Cited by 138Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

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Structural plasticity underlies experience-dependent functional plasticity of cortical circuits.

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Wilbrecht, Linda, Holtmaat, Anthony, Wright, Nick, Fox, Kevin, Svoboda, Karel·2010·The Journal of Neuroscience

DOI 10.1523/jneurosci.6403-09.2010PMC PMC2910869

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Abstract

The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that alphaCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.

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Authors: Wilbrecht, L., Holtmaat, A., Wright, N., Fox, K., & Svoboda, K.
Affiliations: Howard Hughes Medical Institute (US)
University of Geneva (CH)
ORCID: Wilbrecht, Linda
Holtmaat, Anthony
Fox, Kevin
Svoboda, Karel
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2010-04-06
Volume: 30
Issue: 14
Pages: 4927-4932
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.6403-09.2010
PMC: PMC2910869
OpenAlex: W2012985621
Cited by: 138
References: 27
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 10 · 2017: 10 · 2016: 4 · 2015: 14 · 2014: 12 · 2013: 17 · 2012: 13
FWCI: 7.12
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders: Howard Hughes Medical Institute
National Institutes of Health
Medical Research Council
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke (R01NS038259)
National Institute of Child Health and Human Development
Eunice Kennedy Shriver National Institute of Child Health and Human Development (F32HD047104)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: structural plasticity, experience-dependent plasticity, barrel cortex, whisker trimming, CaMKIIα, autophosphorylation, layer 5 neurons, barrel columns, cortical circuits, sensory deprivation
MeSH terms: Animals, Cerebral Cortex, Learning, Male, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neuronal Plasticity, Synapses, Vibrissae, Dendritic Spines, Mice

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Structural plasticity underlies experience-dependent functional plasticity of cortical circuits.

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