M. R., Gardus, J. D., Huang, C., Palekar, N., Slifstein, M., Záborszky, L., Parsey, R. V., Talmage, D. A., DeLorenzo, C., & Role, L. W. (2024) · Research Square · doi:10.21203/rs.3.rs-3851086/v1
Self-citationAnanth, M. R., Gardus, J. D., Huang, C., Palekar, N., Slifstein, M., Záborszky, L., Parsey, R. V., Talmage, D. A., DeLorenzo, C., & Role, L. W. (2024) · Research Square · doi:10.21203/rs.3.rs-3851086/v2
Self-citationBrahmia, B., Naaldijk, Y., Sarkar, P., Parisiadou, L., & Hilfiker, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.16.603799
A disinhibitory basal forebrain-to-cortex projection supports sustained attention
Li, S.-J., Hangya, B., Gupta, U., Singh, H., Fischer, K. B., Sturgill, J. F., Callaway, E. M., & Kepecs, Á. (2026) · Cell · doi:10.1016/j.cell.2026.05.046
- Authors
- Ananth, M. R., Rajebhosale, P., Kim, R., Talmage, D. A., & Role, L. W.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Ananth, Mala R.
- Role, Lorna W.
- Venue
- Nature Reviews Neuroscience
- Published
- 2023-02-23
- Volume
- 24
- Issue
- 4
- Pages
- 233-251
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC10439770
- OpenAlex
- W4321610346
- Semantic Scholar
- 87c380ffb1b9cea07172adcaa43cedaefb324e5a
- Cited by
- 148
- References
- 268
- Citations by year
- 2026: 44 · 2025: 63 · 2024: 36 · 2023: 5
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1zians009424-02, ZIA NS009424)
- National Institute of Neurological Disorders and Stroke
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- basal forebrain cholinergic neurons, acetylcholine, cholinergic neurotransmission, cognitive behavior
- MeSH terms
- Acetylcholine, Cognition, Humans, Signal Transduction, Cholinergic Agents, Basal Forebrain
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