The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Structural plasticity underlies experience-dependent functional plasticity of cortical circuits.
Open accessAbstract
The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that alphaCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.
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“In αCaMKII-T286A defective mice, chessboard trimming failed to increase stabilization of new persistent spines at the border between spared and deprived barrels (Wilbrecht et al., 2010).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Wilbrecht et al., 2010
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Metadata
- Authors
- Wilbrecht, L., Holtmaat, A., Wright, N., Fox, K., & Svoboda, K.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Geneva (CH)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-04-06
- Volume
- 30
- Issue
- 14
- Pages
- 4927-4932
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2910869
- OpenAlex
- W2012985621
- Cited by
- 138
- References
- 27
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 10 · 2017: 10 · 2016: 4 · 2015: 14 · 2014: 12 · 2013: 17 · 2012: 13
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Medical Research Council
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke (R01NS038259)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (F32HD047104)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- structural plasticity, experience-dependent plasticity, barrel cortex, whisker trimming, CaMKIIα, autophosphorylation, layer 5 neurons, barrel columns, cortical circuits, sensory deprivation
- MeSH terms
- Animals, Cerebral Cortex, Learning, Male, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neuronal Plasticity, Synapses, Vibrissae, Dendritic Spines, Mice
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