INFLUENCE OF GROWTH HORMONE ON SPLANCHNIC GLUCOSE PRODUCTION IN MAN
Abstract
The influence of growth hormone (GH) on splanchnic exchange of glucose and glucogenic precursors was investigated in 11 healthy subjects using the hepatic venous catheter technique. GH was infused intravenously at the rate of 40 μg/kg body weight over 30 min. A peak plasma GH level of 219 ± 25 ng/ml was obtained. During GH infusion the blood glucose concentration fell slightly but significantly. In addition, the splanchnic glucose output decreased by approximately 35–40% during and immediately after GH infusion. The splanchnic uptake of the glucogenic precursors lactate, pyruvate, alanine and glycerol was not significantly influenced by GH infusion. The arterial concentration of insulin fell slightly, while the glucagon level remained unchanged during the infusion but decreased 20–30 min after the end of GH infusion. Indirect estimates of the peripheral glucose utilization indicated that GH infusion was accompanied by a 25% reduction in peripheral glucose uptake. The influence of GH on the inhibition of splanchnic glucose output induced by endogenous insulin in connection with intravenous glucose infusion (2 mg/kg/min) was studied in 6 subjects. GH infusion, given 60 min before the onset of glucose administration, did not significantly modify the splanchnic glucose output response to glucose infusion. It is concluded that a) GH may exert a direct inhibitory influence on splanchnic glucose output which is independent of changes in insulin and glucagon, b) hepatic glycogenolysis, but probably not gluconeogenesis is influenced by GH, and c) GH infusion is accompanied by decreased peripheral utilization of glucose.
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In the basal state, growth hormone administration induces an early insulin-like effect on glucose metabolism.
“earlier studies indicated that in the basal state, GH administration induces an early insulin-like effect on glucose metabolism [6,7]”
From Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man (1989) · cites this paper as [6]
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M�ller, N., Butler, P. C., Antsiferov, M. A., & Alberti, K. G. M. M. (1989) · Diabetologia · doi:10.1007/bf00505182 · Cited by 192 · see citing works
“[7] have suggested that GH, in the basal state, exerts an acute insulin agonistic effect on the liver and hepatic venous catheterisation has indicated that administration of pharmacological GH doses decreases splanchnic glucose output by 35-40% in man [6].”
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“However, these insulin antagonistic effects of growth hormone are characteristically preceded by a rapid-onset insulin-like action on glucose and lipid metabolism [10-14].”
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“This has previously been shown by other workers [26, 27] although a decrease in insulin secretion has also been observed [28].”
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1 Liver disease, carbohydrate metabolism and diabetes
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“It is also possible that this dose lowers glucose levels by inhibition of splanchnic glucose production (41), or by direct -cell stimulation.”
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“Several investigators have demonstrated that growth hormone has early insulin-like effects [ 36-38 ].”
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- Authors
- Adamson, U., Wahren, J., & Cerasi, E.
- Affiliations
- Karolinska University Hospital (SE)
- ORCID
- Cerasi, Erol
- Venue
- Acta Endocrinologica
- Publisher
- Oxford University Press (OUP)
- Published
- 1977-12
- Volume
- 86
- Issue
- 4
- Pages
- 803-812
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2157667727
- Cited by
- 33
- References
- 0
- Citations by year
- 2020: 1
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- growth hormone, hepatic glycogenolysis, gluconeogenesis, lactate, pyruvate, alanine, glycerol, peripheral glucose utilization, insulin, glucagon, blood glucose, glucose infusion
- MeSH terms
- Adult, Alanine, Blood Glucose, Depression, Chemical, Gluconeogenesis, Glucose, Glycerol, Humans, Lactates, Liver, Liver Glycogen, Male, Middle Aged, Pyruvates, Growth Hormone
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