MYC and tumor metabolism: chicken and egg

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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The Warburg Effect: How Does it Benefit Cancer Cells?

Liberti, M. V., & Locasale, J. W. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.12.001 · Cited by 5,150

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

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MYC on the Path to Cancer

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Endoplasmic reticulum stress: cell life and death decisions

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

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Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

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The anti-cancer effect of quercetin: molecular implications in cancer metabolism

Reyes-Farias, M., & Carrasco-Pozo, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133177 · Cited by 689

PKM2, function and expression and regulation

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R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis

Qing, Y., Dong, L., Gao, L., Li, C., Li, Y., Han, L., Prince, E. A., Tan, B., Deng, X., Wetzel, C., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.12.026 · Cited by 328

The metabolic landscape of RAS-driven cancers from biology to therapy

Mukhopadhyay, S., Vander Heiden, M. G., & McCormick, F. (2021) · Nature Cancer · doi:10.1038/s43018-021-00184-x · Cited by 315

Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00018.2019 · Cited by 310

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Carroll, P. A., Freie, B. W., Mathsyaraja, H., & Eisenman, R. N. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0650-z · Cited by 289

Metabolic reprogramming in triple-negative breast cancer

Sun, X., Wang, M., Wang, M., Yu, X., Guo, J., Sun, T., Li, X., Yao, L., Dong, H., & Xu, Y. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00428 · Cited by 243

Polyamine synthesis as a target of MYC oncogenes

Bachmann, A. S., & Geerts, D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm118.003336 · Cited by 148

The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells

Prochownik, E. V., & Wang, H. (2021) · Cells · doi:10.3390/cells10040762 · Cited by 150

c-Myc-Targeting PROTAC Based on a TNA-DNA Bivalent Binder for Combination Therapy of Triple-Negative Breast Cancer

Li, X., Zhang, Z., Gao, F., Ma, Y., Wei, D., Lu, Z., Chen, S., Wang, M., Wang, Y., Xu, K., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c02619 · Cited by 145

ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma

Zhang, Z., Liu, R., Shuai, Y., Huang, Y., Jin, R., Wang, X., & Luo, J. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0637-9 · Cited by 125

Metabolic reprogramming and the role of mitochondria in polycystic kidney disease

Podrini, C., Cassina, L., & Boletta, A. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109495 · Cited by 124

Computer-aided drug repurposing for cancer therapy: Approaches and opportunities to challenge anticancer targets

Mottini, C., Napolitano, F., Li, Z., Gao, X., & Cardone, L. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.09.023 · Cited by 125

Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways

Podrini, C., Rowe, I., Pagliarini, R., Costa, A. S. H., Chiaravalli, M., Meo, I. D., Kim, H., Distefano, G., Tiranti, V., Qian, F., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0200-x · Cited by 118

Signaling, metabolism, and cancer: An important relationship for therapeutic intervention

Vaghari‐Tabari, M., Ferns, G. A., Qujeq, D., Andevari, A. N., Sabahi, Z., & Moein, S. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30276 · Cited by 126

Epstein–Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis

Elsharkawy, A. M., Zaidan, L. A., & Malki, A. M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00265 · Cited by 109

Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration

Clark, A. R., & Ohlmeyer, M. H. J. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.016 · Cited by 108

The role of Wnt signaling pathway in tumor metabolic reprogramming

Mo, Y., Wang, Y., Zhang, L., Yang, L., Zhou, M., Li, X., Li, Y., Li, G., Zeng, Z., Xiong, W., et al. (2019) · Journal of Cancer · doi:10.7150/jca.31166 · Cited by 106

Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster?

Jiang, J., Srivastava, S., & Zhang, J. (2019) · Cancers · doi:10.3390/cancers11060804 · Cited by 108

Metabolic flexibility in melanoma: A potential therapeutic target

Ruocco, M. R., Avagliano, A., Granato, G., Vigliar, E., Masone, S., Montagnani, S., & Arcucci, A. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.016 · Cited by 106

Elevated Polyamines in Saliva of Pancreatic Cancer

Asai, Y., Itoi, T., Sugimoto, M., Sofuni, A., Tsuchiya, T., Tanaka, R., Tonozuka, R., Honjo, M., Mukai, S., Fujita, M., et al. (2018) · Cancers · doi:10.3390/cancers10020043 · Cited by 102

Deubiquitination of MYC by OTUB1 contributes to HK2 mediated glycolysis and breast tumorigenesis

Han, X., Ren, C., Lü, C., Qiao, P., Yang, T., & Yu, Z. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00971-8 · Cited by 103

The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis

Zhu, Y., Jin, L., Shi, R., Li, J., Wang, Y., Zhang, L., chao-zhao, L., Narayana, V. K., Souza, D. P. D., Thorne, R. F., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2021.11.017 · Cited by 101

Metabolic Plasticity of Tumor Cell Mitochondria

Cannino, G., Ciscato, F., Masgras, I., Sànchez‐Martìn, C., & Rasola, A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00333 · Cited by 97

High OGT activity is essential for MYC-driven proliferation of prostate cancer cells

Itkonen, H. M., Urbanucci, A., Martin, S. E. S., Khan, A., Mathelier, A., Thiede, B., Walker, S., & Mills, I. G. (2019) · Theranostics · doi:10.7150/thno.30834 · Cited by 93

Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets

Nan, D., Yao, W., Huang, L., Liu, R., Chen, X., Xia, W., Sheng, H., Zhang, H., Liang, X., & Lü, Y. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-024-02018-6 · Cited by 98

LncRNA PDIA3P interacts with c-Myc to regulate cell proliferation via induction of pentose phosphate pathway in multiple myeloma

Yang, X., Ye, H., He, M., Zhou, X., Sun, N., Guo, W., Lin, X., Huang, H. F., Lin, Y., Yao, R., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.211 · Cited by 87

MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing

Yu, L., Kim, J., Jiang, L., Feng, B., Yue, Y., Ji, K., Tang, Q., Chen, W., Mai, T., Dou, W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14437-3 · Cited by 87

Glutamine as an Essential Amino Acid for KRas-Driven Cancer Cells

Bernfeld, E., & Foster, D. A. (2019) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2019.03.003 · Cited by 85

Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage

Askenase, M. H., Goods, B. A., Beatty, H. E., Steinschneider, A. F., Velazquez, S. E., Osherov, A., Landreneau, M. J., Carroll, S. L., Tran, T. B., Avram, V., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abd6279 · Cited by 82

Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle

Popov, D. V., Makhnovskii, P. A., Shagimardanova, E. I., Gazizova, G. R., Lysenko, E. A., Gusev, O., & Виноградова, О. Л. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00449.2018 · Cited by 82

Salivary metabolomics with alternative decision tree-based machine learning methods for breast cancer discrimination

Murata, T., Yanagisawa, T., Kurihara, T., Kaneko, M., Ota, S., Enomoto, A., Tomita, M., Sugimoto, M., Sunamura, M., Hayashida, T., et al. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05330-9 · Cited by 80

LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on GLUT1 and PKM2

Wang, F., Hu, Y., Wang, H., Hu, P., Xiong, H., Zeng, Z., Han, S., Wang, D., Wang, J., Zhao, Y. B., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02847-2 · Cited by 80

Metabolic heterogeneity in cancer: An overview and therapeutic implications

Yu, T., Gao, W., & Liu, Y. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188421 · Cited by 70

Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake

Zhang, P., Wang, Q., Lin, Z., Yang, P., Dou, K., & Zhang, R. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s235667 · Cited by 68

Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

Canesin, G., Ruscio, A. D., Li, M., Ummarino, S., Hedblom, A., Choudhury, R., Krzyzanowska, A., Csizmadia, E., Palominos, M., Stiehm, A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108181 · Cited by 61

Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

Čižmáriková, M., Michalková, R., Mirossay, L., Mojžišová, G., Zigová, M., Bardelčíková, A., & Mojžíš, J. (2023) · Biomolecules · doi:10.3390/biom13111653 · Cited by 73

Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis

Pinal, N., Martín, M. J., Medina, I., & Morata, G. (2018) · Nature Communications · doi:10.1038/s41467-018-04000-6 · Cited by 58

Long Noncoding RNA DCST1-AS1 Promotes Cell Proliferation and Metastasis in Triple-negative Breast Cancer by Forming a Positive Regulatory Loop with miR-873-5p and MYC

Tang, L. P., Chen, Y., Tang, X., Wei, D., Xu, X., & Yan, F. (2019) · Journal of Cancer · doi:10.7150/jca.33982 · Cited by 58

Homeodomain‐interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer

Qin, Y., Hu, Q., Ji, S., Xu, J., Dai, W., Liu, W., Xu, W., Sun, Q., Zhang, Z., Ni, Q., et al. (2019) · Cell Proliferation · doi:10.1111/cpr.12603 · Cited by 54

Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin

Papadopoli, D. J., Uchenunu, O., Palia, R., Chekkal, N., Hulea, L., Topisirović, I., Pollak, M., & St‐Pierre, J. (2021) · Neoplasia · doi:10.1016/j.neo.2021.02.003 · Cited by 54

The role of metabolic checkpoint regulators in B cell survival and transformation

Jellusova, J. (2020) · Immunological Reviews · doi:10.1111/imr.12855 · Cited by 50

Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia

Fang, K., Sun, M., Leng, Z., Chu, Y., Zhao, Z., Li, Z., Zhang, Y., Xu, A., Zhang, Z., Zhang, L., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02623-2 · Cited by 49

Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent signaling pathway

Lan, Y., Lou, J., Hu, J., Yu, Z., Lyu, W., & Zhang, B. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0164 · Cited by 46

Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies

Madala, H. R., Punganuru, S. R., Arutla, V., Misra, S., Thomas, T., & Srivenugopal, K. S. (2018) · Cancers · doi:10.3390/cancers10020049 · Cited by 46

PBK promotes aggressive phenotypes of cervical cancer through ERK/c‐Myc signaling pathway

Ma, H., Han, F., Yan, X., Qi, G., Li, Y., Li, R., Yan, S., Yuan, C., Song, K., & Kong, B. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30134 · Cited by 46

PTEN suppresses epithelial–mesenchymal transition and cancer stem cell activity by downregulating Abi1

Qi, Y., Liu, J., Chao, J. C., Scheuerman, M. P., Rahimi, S. A., Lee, L. Y., & Li, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-69698-1 · Cited by 45

Radioactive nano-oxygen generator enhance anti-tumor radio-immunotherapy by regulating tumor microenvironment and reducing proliferation

Pei, P., Shen, W., Zhang, Y., Zhang, Y., Qi, Z., Zhou, H., Liu, T., Sun, L., & Yang, K. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121326 · Cited by 47

Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review

Zhao, M., Feng, W., Sun, G., Wen, Y., Xiang, J., Su, F., Zhan, L., Nian, Q., Chen, Y., & Zeng, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1004383 · Cited by 45

De novo pyrimidine synthesis fuels glycolysis and confers chemoresistance in gastric cancer

He, D., Chen, M., Chang, L., Gu, J., Liu, F., Gao, X., & Ruan, Y. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215837 · Cited by 45

Matrine Promotes Human Myeloid Leukemia Cells Apoptosis Through Warburg Effect Mediated by Hexokinase 2

Lin, G., Wu, Y., Cai, F., Li, Z., Su, S., Wang, J., Cao, J., & Ma, L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01069 · Cited by 42

Regulation of PI3K signaling in cancer metabolism and PI3K-targeting therapy

Han, B., Lin, X., & Hu, H. (2024) · Translational Breast Cancer Research · doi:10.21037/tbcr-24-29 · Cited by 44

The molecular chaperone TRAP1 in cancer: From the basics of biology to pharmacological targeting

Masgras, I., Laquatra, C., Cannino, G., Serapian, S. A., Colombo, G., & Rasola, A. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.07.002 · Cited by 42

Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma

Ruiz-Pérez, M. V., Sainero‐Alcolado, L., Oliynyk, G., Matuschek, I., Balboni, N., Ubhayasekera, S. J. K. A., Snaebjornsson, M. T., Makowski, K., Aaltonen, K. E., Bexell, D., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102128 · Cited by 39

Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling

Zhou, X., & Torres, V. E. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.981963 · Cited by 42

AMPK promotes survival of c‐Myc‐positive melanoma cells by suppressing oxidative stress

Kfoury, A., Armaro, M., Collodet, C., Sordet‐Dessimoz, J., Giner, M. P., Christen, S., Moco, S., Leleu, M., de Leval, L., Koch, U., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201797673 · Cited by 40

Exploring the metabolic alterations in cervical cancer induced by HPV oncoproteins: From mechanisms to therapeutic targets

Gore, M., Kabekkodu, S. P., & Chakrabarty, S. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189292 · Cited by 41

TAZ functions as a tumor suppressor in multiple myeloma by downregulating MYC

Grieve, S., Wajnberg, G., Lees, M., Chacko, S. M., Weir, J. A., Crapoulet, N., & Reiman, T. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000374 · Cited by 37

Role ofMycProto-Oncogene as a Transcriptional Hub to Regulate the Expression of Regeneration-Associated Genes following Preconditioning Peripheral Nerve Injury

Shin, H. Y., Kwon, M. J., Lee, E. M., Kim, K., Oh, Y. J., Kim, H. S., Hwang, D. H., & Kim, B. G. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1745-20.2020 · Cited by 36

Targeting RAS mutants in malignancies: successes, failures, and reasons for hope

Yang, H. S., Zhou, X., Fu, D., Le, C., Wang, J., Zhou, Q., Liu, X., Yuan, Y., Ding, K., & Xiao, Q. (2022) · 癌症：英文版 · doi:10.1002/cac2.12377 · Cited by 38

Dihydroartemisinin and artesunate inhibit aerobic glycolysis via suppressing c-Myc signaling in non-small cell lung cancer

Zhang, Y., Wang, Y., Li, Y., Huang, C., Xiao, X., Zhong, Z., Tang, J., Lu, H., Tang, Y., & Yang, J. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114941 · Cited by 35

Molecular Mediators of Metabolic Reprogramming in Cancer: Mechanisms, Regulatory Networks, and Therapeutic Strategies

Ahuja, S., & Zaheer, S. (2025) · Immunology · doi:10.1111/imm.70045 · Cited by 43

Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity

Alptekin, A., Ye, B., Yu, Y., Poole, C. J., van Riggelen, J., Zha, Y., & Ding, H. (2019) · Oncogene · doi:10.1038/s41388-019-0967-3 · Cited by 35

Prognostic implications of metabolism-associated gene signatures in colorectal cancer

Miao, Y., Li, Q., Wang, J., Quan, W., Li, C., Yang, Y., & Mi, D. (2020) · PeerJ · doi:10.7717/peerj.9847 · Cited by 35

mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A

Zhao, L., Su, H., Liu, X., Wang, H., Feng, Y., Wang, Y., Chen, H., Dai, L., Lai, S., Xu, S., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00919-y · Cited by 35

c-Myc directly targets an over-expression of pyruvate carboxylase in highly invasive breast cancer

Lao-On, U., Rojvirat, P., Chansongkrow, P., Phannasil, P., Siritutsoontorn, S., Charoensawan, V., & Jitrapakdee, S. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165656 · Cited by 33

N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma

Tjaden, B., Baum, K., Marquardt, V., Simon, M., Trajkovic‐Arsic, M., Kouril, T., Siebers, B., Lisec, J., Siveke, J. T., Schulte, J. H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-64040-1 · Cited by 34

Polydatin Inhibits Cell Viability, Migration, and Invasion Through Suppressing the c-Myc Expression in Human Cervical Cancer

Bai, L., Ma, Y., Wang, X., Feng, Q., Zhang, Z., Wang, S., Zhang, H., Lu, X., Xu, Y., Zhao, E., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.587218 · Cited by 34

The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics

Deng, Z., & Richardson, D. R. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000795 · Cited by 32

Immunosurveillance encounters cancer metabolism

Chuang, Y., Tzeng, S., Ho, P., & Tsai, C. (2024) · EMBO Reports · doi:10.1038/s44319-023-00038-w · Cited by 33

Salivary metabolomics for cancer detection

Sugimoto, M. (2020) · Expert Review of Proteomics · doi:10.1080/14789450.2020.1846524 · Cited by 33

Metabolic reprogramming as an emerging mechanism of resistance to endocrine therapies in prostate cancer

Chetta, P., & Zadra, G. (2021) · Cancer Drug Resistance · doi:10.20517/cdr.2020.54 · Cited by 32

A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?

Jiang, Z., He, J., Zhang, B., Wang, L., Long, C., Zhao, B., Yang, Y., Du, L., Luo, W., Hu, J., et al. (2024) · Aging and Disease · doi:10.14336/ad.2023.1227 · Cited by 32

CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism

Huang, W., Abudureheman, T., Xia, J., Chu, L., Zhou, H., Zheng, W., Zhou, N., Shi, R., Li, M., Zhu, J., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.641271 · Cited by 31

Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity

Iftikhar, R., Penrose, H. M., King, A. N., Samudre, J. S., Collins, M. E., Hartono, A. B., Lee, S. B., Lau, F. H., Baddoo, M., Flemington, E. F., et al. (2021) · Oncogenesis · doi:10.1038/s41389-021-00373-4 · Cited by 32

Tumor suppression by the EGR1, DMP1, ARF, p53, and PTEN Network

Inoue, K., & Fry, E. A. (2018) · Cancer Investigation · doi:10.1080/07357907.2018.1533965 · Cited by 27

MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2

Ding, Y., Yang, J., Ma, Y., Yao, T., Chen, X., Ge, S., Wang, L., & Fan, X. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1492-5 · Cited by 29

MYC Ran Up the Clock: The Complex Interplay between MYC and the Molecular Circadian Clock in Cancer

Burchett, J. B., Knudsen-Clark, A. M., & Altman, B. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147761 · Cited by 32

METTL13 inhibits progression of clear cell renal cell carcinoma with repression on PI3K/AKT/mTOR/HIF-1α pathway and c-Myc expression

Liu, Z., Sun, T., Piao, C., Zhang, Z., & Kong, C. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02879-2 · Cited by 28

MYC Drives mRNA Pseudouridylation to Mitigate Proliferation-Induced Cellular Stress during Cancer Development

Ding, J., Bansal, M., Cao, Y. X., Ye, B., Mao, R., Gupta, A., Sudarshan, S., & Ding, H. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-1102 · Cited by 29

Tumor Metabolism as a Regulator of Tumor–Host Interactions in the B-Cell Lymphoma Microenvironment—Fueling Progression and Novel Brakes for Therapy

Beielstein, A. C., & Pallasch, C. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174158 · Cited by 26

Metabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer

Tan, K. N., Avery, V. M., & Carrasco‐Pozo, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186622 · Cited by 28

c-Myc protects hepatocellular carcinoma cell from ferroptosis induced by glutamine deprivation via upregulating GOT1 and Nrf2

Zhao, Y., Wang, Y., Miao, Z., Liu, Y., & Yang, Q. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08495-1 · Cited by 26

A novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer progression and redox balance in human hepatocellular carcinoma

Chu, J., Jiang, J., Fan, X., Liu, J., Gao, K., Jiang, Y. X., Li, M., Xi, W., Zhang, L., Bian, K., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01324-3 · Cited by 25

Natural Products and Altered Metabolism in Cancer: Therapeutic Targets and Mechanisms of Action

Talib, W. H., Baban, M. M., Bulbul, M. F., Al-Zaidaneen, E., Allan, A., Al-Rousan, E. W., Ahmad, R. H. Y., Alshaeri, H. K., Alasmari, M. M., & Law, D. S. N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179593 · Cited by 25

A Computational Framework for Prediction and Analysis of Cancer Signaling Dynamics from RNA Sequencing Data—Application to the ErbB Receptor Signaling Pathway

Imoto, H., Zhang, S., & Okada, M. (2020) · Cancers · doi:10.3390/cancers12102878 · Cited by 24

Crosstalk between oncogenic MYC and noncoding RNAs in cancer

Tu, R., Chen, Z., Bao, Q., Liu, H., & Qing, G. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.10.014 · Cited by 25

Polyamine metabolism and anti-tumor immunity

Wu, J., Zeng, Y. J., You, Y.-Y., & Chen, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1529337 · Cited by 25

c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis

Vollmuth, N., Schlicker, L., Guo, Y., Hovhannisyan, P., Janaki‐Raman, S., Kurmasheva, N., Schmitz, W., Schulze, A., Stelzner, K., Rajeeve, K., et al. (2022) · eLife · doi:10.7554/elife.76721 · Cited by 29

Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease

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MYC modulators in cancer: a patent review

Wang, X., Su, X., Cheng, S.-Q., Zhi-yin, S., Huang, Z., & Ou, T. (2019) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2019.1612878 · Cited by 25

Inhibition of hepatocellular carcinoma by metabolic normalization

Wang, H., Lu, J. L., Dolezal, J. M., Kulkarni, S., Zhang, W., Chen, A., Gorka, J. E., Mandel, J. A., & Prochownik, E. V. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218186 · Cited by 22

Transcriptomics and Metabolomics Integration Reveals Redox-Dependent Metabolic Rewiring in Breast Cancer Cells

Bonanomi, M., Salmistraro, N., Fiscon, G., Conte, F., Paci, P., Bravatà, V., Forte, G. I., Volpari, T., Scorza, M., Mastroianni, F., et al. (2021) · Cancers · doi:10.3390/cancers13205058 · Cited by 23

Metabolism in Cancer Stem Cells: Targets for Clinical Treatment

Wen, G.-M., Xiaoyan, X., & Pu, X. (2022) · Cells · doi:10.3390/cells11233790 · Cited by 23

MYC as a Target for Cancer Treatment: from Undruggable to Druggable?

Duffy, M. J., Tang, M., & Crown, J. P. (2025) · Targeted Oncology · doi:10.1007/s11523-025-01169-x · Cited by 24

c-MYC and HIF1α promoter G-quadruplexes dependent metabolic regulation mechanism of berberine in colon cancer

Wen, L., Han, Z., Li, J., & Du, Y. (2022) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-22-389 · Cited by 22

TIPE3 promotes non-small cell lung cancer progression via the protein kinase B/extracellular signal-regulated kinase 1/2-glycogen synthase kinase 3β-β-catenin/Snail axis

Li, Q., Yu, D., Yu, Z., Gao, Q., Chen, R., Zhou, L., Wang, R., Li, Y., Qian, Y., Zhao, J., et al. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-21-147 · Cited by 21

Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins

Chi, Y., Yeh, T., Ke, Y., Lin, W., Tsai, C., Wang, W.-P., Chen, Y., Su, Y., Wang, P., Chen, Y.-F., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01806 · Cited by 21

Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin’s Lymphoma

Alfaifi, A., Refai, M. Y., Alsaadi, M., Bahashwan, S., Malhan, H. M., Al-Kahiry, W., Dammag, E. A. M., Ageel, A., Mahzary, A., Albiheyri, R. S., et al. (2023) · Diagnostics · doi:10.3390/diagnostics13050861 · Cited by 21

Regulation of cancer cell metabolism: Oncogenic MYC in the driver’s seat

Dong, Y., Tu, R., Liu, H., & Qing, G. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00235-2 · Cited by 405

MYC-induced metabolic stress and tumorigenesis

Wolpaw, A. J., & Dang, C. V. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.05.003 · Cited by 52

Rewired Metabolism Caused by the Oncogenic Deregulation of MYC as an Attractive Therapeutic Target in Cancers

Vízkeleti, L., & Spisák, S. (2023) · Cells · doi:10.3390/cells12131745 · Cited by 10

MYC Regulation of Metabolism and Cancer

Gouw, A. M., Hsieh, A. L., Stine, Z. E., & Dang, C. V. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1824-5_5 · Cited by 2

Impact of MYC in regulation of tumor cell metabolism

Wahlström, T., & Arsenian‐Henriksson, M. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.07.004 · Cited by 176