Effect of growth hormone on oral glucose tolerance and circulating metabolic fuels in man
Open accessAbstract
We infused growth hormone into normal subjects in doses that raised circulating hormone to levels (30-35 ng/ml) similar to those seen during stress. Growth hormone excess failed to alter fasting glucose and somatomedin concentrations. However, non-esterified fatty acids and ketones increased by 50% (p less than 0.05) and 120% (p less than 0.01), respectively, despite 35% higher plasma insulin concentrations. When oral glucose was ingested 5 h after initiating the growth hormone infusion, plasma glucose rose by 2-2.5 mmol/l above control (saline infusion) values and the area under the glucose curve increased twofold (p less than 0.005). This occurred in the face of twofold higher insulin levels and normal suppression of glucagon. Growth hormone also did not affect the hyperglycaemic response to a combined infusion of cortisol, glucagon and adrenaline, but accentuated the rise in non-esterified fatty acids, ketones, and insulin caused by these hormones. Our data suggest that growth hormone excess rapidly produces insulin antagonistic effects that may contribute to stress-induced glucose intolerance and lipolysis, even though fasting glucose levels remain unchanged.
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Most reports have shown that in man exogenous growth hormone augments lipolysis.
“Most [9,10], but not all [3] reports, have shown that in man exogenous GH augments lipolysis”
From Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man (1989) · cites this paper as [10]
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Impaired Glucose Tolerance as a Disorder of Insulin Action
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Importance of Raised Growth Hormone Levels in Mediating the Metabolic Derangements of Diabetes
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Self-citationEffects of a growth hormone pulse on total and forearm substrate fluxes in humans
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Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man
M�ller, N., Butler, P. C., Antsiferov, M. A., & Alberti, K. G. M. M. (1989) · Diabetologia · doi:10.1007/bf00505182 · Cited by 192 · see citing works
Keller, U., Schnell, H., Girard, J., & Stauffacher, W. (1984) · Diabetologia · doi:10.1007/bf00281115 · Cited by 55 · see citing works
- Authors
- Sherwin, R. S., Schulman, G. A., Hendler, R., Walesky, M., Belous, A., & Tamborlane, W.
- Affiliations
- Yale University (US)
- ORCID
- Tamborlane, W.
- Venue
- Diabetologia
- Published
- 1983-03
- Volume
- 24
- Issue
- 3
- Pages
- 155-61
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2027738823
- Cited by
- 83
- References
- 43
- Citations by year
- 2023: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 1
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01am020495-09a1)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- growth hormone, oral glucose tolerance, insulin resistance, free fatty acids, ketones, stress hyperglycemia, glucagon, cortisol, epinephrine, lipolysis, insulin-like growth factor
- MeSH terms
- Adult, Amino Acids, Blood Glucose, Epinephrine, Fatty Acids, Nonesterified, Female, Glucagon, Glucose Tolerance Test, Humans, Hydrocortisone, Insulin, Ketone Bodies, Male, Growth Hormone
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