Adsorption, Lubrication, and Wear of Lubricin on Model Surfaces: Polymer Brush-Like Behavior of a Glycoprotein
Open accessAbstract
Using a surface force apparatus, we have measured the normal and friction forces between layers of the human glycoprotein lubricin, the major boundary lubricant in articular joints, adsorbed from buffered saline solution on various hydrophilic and hydrophobic surfaces: i), negatively charged mica, ii), positively charged poly-lysine and aminothiol, and iii), hydrophobic alkanethiol monolayers. On all these surfaces lubricin forms dense adsorbed layers of thickness 60-100 nm. The normal force between two surfaces is always repulsive and resembles the steric entropic force measured between layers of end-grafted polymer brushes. This is the microscopic mechanism behind the antiadhesive properties showed by lubricin in clinical tests. For pressures up to approximately 6 atm, lubricin lubricates hydrophilic surfaces, in particular negatively charged mica (friction coefficient mu = 0.02-0.04), much better than hydrophobic surfaces (mu > 0.3). At higher pressures, the friction coefficient is higher (mu > 0.2) for all surfaces considered and the lubricin layers rearrange under shear. However, the glycoprotein still protects the underlying substrate from damage up to much higher pressures. These results support recent suggestions that boundary lubrication and wear protection in articular joints are due to the presence of a biological polyelectrolyte on the cartilage surfaces.
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Cites
Intermolecular and Surface Forces
(2011) · Elsevier eBooks · doi:10.1016/b978-0-12-391927-4.10024-6 · Cited by 17,234 · see citing works
Intermolecular and Surface Forces
(2011) · Elsevier eBooks · doi:10.1016/c2011-0-05119-0 · Cited by 9,144 · see citing works
Polymers at an interface; a simplified view
de Gennes, P. G. (1987) · Advances in Colloid and Interface Science · doi:10.1016/0001-8686(87)85003-0 · Cited by 1,688 · see citing works
Pashley, R. M. (1981) · Journal of Colloid and Interface Science · doi:10.1016/0021-9797(81)90348-9 · Cited by 958 · see citing works
Lubrication by charged polymers
Raviv, U., Giasson, S., Kampf, N., Gohy, J.-F., Jérôme, R., & Klein, J. (2003) · Nature · doi:10.1038/nature01970 · Cited by 910 · see citing works
Articular cartilage and osteoarthritis
Dziak, R. (1992) · Bone and Mineral · doi:10.1016/0169-6009(92)90848-8 · Cited by 850 · see citing works
Articular Cartilage and Osteoarthritis
Buckwalter, J. A., Mankin, H. J., & Grodzinsky, A. J. (1954) · BMJ · doi:10.1136/bmj.1.4860.506 · Cited by 767 · see citing works
Thin film studies using multiple-beam interferometry
Israelachvili, J. N. (1973) · Journal of Colloid and Interface Science · doi:10.1016/0021-9797(73)90218-x · Cited by 759 · see citing works
Self-citationFluidity of Bound Hydration Layers
Raviv, U., & Klein, J. (2002) · Science · doi:10.1126/science.1074481 · Cited by 721 · see citing works
Intermolecular forces in biology
Leckband, D. E., & Israelachvili, J. N. (2001) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583501003687 · Cited by 697 · see citing works
Self-citationThe frictional properties of animal joints
McCutchen, C. W. (1962) · Wear · doi:10.1016/0043-1648(62)90176-x · Cited by 640 · see citing works
The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
Rhee, D. K., Marcelino, J. R., Baker, M., Gong, Y., Smits, P. J., Lefebvre, V., Jay, G. D., Stewart, M. C., Wang, H., Warman, M. L., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522263 · Cited by 630 · see citing works
Self-citationReduction of frictional forces between solid surfaces bearing polymer brushes
Klein, J., Kumacheva, E., Mahalu, D., Perahia, D., & Fetters, L. J. (1994) · Nature · doi:10.1038/370634a0 · Cited by 615 · see citing works
Friction, lubrication, and wear technology
Blau, P. J., & Davis, J. R. (1992) · Medical Entomology and Zoology · Cited by 599 · see citing works
Moro, T., Takatori, Y., Ishihara, K., Konno, T., Takigawa, Y., Matsushita, T., Chung, U.-I., Nakamura, K., & Kawaguchi, H. (2004) · Nature Materials · doi:10.1038/nmat1233 · Cited by 572 · see citing works
The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
Rhee, D. K., Marcelino, J. R., Baker, M., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22263 · Cited by 501 · see citing works
The Influence of Loading Time and Lubricant on the Friction of Articular Cartilage
Forster, H., & Fisher, J. (1996) · Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine · doi:10.1243/pime_proc_1996_210_399_02 · Cited by 386 · see citing works
Thin Film Rheology and Tribology of Confined Polymer Melts: Contrasts with Bulk Properties
Luengo, G. S., Schmitt, F., Hill, R., & Israelachvili, J. N. (1997) · Macromolecules · doi:10.1021/ma9519122 · Cited by 379 · see citing works
Self-citationBansil, R., Stanley, E., & LaMont, J. T. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003223 · Cited by 352 · see citing works
Direct Measurement of a Tethered Ligand-Receptor Interaction Potential
Wong, J. Y., Kuhl, T. L., Israelachvili, J. N., Mullah, N. N., & Zalipsky, S. (1997) · Science · doi:10.1126/science.275.5301.820 · Cited by 255 · see citing works
Self-citationJay, G. D., Tantravahi, U., Britt, D. E., Barrach, H.-J., & Cha, C. (2001) · Journal of Orthopaedic Research® · doi:10.1016/s0736-0266(00)00040-1 · Cited by 252 · see citing works
Self-citationBoundary lubrication by lubricin is mediated by O-linked β(1-3)Gal-GalNAc oligosaccharides
Jay, G. D., Harris, D., & Cha, C. (2001) · Glycoconjugate Journal · doi:10.1023/a:1021159619373 · Cited by 248 · see citing works
Self-citationIsraelachvili, J. N., & McGuiggan, P. M. (1990) · Journal of materials research/Pratt's guide to venture capital sources · doi:10.1557/jmr.1990.2223 · Cited by 242 · see citing works
Self-citationRecent Developments in Synovial Joint Biomechanics
Mow, V. C., & Lai, W. M. (1980) · SIAM Review · doi:10.1137/1022056 · Cited by 235 · see citing works
Swann, D. A., Slayter, H. S., & Silver, F. H. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69297-5 · Cited by 229 · see citing works
Pritchard, M. H. (1980) · Elsevier eBooks · doi:10.1016/c2013-0-11520-6 · Cited by 218 · see citing works
Jay, G. D. (1992) · Connective Tissue Research · doi:10.3109/03008209209014228 · Cited by 213 · see citing works
Self-citationJay, G. D., Britt, D. E., & J, C. (2000) · PubMed · Cited by 206 · see citing works
Self-citationRole of hyaluronic acid in joint lubrication.
Swann, D. A., Radin, E. L., Nazimiec, M. E., Weisser, P. A., Curran, N., & LEWINNEK, G. E. (1974) · Annals of the Rheumatic Diseases · doi:10.1136/ard.33.4.318 · Cited by 194 · see citing works
Separation of a Hyaluronate-free Lubricating Fraction from Synovial Fluid
Radin, E. L., Swann, D. A., & Weisser, P. A. (1970) · Nature · doi:10.1038/228377a0 · Cited by 189 · see citing works
Lee, S., Müller, M., Rezwan, K., & Spencer, N. D. (2005) · Langmuir · doi:10.1021/la050779w · Cited by 187 · see citing works
The lubricating activity of synovial fluid glycoproteins
Swann, D. A., Hendren, R. B., Radin, E. L., & Sotman, S. (1981) · Arthritis & Rheumatism · doi:10.1002/art.1780240104 · Cited by 176 · see citing works
Benz, M., Chen, N., & Israelachvili, J. (2004) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30123 · Cited by 161 · see citing works
Self-citationBuffer dependence of refractive index increments of protein solutions
Ball, V., & Ramsden, J. J. (1998) · Biopolymers · doi:10.1002/(sici)1097-0282(199812)46:7 · Cited by 160 · see citing works
Effect of pH and salt on the adsorption and interactions of an amphoteric polyelectrolyte
Kamiyama, Y., & Israelachvili, J. N. (1992) · Macromolecules · doi:10.1021/ma00045a039 · Cited by 158 · see citing works
Self-citationForces between mica surfaces bearing adsorbed macromolecules in liquid media
Klein, J. E. (1983) · Journal of the Chemical Society Faraday Transactions 1 Physical Chemistry in Condensed Phases · doi:10.1039/f19837900099 · Cited by 152 · see citing works
Comparison of the boundary-lubricating ability of bovine synovial fluid, lubricin, and Healon
Jay, G. D., Haberstroh, K. M., & Cha, C. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19980605)40:3 · Cited by 143 · see citing works
The extended surface forces apparatus. Part I. Fast spectral correlation interferometry
Heuberger, M. P. (2001) · Review of Scientific Instruments · doi:10.1063/1.1347978 · Cited by 142 · see citing works
Mucin Adsorption to Hydrophobic Surfaces
Shi, L., & Caldwell, K. D. (2000) · Journal of Colloid and Interface Science · doi:10.1006/jcis.2000.6724 · Cited by 142 · see citing works
Mucin coating on polymeric material surfaces to suppress bacterial adhesion
Shi, L., Ardehali, R., Caldwell, K. D., & Valint, P. L. (2000) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(99)00121-6 · Cited by 132 · see citing works
Swann, D. A., Sotman, S., Dixon, M. L., & Brooks, C. (1977) · Biochemical Journal · doi:10.1042/bj1610473 · Cited by 131 · see citing works
Bridging attraction by telechelic polymers
Milner, S. T., & Witten, T. A. (1992) · Macromolecules · doi:10.1021/ma00046a057 · Cited by 126 · see citing works
Morrell, K. C., Hodge, W. A., Krebs, D. E., & Mann, R. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507117102 · Cited by 119 · see citing works
Proteoglycan 4 (PRG4) synthesis and immunolocalization in bovine meniscus
Schumacher, B. L., Schmidt, T. A., Voegtline, M. S., Chen, A. C., & Sah, R. L. (2005) · Journal of Orthopaedic Research® · doi:10.1016/j.orthres.2004.11.011 · Cited by 108 · see citing works
Dédinaité, A., Lundin, M., Macáková, L., & Auletta, T. (2005) · Langmuir · doi:10.1021/la0511844 · Cited by 106 · see citing works
Lubricin and surfacing of articular joints
Jay, G. D. (2004) · Current Opinion in Orthopedics · doi:10.1097/01.bco.0000136127.00043.a8 · Cited by 87 · see citing works
Self-citationJay, G. D., LANE, B. P., & Sokoloff, L. (1992) · Connective Tissue Research · doi:10.3109/03008209209016818 · Cited by 87 · see citing works
Self-citationMucin layers on hydrophobic surfaces studied with ellipsometry and surface force measurements
Malmsten, M., Blomberg, E., Claesson, P. M., Carlstedt, I., & Ljusegren, I. (1992) · Journal of Colloid and Interface Science · doi:10.1016/0021-9797(92)90506-h · Cited by 85 · see citing works
Forces between mica surfaces covered with adsorbed mucin across aqueous solution
Perez, É., & Proust, J. E. (1987) · Journal of Colloid and Interface Science · doi:10.1016/0021-9797(87)90447-4 · Cited by 83 · see citing works
POLYMERS AT AN INTERFACE: A SIMPLIFIED VIEW
de Gennes, P. G. (2003) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789812564849_0031 · Cited by 72 · see citing works
Adhesion and coalescence of ductile metal surfaces and nanoparticles
Alcantar, N. A., Park, C., Pan, J., & Israelachvili, J. N. (2002) · Acta Materialia · doi:10.1016/s1359-6454(02)00225-2 · Cited by 66 · see citing works
Self-citationEiser, E., Klein, J. E., Witten, T. A., & Fetters, L. J. (1999) · Physical Review Letters · doi:10.1103/physrevlett.82.5076 · Cited by 64 · see citing works
Lubricin reduces cartilage--cartilage integration.
Schaefer, D., Wendt, D. J., Moretti, M., Jakob, M., Jay, G. D., Heberer, M., & Martín, I. (2004) · PubMed · Cited by 63 · see citing works
Self-citationSurface tension of animal cartilage as it relates to friction in joints
Chappuis, J., Sherman, I. A., & Neumann, A. W. (1983) · Annals of Biomedical Engineering · doi:10.1007/bf02584218 · Cited by 59 · see citing works
Dai, L., & Toprakcioglu, C. (1992) · Macromolecules · doi:10.1021/ma00048a022 · Cited by 56 · see citing works
Israelachvili, J. N., Maeda, N., Rosenberg, K. J., & Akbulut, M. E. S. (2005) · Journal of materials research/Pratt's guide to venture capital sources · doi:10.1557/jmr.2005.0255 · Cited by 55 · see citing works
Self-citationJones, C. F., Stoffel, K., Ozturk, H. E., & Stachowiak, G. (2004) · Tribology Letters · doi:10.1023/b:tril.0000015209.68635.3b · Cited by 52 · see citing works
Interactions between Mucin and Surfactants at Solid−Liquid Interfaces
Dédinaité, A., & Bastardo, L. A. (2002) · Langmuir · doi:10.1021/la0259813 · Cited by 48 · see citing works
Ozturk, H. E., Stoffel, K., Jones, C. F., & Stachowiak, G. (2004) · Tribology Letters · doi:10.1023/b:tril.0000015204.41674.d3 · Cited by 47 · see citing works
Electromobility of Mica Particles Dispersed in Aqueous Solutions
Pashley, R. M. (1985) · Clays and Clay Minerals · doi:10.1346/ccmn.1985.0330304 · Cited by 41 · see citing works
Immunohistochemical collagen analysis of the most superficial layer in adult articular cartilage
Teshima, R., Ono, M., Yamashita, Y., Hirakawa, H., Nawata, K., & Morio, Y. (2004) · Journal of Orthopaedic Science · doi:10.1007/s00776-004-0769-4 · Cited by 34 · see citing works
Ruths, M., Heuberger, M. P., Scheumann, V., Hu, J., & Knoll, W. (2001) · Langmuir · doi:10.1021/la010272v · Cited by 32 · see citing works
Self-citationDynamic Friction by Polymer/Surfactant Mixtures Adsorbed on Surfaces
Qian, L., Charlot, M., Perez, É., Luengo, G. S., Potter, A., & Cazeneuve, C. (2004) · The Journal of Physical Chemistry B · doi:10.1021/jp047605s · Cited by 28 · see citing works
Leckband, D. E., Chen, Y., Israelachvili, J. N., Wickman, H. H., Fletcher, M., & Zimmerman, R. (1993) · Biotechnology and Bioengineering · doi:10.1002/bit.260420204 · Cited by 28 · see citing works
Self-citationRuths, M., Israelachvili, J. N., & Ploehn, H. J. (1997) · Macromolecules · doi:10.1021/ma9609184 · Cited by 25 · see citing works
Self-citationNanorheology of Adsorbed Diblock Copolymer Layers
Pelletier, E., Belder, G. F., Hadziioannou, G., & Subbotin, A. V. (1997) · Journal de Physique II · doi:10.1051/jp2:1997124 · Cited by 16 · see citing works
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- Jay, G. D. 1990. Joint lubrication: a physico-chemical study of a puri- fied lubricating factor from bovine synovial fluid. PhD thesis. State University of New York, Stony Brook, NY.
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Recent Developments and Practical Feasibility of Polymer‐Based Antifouling Coatings
Maan, A. M. C., Hofman, A. H., de Vos, W. M., & Kamperman, M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202000936 · Cited by 729 · see citing works
Klein, J. (2013) · Friction · doi:10.1007/s40544-013-0001-7 · Cited by 567 · see citing works
Recent Progress in Cartilage Lubrication
Lin, W., & Klein, J. E. (2021) · Advanced Materials · doi:10.1002/adma.202005513 · Cited by 460 · see citing works
Lubrication of Articular Cartilage
Jahn, S., Seror, J., & Klein, J. (2016) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-081514-123305 · Cited by 406 · see citing works
The biology of Lubricin: Near frictionless joint motion
Jay, G. D., & Waller, K. A. (2014) · Matrix Biology · doi:10.1016/j.matbio.2014.08.008 · Cited by 342 · see citing works
Self-citationBioinspired Bottle-Brush Polymer Exhibits Low Friction and Amontons-like Behavior
Banquy, X., Burdyńska, J., Lee, D. W., Matyjaszewski, K., & Israelachvili, J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja501770y · Cited by 299 · see citing works
Self-citationCaligaris, M., & Ateshian, G. A. (2008) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2008.02.020 · Cited by 292 · see citing works
Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis
Waller, K. A., Zhang, L. X., Elsaid, K. A., Fleming, B. C., Warman, M. L., & Jay, G. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219289110 · Cited by 266 · see citing works
Self-citationAdaptive mechanically controlled lubrication mechanism found in articular joints
Greene, G. W., Banquy, X., Lee, D. W., Lowrey, D. D., Yu, J., & Israelachvili, J. N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101002108 · Cited by 254 · see citing works
Self-citationAssociation between friction and wear in diarthrodial joints lacking lubricin
Jay, G. D., Torres, J. R., Rhee, D. K., Helminen, H. J., Hyttinen, M. M., Cha, C., Elsaid, K. A., Kim, K., Cui, Y., & Warman, M. L. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22974 · Cited by 252 · see citing works
Self-citationMolecular mechanisms of aqueous boundary lubrication by mucinous glycoproteins
Coles, J. M., Chang, D. P., & Zauscher, S. (2010) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2010.07.002 · Cited by 235 · see citing works
Multivalent counterions diminish the lubricity of polyelectrolyte brushes
Yu, J., Jackson, N. E., Xu, X., Morgenstern, Y., Kaufman, Y., Ruths, M., de Pablo, J. J., & Tirrell, M. (2018) · Science · doi:10.1126/science.aar5877 · Cited by 207 · see citing works
Self-citationNanomechanics of the Cartilage Extracellular Matrix
Lin Han, B., Grodzinsky, A. J., & Ortiz, C. (2011) · Annual Review of Materials Research · doi:10.1146/annurev-matsci-062910-100431 · Cited by 195 · see citing works
Polymer Adhesion: Seeking New Solutions for an Old Problem
Raos, G., & Zappone, B. (2021) · Macromolecules · doi:10.1021/acs.macromol.1c01182 · Cited by 175 · see citing works
Self-citationDas, S., Banquy, X., Zappone, B., Greene, G. W., Jay, G. D., & Israelachvili, J. N. (2013) · Biomacromolecules · doi:10.1021/bm400327a · Cited by 171 · see citing works
Self-citationPhysical biology of the cancer cell glycocalyx
Kuo, J. C., Gandhi, J. G., Zia, R. N., & Paszek, M. J. (2018) · Nature Physics · doi:10.1038/s41567-018-0186-9 · Cited by 160 · see citing works
Jay, G. D., Fleming, B. C., Watkins, B. A., McHugh, K. A., Anderson, S. C., Zhang, L. X., Teeple, E. A., Waller, K. A., & Elsaid, K. A. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27550 · Cited by 162 · see citing works
Self-citationViscous Boundary Lubrication of Hydrophobic Surfaces by Mucin
Yakubov, G. E., McColl, J. T., Bongaerts, J. H. H., & Ramsden, J. J. (2009) · Langmuir · doi:10.1021/la8018666 · Cited by 161 · see citing works
Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4
Coles, J. M., Zhang, L., Blum, J. J., Warman, M. L., Jay, G. D., Guilak, F., & Zauscher, S. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27436 · Cited by 159 · see citing works
Self-citationSeror, J., Merkher, Y., Kampf, N., Collinson, L., Day, A. J., Maroudas, A., & Klein, J. (2011) · Biomacromolecules · doi:10.1021/bm2004912 · Cited by 159 · see citing works
Polymer-brush lubrication: a review of recent theoretical advances
Kreer, T. (2016) · Soft Matter · doi:10.1039/c5sm02919h · Cited by 156 · see citing works
Kang, T., Banquy, X., Heo, J., Lim, C., Lynd, N. A., Lundberg, P., Oh, D. X., Lee, H.-K., Hong, Y., Hwang, D. S., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b06066 · Cited by 154 · see citing works
Self-citationSong, J., Winkeljann, B., & Lieleg, O. (2020) · Advanced Materials Interfaces · doi:10.1002/admi.202000850 · Cited by 155 · see citing works
Zappone, B., Greene, G. W., Oroudjev, E., Jay, G. D., & Israelachvili, J. N. (2007) · Langmuir · doi:10.1021/la702383n · Cited by 147 · see citing works
Self-citationDédinaité, A. (2011) · Soft Matter · doi:10.1039/c1sm06335a · Cited by 144 · see citing works
Chang, D. P., Abu‐Lail, N. I., Guilak, F., Jay, G. D., & Zauscher, S. (2008) · Langmuir · doi:10.1021/la702366t · Cited by 142 · see citing works
Self-citationAl‐Sharif, A., Jamal, M., Zhang, L. X., Larson, K. M., Schmidt, T. A., Jay, G. D., & Elsaid, K. A. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39087 · Cited by 140 · see citing works
Self-citationAlquraini, A., Garguilo, S., D’Souza, G. G. M., Zhang, L. X., Schmidt, T. A., Jay, G. D., & Elsaid, K. A. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0877-x · Cited by 134 · see citing works
Self-citationChang, D. P., Abu‐Lail, N. I., Coles, J. M., Guilak, F., Jay, G. D., & Zauscher, S. (2009) · Soft Matter · doi:10.1039/b907155e · Cited by 130 · see citing works
Self-citationMultivalent ions induce lateral structural inhomogeneities in polyelectrolyte brushes
Yu, J., Jackson, N. E., Xu, X., Brettmann, B. K., Ruths, M., de Pablo, J. J., & Tirrell, M. (2017) · Science Advances · doi:10.1126/sciadv.aao1497 · Cited by 127 · see citing works
Self-citationBiotribology: Recent progresses and future perspectives
Zhou, Z., & Jin, Z. M. (2015) · Biosurface and Biotribology · doi:10.1016/j.bsbt.2015.03.001 · Cited by 124 · see citing works
Boundary mode lubrication of articular cartilage by recombinant human lubricin
Gleghorn, J. P., Jones, A. R. C., Flannery, C. R., & Bonassar, L. J. (2008) · Journal of Orthopaedic Research® · doi:10.1002/jor.20798 · Cited by 117 · see citing works
Modulating Mucin Hydration and Lubrication by Deglycosylation and Polyethylene Glycol Binding
Crouzier, T., Boettcher, K., Geonnotti, A. R., Kavanaugh, N. L., Hirsch, J. B., Ribbeck, K., & Lieleg, O. (2015) · Advanced Materials Interfaces · doi:10.1002/admi.201500308 · Cited by 114 · see citing works
Biomimetic Bottlebrush Polymer Coatings for Fabrication of Ultralow Fouling Surfaces
Xia, Y., Adibnia, V., Huang, R., Murschel, F., Faivre, J., Xie, G., Olszewski, M., Crescenzo, G. D., Qi, W. D., He, Z., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201808987 · Cited by 114 · see citing works
Lubricin: A versatile, biological anti-adhesive with properties comparable to polyethylene glycol
Greene, G. W., Martin, L. L., Tabor, R. F., Michalczyk, A. A., Ackland, M. L., & Horn, R. G. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.086 · Cited by 113 · see citing works
Self-citationTrunfio-Sfarghiu, A.-M., Berthier, Y., Meurisse, M.-H., & Rieu, J.-P. (2008) · Langmuir · doi:10.1021/la8005234 · Cited by 109 · see citing works
The glycosylation of human synovial lubricin: implications for its role in inflammation
Estrella, R. P., Whitelock, J. M., Packer, N. H., & Karlsson, N. G. (2010) · Biochemical Journal · doi:10.1042/bj20100360 · Cited by 103 · see citing works
Restoring articular cartilage: insights from structure, composition and development
Moliner, A. P., Ito, K., Zaucke, F., Kelly, D. J., de Ruijter, M., & Malda, J. (2025) · Nature Reviews Rheumatology · doi:10.1038/s41584-025-01236-7 · Cited by 101 · see citing works
Lubrication by Polyelectrolyte Brushes
Zhulina, E. B., & Rubinstein, M. (2014) · Macromolecules · doi:10.1021/ma500772a · Cited by 100 · see citing works
Friction and Normal Interaction Forces between Irreversibly Attached Weakly Charged Polymer Brushes
Liberelle, B., & Giasson, S. (2008) · Langmuir · doi:10.1021/la702367f · Cited by 96 · see citing works
Vasilev, K. A., Michelmore, A., Martinek, P., Chan, J., Sah, V. R., Griesser, H. J., & Short, R. D. (2010) · Plasma Processes and Polymers · doi:10.1002/ppap.201000030 · Cited by 93 · see citing works
Jay, G. D., Elsaid, K. A., Kelly, K. A., Anderson, S. C., Zhang, L., Teeple, E. A., Waller, K. A., & Fleming, B. C. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33461 · Cited by 93 · see citing works
Self-citationYu, J., Banquy, X., Greene, G. W., Lowrey, D. D., & Israelachvili, J. N. (2011) · Langmuir · doi:10.1021/la203851w · Cited by 91 · see citing works
Self-citationMajd, S. E., Kuijer, R., Köwitsch, A., Groth, T., Schmidt, T. A., & Sharma, P. K. (2014) · Langmuir · doi:10.1021/la504345c · Cited by 91 · see citing works
Seror, J., Merkher, Y., Kampf, N., Collinson, L., Day, A. J., Maroudas, A., & Klein, J. (2012) · Biomacromolecules · doi:10.1021/bm301283f · Cited by 89 · see citing works
Normal and friction forces between mucin and mucin–chitosan layers in absence and presence of SDS
Pettersson, T., & Dédinaité, A. (2008) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2008.04.055 · Cited by 84 · see citing works
Protein-based bioactive coatings: from nanoarchitectonics to applications
Fu, C., Wang, Z., Zhou, X., Hu, B., Li, C., & Yang, P. (2024) · Chemical Society Reviews · doi:10.1039/d3cs00786c · Cited by 82 · see citing works
Molecularly Engineered Biolubricants for Articular Cartilage
Morgese, G., Benetti, E. M., & Zenobi‐Wong, M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701463 · Cited by 79 · see citing works
Boundary cartilage lubrication: review of current concepts
Daniel, M. (2013) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-013-0240-2 · Cited by 78 · see citing works
Lubricants for osteoarthritis treatment: From natural to bioinspired and alternative strategies
Yuan, H., Mears, L. L. E., Wang, Y., Su, R., Qi, W. D., He, Z., & Valtiner, M. (2022) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2022.102814 · Cited by 77 · see citing works
Lubricin: a novel potential biotherapeutic approaches for the treatment of osteoarthritis
Bao, J., Chen, W., & Wu, L. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-9949-9 · Cited by 76 · see citing works
Influence of ionic strength on the tribological properties of pre-adsorbed salivary films
Macáková, L., Yakubov, G. E., Plunkett, M. A., & Stokes, J. R. (2011) · Tribology International · doi:10.1016/j.triboint.2010.12.006 · Cited by 75 · see citing works
Mucin-Inspired Lubrication on Hydrophobic Surfaces
Käsdorf, B. T., Weber, F., Petrou, G., Srivastava, V., Crouzier, T., & Lieleg, O. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00605 · Cited by 74 · see citing works
Influence of synovia constituents on tribological behaviors of articular cartilage
MURAKAMI, T., Yarimitsu, S., Nakashima, K., Sawae, Y., & SAKAI, N. (2013) · Friction · doi:10.1007/s40544-013-0010-6 · Cited by 74 · see citing works
Active agents, biomaterials, and technologies to improve biolubrication and strengthen soft tissues
Cooper, B. G., Bordeianu, C., Nazarian, A., Snyder, B. D., & Grinstaff, M. W. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.040 · Cited by 73 · see citing works
Recent Advances in Understanding the Role of Cartilage Lubrication in Osteoarthritis
Li, Y., Yuan, Z., Yang, H. L., Zhong, H., Peng, W., & Xie, R. (2021) · Molecules · doi:10.3390/molecules26206122 · Cited by 74 · see citing works
Extracellular matrix in intervertebral disc: basic and translational implications
Zhang, S., Liu, W., Chen, S., Wang, B., Wang, P., Hu, B., Lv, X., & Shao, Z. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03662-5 · Cited by 71 · see citing works
Sorkin, R., Kampf, N., Zhu, L., & Klein, J. E. (2016) · Soft Matter · doi:10.1039/c5sm02475g · Cited by 69 · see citing works
Gourdon, D., Lin, Q., Oroudjev, E., Hansma, H. G., Golan, Y., Arad, S. M., & Israelachvili, J. N. (2007) · Langmuir · doi:10.1021/la702259c · Cited by 67 · see citing works
Self-citationHarvey, N. M., Yakubov, G. E., Stokes, J. R., & Klein, J. (2011) · Biomacromolecules · doi:10.1021/bm101369d · Cited by 67 · see citing works
Regulation of lubricin for functional cartilage tissue regeneration: a review
Lee, Y., Choi, J., & Hwang, N. S.-Y. (2018) · Biomaterials Research · doi:10.1186/s40824-018-0118-x · Cited by 66 · see citing works
Ali, L., Flowers, S. A., Jin, C., Bennet, E. P., Ekwall, A. H., & Karlsson, N. G. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.040865 · Cited by 64 · see citing works
Interaction of lubricin with type II collagen surfaces: Adsorption, friction, and normal forces
Chang, D. P., Guilak, F., Jay, G. D., & Zauscher, S. (2013) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2013.11.048 · Cited by 63 · see citing works
Self-citationQadri, M. M., Jay, G. D., Zhang, L. X., Wong, W., Reginato, A. M., Sun, C., Schmidt, T. A., & Elsaid, K. A. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1693-x · Cited by 64 · see citing works
Self-citationBanquy, X., Lee, D. W., Das, S., Hogan, J., & Israelachvili, J. N. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201302959 · Cited by 60 · see citing works
Self-citationBoundary Lubrication in Natural Articular Joints
Crockett, R. (2009) · Tribology Letters · doi:10.1007/s11249-009-9430-x · Cited by 61 · see citing works
Abubacker, S., Dorosz, S. G., Ponjevic, D., Jay, G. D., Matyas, J. R., & Schmidt, T. A. (2015) · Annals of Biomedical Engineering · doi:10.1007/s10439-015-1390-8 · Cited by 59 · see citing works
Self-citationCharge and Interfacial Behavior of Short Side-Chain Heavily Glycosylated Porcine Stomach Mucin
Yakubov, G. E., Papagiannopoulos, A., Rat, E., & Waigh, T. A. (2007) · Biomacromolecules · doi:10.1021/bm700721c · Cited by 59 · see citing works
The nonlinear viscoelasticity of hyaluronic acid and its role in joint lubrication
Zhang, Z., & Christopher, G. F. (2015) · Soft Matter · doi:10.1039/c5sm00131e · Cited by 58 · see citing works
Rheological effects of macromolecular interactions in synovial fluid
Martin‐Alarcon, L., & Schmidt, T. A. (2016) · Biorheology · doi:10.3233/bir-15104 · Cited by 58 · see citing works
Faivre, J., Shrestha, B. R., Xie, G., Olszewski, M., Adibnia, V., Moldovan, F., Montembault, A., Sudre, G., Delair, T., David, L., et al. (2018) · Chemistry of Materials · doi:10.1021/acs.chemmater.8b01676 · Cited by 56 · see citing works
Interactions between Lubricin and Hyaluronic Acid Synergistically Enhance Antiadhesive Properties
Ye, H., Han, M., Huang, R., Schmidt, T. A., Qi, W. D., He, Z., Martin, L. L., Jay, G. D., Su, R., & Greene, G. W. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b01493 · Cited by 55 · see citing works
Self-citationLiposomes as lubricants: beyond drug delivery
Goldberg, R., & Klein, J. (2012) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2011.11.007 · Cited by 53 · see citing works
Friction between ring polymer brushes
Erbaş, A., & Paturej, J. (2015) · Soft Matter · doi:10.1039/c4sm02818j · Cited by 54 · see citing works
Lubricin Surface Modification Improves Extrasynovial Tendon Gliding in a Canine Model in Vitro
Taguchi, M., Sun, Y.-L., Zhao, C., Zobitz, M. E., Cha, C., Jay, G. D., An, K., & Amadio, P. C. (2008) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.g.00045 · Cited by 54 · see citing works
Self-citationZappone, B., Thurner, P. J., Adams, J. D., Fantner, G. E., & Hansma, P. K. (2008) · Biophysical Journal · doi:10.1529/biophysj.108.135889 · Cited by 53 · see citing works
Self-citationSamsom, M. L., Chan, A., Iwabuchi, Y., Subbaraman, L. N., Jones, L., & Schmidt, T. A. (2014) · Tribology International · doi:10.1016/j.triboint.2014.11.022 · Cited by 53 · see citing works
Surface tension in human pathophysiology and its application as a medical diagnostic tool
Azarbayjani, A. F., & Jouyban, A. (2015) · Bioimpacts · doi:10.15171/bi.2015.06 · Cited by 53 · see citing works
Polymers in living systems: from biological lubrication to tissue engineering and biomedical devices
Klein, J. E. (2012) · Polymers for Advanced Technologies · doi:10.1002/pat.3038 · Cited by 53 · see citing works
Trunfio-Sfarghiu, A.-M., Berthier, Y., Meurisse, M.-H., & Rieu, J.-P. (2007) · Tribology International · doi:10.1016/j.triboint.2007.02.008 · Cited by 52 · see citing works
“Grafting-Through”: Growing Polymer Brushes by Supplying Monomers through the Surface
Sejoubsari, R. M., Martinez, A. P., Kutes, Y., Wang, Z., Dobrynin, A. V., & Adamson, D. H. (2016) · Macromolecules · doi:10.1021/acs.macromol.6b00183 · Cited by 52 · see citing works
Qadri, M. M., Jay, G. D., Zhang, L. X., Richendrfer, H. A., Schmidt, T. A., & Elsaid, K. A. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02207-x · Cited by 52 · see citing works
Self-citationDesign, preparation, and characterization of lubricating polymer brushes for biomedical applications
Song, X., Man, J., Qiu, Y., Wang, J., Liu, J., Li, R., Zhang, Y., Li, J., Li, J., & Chen, Y. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.12.024 · Cited by 49 · see citing works
Lundin, M., Sandberg, T., Caldwell, K. D., & Blomberg, E. (2009) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2009.03.061 · Cited by 49 · see citing works
Greene, G. W., Zappone, B., Söderman, O., Topgaard, D., Rata, G., Zeng, H., & Israelachvili, J. N. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.102 · Cited by 49 · see citing works
Self-citationElastohydrodynamics of wet bristles, carpets and brushes
Gopinath, A., & Mahadevan, L. (2011) · Proceedings of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rspa.2010.0228 · Cited by 49 · see citing works
Sotres, J., & Arnebrant, T. (2013) · Lubricants · doi:10.3390/lubricants1040102 · Cited by 47 · see citing works
Structure and Property Changes in Self-Assembled Lubricin Layers Induced by Calcium Ion Interactions
Greene, G. W., Thapa, R., Holt, S. A., Wang, X., Garvey, C. J., & Tabor, R. F. (2017) · Langmuir · doi:10.1021/acs.langmuir.6b03992 · Cited by 47 · see citing works
Self-citationGreene, G. W., Zappone, B., Zhao, B., Söderman, O., Topgaard, D., Rata, G., & Israelachvili, J. N. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.07.046 · Cited by 47 · see citing works
Self-citationCarrillo, J. Y., Russano, D., & Dobrynin, A. V. (2011) · Langmuir · doi:10.1021/la203525r · Cited by 46 · see citing works
Greene, G. W., Ortiz, V., Pozo‐Gonzalo, C., Moulton, S. E., Wang, X., Martin, L. L., Michalczky, A., & Howlett, P. C. (2018) · Advanced Materials Interfaces · doi:10.1002/admi.201701296 · Cited by 46 · see citing works
Self-citationRole of Structure and Glycosylation of Adsorbed Protein Films in Biolubrication
Veeregowda, D. H., Busscher, H. J., Vissink, A., Jager, D. H. J., Sharma, P. K., & van der Mei, H. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042600 · Cited by 45 · see citing works
Biphasic and boundary lubrication mechanisms in artificial hydrogel cartilage: A review
MURAKAMI, T., Yarimitsu, S., Nakashima, K., SAKAI, N., Yamaguchi, T., Sawae, Y., & Suzuki, A. (2015) · Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine · doi:10.1177/0954411915611160 · Cited by 45 · see citing works
Importance of adaptive multimode lubrication mechanism in natural synovial joints
MURAKAMI, T., Yarimitsu, S., SAKAI, N., Nakashima, K., Yamaguchi, T., & Sawae, Y. (2016) · Tribology International · doi:10.1016/j.triboint.2016.12.052 · Cited by 45 · see citing works
Advances in Tribology of Lubricin and Lubricin-Like Synthetic Polymer Nanostructures
Bayer, I. S. (2018) · Lubricants · doi:10.3390/lubricants6020030 · Cited by 44 · see citing works
Dédinaité, A., & Claesson, P. M. (2017) · Physical Chemistry Chemical Physics · doi:10.1039/c7cp03517a · Cited by 44 · see citing works
Lamellar lubrication in vivo and vitro: Friction testing of hexagonal boron nitride
Pawlak, Z., Pai, R., Bayraktar, E., Kałdoński, T., & Oloyede, A. (2008) · Biosystems · doi:10.1016/j.biosystems.2008.05.029 · Cited by 43 · see citing works
Effects of molecular weight of grafted hyaluronic acid on wear initiation
Lee, D. W., Banquy, X., Das, S., Cadirov, N. A., Jay, G. D., & Israelachvili, J. N. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.01.013 · Cited by 41 · see citing works
Self-citationRoles of adsorbed film and gel layer in hydration lubrication for articular cartilage
MURAKAMI, T., Nakashima, K., Sawae, Y., Sakai, N., & Hosoda, N. (2009) · Proceedings of the Institution of Mechanical Engineers Part J Journal of Engineering Tribology · doi:10.1243/13506501jet536 · Cited by 39 · see citing works
- Authors
- Zappone, B., Ruths, M., Greene, G. W., Jay, G. D., & Israelachvili, J. N.
- Affiliations
- University of California, Santa Barbara (US)
- University of Massachusetts Lowell (US)
- Brown University (US)
- Corresponding author
- Israelachvili, Jacob N.
- Venue
- Biophysical Journal
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 92
- Issue
- 5
- Pages
- 1693-1708
- ISSN
- 0006-3495 (ISSN-L)
- PMC
- PMC1796837
- OpenAlex
- W2064741792
- Cited by
- 341
- References
- 65
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 19 · 2023: 17 · 2022: 18 · 2021: 15 · 2020: 21 · 2019: 14 · 2018: 19 · 2017: 19 · 2016: 13 · 2015: 21 · 2014: 29 · 2013: 20 · 2012: 12
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biophysical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Funders
- National Institutes of Health (KO8AG/AR01008)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Force Microscopy Techniques and Applications
- Physical Sciences › Engineering › Mechanical Engineering › Lubricants and Their Additives
- Keywords
- lubricin, boundary lubrication, friction coefficient, wear protection, articular cartilage, mica, polylysine, aminothiols, alkanethiol monolayers, polyelectrolytes, adhesion prevention, surface forces
- MeSH terms
- Proteoglycan 4, Aluminum Silicates, Glycoproteins, Humans, Lubrication, Polylysine, Polymers, Surface Properties, Synovial Fluid, Shear Strength, Hydrophobic and Hydrophilic Interactions
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