Cited by 124NF-κB Signaling PathwaysAdvanced Proteomics Techniques and ApplicationsT-cell and B-cell Immunology

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Systems‐wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation

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Satpathy, Shankha, Wagner, Sebastian A, Beli, Petra, Gupta, Rajat, Kristiansen, Trine A, Malinova, Dessislava, Francavilla, Chiara, Tolar, Pavel, Bishop, Gail A, Hostager, Bruce S, Choudhary, Chunaram·2015·Molecular Systems Biology

DOI 10.15252/msb.20145880PMC PMC4501846

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Abstract

B‐cell receptor (BCR) signaling is essential for the development and function of B cells; however, the spectrum of proteins involved in BCR signaling is not fully known. Here we used quantitative mass spectrometry‐based proteomics to monitor the dynamics of BCR signaling complexes (signalosomes) and to investigate the dynamics of downstream phosphorylation and ubiquitylation signaling. We identify most of the previously known components of BCR signaling, as well as many proteins that have not yet been implicated in this system. BCR activation leads to rapid tyrosine phosphorylation and ubiquitylation of the receptor‐proximal signaling components, many of which are co‐regulated by both the modifications. We illustrate the power of multilayered proteomic analyses for discovering novel BCR signaling components by demonstrating that BCR‐induced phosphorylation of RAB7A at S72 prevents its association with effector proteins and with endo‐lysosomal compartments. In addition, we show that BCL10 is modified by LUBAC‐mediated linear ubiquitylation, and demonstrate an important function of LUBAC in BCR‐induced NF‐κB signaling. Our results offer a global and integrated view of BCR signaling, and the provided datasets can serve as a valuable resource for further understanding BCR signaling networks.

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Authors: Satpathy, S., Wagner, S. A., Beli, P., Gupta, R., Kristiansen, T. A., Malinova, D., Francavilla, C., Tolar, P., Bishop, G. A., Hostager, B. S., & Choudhary, C.
Affiliations: University of Copenhagen (DK)
National Institute for Medical Research (GB)
University of Iowa (US)
Corresponding author: Choudhary, Chunaram
ORCID: Satpathy, Shankha
Wagner, Sebastian A
Beli, Petra
Kristiansen, Trine A
Malinova, Dessislava
Francavilla, Chiara
Tolar, Pavel
Bishop, Gail A
Hostager, Bruce S
Choudhary, Chunaram
Venue: Molecular Systems Biology
Publisher: Springer Science and Business Media LLC
Published: 2015-06-01
Volume: 11
Issue: 6
Pages: 810-810
ISSN: 1744-4292 (ISSN-L)
DOI: 10.15252/msb.20145880
PMC: PMC4501846
OpenAlex: W1894912312
Cited by: 124
References: 92
Citations by year: 2026: 3 · 2025: 3 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 17 · 2020: 19 · 2019: 7 · 2018: 14 · 2017: 15 · 2016: 16 · 2015: 2
FWCI: 5.18
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 1 d)
Locations: Molecular Systems Biology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Figshare (submittedVersion, cc-by)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: EMBO long‐term Fellowship
Novo Nordisk Foundation (NNF14CC0001)
EMBO Young Investigator Program
Sapere Aude Program
Danish Council for Independent Research
Biological Sciences Funding Program
Medical Research Council UK (U117597138)
LOEWE Program Ubiquitin Networks (Ub‐Net) of the State of Hesse
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: B cell receptor signaling, signalosome, tyrosine phosphorylation, ubiquitination, LUBAC, Rab7, BCL10, NF-κB signaling, B cell development
MeSH terms: B-Cell CLL-Lymphoma 10 Protein, B-Lymphocytes, HeLa Cells, Humans, Membrane Proteins, Phosphorylation, Receptors, Antigen, B-Cell, Signal Transduction, NF-kappa B, Proteomics, Ubiquitin-Protein Ligases, Adaptor Proteins, Signal Transducing, Ubiquitination, HEK293 Cells

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Systems‐wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation

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