Cited by 657Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and MetabolismBacterial Cancer Therapy

The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.

Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine

Open access

Zhang, Ji, Pavlova, Natalya N, Thompson, Craig B·2017·The EMBO Journal

DOI 10.15252/embj.201696151PMC PMC5430235

Open this paper in CoChat — free account

Abstract

Biochemistry textbooks and cell culture experiments seem to be telling us two different things about the significance of external glutamine supply for mammalian cell growth and proliferation. Despite the fact that glutamine is a nonessential amino acid that can be synthesized by cells from glucose-derived carbons and amino acid-derived ammonia, most mammalian cells in tissue culture cannot proliferate or even survive in an environment that does not contain millimolar levels of glutamine. Not only are the levels of glutamine in standard tissue culture media at least ten-fold higher than other amino acids, but glutamine is also the most abundant amino acid in the human bloodstream, where it is assiduously maintained at approximately 0.5 mM through a combination of dietary uptake, de novo synthesis, and muscle protein catabolism. The complex metabolic logic of the proliferating cancer cells' appetite for glutamine-which goes far beyond satisfying their protein synthesis requirements-has only recently come into focus. In this review, we examine the diversity of biosynthetic and regulatory uses of glutamine and their role in proliferation, stress resistance, and cellular identity, as well as discuss the mechanisms that cells utilize in order to adapt to glutamine limitation.

Integrity signals

Registry

Crossref · 10.15252/embj.201696151

Cites

129 of 129 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The emerging hallmarks of cancer metabolism
Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926 · cited 1×
“Thus, levels of certain metabolites are continuously monitored by a cell, directly informing cellular decisions on gene expression, affecting cellular differentiation as a result (Pavlova & Thompson, 2016).”
Self-citation
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154
Self-citation
Modulation of oxidative stress as an anticancer strategy
Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4002 · Cited by 3,579
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Harding, H. P., Novoa, I., Zhang, Y., Zeng, H., Wek, R. C., Schapira, M., & Ron, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00108-8 · Cited by 3,344
Untitled work
(1989) · PubMed · Cited by 3,343
Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.015 · Cited by 2,766
Self-citation
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
Self-citation
Recurring mutations found by sequencing an acute myeloid leukemia genome
Mardis, E. R., Ding, L., Dooling, D. J., Larson, D. E., McLellan, M. D., Chen, K., Koboldt, D. C., Fulton, R. S., Delehaunty, K. D., McGrath, S. D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0903840 · Cited by 2,219
Regulation of glutathione synthesis
Lu, S. C.-L. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.05.005 · Cited by 2,131

Flagged first, then by citations

Show all 129 references

Sorted by citations

Items 401–500 of 657

Qici Sanling Decoction Suppresses Glutamine Consumption and Bladder Cancer Cell Growth through Inhibiting c-Myc Expression
Chen, W., Wang, W., Zhang, J., Liao, G., Bai, J., Yang, B., Tan, M., & Gong, H. C. (2022) · Journal of Oncology · doi:10.1155/2022/7985468 · Cited by 9
Self-citation
Combination of Plasma-Based Metabolomics and Machine Learning Algorithm Provides a Novel Diagnostic Strategy for Malignant Mesothelioma
Li, N., Yang, C., Zhou, S., Song, S., Jin, Y., Wang, D., Liu, J., Gao, Y. L., Yang, H., Mao, W., et al. (2021) · Diagnostics · doi:10.3390/diagnostics11071281 · Cited by 9
Oxygen and metabolic reprogramming in the tumor microenvironment influences metastasis homing
Bisht, V. S., Giri, K., Kumar, D., & Ambatipudi, K. (2021) · Cancer Biology & Therapy · doi:10.1080/15384047.2021.1992233 · Cited by 8
Longitudinal change in castration-resistant prostate cancer biomarker AST/ALT ratio reflects tumor progression
Mitsui, Y., Yamabe, F., Hori, S., Uetani, M., Aoki, H., Sakurabayashi, K., Okawa, M., Kobayashi, H., Nagao, K., & Nakajima, K. (2023) · Scientific Reports · doi:10.1038/s41598-023-42711-z · Cited by 8
Organic pollutant sensing for human health based on carbon dots
Zhang, Q., Xing, S., Han, J., Feng, L., Li, J., Qian, Z., & Zhou, J. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.110117 · Cited by 8
SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL
Zhang, M., Chen, C., Zhang, H., Long, T., Wang, T., Ding, N., Long, R., Wu, H. J., Ma, Z., Cheng, Z., et al. (2025) · Gut · doi:10.1136/gutjnl-2025-335729 · Cited by 8
Presence of human breast cancer xenograft changes the diurnal profile of amino acids in mice
Paula, R., Sonehara, N. M., Jardim‐Perassi, B. V., Pál, Á., Asad, Y. J., Chuffa, L. G. D. A., Chammas, R. J., Raynaud, F. I., & Zuccari, D. A. P. D. C. (2022) · Scientific Reports · doi:10.1038/s41598-022-04994-6 · Cited by 8
Screening and Identification of Novel Laccase Producing Entomopathogenic Fungus Beauveria pseudobassiana PHF4 and Optimization of Production Conditions of Enzyme
Sharma, D. K., Kaur, M., Borkar, S. R., & Gupta, R. (2023) · ACTA SCIENTIFIC MICROBIOLOGY · doi:10.31080/asmi.2023.06.1259 · Cited by 8
SLC1A5 regulates cell proliferation and self-renewal through β-catenin pathway mediated by redox signaling in arsenic-treated uroepithelial cells
Li, S., Pei, L., Zhou, Q., Fu, Z., Zhang, L., Liu, P., Yan, N., & Xi, S. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115204 · Cited by 8
MMP3C: anin-silicoframework to depict cancer metabolic plasticity using gene expression profiles
Chen, X., Deng, M., Wang, Z., & Huang, C. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad471 · Cited by 8
Protective effect of wheat gluten peptides against ethanol-stress damage in yeast cell and identification of anti-ethanol peptides
Yang, H., Huang, L., Zhao, D., Zhao, H., Chen, Y., Li, Y., & Zeng, Y. (2024) · LWT · doi:10.1016/j.lwt.2024.115732 · Cited by 8
Acetyl-CoA synthetase 2 contributes to a better prognosis for liver cancer by switching acetate-glucose metabolism
Jung, K. H., Lee, S., Kim, H. S., Kim, J., Lee, Y. J., Park, M. S., Seo, M.-S., Lee, M., Yun, M., Park, S., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01185-3 · Cited by 8
Glutamine: A key player in human metabolism as revealed by hyperpolarized magnetic resonance
dos Santos, K. C., Bertho, G., Baudin, M., & Giraud, N. (2024) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2024.05.003 · Cited by 9
TFAP2A Activates S100A2 to Mediate Glutamine Metabolism and Promote Lung Adenocarcinoma Metastasis
Zeng, T., Ren, W., Zeng, H., Wang, D., Wu, X., & Guo, X. (2024) · The Clinical Respiratory Journal · doi:10.1111/crj.13825 · Cited by 8
Genetic variants in glutamine metabolic pathway genes predict cutaneous melanoma‐specific survival
Chen, K., Liu, H., Liu, Z., Bloomer, W., Amos, C. I., Lee, J. E., Li, X., Nan, H., & Wei, Q. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.23100 · Cited by 8
Asparagine sustains cellular proliferation and c‑Myc expression in glutamine‑starved cancer cells
Chiodi, I., Perini, C., Berardi, D., & Mondello, C. (2021) · Oncology Reports · doi:10.3892/or.2021.8047 · Cited by 8
Use of oral glutamine in radiation‑induced adverse effects in patients with thoracic and upper aerodigestive malignancies: Results of a prospective observational study
Papanikolopoulou, A., Syrigos, N. K., Vini, L., Papasavva, M., Lazopoulos, G., Kteniadakis, S., Spandidos, D. A., Charpidou, A., & Drakoulis, N. (2021) · Oncology Letters · doi:10.3892/ol.2021.13137 · Cited by 8
Benzo[a]pyrene mediated time- and dose-dependent alteration in cellular metabolism of primary pig bladder cells with emphasis on proline cycling
Verma, N., Pink, M., Kersch, C., Rettenmeier, A. W., & Schmitz‐Spanke, S. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02521-7 · Cited by 8
Glutamine protects intestinal mucosa and promotes its transport after burn injury in rats.
Shi, Y., Wang, Z.-E., Wu, W., Wu, D., Wang, C., & Peng, X. (2018) · PubMed Central · Cited by 8
Macrophage Stimulated by Low Ambient Temperature Hasten Tumor Growth via Glutamine Production
Lee, E., Chung, T., Kim, K., Bae, B., Kim, B., Kim, S., Ryu, D., Bae, S., & Ha, K. (2020) · Biomedicines · doi:10.3390/biomedicines8100381 · Cited by 8
Oncogenic Control of MetabolismPreprint
Pavlova, N. N., & Thompson, C. B. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041531 · Cited by 9
Self-citation
Mitochondrial dysfunction significantly contributes to the sensitivity of tumor cells to anoikis and their metastatic potential
Solyanik, G. I., Kolesnik, D. L., Prokhorova, I. V., Yurchenko, O. V., & Pyaskovskaya, O. N. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32626 · Cited by 7
HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis
Kim, G. W., Cha, M., Ong, H. T. M., Yoo, J. H., Jeon, Y. H., Lee, S. W., Oh, S. Y., Kang, M., Kim, Y. S., & Kwon, S. H. (2025) · Advanced Science · doi:10.1002/advs.202501553 · Cited by 8
C-type natriuretic peptide attenuates enhanced glycolysis and de novo pyrimidine synthesis in pericytes of patients with pulmonary arterial hypertension
Noh, M., Mitra, A., Krebes, L., Schmitz, W., Dudek, J., Agarwal, S., Maack, C., Arias-Loza, P.-A., Higuchi, T., Aleksić, I., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08661-0 · Cited by 7
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights
Xiao, W., Tan, D., Zeng, W., Nie, X., & Wang, M. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102054 · Cited by 8
Emerging roles and regulatory mechanisms involved in glutamine metabolism
Ryu, K. W., Fung, T. S., & Thompson, C. B. (2026) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2026.04.008 · Cited by 9
Self-citation
Glutamine promotes the proliferation of epithelial cells via mTOR / S6 pathway in oral lichen planus
Hu, J., Ling, Z., Li, W., Su, Z., Lu, J., Zeng, Q., Cheng, B., & Tao, X. (2022) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.13391 · Cited by 7
Nutritional Metabolomics in Diet–Breast Cancer Relations: Current Research, Challenges, and Future Directions—A Review
Vahid, F., Hajizadeghan, K., & Khodabakhshi, A. (2023) · Biomedicines · doi:10.3390/biomedicines11071845 · Cited by 8
Gut microbiota influence on lung cancer risk through blood metabolite mediation: from a comprehensive Mendelian randomization analysis and genetic analysis
Du, Y., Wang, Q., Zheng, Z., Zhou, H., Han, Y., Qi, A., Jiao, L., & Gong, Y. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1425802 · Cited by 7
Effects of intestinal trefoil factor on intestinal mucus barrier in burned mice.
Wang, Z.-E., Peng, J., Wu, D., Zheng, J., & Peng, X. (2020) · PubMed Central · Cited by 7
Systematic analysis of glutamine metabolism family genes and exploration of the biological role of GPT in colorectal cancer
Dai, W., Mo, W., Xu, W., Han, D., & Xu, X. (2023) · Aging · doi:10.18632/aging.205079 · Cited by 6
Influence of glutamine metabolism on diabetes Development:A scientometric review
Zhao, M., Wang, K., Rui, L., Mu, F., Cui, J., Tao, X., Weng, Y., & Wang, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25258 · Cited by 7
Effects of Ala-Gln on growth, biochemical indicators and stress-related gene expression of largemouth bass (Micropterus salmoides) under dual stress of flow rate and density
Lin, Y.-J., Chen, J., Chen, X.-M., Li, X.-N., Jin, X.-Y., Sun, J.-X., Niu, X., Kong, Y., Li, M., & Wang, G. (2024) · Aquaculture Reports · doi:10.1016/j.aqrep.2024.101961 · Cited by 7
Prognostic Value of the Largest Lesion Size for Progression-Free Survival in Patients with NET Undergoing Salvage PRRT with [177Lu]Lu-DOTATOC
Galler, M., Rogasch, J. M. M., Huang, K., Jann, H., Plehm, K., Wetz, C., & Amthauer, H. (2022) · Cancers · doi:10.3390/cancers14071768 · Cited by 7
The metabolic fate of abalone: transport and recovery of Haliotis iris gills as a case study
Venter, L., Alfaro, A. C., Lindeque, J. Z., & van Rensburg, P. J. (2024) · New Zealand Journal of Marine and Freshwater Research · doi:10.1080/00288330.2023.2297912 · Cited by 6
Reprogrammed mitochondria: a central hub of cancer cell metabolism
Ciccarone, F., & Ciriolo, M. R. (2024) · Biochemical Society Transactions · doi:10.1042/bst20231090 · Cited by 8
Recent advances in lung cancer organoid (tumoroid) research (Review)
Zhang, Q., & Zhang, M. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12672 · Cited by 8
Metabolic flux and flux balance analyses indicate the relevance of metabolic thermogenesis and aerobic glycolysis in cancer cells
Okahashi, N., Shima, T., Kondo, Y., Araki, C., Tsuji, S., Sawai, A., Uehara, H., Kohno, S., Shimizu, H., Takahashi, C., et al. (2025) · Metabolic Engineering · doi:10.1016/j.ymben.2025.08.002 · Cited by 6
Investigating the role of GLUL as a survival factor in cellular adaptation to glutamine depletion via targeted stable isotope resolved metabolomics
Bayram, Ş., Razzaque, Y. S., Geisberger, S., Pietzke, M., Fürst, S., Vechiatto, C., Forbes, M., Mastrobuoni, G., & Kempa, S. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.859787 · Cited by 6
A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase
Shankar, S., Ramachandran, S., Tulsian, N. K., Sridhar, R., Jobichen, C., & Sivaraman, J. (2022) · FEBS Journal · doi:10.1111/febs.16658 · Cited by 6
Unraveling the Sweet Secrets of HCC: Glucometabolic Rewiring in Hepatocellular Carcinoma
Bhat, S. A., Farooq, Z., Ismail, H., Corona‐Avila, I., & Khan, M. W. (2023) · Technology in Cancer Research & Treatment · doi:10.1177/15330338231219434 · Cited by 6
Metabolic fingerprinting reveals extensive consequences of GLS hyperactivity
Rumping, L., Pras‐Raves, M. L., Gerrits, J., Tang, Y. F., Willemsen, M., Houwen, R. H. J., van Haaften, G. W., van Hasselt, P. M., Verhoeven‐Duif, N. M., & Jans, J. J. M. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.129484 · Cited by 6
Expression of pyruvate carboxylase in cultured human astrocytoma, glioblastoma and neuroblastoma cells
Gondáš, E., Trancikova, A. K., Majerčíková, Z., Pokusa, M., Baranovičová, E., Bystrický, P., Dobrota, D., & Murín, R. (2021) · General Physiology and Biophysics · doi:10.4149/gpb_2021003 · Cited by 6
Roles of non-coding RNAs in the metabolism and pathogenesis of bladder cancer
Sanya, D. R. A., & Onésime, D. (2023) · Human Cell · doi:10.1007/s13577-023-00915-5 · Cited by 6
Extracellular matrix detached cancer cells resist oxidative stress by increasing histone demethylase KDM6 activity
Alfaleh, M. A., Mohammed, M. R. S., Hashem, A. M., Abujamel, T. S., Alhakamy, N. A., & Khan, M. I. (2023) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2023.103871 · Cited by 6
UPLC‑MS/MS‑based metabolomic characterization and comparison of pancreatic adenocarcinoma tissues using formalin‑fixed, paraffin‑embedded and optimal cutting temperature‑embedded materials
Feng, D., Yuan, J., Liu, Q., Liu, L., Zhang, X., Wu, Y., Qian, Y., Chen, L., Shi, Y. X., & Gu, M. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4898 · Cited by 6
Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and femalesPreprint
Patton, M. E., Kelekar, S., Taylor, L. J., Dean, A. E., Zuo, Q., Thakare, R. N., Lee, S. H., Gentry, E. C., Panitchpakdi, M. W., Dorrestein, P. C., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.25.172635 · Cited by 8
Yuanhuacine suppresses head and neck cancer growth by promoting ASCT2 degradation and inhibiting glutamine uptake
Chen, X., Chen, X., Liang, X., Lu, D., Pan, R., Xiong, Q.-Y., Liu, X., Lin, J.-Y., Zhang, L., Chen, H., et al. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01562-2 · Cited by 6
Mitochondria and tumorigenesis: Molecular basis and therapeutic implications
Huang, C. Y., Xie, Z., Li, J., & Zhang, C. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101806 · Cited by 6
Metabolism and structure of PDA as the target for new therapies: possibilities and limitations for nanotechnology
Zygmunt, A., & Gubernator, J. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2370492 · Cited by 5
Resveratrol Enhances Antioxidant and Anti-Apoptotic Capacities in Chicken Primordial Germ Cells through m6A Methylation: A Preliminary Investigation
Qiao, Y., Xiao, G., Zhu, X., Wen, J., Bu, Y., Zhang, X., Kong, J., Bai, Y., & Xie, Q. (2024) · Animals · doi:10.3390/ani14152214 · Cited by 5
The signature of extracellular vesicles in hypoxic breast cancer and their therapeutic engineering
Zhu, B., Xiang, K., Li, T., Li, X., & Shi, F. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01870-w · Cited by 5
Exploring Metabolic Approaches for Epithelial Ovarian Cancer Therapy
Kumari, S., Gupta, S., Jamil, A., Tabatabaei, D., & Karakashev, S. V. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31495 · Cited by 5
Cell-Free DNA (cfDNA) Regulates Metabolic Remodeling, Sustaining Proliferation, Quiescence, and Migration in MDA-MB-231, a Triple-Negative Breast Carcinoma (TNBC) Cell Line
Lemos, I., Freitas-Dias, C., Hipólito, A., Ramalho, J. S., Cartenì, F., Gonçalves, L. G., Mazzoleni, S., & Serpa, J. (2025) · Metabolites · doi:10.3390/metabo15040227 · Cited by 5
Exploring cellular metabolic kinetics through spectroscopic analysis of extracellular environments
Mirveis, Z., Patil, N., & Byrne, H. J. (2025) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2025.126308 · Cited by 5
The Role of Antioxidant on Health and Age-Related Diseases in Aging
Tan, B. L., & Norhaizan, M. E. (2021) · Springer eBooks · doi:10.1007/978-3-030-82859-2_7 · Cited by 5
Glutamine metabolism-related genes predict prognosis and reshape tumor microenvironment immune characteristics in diffuse gliomas
Fan, H., Zhang, S., Yuan, Y., Chen, S., Li, W., Wang, Z., Xiang, Y., Li, J., Ma, X., & Liu, Y. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1104738 · Cited by 5
Tripartite motif containing 33 demonstrated anticancer effect by degrading c‑Myc: Limitation of glutamine metabolism and proliferation in endometrial carcinoma cells
Qi, Y., Ma, N., & Zhang, J. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5581 · Cited by 5
Self-citation
RNA Modifications in Cancer Metabolism and Tumor Microenvironment
Qing, Y., Dong, W., Deng, X., Chen, J., & Su, R. J. (2023) · Cancer treatment and research · doi:10.1007/978-3-031-45654-1_1 · Cited by 5
Changes in cuproptosis-related gene expression in periodontitis: An integrated bioinformatic analysis
Liu, N., He, Y., Chen, X., Qiu, G., Wu, Y., & Shen, Y. (2024) · Life Sciences · doi:10.1016/j.lfs.2023.122388 · Cited by 5
A prognostic model built on amino acid metabolism patterns in HPV-associated head and neck squamous cell carcinoma
Jing, F., Zhu, L., Bai, J., Zhou, X., Sun, L., Zhang, H., & Li, T. (2024) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2024.105975 · Cited by 5
Microbiota and detrimental protein derived metabolites in colorectal cancer
González, A., Odriozola, I., Fullaondo, A., & Odriozola, A. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.06.001 · Cited by 7
A Novel Glutamine Metabolism-Related Gene Signature in Prognostic Prediction of Osteosarcoma
Wan, L., Zhang, W., Liu, Z., Yang, Z., Tu, C., & Li, Z. (2022) · International Journal of General Medicine · doi:10.2147/ijgm.s352859 · Cited by 5
A Five Glutamine-Associated Signature Predicts Prognosis of Prostate Cancer and Links Glutamine Metabolism with Tumor Microenvironment
Wang, H., Chen, Y., Zhao, W., Liu, H., Tu, H., Xia, Z., Wang, R., Tang, J., Zhu, C., Li, R., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062243 · Cited by 5
Role of asparagine biosynthesis pathway in Siniperca chuatsi rhabdovirus proliferation
Li, F., Fu, X., Luo, X., Lin, Q., Liang, H., Niu, Y., Liu, L., & Li, N. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1165491 · Cited by 5
Enterogenic metabolomics signatures of depression: what are the possibilities for the future
Zhang, Y., Chen, X., Mo, X., Xiao, R., Cheng, Q., Wang, H., Liu, L., & Xie, P. (2023) · Expert Review of Proteomics · doi:10.1080/14789450.2023.2279984 · Cited by 5
Capillary electrophoresis/visible‐LED induced fluorescence of tryptophan: What's new?
Perquis, L., Ta, H. Y., Ong‐Meang, V., Poinso, A., Collin, F., Poinsot, V., & Couderc, F. (2019) · Electrophoresis · doi:10.1002/elps.201900058 · Cited by 5
Amino Acids | Glutamine
Watford, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00028-1 · Cited by 5
Lactic acid metabolism: gynecological cancer's Achilles’ heel
Zhang, T., Zhou, W., Fan, T., Yuan, Y., Tang, X., Zhang, Q., Zou, J., & Li, Y. (2025) · Discover Oncology · doi:10.1007/s12672-025-02364-y · Cited by 4
Deciphering the critical roles of the AMPK/mTOR signaling pathway in cancer cell metabolism (Review)
Alasadi, A., Fadhil, N. M., & Chen, S. (2025) · World Academy of Sciences Journal · doi:10.3892/wasj.2025.391 · Cited by 7
Glutaminase I and glutamine transaminase–ω-amidase pathways in colorectal cancer: Metabolic reprogramming and emerging therapeutic strategies
Voor, S. F., Cooper, A. J. L., & Pinto, J. T. (2025) · Analytical Biochemistry · doi:10.1016/j.ab.2025.115989 · Cited by 4
Cdk5 regulates glutamine metabolism in colorectal cancer via the EZH2-GLS1 axis
Wu, Q., Zhu, X., Wan, X., Lu, X., Chen, J., Ying, Z., Li, Y., Hu, X., Jia-hai, L., Lou, Y., et al. (2025) · Cancer & Metabolism · doi:10.1186/s40170-025-00414-1 · Cited by 4
Research Progress of Liver Cancer Recurrence Based on Energy Metabolism of Liver Cancer Stem Cells
Wu, M., Wang, H., Wu, X., Zeng, H., Miao, M., & Song, Y. (2025) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s500638 · Cited by 4
Multi-omics analysis revealed the addiction to glutamine and susceptibility to de novo lipogenesis of endometrial neoplasm
Zhu, Y., Zheng, Y., Zhang, Q., Chen, L., Ouyang, Y., Song, Z., Zhao, B., Gu, C., Kong, B., Huang, H., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2761-y · Cited by 4
Synergistic effects of low-dose arsenic and N-methyl-N′-nitro-N-nitrosoguanidine co-exposure by altering gut microbiota and intestinal metabolic profile in rats
Wang, K., Lin, X., Wang, T., Zhang, X., Cheng, W., Xu, F., Wang, L., Li, B., Wang, M., Wang, W., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115195 · Cited by 4
Enhancing breast cancer outcomes with machine learning-driven glutamine metabolic reprogramming signature
Li, X., Li, X., Yang, B., Sun, S., Wang, S., Yu, F., & Wang, T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1369289 · Cited by 4
AGC1-mediated Metabolic Reprogramming and Autophagy Sustain Survival of Hepatocellular Carcinoma Cells under Glutamine Deprivation
Liu, Y., Miao, Z., & Yang, Q. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01311-y · Cited by 5
Amino Acid Deprivation in Glioblastoma: The Role in Survival and the Tumour Microenvironment—A Narrative Review
Du, K., Grocott, L., Anichini, G., O’Neill, K., & Syed, N. (2024) · Biomedicines · doi:10.3390/biomedicines12112481 · Cited by 4
Impact of bee pollen cell-wall disrupting techniques on the structural integrity, functional attributes, and nutritional quality of bee pollen protein isolates for food application
Sharma, A., Thakur, A., & Nanda, V. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141179 · Cited by 4
Metabolic Plasticity of Tumor Cells: How They Do Adapt to Food Deprivation
Schoonjans, C. A., & Gallez, B. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34025-4_6 · Cited by 4
NAD+ as a Target for Cancer Treatment
Helman, T. J., & Braidy, N. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_269-1 · Cited by 4
An algorithm-based technique for counting mitochondria in cells using immunohistochemical staining of formalin-fixed and paraffin-embedded sections
Sakashita, M., Motoi, N., Yamamoto, G., Gambe, E., Suzuki, M., Yoshida, Y., WATANABE, S.-I. J., Takazawa, Y., Aoki, K., Ochiai, A., et al. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05653-1 · Cited by 4
Phosphoribosyl pyrophosphate amidotransferase: Novel biomarker and therapeutic target for nasopharyngeal carcinoma
Kitagawa, Y., Kondo, S., Fukuyo, M., Wakae, K., Dochi, H., Mizokami, H., Komura, S., Kobayashi, E., Hirai, N., Ueno, T., et al. (2024) · Cancer Science · doi:10.1111/cas.16314 · Cited by 4
Characterization and Determination of 13C-Labeled Nonessential Amino Acids in a 13C5-Glutamine Isotope Tracer Experiment with a Mass Spectrometry Strategy Combining Parallel Reaction Monitoring and Multiple Reaction Monitoring
Zheng, Y., Zhao, H., Tong, M., Zhu, L., Ma, S., & Cai, Z. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c02554 · Cited by 4
HepaCAM‑PIK3CA axis regulates the reprogramming of glutamine metabolism to inhibit prostate cancer cell proliferation
He, Z., Gao, Y., Li, T., Yu, C., Ou, L., & Luo, C. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5327 · Cited by 5
Short-term in vitro glutamine restriction differentially impacts the chromosomal stability of transformed and non-transformed cells
Yan, L., Zhao, Z., Wang, X., Lyu, T., Li, J., Qi, Y., Wang, X., & Guo, X. (2020) · Mutagenesis · doi:10.1093/mutage/geaa026 · Cited by 4
A mixed nitrogen diet and compartmentalized utilization for Mycobacterium tuberculosis replicating in host cells: results of a systems-based analysisPreprint
Borah, K., Beyß, M., Theorell, A., Wu, H., Basu, P., Mendum, T. A., Nöh, K., Beste, D. J. V., & McFadden, J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/542480 · Cited by 4
Interplay of serum taurine, S-adenosylmethionine, and cysteine levels in cancer risk: a prospective study
Liu, C., Liu, T., Wei, Y., Shi, J., Deng, L., Song, M., & Shi, H. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1507125 · Cited by 3
Integrative multidimensional analysis of age-associated synthetic lethal genes and development of a prognostic model in breast cancer
Wu, Q., Ma, D., Cao, H., Wang, X., Zhang, W., & Zhang, W. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1690301 · Cited by 3
HIF2α inhibits glutaminase clustering in mitochondria to sustain growth of clear cell renal cell carcinoma
Zhao, W., Demczyszyn, S. M., Coffey, N. J., Jiang, Y., Kim, B., Bowers, S., Bowman, C. E., Noji, M., Jang, C., Simon, M. C., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.182711 · Cited by 3
SLC38A3 deficiency reveals a critical role of blood-derived glutamine in brain development
Radzishevsky, I. S., Harb, L., Odeh, M., Maoz, I., Saeed, A., Lahkar, A., Agranovich, B., Abramovich, I., Chaudhry, F. A., Avital, A., et al. (2025) · Brain · doi:10.1093/brain/awaf473 · Cited by 4
Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction
Lisci, M., Vericel, F., Liu, Y., Gallart‐Ayala, H., Ivanišević, J., Skinner, O. S., & Jourdain, A. A. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.02.002 · Cited by 4
Integrative spatial multi-omics reveals the tumor ecosystem: From mechanistic insights to therapeutic strategies
Chang, W., Zhang, W., Li, K., & Huang, P. (2026) · iScience · doi:10.1016/j.isci.2026.116349 · Cited by 4
Ligand‐Independent Activation of Aryl Hydrocarbon Receptor and Attenuation of Glutamine Levels by Natural Deep Eutectic Solvent
Denis, A. A., Toledo, D., Hakim, Q. A., Quintana, A. A., Escobar, C. R., Oluwole, S. A., Costa, A., Garcia, E. G., Hill, A. R., & Agatemor, C. (2023) · ChemBioChem · doi:10.1002/cbic.202300540 · Cited by 3
Metabolic hallmarks of trastuzumab resistance
Martín-Castillo, B., Verdura, S., Llop‐Hernández, À., Lupu, R., Cuyàs, E., & Menéndez, J. A. (2025) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2025.2532394 · Cited by 3
Metabolic Reprogramming as a Therapeutic Target in Cancer: A Qualitative Systematic Review (QualSR) of Natural Compounds Modulating Glucose and Glutamine Pathways
Enwere, M., Irobi, E., Chime, V., Ezeogu, A., Onu, A., Hussein, M. T. E., Ogungbade, G. O., Davies, E., Omoniwa, O., Omale, C., et al. (2025) · Onco · doi:10.3390/onco5030043 · Cited by 3
NMR spectroscopy for mixture analysis – both a blessing and a curse: dissecting cell growth media as an example
Marx, U. C., & Oey, M. (2025) · Australian Journal of Chemistry · doi:10.1071/ch25117 · Cited by 3
New Q(ues) to keep blood vessels growing
Andrade, J., & Potente, M. (2017) · The EMBO Journal · doi:10.15252/embj.201797764 · Cited by 3
Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1+/−/ODC transgenic mice
Li, C., Mishra, B., Kashyap, M. P., Weng, Z., Andrabi, S. A., Mukhtar, S. M., Kim, A. L., Bickers, D. R., Kopelovich, L., & Athar, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-49470-w · Cited by 3
An NAD+ dependent/sensitive transcription system: Toward a novel anti-cancer therapy
Uchiumi, F., Sato, A., Asai, M., & Tanuma, S. (2020) · AIMS molecular science · doi:10.3934/molsci.2020002 · Cited by 3

Authors: Zhang, J., Pavlova, N. N., & Thompson, C. B.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
Corresponding author: Thompson, Craig B
ORCID: Zhang, Ji
Pavlova, Natalya N
Thompson, Craig B
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 2017-04-18
Volume: 36
Issue: 10
Pages: 1302-1315
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.15252/embj.201696151
PMC: PMC5430235
OpenAlex: W2606441315
Cited by: 651
References: 129
Citations by year: 2026: 52 · 2025: 85 · 2024: 93 · 2023: 80 · 2022: 83 · 2021: 74 · 2020: 68 · 2019: 64 · 2018: 43 · 2017: 9
FWCI: 5.12
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: The EMBO Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Terri Brodeur Breast Cancer Foundation
HHS|National Institutes of Health (P30 CA008748, P01 CA104838)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
Keywords: glutamine, cancer metabolism, non-essential amino acids, glutamine synthesis, glutamine limitation, cellular stress resistance, cell proliferation, cell identity, muscle protein degradation, protein synthesis
MeSH terms: Animals, Glutamine, Humans, Neoplasms, Cell Proliferation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks