Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine

The emerging hallmarks of cancer metabolism

Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926 · cited 1×

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154

Modulation of oxidative stress as an anticancer strategy

Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4002 · Cited by 3,579

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

Harding, H. P., Novoa, I., Zhang, Y., Zeng, H., Wek, R. C., Schapira, M., & Ron, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00108-8 · Cited by 3,344

Untitled work

(1989) · PubMed · Cited by 3,343

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.015 · Cited by 2,766

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622

Recurring mutations found by sequencing an acute myeloid leukemia genome

Mardis, E. R., Ding, L., Dooling, D. J., Larson, D. E., McLellan, M. D., Chen, K., Koboldt, D. C., Fulton, R. S., Delehaunty, K. D., McGrath, S. D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0903840 · Cited by 2,219

Regulation of glutathione synthesis

Lu, S. C.-L. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.05.005 · Cited by 2,131

Endoplasmic reticulum stress signals in the tumour and its microenvironment

Chen, X., & Cubillos-Ruiz, J. R. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-020-00312-2 · Cited by 1,356

Glutathione metabolism in cancer progression and treatment resistance

Bansal, A., & Simon, M. C. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201804161 · Cited by 1,253

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Leone, R. D., Zhao, L., Englert, J. M., Sun, I.-M., Oh, M.-H., Sun, I.-H., Arwood, M. L., Bettencourt, I. A., Patel, C. H., Wen, J., et al. (2019) · Science · doi:10.1126/science.aav2588 · Cited by 1,169

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121110 · Cited by 1,168

Glutamine reliance in cell metabolism

Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021

Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma

Du, D., Liu, C., Qin, M., Zhang, X., Xi, T., Yuan, S., Hao, H., & Xiong, J. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.09.019 · Cited by 665

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

Kim, J., & DeBerardinis, R. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.013 · Cited by 606

Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation

Schiliro, C., & Firestein, B. L. (2021) · Cells · doi:10.3390/cells10051056 · Cited by 659

Cancer-associated adipocytes: key players in breast cancer progression

Wu, Q., Li, B., Li, Z., Li, J., Sun, S., & Sun, S. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0778-6 · Cited by 462

N6-methyladenosine links RNA metabolism to cancer progression

Dai, D., Wang, H., Zhu, L., Jin, H., & Wang, X. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0129-x · Cited by 472

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Aßmann, N., Kedia-Mehta, N., O’Brien, K., Garcia, A., Gillespie, C. S., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04719-2 · Cited by 403

Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer

Edwards, D. N., Ngwa, V. M., Raybuck, A. L., Wang, S., Hwang, Y., Kim, L. C., Cho, S. H., Paik, Y., Wang, Q., Zhang, S., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci140100 · Cited by 389

Role of glutamine and interlinked asparagine metabolism in vessel formation

Huang, H., Vandekeere, S., Kalucka, J., Bierhansl, L., Zecchin, A., Brüning, U., Visnagri, A., Yuldasheva, N., Goveia, J., Cruys, B., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201695518 · Cited by 320

Rewiring urea cycle metabolism in cancer to support anabolism

Keshet, R., Szlosarek, P. W., Carracedo, A., & Erez, A. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0054-z · Cited by 330

Tumor microenvironment signaling and therapeutics in cancer progression

Goenka, A., Khan, F., Verma, B., Sinha, P., Dmello, C. C., Jogalekar, M. P., Gangadaran, P., & Ahn, B. (2023) · Cancer Communications · doi:10.1002/cac2.12416 · Cited by 323

Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism

Walsh, C. T., Tu, B. P., & Tang, Y. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00510 · Cited by 315

Amino Acid Depletion Therapies: Starving Cancer Cells to Death

Butler, M., van der Meer, L. T., & van Leeuwen, F. N. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.03.003 · Cited by 277

Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells

Yu, Y., Newman, H., Shen, L., Sharma, D., Hu, G., Mirando, A. J., Zhang, H., Knudsen, E., Zhang, G.-F., Hilton, M. J., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.016 · Cited by 253

グルタミン窒素代謝シフトはヒトがんの悪性化に寄与する

Kodama, M. (2020) · Institutional Repositories DataBase (IRDB) · Cited by 267

Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment

Ma, G., Zhang, Z., Li, P., Zhang, Z., Zeng, M., Liang, Z., Li, D., Wang, L., Chen, Y., Liang, Y., et al. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00909-0 · Cited by 241

Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism

Somasundaram, V., Basudhar, D., Bharadwaj, G., No, J. H., Ridnour, L. A., Cheng, R. Y. S., Fujita, M., Thomas, D. D., Anderson, S. K., McVicar, D. W., et al. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7527 · Cited by 217

Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment

Wu, P., Gao, W. Q., Su, M., Nice, E. C., Zhang, W., Lin, J., & Xie, N. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.641469 · Cited by 218

Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer

Bell, H. N., Huber, A. K., Singhal, R., Korimerla, N., Rebernick, R. J., Kumar, R., El-Derany, M. O., Sajjakulnukit, P., Das, N. K., Kerk, S. A., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.013 · Cited by 201

Integration of Hippo-YAP Signaling with Metabolism

Ibar, C., & Irvine, K. D. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.025 · Cited by 190

Cancer Metabolism and the Evasion of Apoptotic Cell Death

Sharma, A., Boise, L., & Shanmugam, M. (2019) · Cancers · doi:10.3390/cancers11081144 · Cited by 202

Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth

Scalise, M., Pochini, L., Galluccio, M., Console, L., & Indiveri, C. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00306 · Cited by 183

Metabolic Plasticity in Chemotherapy Resistance

Desbats, M. A., Giacomini, I., Prayer‐Galetti, T., & Montopoli, M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00281 · Cited by 190

Connections between metabolism and epigenetics in cancers

Thakur, C., & Chen, F. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.06.006 · Cited by 176

Acetyl-CoA regulates lipid metabolism and histone acetylation modification in cancer

He, W., Li, Q., & Li, X. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188837 · Cited by 182

HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells

Lee, S.-H., Golinska, M., & Griffiths, J. R. (2021) · Cells · doi:10.3390/cells10092371 · Cited by 169

Metabolic Plasticity of Acute Myeloid Leukemia

Kreitz, J., Schönfeld, C., Seibert, M., Stolp, V., Alshamleh, I., Oellerich, T., Steffen, B., Schwalbe, H., Schnütgen, F., Kurrle, N., et al. (2019) · Cells · doi:10.3390/cells8080805 · Cited by 177

The Role of NRF2/KEAP1 Signaling Pathway in Cancer Metabolism

Song, M.-Y., Lee, D.-Y., Chun, K., & Kim, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094376 · Cited by 170

Microenvironmental Metabolism Regulates Antitumor Immunity

Ngwa, V. M., Edwards, D. N., Philip, M., & Chen, J. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-0617 · Cited by 156

The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance

Biancur, D. E., & Kimmelman, A. C. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.04.011 · Cited by 152

Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

Gallipoli, P., Giotopoulos, G., Tzelepis, K., Costa, A. S. H., Vohra, S., Medina-Pérez, P., Basheer, F., Marando, L., Lisio, L. D., Dias, J. M. L., et al. (2018) · Blood · doi:10.1182/blood-2017-12-820035 · Cited by 158

Hypoxia-Driven Effects in Cancer: Characterization, Mechanisms, and Therapeutic Implications

Shi, R., Liao, C., & Zhang, Q. H. (2021) · Cells · doi:10.3390/cells10030678 · Cited by 151

Obesity: Pathophysiology, monosodium glutamate-induced model and anti-obesity medicinal plants

Hernández-Bautista, R., Mahmoud, A. M., Königsberg, M., & López‐Díazguerrero, N. E. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.108 · Cited by 158

Role of hypoxia in the tumor microenvironment and targeted therapy

Chen, G., Wu, K., Li, H., Xia, D., & He, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.961637 · Cited by 148

Dysregulated metabolic pathways in age-related macular degeneration

Zhang, M., Jiang, N., Chu, Y., Postnikova, O. A., Varghese, R. S., Horvath, A., Cheema, A. K., & Golestaneh, N. (2020) · Scientific Reports · doi:10.1038/s41598-020-59244-4 · Cited by 135

5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA -Mutant Colorectal Cancers

Zhao, Y., Feng, X., Chen, Y., Selfridge, J. E., Gorityala, S., Du, Z., Wang, J. M., Hao, Y., Cioffi, G., Conlon, R. A., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0600 · Cited by 130

Glutamine Metabolism Controls Chondrocyte Identity and Function

Stegen, S., Rinaldi, G., Loopmans, S., Stockmans, I., Moermans, K., Thienpont, B., Fendt, S., Carmeliet, P., & Carmeliet, G. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.05.001 · Cited by 130

Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses

Morrot, A., da Fonseca, L. M., Salustiano, E. J., Gentile, L. B., Conde, L., Filardy, A. A., Franklim, T. N., da Costa, K. M., Freire-de-Lima, C. G., & Freire‐de‐Lima, L. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00081 · Cited by 128

Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma

Wu, S., Fukumoto, T., Lin, J., Nacarelli, T., Wang, Y., Ong, D., Liu, H., Fatkhutdinov, N., Zundell, J. A., Karakashev, S. V., et al. (2021) · Nature Cancer · doi:10.1038/s43018-020-00160-x · Cited by 132

Towards resource-efficient and cost-efficient cultured meat

Hubalek, S., Post, M. J., & Moutsatsou, P. (2022) · Current Opinion in Food Science · doi:10.1016/j.cofs.2022.100885 · Cited by 145

ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma

Zhang, Z., Liu, R., Shuai, Y., Huang, Y., Jin, R., Wang, X., & Luo, J. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0637-9 · Cited by 125

Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance

Wei, F., Wang, D., Wei, J., Tang, N., Tang, L. M., Xiong, F., Guo, C. J., Zhou, M., Li, X., Li, G., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03581-0 · Cited by 128

Role of amino acid metabolism in mitochondrial homeostasis

Li, Q., & Hoppe, T. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1127618 · Cited by 129

Glutamine deprivation alters the origin and function of cancer cell exosomes

Fan, S., Kroeger, B., Marie, P. P., Bridges, E. M., Mason, J. D., McCormick, K., Zois, C. E., Sheldon, H., Khalid Alham, N., Johnson, E., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019103009 · Cited by 130

Metabolic vulnerability of cisplatin‐resistant cancers

Obrist, F., Michels, J., Durand, S., Chery, A., Pol, J. G., Lévesque, S., Joseph, A., Astesana, V., Pietrocola, F., Wu, G. S., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201798597 · Cited by 122

Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential

Zhu, T., Hong, L., & Ling, Z. (2023) · Biomarker Research · doi:10.1186/s40364-023-00499-0 · Cited by 121

Single-cell transcriptomic analysis deciphers heterogenous cancer stem-like cells in colorectal cancer and their organ-specific metastasis

Li, R., Liu, X., Huang, X., Zhang, D., Chen, Z., Zhang, J., Bai, R., Zhang, S., Zhao, H., Xu, Z., et al. (2023) · Gut · doi:10.1136/gutjnl-2023-330243 · Cited by 138

Cystine deprivation triggers CD36-mediated ferroptosis and dysfunction of tumor infiltrating CD8+ T cells

Han, C., Ge, M., Xing, P., Xia, T., Zhang, C., Ma, K., Ma, Y., Li, S., Li, W., Liu, X., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06503-1 · Cited by 116

HIV infection and latency induce a unique metabolic signature in human macrophages

Castellano, P., Prevedel, L., Valdebenito, S., & Eugenín, E. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-39898-5 · Cited by 117

Cancer cell metabolic reprogramming: a keystone for the response to immunotherapy

Cerezo, M., & Rocchi, S. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03175-5 · Cited by 118

Recent trends in analytical methods for the determination of amino acids in biological samples

Song, Y., Xu, C., Kuroki, H., Liao, Y., & Tsunoda, M. (2017) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2017.08.050 · Cited by 111

O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1

Zhu, Q., Zhou, H., Wu, L., Lai, Z., Geng, D., Yang, W., Zhang, J., Fan, Z., Qin, W., Wang, Y., et al. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01085-5 · Cited by 107

TSPAN8 + myofibroblastic cancer–associated fibroblasts promote chemoresistance in patients with breast cancer

Fan, G., Yu, B., Tang, L., Zhu, R., Chen, J., Zhu, Y., Huang, H., Zhou, L., Liu, J., Wang, W., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adj5705 · Cited by 116

Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster?

Jiang, J., Srivastava, S., & Zhang, J. (2019) · Cancers · doi:10.3390/cancers11060804 · Cited by 108

The Role of Diet in Cancer Prevention and Chemotherapy Efficacy

Mittelman, S. D. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-013120-041149 · Cited by 111

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

Qie, S., Yoshida, A., Parnham, S. R., Oleinik, N. V., Beeson, G. C., Beeson, C. C., Öğretmen, B., Bass, A. J., Wong, K., Rustgi, A. K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09179-w · Cited by 101

Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles

Tang, K., Zhang, H., Deng, J., Wang, D., Liu, S., Lu, S., Cui, Q., Chen, C., Liu, J., Yang, Z., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01365-1 · Cited by 105

Lactate: The Mediator of Metabolism and Immunosuppression

Zhang, Y., Zhai, Z., Duan, J., Wang, X., Zhong, J., Wu, L., Li, A., Cao, M., Wu, Y., Shi, H., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.901495 · Cited by 108

p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake

Lowman, X. H., Hanse, E. A., Yang, Y., Gabra, M. B. I., Tran, T. Q., Li, H., & Kong, M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.037 · Cited by 102

Arginine: at the crossroads of nitrogen metabolism

Fung, T. S., Ryu, K. W., & Thompson, C. B. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00379-3 · Cited by 113

The RNA-Binding Protein YBX3 Controls Amino Acid Levels by Regulating SLC mRNA Abundance

Cooke, A. M., Schwarzl, T., Huppertz, I., Kramer, G., Mantas, P., Alleaume, A.-M., Huber, W. K., Krijgsveld, J., & Hentze, M. W. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.039 · Cited by 98

The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives

Panieri, E., Telkoparan‐Akillilar, P., Süzen, S., & Saso, L. (2020) · Biomolecules · doi:10.3390/biom10050791 · Cited by 102

Metabolic Plasticity of Tumor Cell Mitochondria

Cannino, G., Ciscato, F., Masgras, I., Sànchez‐Martìn, C., & Rasola, A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00333 · Cited by 97

Asparagine: A Metabolite to Be Targeted in Cancers

Jiang, J., Batra, S., & Zhang, J. (2021) · Metabolites · doi:10.3390/metabo11060402 · Cited by 99

Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition

Han, S., Zhu, L., Zhu, Y., Meng, Y. G., Li, J., Song, P., Yousafzai, N. A., Feng, L., Chen, M., Wang, Y., et al. (2021) · Theranostics · doi:10.7150/thno.60028 · Cited by 95

Cell Programmed Nutrient Partitioning in the Tumor MicroenvironmentPreprint

Reinfeld, B. I., Madden, M. Z., Wolf, M., Chytil, A. M., Bader, J. E., Patterson, A. R., Cohen, A., Ali, A. K., Do, B. T., Muir, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.10.238428 · Cited by 96

Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease

Ushio‐Fukai, M., Ash, D., Nagarkoti, S., de Chantemèle, E. J. B., Fulton, D. J., & Fukai, T. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8161 · Cited by 99

RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease

Mandigo, A. C., Yuan, W., Xu, K., Gallagher, P., Pang, A., Guan, Y. F., Shafi, A. A., Thangavel, C., Sheehan, B., Bogdan, D., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1114 · Cited by 91

The Interplay Between TGF-β Signaling and Cell Metabolism

Liu, H., & Chen, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.846723 · Cited by 102

The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling pathways

Bakhtiyari, M., Liaghat, M., Aziziyan, F., Shapourian, H., Yahyazadeh, S., Alipour, M., Shahveh, S., Maleki‐Sheikhabadi, F., Halimi, H., Forghaniesfidvajani, R., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01282-2 · Cited by 93

Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression

Ni, F., Yu, W., Li, Z., Graham, D. K., Jin, L., Kang, S., Rossi, M. R., Li, S., Broxmeyer, H. E., & Qu, C. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0039-6 · Cited by 89

Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets

Nan, D., Yao, W., Huang, L., Liu, R., Chen, X., Xia, W., Sheng, H., Zhang, H., Liang, X., & Lü, Y. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-024-02018-6 · Cited by 98

Glutamine as an Essential Amino Acid for KRas-Driven Cancer Cells

Bernfeld, E., & Foster, D. A. (2019) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2019.03.003 · Cited by 85

Glutamine Synthetase as a Therapeutic Target for Cancer Treatment

Kim, G. W., Lee, D. H., Jeon, Y. H., Yoo, J. H., Kim, S. Y., Lee, S. W., Cho, H. Y., & Kwon, S. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041701 · Cited by 86

Ovarian aging: energy metabolism of oocytes

Bao, S., Yin, T., & Liu, S. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-024-01427-y · Cited by 92

Intracellular Mycobacterium tuberculosis Exploits Multiple Host Nitrogen Sources during Growth in Human Macrophages

Borah, K., Beyß, M., Theorell, A., Wu, H., Basu, P., Mendum, T. A., Nöh, K., Beste, D. J. V., & McFadden, J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.037 · Cited by 84

The Role of SLC7A11 in Cancer: Friend or Foe?

Li, S., Lu, Z., Sun, R., Guo, S., Gao, F., Cao, B., & Aa, J. (2022) · Cancers · doi:10.3390/cancers14133059 · Cited by 87

Targeting glutamine metabolic reprogramming of SLC7A5 enhances the efficacy of anti-PD-1 in triple-negative breast cancer

Huang, R., Wang, H., Hong, J., Wu, J., Huang, O., He, J., Chen, W., Li, Y., Chen, X., Shen, K., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1251643 · Cited by 85

The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy

Russell, B. L., Sooklal, S. A., Malindisa, S. T., Daka, L. J., & Ntwasa, M. M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.641428 · Cited by 86

Endoplasmic Reticulum Stress Responses in Intratumoral Immune Cells: Implications for Cancer Immunotherapy

Song, M., & Cubillos‐Ruiz, J. R. (2019) · Trends in Immunology · doi:10.1016/j.it.2018.12.001 · Cited by 82

DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation

Li, M., Thorne, R. F., Shi, R., Zhang, X. D., Li, J., Li, J., Zhang, Q., Wu, M., & Liu, L. (2021) · Advanced Science · doi:10.1002/advs.202003732 · Cited by 81

MYC Rules: Leading Glutamine Metabolism toward a Distinct Cancer Cell Phenotype

Tambay, V., Raymond, V., & Bilodeau, M. (2021) · Cancers · doi:10.3390/cancers13174484 · Cited by 91

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

Tompkins, S. C., Sheldon, R. D., Rauckhorst, A. J., Noterman, M. F., Solst, S. R., Buchanan, J. L., Mapuskar, K. A., Pewa, A. D., Gray, L. R., Oonthonpan, L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.098 · Cited by 79

Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma

Recouvreux, M. V., Grenier, S. F., Zhang, Y., Esparza, E., Lambies, G., Galapate, C. M., Maganti, S., Duong‐Polk, K., Bhullar, D., Naeem, R. F., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00649-1 · Cited by 79

Glutamine-Directed Migration of Cancer-Activated Fibroblasts Facilitates Epithelial Tumor Invasion

Mestre‐Farrera, A., Bruch‐Oms, M., Peña, R., Rodríguez-Morató, J., Alba‐Castellón, L., Comerma, L., Quintela-Fandiño, M., Duñach, M., Baulida, J., Pozo, Ó. J., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0622 · Cited by 81

The Architecture of the Rag GTPase Signaling Network

Nicastro, R., Sardu, A., Panchaud, N., & VIRGILIO, C. D. (2017) · Biomolecules · doi:10.3390/biom7030048 · Cited by 76

The multifaceted role of cell cycle regulators in the coordination of growth and metabolism

Huber, K., Mestres‐Arenas, A., Fajas, L., & Leal-Esteban, L. C. (2020) · FEBS Journal · doi:10.1111/febs.15586 · Cited by 78

Transcriptome and methylome analysis reveals three cellular origins of pituitary tumors

Taniguchi‐Ponciano, K., Andonegui-Elguera, S., Peña-Martínez, E., Silva-Román, G., Vela-Patiño, S., Apo, E. G., Chávez-Macías, L., Vargas‐Ortega, G., Espinosa-de-los-Monteros, L., González‐Virla, B., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76555-8 · Cited by 74

Translation in amino-acid-poor environments is limited by tRNAGln charging

Pavlova, N. N., King, B., Josselsohn, R., Violante, S. N., Macera, V. L., Vardhana, S. A., Cross, J. R., & Thompson, C. B. (2020) · eLife · doi:10.7554/elife.62307 · Cited by 73

Low-dose exposure to phytosynthesized gold nanoparticles combined with glutamine deprivation enhances cell death in the cancer cell line HeLa via oxidative stress-mediated mitochondrial dysfunction and G0/G1 cell cycle arrest

Prasad, A., Khatua, A., Mohanta, Y. K., Saravanan, M., Meena, R., & Ghosh, I. (2022) · Nanoscale · doi:10.1039/d2nr02150a · Cited by 72

Glutathione-Dependent Pathways in Cancer Cells

Kalinina, E. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158423 · Cited by 79

Role of tyrosine phosphorylation in modulating cancer cell metabolism

Taddei, M. L., Pardella, E., Pranzini, E., Raugei, G., & Paoli, P. D. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188442 · Cited by 70

Tumor Metabolic Reprogramming by Adipokines as a Critical Driver of Obesity-Associated Cancer Progression

Pham, D., & Park, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031444 · Cited by 73

Metabolic reprogramming in cervical cancer and metabolomics perspectives

Li, B., & Sui, L. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00615-7 · Cited by 76

Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches

Carvalho, T. M. A., Molfetta, D. D., Greco, M. R., Koltai, T., Alfarouk, K. O., Reshkin, S. J., & Cardone, R. A. (2021) · Cancers · doi:10.3390/cancers13236135 · Cited by 76

Regulation of Ferroptosis by Amino Acid Metabolism in Cancer

Yang, J., Dai, X., Xu, H., Tang, Q., & Bi, F. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.64982 · Cited by 70

Glutaminolysis: A Hallmark of Cancer Metabolism

Yang, L., Venneti, S., & Nagrath, D. (2017) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071516-044546 · Cited by 859

Glutamine metabolism in cancer therapy

Nguyen, T.-L., & Durán, R. V. (2018) · Cancer Drug Resistance · doi:10.20517/cdr.2018.08 · Cited by 56

Hopefully devoted to Q: targeting glutamine addiction in cancer

Still, E. R., & Yuneva, M. O. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.113 · Cited by 142

Glutamine: pleiotropic roles in tumor growth and stress resistance

Shanware, N. P., Mullen, A. R., DeBerardinis, R. J., & Abraham, R. T. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0731-9 · Cited by 176

Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster?

Jiang, J., Srivastava, S., & Zhang, J. (2019) · Cancers · doi:10.3390/cancers11060804 · Cited by 108