Gene expression profiling of human adrenocortical tumors using complementary deoxyribonucleic acid microarrays identifies several candidate genes as markers of malignancy
Open accessAbstract
The aim of this study was to identify predictor sets of genes whose over- or underexpression in human sporadic adrenocortical tumors would help to identify malignant vs. benign tumors and to predict postsurgical metastatic recurrence. For this, we analyzed the expression of 230 candidate genes using cDNA microarrays in a series of 57 well-characterized human sporadic adrenocortical tumors (33 adenomas and 24 carcinomas). We identified two clusters of genes (the IGF-II cluster containing eight genes, including IGF-II, and the steroidogenesis cluster containing six genes encoding steroidogenic enzymes plus eight other genes) whose combined levels of expression appeared to be good predictors of malignancy. This predictive value was as strong as that of the pathological score of Weiss. The analysis of the population of carcinomas (13 tumors) for genes whose expression would be strongly different between recurring and nonrecurring tumors allowed identification of 14 genes meeting these criteria. Among these genes, there are probably new markers of tumor evolution that will deserve additional validation on a larger scale. Taken together, these results show that the parallel analysis of the expression levels of a selected group of genes on microgram quantities of tumor RNA (a quantity that can be obtained from fine needle aspirations) appears as a complementary method to histopathology for the diagnosis and prognosis of evolution of adrenocortical carcinomas.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ACCs show elevated expression of genes involved in cell proliferation, such as IGF2, compared with increased expression of steroidogenic genes in ACAs.
“An initial study identified elevated expression of genes involved in cell proliferation in ACCs, such as IGF2, compared with increased expression of steroidogenic genes in ACAs (steroidogenic cluster) (190).”
From Adrenocortical carcinoma (2014) · cites this paper as [190]
ACAs and ACCs have distinct expression profiles.
“ACAs and ACCs have distinct expression profiles (174, 190–192).”
From Adrenocortical carcinoma (2014) · cites this paper as [190]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,232 · see citing works
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158 · see citing works
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 12,617 · see citing works
Sørlie, T., Perou, C., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M., van de Rijn, M., Jeffrey, S., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.191367098 · Cited by 11,695 · see citing works
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Alizadeh, A. A., Eisen, M. B., Davis, R. E., Ma, C., Lossos, I. S., Rosenwald, A., Boldrick, J. C., Sabet, H., Tran, T., Yu, X., et al. (2000) · Nature · doi:10.1038/35000501 · Cited by 9,925 · see citing works
Integrins: Versatility, modulation, and signaling in cell adhesion
Hynes, R. O. (1992) · Cell · doi:10.1016/0092-8674(92)90115-s · Cited by 9,857 · see citing works
Bhattacharjee, A., Richards, W. G., Staunton, J. E., Li, C., Monti, S., Vasa, P. P., Ladd, C., Beheshti, J., Bueno, R., Gillette, M. A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191502998 · Cited by 2,540 · see citing works
Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors
Weiss, L. M. (1984) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198403000-00001 · Cited by 920 · cited 13× · see citing works
“The analysis of the expression level of this group of 22 genes appeared almost as powerful as the well recognized histological score of Weiss at identifying the true carcinomas.”
MethodInfluentialA Survey on Adrenal Incidentaloma in Italy
Mantero, F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.2.637 · Cited by 907 · see citing works
Pathologic features of prognostic significance in adrenocortical carcinoma
Weiss, L. M., Medeiros, L. J., & Vickery, A. L. (1989) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198903000-00004 · Cited by 818 · cited 13× · see citing works
“The analysis of the expression level of this group of 22 genes appeared almost as powerful as the well recognized histological score of Weiss at identifying the true carcinomas.”
MethodInfluentialThe clinically inapparent adrenal mass: update in diagnosis and management
Mansmann, G., Lau, J., Balk, E., Rothberg, M., Miyachi, Y., & Bornstein, S. R. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0031 · Cited by 781 · see citing works
Luton, J.-P., Cerdas, S., Billaud, L., Thomas, G., Guilhaume, B., Bertagna, X., Laudat, M.-H., Louvel, A., Chapuis, Y., Blondeau, P., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199004263221705 · Cited by 717 · see citing works
Self-citationMatese, J. C., Sorlie, T., Tibshirani, R., et al. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/qpxp-y103 · Cited by 699 · see citing works
FGFR‐4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.
Partanen, J., Mäkelä, T., Eerola, E., Korhonen, J., Hirvonen, H., Claesson-Welsh, L., & Alitalo, K. (1991) · EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07654.x · Cited by 511 · see citing works
Takahashi, M., Rhodes, D. R., Furge, K. A., Kanayama, H., Kagawa, S., Haab, B. B., & Teh, B. T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171209998 · Cited by 403 · see citing works
Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis
Giordano, T. J., Thomas, D. G., Kuick, R., Lizyness, M., Misek, D. E., Smith, A. L., Sanders, D., Aljundi, R. T., Gauger, P. G., Thompson, N. W., et al. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63846-1 · Cited by 383 · see citing works
Gicquel, C., BERTAGNA, X. Y., Gaston, V., Coste, J., Louvel, A., Baudin, É., Bertherat, J. Y., Chapuis, Y., Duclos, J. M., Schlumberger, M. J., et al. (2001) · PubMed · Cited by 285 · see citing works
Self-citationHughes, S. (1997) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549704500710 · Cited by 283 · see citing works
Molecular portraits and the family tree of cancer
Chung, C. H., Bernard, P. S., & Perou, C. M. (2002) · Nature Genetics · doi:10.1038/ng1038 · Cited by 264 · see citing works
Angeli, A., Osella, G., Ali, A., & Terzolo, M. (1997) · Hormone Research · doi:10.1159/000185477 · Cited by 259 · cited 1× · see citing works
“3 Introduction: Although adrenocortical tumors are highly prevalent in the human population (3 to 7% at autopsy and/or in radiological series), only a small proportion cause endocrine disorders and less than 5% are malignant (1, 2).”
BackgroundGicquel, C., BERTAGNA, X. Y., Schneid, H., Leblond‐Francillard, M., LUTON, J. P., Girard, F., & Bouc, Y. L. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.7911125 · Cited by 224 · see citing works
Self-citationGicquel, C., Raffin‐Sanson, M., Gaston, V., BERTAGNA, X. Y., Plouin, P., Schlumberger, M. J., Louvel, A., LUTON, J. P., & Bouc, Y. L. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4170 · Cited by 213 · see citing works
Self-citationMüllbacher, A., Waring, P., Hla, R. T., Tran, T., Chin, S., Stehlé, T., Muşeţeanu, C., & Simon, M. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13950 · Cited by 198 · see citing works
Kjellman, M., Kallioniemi, O., Karhu, R., Höög, A., Farnebo, L. ‐., Auer, G., Larsson, C., & Bäckdahl, M. (1996) · PubMed · Cited by 190 · see citing works
Gicquel, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.8.2559 · Cited by 186 · see citing works
Self-citationThe molecular pathogenesis of hereditary and sporadic adrenocortical and adrenomedullary tumors
Koch, C. A., Pacak, K., & Chrousos, G. P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021069 · Cited by 177 · see citing works
Zhang, D., Beresford, P. J., Greenberg, A. H., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101329598 · Cited by 172 · see citing works
Adrenocortical Tumors: Recent Advances in Basic Concepts and Clinical Management
Bornstein, S. R., Stratakis, C. A., & Chrousos, G. P. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-9-199905040-00017 · Cited by 156 · see citing works
Comparative Genomic Hybridization Analysis of Adrenocortical Tumors
Sidhu, S. B., Marsh, D. J., Theodosopoulos, G., Philips, J. N., Bambach, C. P., Campbell, P. R., Magarey, C. J., Russell, C. F. J., Schulte, K., Röher, H. D., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.7.8697 · Cited by 144 · see citing works
Bourdeau, I., Antonini, S. R. R., Lacroix, A., Kirschner, L. S., Matyakhina, L., Lorang, D., Libutti, S. K., & Stratakis, C. A. (2004) · Oncogene · doi:10.1038/sj.onc.1207277 · Cited by 130 · see citing works
Clonal composition of human adrenocortical neoplasms.
Beuschlein, F., Reincke, M., Karl, M., Travis, W. D., Jaursch-Hancke, C., Abdelhamid, S., Chrousos, G. P., & Allolio, B. (1994) · PubMed · Cited by 129 · see citing works
Gene expression profiles of poor-prognosis primary breast cancer correlate with survival
Bertucci, F. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.8.863 · Cited by 129 · see citing works
Clonal analysis of human adrenocortical carcinomas and secreting adenomas
Gicquel, C., Leblond‐Francillard, M., Bertagna, X., Louvel, A., Chapuls, Y., Luton, J., Girard, F., & Le Bouc, Y. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02485.x · Cited by 111 · see citing works
Self-citationThe proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.
Gaudino, G., Avantaggiato, V., Follenzi, A., et al. (1995) · PubMed · Cited by 101 · see citing works
Lu, S., Gu, X., Hoestje, S. M., & Epner, D. E. (2002) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(01)00359-1 · Cited by 94 · see citing works
Cytotoxic treatment of adrenocortical carcinoma
Ahlman, H., Khorram‐Manesh, A., Jansson, S. K. G., Wängberg, B., Nilsson, O., Jacobsson, C., & Lindstedt, S. (2001) · World Journal of Surgery · doi:10.1007/s00268-001-0031-6 · Cited by 78 · see citing works
Perrin, A., PASCAL, O., Defaye, G., Feige, J., & CHAMBAZ, E. M. (1991) · Endocrinology · doi:10.1210/endo-128-1-357 · Cited by 66 · see citing works
Self-citationGroussin, L., Massias, J. F., BERTAGNA, X. Y., & Bertherat, J. Y. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6307 · Cited by 64 · see citing works
Self-citationBrand, C., Cherradi, N., Defaye, G., Chinn, A. M., CHAMBAZ, E. M., Feige, J., & Bailly, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.11.6410 · Cited by 62 · see citing works
Self-citationFine tuning of adrenocortical functions by locally produced growth factors
Feige, J., Vilgrain, I., Brand, C., Bailly, S., & Souchelnitskiy, S. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1580007 · Cited by 59 · see citing works
Self-citationExpression scanning of an array of growth control genes in human tumor cell lines
Bertucci, F., Hulst, S. V., Bernard, K., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202731 · Cited by 58 · see citing works
Growth factor regulation of adrenal cortex growth and function
Feige, J., & Baird, A. (1991) · Progress in Growth Factor Research · doi:10.1016/s0955-2235(05)80002-x · Cited by 54 · see citing works
Self-citationTransforming Growth Factor ß1: An Autocrine Regulator of Adrenocortical Steroidogenesis
Feige, J., Cochet, C., Savona‐Baron, C., Shi, D., Kéramidas, M., Defaye, G., & CHAMBAZ, E. M. (1991) · Endocrine Research · doi:10.1080/07435809109027201 · Cited by 41 · see citing works
Self-citationBoulle, N., Gicquel, C., Logié, A., Christol, R., Feige, J., & Bouc, Y. L. (2000) · Endocrinology · doi:10.1210/endo.141.9.7632 · Cited by 39 · see citing works
Self-citationDustin, M. L., García‐Aguilar, J., Hibbs, M. L., et al. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.089 · Cited by 33 · see citing works
Epner, D. E., Sawa, A., & Isaacs, J. T. (1999) · Biology of Reproduction · doi:10.1095/biolreprod61.3.687 · Cited by 20 · see citing works
Boccuzzi, A., Terzolo, M., Cappia, S., et al. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00683.x · Cited by 9 · see citing works
Transforming Growth Factor β1: Implications in Adrenocortical Tumorigenesis
Arnaldi, G., Freddi, S., Mancini, T., et al. (2000) · Endocrine Research · doi:10.3109/07435800009048615 · Cited by 6 · see citing works
Molecular genetics of adrenal cortical tumors
Kjellman, M., Roshani, L., Bäckdahl, M., & Larsson, C. (1999) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-199902000-00012 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Dustin ML, Garcia-Aguilar J, Hibbs ML, Larson RS, Stacker SA, Staunton 1828 J Clin Endocrinol Metab, March 2005, 90(3):1819 -1829
Cited by
Sorted by citations
Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892 · see citing works
Tissier, F., Cavard, C., Groussin, L., Perlemoine, K., Fumey, G., Hagneré, A.-M., René-Corail, F., Jullian, E., Gicquel, C., Bertagna, X., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0593 · Cited by 474 · see citing works
Self-citationUrine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors
Arlt, W., Biehl, M., Taylor, A. E., Hahner, S., Libé, R., Hughes, B. A., Schneider, P., Smith, D. J., Stiekema, H., Krone, N., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1565 · Cited by 458 · see citing works
Self-citationExtent of disease at presentation and outcome for adrenocortical carcinoma: have we made progress?
Kebebew, E., Reiff, E., Duh, Q., Clark, O. H., & McMillan, A. (2006) · World Journal of Surgery · doi:10.1007/s00268-005-0329-x · Cited by 451 · see citing works
Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling
Giordano, T. J., Kuick, R., Else, T., Gauger, P. G., Vinco, M., Bauersfeld, J., Sanders, D., Thomas, D. G., Doherty, G., & Hammer, G. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1067 · Cited by 401 · see citing works
Adrenocortical carcinoma: a clinician’s update
Fassnacht, M., Libé, R., Kroiss, M., & Allolio, B. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.235 · Cited by 396 · see citing works
de Reyniès, A., Assié, G., Rickman, D. S., Tissier, F., Groussin, L., René-Corail, F., Dousset, B., Bertagna, X., Clauser, E., & Bertherat, J. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.5678 · Cited by 382 · see citing works
Self-citationClinical management of adrenocortical carcinoma
Fassnacht, M., & Allolio, B. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.10.008 · Cited by 349 · see citing works
Prognostic parameters of metastatic adrenocortical carcinoma
Assié, G., Antoni, G., Tissier, F., Caillou, B., Abiven, G., Gicquel, C., Leboulleux, S., Travagli, J.-P., Dromain, C., Bertagna, X., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0706 · Cited by 236 · see citing works
Self-citationAlmeida, M. Q., Fragoso, M. C. B. V., Lotfi, C. F. P., Santos, M. G., Nishi, M. Y., Costa, M. H. S., Lerario, A. M., Maciel, C. C., Mattos, G. E., Jorge, A. A. L., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0065 · Cited by 176 · see citing works
Heaton, J. H., Wood, M. A., Kim, A. C., Lima, L. O., Barlaskar, F. M., Almeida, M. Q., Fragoso, M. C. B. V., Kuick, R., Lerario, A. M., Simon, D. P., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.05.026 · Cited by 173 · see citing works
MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy
Patterson, E. E., Holloway, A. K., Weng, J., Fojo, T., & Kebebew, E. (2011) · Cancer · doi:10.1002/cncr.25724 · Cited by 171 · see citing works
Molecular genetics of adrenocortical tumours, from familial to sporadic diseases
Libé, R., & Bertherat, J. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.02004 · Cited by 168 · see citing works
Self-citationRagazzon, B., Libé, R., Gaujoux, S., Assié, G., Fratticci, A., Launay, P., Clauser, E., Bertagna, X., Tissier, F., de Reyniès, A., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2014 · Cited by 152 · see citing works
Self-citationWnt/β-catenin signalling in adrenal physiology and tumour development
Berthon, A., Martinez, A., Bertherat, J., & Val, P. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.009 · Cited by 125 · see citing works
Self-citation60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH
Gallo-Payet, N. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0257 · Cited by 98 · see citing works
Fragoso, M. C. B. V., Almeida, M. Q., Mazzuco, T. L., Mariani, B. M. P., Brito, L. P., Gonçalves, T. C., Alencar, G. A., Lima, L. D. O., Faria, A. M., Bourdeau, I., et al. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-0806 · Cited by 93 · see citing works
[131I]Iodometomidate for targeted radionuclide therapy of advanced adrenocortical carcinoma
Hahner, S., Kreissl, M. C., Fassnacht, M., Haenscheid, H., Knoedler, P., Lang, K., Buck, A. K., Reiners, C., Allolio, B., & Schirbel, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2765 · Cited by 87 · see citing works
Proposal for modification of the ENSAT staging system for adrenocortical carcinoma using tumor grade
Miller, B. S., Gauger, P. G., Hammer, G. D., Giordano, T. J., & Doherty, G. M. (2010) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-010-0698-y · Cited by 84 · see citing works
Long-term outcome following laparoscopic adrenalectomy for large solid adrenal cortex tumors
Palazzo, F. F., Sebag, F., Sierra, M., Ippolito, G., Souteyrand, P., & Henry, J. (2006) · World Journal of Surgery · doi:10.1007/s00268-005-0288-2 · Cited by 74 · see citing works
Challenges in surgical pathology of adrenocortical tumours
Erickson, L. A. (2018) · Histopathology · doi:10.1111/his.13255 · Cited by 70 · see citing works
Combination of sorafenib and everolimus impacts therapeutically on adrenocortical tumor models
Mariniello, B., Rosato, A., Zuccolotto, G., Rubin, B., Cicala, M. V., Finco, I., Iacobone, M., Frigo, A. C., Fassina, A., Pezzani, R., et al. (2012) · Endocrine Related Cancer · doi:10.1530/erc-11-0337 · Cited by 63 · see citing works
Papotti, M., Duregon, E., Volante, M., & McNicol, A. M. (2014) · Endocrine Pathology · doi:10.1007/s12022-013-9291-6 · Cited by 33 · see citing works
McNicol, A. M. (2008) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2008-132-1263-lotac · Cited by 28 · see citing works
- Authors
- de Fraipont, F., El Atifi, M., Cherradi, N., Le Moigne, G., Defaye, G., Houlgatte, R., Bertherat, J., Bertagna, X., Plouin, P.-F., Baudin, E., Berger, F., Gicquel, C., Chabre, O., & Feige, J.-J.
- Affiliations
- Hôpital Européen Georges-Pompidou (FR)
- Inserm (FR)
- Hôpital Cochin (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Hôpital Armand-Trousseau (FR)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2005-03
- Volume
- 90
- Issue
- 3
- Pages
- 1819-1829
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2158106539
- Cited by
- 261
- References
- 49
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 5 · 2018: 9 · 2017: 6 · 2016: 15 · 2015: 15 · 2014: 16 · 2013: 14 · 2012: 19
- FWCI
- 18.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Groupement des Entreprises Françaises dans la lutte contre le Cancer
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- adrenocortical tumors, adrenocortical carcinoma, adrenal adenoma, gene expression profiling, malignancy marker, insulin-like growth factor II, distant recurrence, tumor progression, fine-needle aspiration, prognosis, Weiss score
- MeSH terms
- Adolescent, Adrenal Cortex Neoplasms, Adult, Aged, Female, Genetic Markers, Humans, Male, Middle Aged, RNA, Messenger, Steroids, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Disease-Free Survival, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
