The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Differential Involvement of the Basolateral Amygdala and Mediodorsal Thalamus in Instrumental Action Selection
Open accessAbstract
Although it has been shown that the basolateral amygdala (BLA) and the mediodorsal thalamus (MD) are critical for goal-directed instrumental performance, much remains unknown about the respective contributions of these structures to action selection. The current study assessed the effects of post-training BLA and MD lesions on several tests of instrumental action selection. We found that MD damage disrupted the influence of pavlovian cues over action selection but left intact rats' ability to select actions based on either the expected value or the discriminative stimulus properties of the outcome. In contrast, BLA lesions impaired performance on all three tests of action selection. Because both lesion types disrupted the influence of cues that signal reward over instrumental performance, we then investigated the involvement of these structures in pavlovian contingency learning using a task in which the predictive status of one of two cues is degraded by delivering its outcome noncontingently during the intertrial interval. As expected, the sham group selectively suppressed their conditioned approach performance to the cue that no longer signaled its outcome but continued to respond to the control stimulus. In contrast, both lesioned groups were impaired on this task. Interestingly, whereas the MD group displayed a nonspecific reduction in responding to both cues, the BLA group continued to show high levels of responding to both cues as if their performance was completely insensitive to this contingency manipulation. These findings demonstrate that the BLA and MD make important yet distinct contributions to instrumental action selection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“BLA→DMS pathway function in action-outcome learning is consistent with evidence that BLA lesion or BLA/DMS disconnection disrupts goal-directed behavior29,48,49.”
From A dual-pathway architecture for stress to disrupt agency and promote habit (2025) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hebb, D. O. (2005) · doi:10.4324/9781410612403 · Cited by 9,825
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,514
Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627
Goal-directed instrumental action: contingency and incentive learning and their cortical substrates
Balleine, B. W., & Dickinson, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00033-1 · Cited by 1,541
Self-citationThe role of the dorsomedial striatum in instrumental conditioning
Yin, H. H., Ostlund, S. B., Knowlton, B. J., & Balleine, B. W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04218.x · Cited by 1,099
Self-citationCoordination of Actions and Habits in the Medial Prefrontal Cortex of Rats
Killcross, S. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.4.400 · Cited by 748
Parallel incentive processing: an integrated view of amygdala function
Balleine, B. W., & Killcross, S. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.002 · Cited by 622
Self-citationCorbit, L. H., & Balleine, B. W. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4507-04.2005 · Cited by 589
Self-citationHatfield, T., Han, J.-S., Conley, M., Gallagher, M., & Holland, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-16-05256.1996 · Cited by 555
Theories of Associative Learning in Animals
Pearce, J. M., & Bouton, M. E. (2001) · Annual Review of Psychology · doi:10.1146/annurev.psych.52.1.111 · Cited by 512
Cited by
Sorted by citations
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229
Balleine, B. W., & O'Doherty, J. P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.131 · Cited by 1,775
Self-citationNeuronal Reward and Decision Signals: From Theories to Data
Schultz, W. (2015) · Physiological Reviews · doi:10.1152/physrev.00023.2014 · Cited by 1,126
The transition to compulsion in addiction
Lüscher, C., Robbins, T. W., & Everitt, B. J. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0289-z · Cited by 512
Yin, H. H., Ostlund, S. B., & Balleine, B. W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06422.x · Cited by 416
Self-citation
Metadata
- Authors
- Ostlund, S. B., & Balleine, B. W.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-04-23
- Volume
- 28
- Issue
- 17
- Pages
- 4398-4405
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2652225
- OpenAlex
- W2002961865
- Cited by
- 198
- References
- 38
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 8 · 2023: 12 · 2022: 12 · 2021: 11 · 2020: 7 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 12 · 2015: 15 · 2014: 8 · 2013: 16 · 2012: 10
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (NIMH 56446)
- National Institute of Mental Health (R29MH056446, 56446)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- basolateral amygdala, mediodorsal thalamus, classical conditioning, reward prediction, lesion studies, rats
- MeSH terms
- Amygdala, Animals, Conditioning, Operant, Female, Motivation, Reward, Rats, Long-Evans, Mediodorsal Thalamic Nucleus, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
