The postsubiculum and spatial learning: the role of postsubicular synaptic activity and synaptic plasticity in hippocampal place cell, object, and object-location memory
Open accessAbstract
Visual landmarks exert stimulus control over spatial behavior and the spatially tuned firing of place, head-direction, and grid cells in the rodent. However, the neural site of convergence for representations of landmarks and representations of space has yet to be identified. A potential site of plasticity underlying associations with landmarks is the postsubiculum. To test this, we blocked glutamatergic transmission in the rat postsubiculum with CNQX, or NMDA receptor-dependent plasticity with d-AP5. These infusions were sufficient to block evoked potentials from the lateral dorsal thalamus and long-term depression following tetanization of this input to the postsubiculum, respectively. In a second experiment, CNQX disrupted the stability of rat hippocampal place cell fields in a familiar environment. In a novel environment, blockade of plasticity with d-AP5 in the postsubiculum did not block the formation of a stable place field map following a 6 h delay. In a final behavioral experiment, postsubicular infusions of both compounds blocked object-location memory in the rat, but did not affect object recognition memory. These results suggest that the postsubiculum is necessary for the recognition of familiar environments, and that NMDA receptor-dependent plasticity in the postsubiculum is required for the formation of new object-place associations that support recognition memory. However, plasticity in the postsubiculum is not necessary for the formation of new spatial maps.
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Pre-sample infusion of CNQX or AP5 into the rat postsubiculum impaired long-term OPP but not NOP performance.
“Pre-sample infusion of CNQX or AP5 into the rat postsubiculum also impaired long-term OPP, but not NOP, performance”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Bett et al., 2013
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Cites
Microstructure of a spatial map in the entorhinal cortex
Hafting, T., Fyhn, M., Molden, S., Moser, M.-B., & Moser, E. I. (2005) · Nature · doi:10.1038/nature03721 · Cited by 4,068 · see citing works
Taube, J., Muller, R., & Ranck, J. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-02-00420.1990 · Cited by 1,809 · see citing works
Dudek, S. M., & Bear, M. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4363 · Cited by 1,708 · see citing works
Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus
Leutgeb, J. K., Leutgeb, S., Moser, M.-B., & Moser, E. I. (2007) · Science · doi:10.1126/science.1135801 · Cited by 1,601 · see citing works
The effects of changes in the environment on the spatial firing of hippocampal complex-spike cells
Muller, R., & Kubie, J. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-07-01951.1987 · Cited by 1,581 · see citing works
Hippocampal place units in the freely moving rat: Why they fire where they fire
O'Keefe, J. M., & Conway, D. H. (1978) · Experimental Brain Research · doi:10.1007/bf00239813 · Cited by 1,007 · see citing works
Taube, J. S., Muller, R., & Ranck, J. B. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-02-00436.1990 · Cited by 887 · see citing works
When Is the Hippocampus Involved in Recognition Memory?
Barker, G. R. I., & Warburton, E. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6413-10.2011 · Cited by 818 · see citing works
What determines our navigational abilities?
Wolbers, T., & Hegarty, M. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.01.001 · Cited by 818 · see citing works
Head direction cells recorded in the anterior thalamic nuclei of freely moving rats
Taube, J. S. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00070.1995 · Cited by 688 · see citing works
Burwell, R. D., Witter, M. P., & Amaral, D. G. (1995) · Hippocampus · doi:10.1002/hipo.450050503 · Cited by 532 · see citing works
Grid cells in pre- and parasubiculum
Boccara, C. N., Sargolini, F., Thoresen, V. H., Solstad, T., Witter, M. P., Moser, E. I., & Moser, M. (2010) · Nature Neuroscience · doi:10.1038/nn.2602 · Cited by 518 · see citing works
The Parahippocampal Region: Corticocortical Connectivity
Burwell, R. D. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06717.x · Cited by 513 · see citing works
Stimulus control of spatial behavior on the eight-arm maze in rats
Suzuki, S., Augerinos, G., & Black, A. H. (1980) · Learning and Motivation · doi:10.1016/0023-9690(80)90018-1 · Cited by 485 · see citing works
Abolition of Long-Term Stability of New Hippocampal Place Cell Maps by NMDA Receptor Blockade
Kentros, C., Hargreaves, E., Hawkins, R. D., Kandel, E. R., Shapiro, M., & Muller, R. V. (1998) · Science · doi:10.1126/science.280.5372.2121 · Cited by 484 · see citing works
Representation of Non-Spatial and Spatial Information in the Lateral Entorhinal Cortex
Deshmukh, S. S., & Knierim, J. J. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00069 · Cited by 454 · see citing works
Hippocampal Plasticity across Multiple Days of Exposure to Novel Environments
Frank, L. M., Stanley, G. B., & Brown, E. N. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1958-04.2004 · Cited by 410 · see citing works
Spatial information content and reliability of hippocampal CA1 neurons: Effects of visual input
Markus, E. J., Barnes, C. A., McNaughton, B. L., Gladden, V. L., & Skaggs, W. E. (1994) · Hippocampus · doi:10.1002/hipo.450040404 · Cited by 397 · see citing works
Robust Conjunctive Item–Place Coding by Hippocampal Neurons Parallels Learning What Happens Where
Komorowski, R. W., Manns, J. R., & Eichenbaum, H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1378-09.2009 · Cited by 372 · see citing works
Witter, M. P., & Amaral, D. G. (2004) · Elsevier eBooks · doi:10.1016/b978-012547638-6/50022-5 · Cited by 344 · see citing works
Cue control and head direction cells.
Goodridge, J. P., Dudchenko, P. A., Worboys, K. A., Golob, E. J., & Taube, J. S. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.4.749 · Cited by 229 · see citing works
Self-citationGoodridge, J. P., & Taube, J. S. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09315.1997 · Cited by 228 · see citing works
A New Role for the Parahippocampal Cortex in Representing Space
Mullally, S. L., & Maguire, E. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0267-11.2011 · Cited by 197 · see citing works
Dopamine facilitates long-term depression of glutamatergic transmission in rat prefrontal cortex
Otani, S., Blond, O., Desce, J. M., & Crépel, F. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00677-5 · Cited by 196 · see citing works
Cooper, B. G., & Mizumori, S. J. Y. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-03986.2001 · Cited by 196 · see citing works
A driveable bundle of microwires for collecting single-unit data from freely-moving rats
Kubie, J. L. (1984) · Physiology & Behavior · doi:10.1016/0031-9384(84)90080-5 · Cited by 191 · see citing works
Hippocampal Place Cell Instability after Lesions of the Head Direction Cell Network
Calton, J. L., Stackman, R. W., Goodridge, J. P., Archey, W. B., Dudchenko, P. A., & Taube, J. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-30-09719.2003 · Cited by 179 · see citing works
Self-citationOrigins of landmark encoding in the brain
Yoder, R. M., Clark, B. J., & Taube, J. S. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.08.004 · Cited by 155 · see citing works
Bast, T., da Silva, B. M., & Morris, R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0698-05.2005 · Cited by 148 · see citing works
van Groen, T., & Wyss, J. M. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903240310 · Cited by 143 · see citing works
Attenuated hippocampal long-term potentiation in basolateral amygdala-lesioned rats
Ikegaya, Y., Saitō, H., & Abe, K. (1994) · Brain Research · doi:10.1016/0006-8993(94)91377-3 · Cited by 142 · see citing works
Lesions of the rat postsubiculum impair performance on spatial tasks
Taube, J. S., Kesslak, J. P., & Cotman, C. W. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90629-i · Cited by 134 · see citing works
Barker, G. R. I., & Warburton, E. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4447-07.2008 · Cited by 118 · see citing works
Clark, B. J., Bassett, J. P., Wang, S. S., & Taube, J. S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3380-09.2010 · Cited by 114 · see citing works
Single Neuron Activity and Theta Modulation in Postrhinal Cortex during Visual Object Discrimination
Furtak, S. C., Ahmed, O. J., & Burwell, R. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.039 · Cited by 92 · see citing works
Neural Correlates of Object-in-Place Learning in Hippocampus and Prefrontal Cortex
Kim, J., Delcasso, S., & Lee, I. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2859-11.2011 · Cited by 91 · see citing works
Head direction cells and episodic spatial information in rats without a hippocampus
Golob, E. J., & Taube, J. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7645 · Cited by 88 · see citing works
Golob, E. J., & Taube, J. S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-07198.1999 · Cited by 71 · see citing works
Muir, G. M., & Bilkey, D. K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-04016.2001 · Cited by 64 · see citing works
Presubiculum layer III conveys retrosplenial input to the medial entorhinal cortex
Kononenko, N. L., & Witter, M. P. (2011) · Hippocampus · doi:10.1002/hipo.20949 · Cited by 57 · see citing works
Dudchenko, P. A. (2010) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199210862.001.0001 · Cited by 51 · see citing works
Self-citationLiu, P., Jarrard, L. E., & Bilkey, D. K. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.1.112 · Cited by 44 · see citing works
Why People Get Lost: The Psychology and Neuroscience of Spatial Cognition
Dudchenko, P. A. (2010) · Cited by 41 · see citing works
Self-citationA stable hippocampal representation of a space requires its direct experience
Rowland, D. C., Yanovich, Y., & Kentros, C. G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105445108 · Cited by 40 · see citing works
Long-term potentiation and depression of synaptic transmission in rat posterior cingulate cortex
Hedberg, T. G., & Stanton, P. K. (1995) · Brain Research · doi:10.1016/0006-8993(94)01254-f · Cited by 37 · see citing works
Liu, P., Jarrard, L. E., & Bilkey, D. K. (2003) · Hippocampus · doi:10.1002/hipo.10161 · Cited by 32 · see citing works
The postsubiculum is necessary for spatial alternation but not for homing by path integration.
Bett, D., Wood, E. R., & Dudchenko, P. A. (2012) · Behavioral Neuroscience · doi:10.1037/a0027163 · Cited by 21 · see citing works
Self-citationFear conditioning is disrupted by damage to the postsubiculum
Robinson, S., & Bucci, D. J. (2011) · Hippocampus · doi:10.1002/hipo.20987 · Cited by 12 · see citing works
Nerad, L., Liu, P., & Bilkey, D. K. (2008) · Hippocampus · doi:10.1002/hipo.20517 · Cited by 11 · see citing works
Shires, K. L., Hawthorne, J. P., Hope, A. M. J., et al. (2013) · Hippocampus · doi:10.1002/hipo.22114 · Cited by 7 · see citing works
Self-citationLepage (1998) · doi:10.1002/(sici)1098-1063(1998)8:4
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Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
- Authors
- Bett, D., Stevenson, C. H., Shires, K. L., Smith, M. T., Martin, S. J., Dudchenko, P. A., & Wood, E. R.
- Affiliations
- University of Stirling (GB)
- University of Edinburgh (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-04-17
- Volume
- 33
- Issue
- 16
- Pages
- 6928-6943
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6618890
- OpenAlex
- W2153135146
- Cited by
- 27
- References
- 52
- Citations by year
- 2026: 3 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 1 · 2013: 2
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by-nc-sa)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Stirling Online Research Repository (University of Stirling) (submittedVersion, public-domain)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/D001714/1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- postsubiculum, spatial learning, object location memory, object recognition memory, long-term depression, CNQX, D-AP5, hippocampal place fields, spatial maps, visual landmarks, rodents
- MeSH terms
- Action Potentials, Animals, Conditioning, Operant, Exploratory Behavior, Hippocampus, Learning, Male, Neural Pathways, Neuronal Plasticity, Neurons, Photic Stimulation, Spatial Behavior, Visual Perception, 2-Amino-5-phosphonovalerate, Excitatory Amino Acid Antagonists, 6-Cyano-7-nitroquinoxaline-2,3-dione, Excitatory Postsynaptic Potentials, Recognition, Psychology, Rats
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