Cited by 247Cancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

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MYC and tumor metabolism: chicken and egg

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Dejure, Francesca R, Eilers, Martin·2017·The EMBO Journal

DOI 10.15252/embj.201796438PMC PMC5709748

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Abstract

Transcription factors of the MYC family are deregulated in the majority of all human cancers. Oncogenic levels of MYC reprogram cellular metabolism, a hallmark of cancer development, to sustain the high rate of proliferation of cancer cells. Conversely, cells need to modulate MYC function according to the availability of nutrients, in order to avoid a metabolic collapse. Here, we review recent evidence that the multiple interactions of MYC with cell metabolism are mutual and review mechanisms that control MYC levels and function in response to metabolic stress situations. The main hypothesis we put forward is that regulation of MYC levels is an integral part of the adaptation of cells to nutrient deprivation. Since such mechanisms would be particularly relevant in tumor cells, we propose that-in contrast to growth factor-dependent controls-they are not disrupted during tumorigenesis and that maintaining flexibility of expression is integral to MYC's oncogenic function.

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RETRACTED: The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation
Csibi, A., Lee, G., Yoon, S.-O., Tong, H., Ilter, D., Elia, I., Fendt, S., Roberts, T. M., & Blenis, J. (2014) · Current Biology · doi:10.1016/j.cub.2014.08.007 · Cited by 253
Retracted
RETRACTED ARTICLE: Therapeutic potential of targeting IRES-dependent c-myc translation in multiple myeloma cells during ER stress
Shi, Y., Yang, Y., Hoang, B. Q., Bardeleben, C., Holmes, B., Gera, J., & Lichtenstein, A. K. (2015) · Oncogene · doi:10.1038/onc.2015.156 · Cited by 68
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The Warburg Effect: How Does it Benefit Cancer Cells?
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The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
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MYC on the Path to Cancer
Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390
Endoplasmic reticulum stress: cell life and death decisions
Xu, C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26373 · Cited by 2,291
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 2×
“In activated T cells, MYC increases the expression of G6PDH, encoding for glucose-6phosphate dehydrogenase, which catalyzes the first reaction of the oxidative phase, and TKT, which encodes for transketolase, an enzyme of the non-oxidative branch (Wang et al, 2011).”
Background
Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins
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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
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Authors: Dejure, F. R., & Eilers, M.
Affiliations: University of Würzburg (DE)
Corresponding author: Eilers, Martin
ORCID: Eilers, Martin
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 2017-12-01
Volume: 36
Issue: 23
Pages: 3409-3420
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.15252/embj.201796438
PMC: PMC5709748
OpenAlex: W2767348608
Cited by: 240
References: 127
Citations by year: 2026: 13 · 2025: 24 · 2024: 21 · 2023: 30 · 2022: 29 · 2021: 43 · 2020: 31 · 2019: 35 · 2018: 13
FWCI: 2.20
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: The EMBO Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (DFG222/12‐1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: c-Myc, cancer metabolism, metabolic reprogramming, nutrient deprivation, metabolic stress, MYC regulation, carcinogenesis
MeSH terms: Forkhead Box Protein O1, Mechanistic Target of Rapamycin Complex 1, Animals, Glucose, Glutamine, Humans, Neoplasms, Nucleotides, Stress, Physiological, Biogenic Polyamines, Genes, myc, Proto-Oncogene Proteins c-myc, Apoptosis, Metabolic Networks and Pathways

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MYC and tumor metabolism: chicken and egg

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