Expression of insulin-like growth factor-II and its receptor in pediatric and adult adrenocortical tumors
Abstract
BACKGROUND: Adrenocortical tumors are heterogeneous neoplasms with incompletely understood pathogenesis. IGF-II overexpression has been consistently demonstrated in adult adrenocortical carcinomas. OBJECTIVES: The objective of the study was to analyze expression of IGF-II and its receptor (IGF-IR) in pediatric and adult adrenocortical tumors and the effects of a selective IGF-IR kinase inhibitor (NVP-AEW541) on adrenocortical tumor cells. PATIENTS: Fifty-seven adrenocortical tumors (37 adenomas and 20 carcinomas) from 23 children and 34 adults were studied. METHODS: Gene expression was determined by quantitative real-time PCR. Cell proliferation and apoptosis were analyzed in NCI H295 cells and a new cell line established from a pediatric adrenocortical adenoma. RESULTS: IGF-II transcripts were overexpressed in both pediatric adrenocortical carcinomas and adenomas. Otherwise, IGF-II was mainly overexpressed in adult adrenocortical carcinomas (270.5 +/- 130.2 vs. 16.1 +/- 13.3; P = 0.0001). IGF-IR expression was significantly higher in pediatric adrenocortical carcinomas than adenomas (9.1 +/- 3.1 vs. 2.6 +/- 0.3; P = 0.0001), whereas its expression was similar in adult adrenocortical carcinomas and adenomas. IGF-IR expression was a predictor of metastases in pediatric adrenocortical tumors in univariate analysis (hazard ratio 1.84; 95% confidence interval 1.28-2.66; P = 0.01). Furthermore, NVP-AEW541 blocked cell proliferation in a dose- and time-dependent manner in both cell lines through a significant increase of apoptosis. CONCLUSION: IGF-IR overexpression was a biomarker of pediatric adrenocortical carcinomas. Additionally, a selective IGF-IR kinase inhibitor had antitumor effects in adult and pediatric adrenocortical tumor cell lines, suggesting that IGF-IR inhibitors represent a promising therapy for human adrenocortical carcinoma.
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In an NCI-H295 xenograft mouse model, IGF pathway inhibition by NVP-AEW541 and IMCA12 showed an antitumor effect.
“In an NCI-H295 xenograft mouse model, IGF pathway inhibition by the small-molecule inhibitor NVP-AEW541 and the monoclonal IGF-1R antibody IMCA12 showed an antitumor effect.”
From Adrenocortical carcinoma (2014) · cites this paper as [223]
Combined treatment of NCI-H295 cells with IGF-1R antagonists and mitotane resulted in a synergistic antiproliferative effect in vitro and in vivo.
“Furthermore, the combined treatment of NCI-H295 cells with IGF-1R antagonists and mitotane resulted in a synergistic antiproliferative effect in vitro and in vivo in tumor xenografts (223, 227).”
From Adrenocortical carcinoma (2014) · cites this paper as [223]
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights
Samani, A. A., Yakar, S., LeRoith, D., & Brodt, P. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0001 · Cited by 999 · see citing works
Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors
Weiss, L. M. (1984) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198403000-00001 · Cited by 920 · cited 1× · see citing works
“Adult adrenocortical tumors were classified according to Weiss criteria: 20 adrenocortical adenomas (Weiss score 3) and 14 carcinomas (Weiss score 4) (26).”
MethodAdrenocortical Carcinoma: Clinical Update
Allolio, B., & Fassnacht, M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2639 · Cited by 775 · see citing works
Mitsiades, C. S., Mitsiades, N., McMullan, C. J., Poulaki, V., Shringarpure, R., Akiyama, M., Hideshima, T., Chauhan, D., Joseph, M. G., Libermann, T. A., et al. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00050-9 · Cited by 616 · see citing works
Garcı́a-Echeverrı́a, C., Pearson, M. A., Marti, A., Meyer, T., Mestan, J., Zimmermann, J., Gao, J., Brueggen, J., Capraro, H., Cozens, R. M., et al. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00051-0 · Cited by 543 · see citing works
Ribeiro, R. C., Sandrini, F., Figueiredo, B., Zambetti, G. P., Michalkiewicz, E., Lafferty, A. R., DeLacerda, L., Rabin, M., Cadwell, C., Sampaio, G., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161479898 · Cited by 541 · see citing works
Gazdar, A. F., Oie, H. K., Shackleton, C. H. L., Chen, T. R., Triche, T. J., Myers, C. E., Chrousos, G. P., Brennan, M. F., Stein, C. A., & Rocca, R. V. L. (1990) · PubMed · Cited by 446 · see citing works
Abiven, G., Coste, J., Groussin, L., Anract, P., Tissier, F., Legmann, P., Dousset, B., Bertagna, X., & Bertherat, J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2730 · Cited by 435 · see citing works
Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis
Giordano, T. J., Thomas, D. G., Kuick, R., Lizyness, M., Misek, D. E., Smith, A. L., Sanders, D., Aljundi, R. T., Gauger, P. G., Thompson, N. W., et al. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63846-1 · Cited by 383 · see citing works
Werner, H., Karnieli, E., Rauscher, F. J., & LeRoith, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8318 · Cited by 370 · see citing works
McDermott, U., Sharma, S. V., Dowell, L., Greninger, P., Montagut, C. O., Lamb, J. A., Archibald, H., Raudales, R., Tam, A., Lee, D. W., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707498104 · Cited by 352 · see citing works
Adrenal Cortical Neoplasms in the Pediatric Population
Wieneke, J. A., Thompson, L. D. �., & Heffess, C. S. (2003) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200307000-00001 · Cited by 350 · see citing works
Berruti, A., Terzolo, M., Sperone, P., Pia, A. R., Casa, S. D., Gross, D. J., Carnaghi, C., Casali, P. G., Porpiglia, F., Mantero, F., et al. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.01025 · Cited by 308 · see citing works
Scotlandi, K., Manara, M. C., Nicoletti, G., Lollini, P., Yani, S. L., Benini, S., Croci, S., Perdichizzi, S., Zambelli, D., Serra, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3192 · Cited by 295 · see citing works
Gicquel, C., BERTAGNA, X. Y., Gaston, V., Coste, J., Louvel, A., Baudin, É., Bertherat, J. Y., Chapuis, Y., Duclos, J. M., Schlumberger, M. J., et al. (2001) · PubMed · Cited by 285 · see citing works
Adrenocortical cancer: pathophysiology and clinical management
Libé, R., Fratticci, A., & Bertherat, J. Y. (2007) · Endocrine Related Cancer · doi:10.1677/erc.1.01130 · Cited by 271 · see citing works
de Fraipont, F., El Atifi, M., Cherradi, N., Le Moigne, G., Defaye, G., Houlgatte, R., Bertherat, J., Bertagna, X., Plouin, P.-F., Baudin, E., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1075 · Cited by 261 · see citing works
Childhood Adrenocortical Tumors1
Sandrini, R., Ribeiro, R. C., & DeLacerda, L. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4057 · Cited by 237 · see citing works
Latronico, A. C., Pinto, E. M., Domenice, S., Fragoso, M. C. B. V., Martin, R. M., Zerbini, M. C., Lucon, A. M., & Mendonca, B. B. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7957 · Cited by 224 · see citing works
Gicquel, C., BERTAGNA, X. Y., Schneid, H., Leblond‐Francillard, M., LUTON, J. P., Girard, F., & Bouc, Y. L. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.7911125 · Cited by 224 · see citing works
Gicquel, C., Raffin‐Sanson, M., Gaston, V., BERTAGNA, X. Y., Plouin, P., Schlumberger, M. J., Louvel, A., LUTON, J. P., & Bouc, Y. L. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4170 · Cited by 213 · see citing works
Childhood Adrenocortical Tumors
Sandrini, R. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.7.2027 · Cited by 202 · see citing works
Latronico, A. C., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3921 · Cited by 190 · see citing works
Gicquel, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.8.2559 · Cited by 186 · see citing works
Gene Expression Profiling of Childhood Adrenocortical Tumors
West, A. N., Neale, G. A. M., Pounds, S. B., de Figueiredo, B. C., Galindo, C. R., Pianovski, M. A. D., Filho, A. G. O., Malkin, D. M., Lalli, E., Ribeiro, R. C., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3767 · Cited by 165 · see citing works
Wrobel, G., Roerig, P., Kokocinski, F., Neben, K., Hahn, M., Reifenberger, G., & Lichter, P. (2004) · International Journal of Cancer · doi:10.1002/ijc.20733 · Cited by 147 · see citing works
Wang, Y., & Sun, Y. (2002) · Current Cancer Drug Targets · doi:10.2174/1568009023333863 · Cited by 123 · see citing works
Mendonca, B. B., Lucón, A. M., Menezes, C. A. V., Saldanha, L. B., Latronico, A. C., Zerbini, M. C. N., Madureira, G., Domenice, S., Albergaria, M. A. P., Camargo, M. H. A., et al. (1995) · The Journal of Urology · doi:10.1016/s0022-5347(01)66673-4 · Cited by 117 · see citing works
Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells
Wen, B., Deutsch, É., Marangoni, E., Frascona, V., Maggiorella, L., Abdulkarim, B., Chavaudra, N., & Bourhis, J. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2171 · Cited by 108 · see citing works
Emerging Treatment Strategies for Adrenocortical Carcinoma: A New Hope
Kirschner, L. S. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1739 · Cited by 107 · see citing works
Höpfner, M., Huether, A., Sutter, A. P., Baradari, V., Schuppan, D., & Scherübl, H. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.02.006 · Cited by 106 · see citing works
Autocrine role of IGF-II in proliferation of human adrenocortical carcinoma NCI H295R cell line
Logié, A., Boulle, N., Gaston, V., Périn, L., Boudou, P., Bouc, Y. L., & Gicquel, C. (1999) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0230023 · Cited by 105 · see citing works
Wilkin, F., Gagné, N., Paquette, J., Oligny, L. L., & Deal, C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.5.6589 · Cited by 99 · see citing works
Insulin-like growth factor receptors in normal and tumorous adult human adrenocortical glands
Weber, M. M., Auernhammer, C. J., Kieß, W., & Engelhardt, D. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1360296 · Cited by 95 · see citing works
Tanno, B., Mancini, C., Vitali, R., Mancuso, M., McDowell, H. P., Dominici, C., & Raschellà, G. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1479 · Cited by 75 · see citing works
Höpfner, M., Baradari, V., Huether, A., Schöfl, C., & Scherübl, H. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.01090 · Cited by 71 · see citing works
Weber, M. M., Fottner, C., Schmidt, P. M., Brodowski, K. M. H., Gittner, K., Lahm, H., Engelhardt, D., & Wolf, E. (1999) · Endocrinology · doi:10.1210/endo.140.4.6660 · Cited by 66 · see citing works
Ghorab, Z., Jordà, M., Ganjei, P., & Nadji, M. (2003) · Applied immunohistochemistry & molecular morphology · doi:10.1097/00129039-200312000-00009 · Cited by 63 · see citing works
Kamio, T., Shigematsu, K., Kawai, K., & Tsuchiyama, H. (1991) · PubMed Central · Cited by 57 · see citing works
A morphometric study of neovascularization in colorectal carcinoma
Pavlopoulos, P. M., Konstantinidou, A. E., Agapitos, E. B., Kavantzas, N., Nikolopoulou, P., & Davaris, P. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19981115)83:10 · Cited by 54 · see citing works
Pinto, E. M., Billerbeck, A. E. C., Fragoso, M. C. B. V., Mendonca, B. B., & Latronico, A. C. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0963 · Cited by 42 · see citing works
Lotfi, C. F. P., & Armelin, H. A. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1680381 · Cited by 35 · see citing works
The Molecular Pathogenesis of Childhood Adrenocortical Tumors
Almeida, M. Q., & Latronico, A. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-981476 · Cited by 33 · see citing works
Insulin-like growth factor binding proteins in the human adrenal gland
Ilvesmäki, V., Blum, W. F., & Voutilainen, R. (1993) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(93)90212-3 · Cited by 29 · see citing works
The Insulin-Like Growth Factor (IGF) Family and Breast Cancer
Perks, C. M., & Holly, J. M. P. (2003) · Breast Disease · doi:10.3233/bd-2003-18106 · Cited by 25 · see citing works
Flagged first, then by citations
3 of the 49 references couldn’t be matched to a known paper.
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Faßnacht, M., Dekkers, O. M., Else, T., Baudin, É., Berruti, A., de Krijger, R. R., Haak, H. R., Mihai, R., Assié, G., & Terzolo, M. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0608 · Cited by 976 · see citing works
Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892 · see citing works
Clinical management of adrenocortical carcinoma
Fassnacht, M., & Allolio, B. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.10.008 · Cited by 349 · see citing works
Doghman, M., Wakil, A. E., Cardinaud, B., Thomas, E., Wang, J., Zhao, W., Peralta-Del Valle, M. H. C., Figueiredo, B. C., Zambetti, G. P., & Lalli, E. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3970 · Cited by 221 · see citing works
Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinoma
Barlaskar, F. M., Spalding, A. C., Heaton, J. H., Kuick, R., Kim, A. C., Thomas, D. G., Giordano, T. J., Ben-Josef, E., & Hammer, G. D. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1456 · Cited by 189 · see citing works
Development of adrenal cortex zonation
Xing, Y., Lerario, A. M., Rainey, W., & Hammer, G. D. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.02.001 · Cited by 174 · see citing works
Heaton, J. H., Wood, M. A., Kim, A. C., Lima, L. O., Barlaskar, F. M., Almeida, M. Q., Fragoso, M. C. B. V., Kuick, R., Lerario, A. M., Simon, D. P., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.05.026 · Cited by 173 · see citing works
MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy
Patterson, E. E., Holloway, A. K., Weng, J., Fojo, T., & Kebebew, E. (2011) · Cancer · doi:10.1002/cncr.25724 · Cited by 171 · see citing works
Human adrenocortical carcinoma cell lines
Wang, T., & Rainey, W. E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.041 · Cited by 149 · see citing works
In Search of Adrenocortical Stem and Progenitor Cells
Kim, A. C., Barlaskar, F. M., Heaton, J. H., Else, T., Kelly, V. R., Krill, K. T., Scheys, J. O., Simon, D. P., Trovato, A., Yang, W., et al. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0039 · Cited by 136 · see citing works
Naing, A., LoRusso, P. M., Fu, S., Hong, D. S., Chen, H. X., Doyle, L. A., Phan, A. T., Habra, M. A., & Kurzrock, R. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.46 · Cited by 134 · see citing works
Genetics and epigenetics of adrenocortical tumors
Lerário, A. M., Moraitis, A. G., & Hammer, G. D. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.10.028 · Cited by 112 · see citing works
Lerário, A. M., Worden, F. P., Ramm, C. A., Hasseltine, E. A., Stadler, W. M., Else, T., Shah, M. H., Agamah, E. S., Rao, K., & Hammer, G. D. (2014) · Hormones and Cancer · doi:10.1007/s12672-014-0182-1 · Cited by 108 · see citing works
New targets and therapeutic approaches for endocrine malignancies☆
Fassnacht, M., Kreissl, M. C., Weismann, D., & Allolio, B. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.03.013 · Cited by 104 · see citing works
Next-generation therapies for adrenocortical carcinoma
Altieri, B., Ronchi, C. L., Kroiß, M., & Faßnacht, M. (2020) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2020.101434 · Cited by 100 · see citing works
Fragoso, M. C. B. V., Almeida, M. Q., Mazzuco, T. L., Mariani, B. M. P., Brito, L. P., Gonçalves, T. C., Alencar, G. A., Lima, L. D. O., Faria, A. M., Bourdeau, I., et al. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-0806 · Cited by 93 · see citing works
Kinases as targets in the treatment of solid tumors
Giamas, G., Man, Y. L., Hirner, H., Bischof, J., Kramer, K. M., Khan, K., Ahmed, S. S. L., Stebbing, J., & Knippschild, U. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.01.011 · Cited by 89 · see citing works
[131I]Iodometomidate for targeted radionuclide therapy of advanced adrenocortical carcinoma
Hahner, S., Kreissl, M. C., Fassnacht, M., Haenscheid, H., Knoedler, P., Lang, K., Buck, A. K., Reiners, C., Allolio, B., & Schirbel, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2765 · Cited by 87 · see citing works
Inhibition of Adrenocortical Carcinoma Cell Proliferation by Steroidogenic Factor-1 Inverse Agonists
Doghman, M., Cazareth, J., Douguet, D., Madoux, F., Hodder, P., & Lalli, E. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2163 · Cited by 85 · see citing works
Almeida, M. Q., Soares, I. C., Ribeiro, T. C., Fragoso, M. C. B. V., Marins, L. V., Wakamatsu, A., Réssio, R. A., Nishi, M. Y., Jorge, A. A. L., Lerário, A. M., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2040 · Cited by 82 · see citing works
Analysis of the Role of Igf2 in Adrenal Tumour Development in Transgenic Mouse Models
Drelon, C., Berthon, A. S., Ragazzon, B., Tissier, F., Bandiera, R., Sahut‐Barnola, I., de Joussineau, C., Batisse‐Lignier, M., Lefrançois‐Martinez, A., Bertherat, J. Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044171 · Cited by 81 · see citing works
Genetics of tumors of the adrenal cortex
Bonnet-Serrano, F., & Bertherat, J. (2018) · Endocrine Related Cancer · doi:10.1530/erc-17-0361 · Cited by 80 · see citing works
Differences in the molecular mechanisms of adrenocortical tumorigenesis between children and adults
Faria, A. M., & Almeida, M. Q. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.040 · Cited by 80 · see citing works
Leal, L. F., Bueno, A. C., Gomes, D. C., Abduch, R. H., de Castro, M., & Antonini, S. R. R. (2015) · Oncotarget · doi:10.18632/oncotarget.5513 · Cited by 72 · see citing works
Lalli, E., & de Figueiredo, B. C. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00023 · Cited by 64 · see citing works
Adrenocortical stem and progenitor cells: Implications for adrenocortical carcinoma
Simon, D. P., & Hammer, G. D. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.12.006 · Cited by 58 · see citing works
Ahmed, A. A., Thomas, A. J., Ganeshan, D., Blair, K. J., Lall, C. G., Lee, J. T., Morshid, A. I., Habra, M. A., & Elsayes, K. M. (2020) · Abdominal Radiology · doi:10.1007/s00261-019-02371-y · Cited by 59 · see citing works
Wnt/β-catenin pathway deregulation in childhood adrenocortical tumors
Leal, L. F., Mermejo, L. M., Ramalho, L. Z., Martinelli, C. E., Yunes, J. A., Seidinger, A. L., Mastellaro, M. J., Cardinalli, I. A., Brandalise, S. R., Moreira, A. C., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0363 · Cited by 55 · see citing works
Everolimus therapy for progressive adrenocortical cancer
Fraenkel, M., Gueorguiev, M., Barak, D. F., Salmon, A. Y., Grossman, A. B., & Gross, D. J. (2013) · Endocrine · doi:10.1007/s12020-013-9878-1 · Cited by 53 · see citing works
Update on adrenocortical carcinoma management and future directions
Varghese, J. M., & Habra, M. A. (2017) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000332 · Cited by 53 · see citing works
Comparison of Aldosterone Production Among Human Adrenocortical Cell Lines
Wang, T., Rowland, J., Parmar, J., Nesterova, M., Seki, T., & Rainey, W. E. (2012) · Hormone and Metabolic Research · doi:10.1055/s-0031-1298019 · Cited by 53 · see citing works
Guillaud-Bataille, M., Ragazzon, B., de Reyniès, A., Chevalier, C., Francillard, I., Barreau, O., Steunou, V., Guillemot, J., Tissier, F., Rizk‐Rabin, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103744 · Cited by 52 · see citing works
Insulin-like growth factor system on adrenocortical tumorigenesis
Ribeiro, T. C., & Latronico, A. C. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.042 · Cited by 49 · see citing works
Martino, M. C. D., van Koetsveld, P. M., Feelders, R. A., Sprij-Mooij, D. M., Waaijers, M., Lamberts, S. W. J., de Herder, W. W., Colao, A., Pivonello, R., & Hofland, L. J. (2012) · Endocrine Related Cancer · doi:10.1530/erc-11-0270 · Cited by 48 · see citing works
Genetic aspects of adrenocortical tumours and hyperplasias
Mazzuco, T. L., Durand, J., Chapman, A., Crespigio, J., & Bourdeau, I. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04403.x · Cited by 47 · see citing works
Current and Emerging Therapies for Advanced Adrenocortical Carcinoma
Tacon, L. J., Prichard, R. S., Soon, P. S. H., Robinson, B. G., Clifton-Bligh, R. J., & Sidhu, S. B. (2011) · The Oncologist · doi:10.1634/theoncologist.2010-0270 · Cited by 42 · see citing works
Adrenocortical Carcinoma in Childhood: A Systematic Review
Riedmeier, M., Decarolis, B., Haubitz, I., Müller, S., Uttinger, K., Boerner, K., Reibetanz, J., Wiegering, A., Härtel, C., Schlegel, P., et al. (2021) · Cancers · doi:10.3390/cancers13215266 · Cited by 46 · see citing works
Assié, G., Guillaud-Bataille, M., Ragazzon, B., BERTAGNA, X. Y., Bertherat, J. Y., & Clauser, É. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.12.009 · Cited by 43 · see citing works
The Genetics of Adrenocortical Tumors
Espiard, S., & Bertherat, J. Y. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.02.004 · Cited by 42 · see citing works
Gene expression profiling in adrenocortical neoplasia
Assié, G., Giordano, T. J., & Bertherat, J. Y. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.044 · Cited by 41 · see citing works
Ronchi, C. L., Leich, E., Sbiera, S., Weismann, D., Rosenwald, A., Allolio, B., & Faßnacht, M. (2012) · Neoplasia · doi:10.1593/neo.111758 · Cited by 40 · see citing works
Gomes, D. C., Leal, L. F., Mermejo, L. M., Scrideli, C. A., Martinelli, C. E., Fragoso, M. C. B. V., Latronico, A. C., Tone, L. G., Tucci, S., Yunes, J. A., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4098 · Cited by 40 · see citing works
Brennan, V. C., Wang, C., & Yang, W. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2011.0158 · Cited by 39 · see citing works
Role of the mTOR Pathway in Normal and Tumoral Adrenal Cells
Martino, M. C. D., van Koetsveld, P. M., Pivonello, R., & Hofland, L. J. (2010) · Neuroendocrinology · doi:10.1159/000314280 · Cited by 39 · see citing works
Wandoloski, M., Bussey, K. J., & Demeure, M. J. (2009) · Surgical Clinics of North America · doi:10.1016/j.suc.2009.06.019 · Cited by 39 · see citing works
Adrenocortical tumors and insulin resistance: What is the first step?
Altieri, B., Tirabassi, G., Casa, S. D., Ronchi, C. L., Balercia, G., Orio, F., Pontecorvi, A., Colao, A., & Muscogiuri, G. (2015) · International Journal of Cancer · doi:10.1002/ijc.29950 · Cited by 37 · see citing works
Martino, M. C. D., van Koetsveld, P. M., Feelders, R. A., de Herder, W. W., Dogan, F., Janssen, J. A. M. J. L., Bruinink, D. H. O., Pivonello, C., Waaijers, A. M., Colao, A., et al. (2019) · Endocrine · doi:10.1007/s12020-019-01869-1 · Cited by 37 · see citing works
Therapy of adrenocortical cancer: present and future.
Maluf, D. F., de Oliveira, B. H., & Lalli, E. (2011) · Europe PMC (PubMed Central) · Cited by 34 · see citing works
Dysregulation of microRNAs in adrenocortical tumors
Singh, P., Soon, P. S. H., Feige, J., Chabre, O., Zhao, J., Cherradi, N., Lalli, E., & Sidhu, S. B. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.041 · Cited by 35 · see citing works
Pediatric adrenocortical tumor – review and management update
Balderrama-Brondani, V., & Fragoso, M. C. B. V. (2020) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000540 · Cited by 35 · see citing works
Update on Biology and Genomics of Adrenocortical Carcinomas: Rationale for Emerging Therapies
Lerário, A. M., Mohan, D. R., & Hammer, G. D. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac012 · Cited by 34 · see citing works
The Insulin and IGF-I Pathway in Endocrine Glands Carcinogenesis
Malaguarnera, R., Morcavallo, A., & Belfiore, A. (2012) · Journal of Oncology · doi:10.1155/2012/635614 · Cited by 32 · see citing works
Ribeiro, R. C., Pinto, E. M., & Zambetti, G. P. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.03.002 · Cited by 32 · see citing works
El‐Dakroury, W. A., Midan, H. M., Abulsoud, A. I., Elshaer, S. S., El-Husseiny, A. A., Fathi, D., Abdelmaksoud, N. M., Mageed, S. S. A., Elballal, M. S., Zaki, M. B., et al. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154665 · Cited by 31 · see citing works
Xie, H., Yin, J., Shah, M. H., Menefee, M. E., Bible, K. C., Reidy‐Lagunes, D. L., Kane, M. A., Quinn, D. I., Gandara, D. R., Erlichman, C., et al. (2019) · Investigational New Drugs · doi:10.1007/s10637-019-00797-1 · Cited by 31 · see citing works
Methylation of IGF2 regulatory regions to diagnose adrenocortical carcinomas
Creemers, S. G., van Koetsveld, P. M., van Kemenade, F. J., Papathomas, T. G., Franssen, G. J. H., Dogan, F., Eekhoff, E. M. W., van der Valk, P., de Herder, W. W., Janssen, J. A. M. J. L., et al. (2016) · Endocrine Related Cancer · doi:10.1530/erc-16-0266 · Cited by 30 · see citing works
The human adrenal cortex: growth control and disorders
Lotfi, C. F. P., Kremer, J. L., Passaia, B. D. S., & Cavalcante, I. P. (2018) · Clinics · doi:10.6061/clinics/2018/e473s · Cited by 30 · see citing works
Hofland, J., Delhanty, P. J. D., Steenbergen, J., Hofland, L. J., van Koetsveld, P. M., van Nederveen, F. H., de Herder, W. W., Feelders, R. A., & de Jong, F. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2328 · Cited by 30 · see citing works
Treatment of biliary tract cancer with NVP-AEW541: Mechanisms of action and resistance
Wolf, S. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i2.156 · Cited by 30 · see citing works
Expression of LIN 28 and its regulatory micro RNA s in adult adrenocortical cancer
Faria, A. M., Sbiera, S., Ribeiro, T. C., Soares, I. C., Mariani, B. M. P., Freire, D. S., de Sousa, G. R. V., Lerário, A. M., Ronchi, C. L., Deutschbein, T., et al. (2014) · Clinical Endocrinology · doi:10.1111/cen.12607 · Cited by 28 · see citing works
Characterization of the mTOR pathway in human normal adrenal and adrenocortical tumors
Martino, M. C. D., Feelders, R. A., de Herder, W. W., van Koetsveld, P. M., Dogan, F., Janssen, J. A. M. J. L., Waaijers, A. M., Pivonello, C., Lamberts, S. W. J., Colao, A., et al. (2014) · Endocrine Related Cancer · doi:10.1530/erc-13-0112 · Cited by 27 · see citing works
IGF2 and IGF1R in pediatric adrenocortical tumors: roles in metastasis and steroidogenesis
Lira, R. C. P., Fedatto, P. F., Antônio, D. S. M., Leal, L. F., Martinelli, C. E., de Castro, M., Tucci, S., Neder, L., Ramalho, L. N. Z., Seidinger, A. L., et al. (2016) · Endocrine Related Cancer · doi:10.1530/erc-15-0426 · Cited by 27 · see citing works
The role of insulin-like growth factor system in the adrenocortical tumors
Altieri, B., Colao, A., & Faggiano, A. (2018) · Minerva Endocrinology · doi:10.23736/s0391-1977.18.02882-1 · Cited by 27 · see citing works
Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis
Decmann, Á., Perge, P., Turai, P. I., Patócs, A., & Igaz, P. (2020) · Cancers · doi:10.3390/cancers12020461 · Cited by 27 · see citing works
Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase in Adrenocortical Carcinoma
Kiseljak‐Vassiliades, K., Zhang, Y., Kar, A., Razzaghi, R., Xu, M., Gowan, K., Raeburn, C. D., Albuja-Cruz, M. B., Jones, K. L., Somerset, H., et al. (2018) · Endocrinology · doi:10.1210/en.2018-00310 · Cited by 25 · see citing works
Primary Cultures and Cell Lines for In Vitro Modeling of the Human Adrenal Cortex
Nanba, K., Blinder, A., & Rainey, W. E. (2021) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.253.217 · Cited by 25 · see citing works
Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma
de Sousa, G. R. V., Ribeiro, T. C., Faria, A. M., Mariani, B. M. P., Lerário, A. M., Zerbini, M. C. N., Soares, I. C., Wakamatsu, A., Alves, V. A. F., Mendonca, B. B., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4261 · Cited by 25 · see citing works
Withanolides are Potent Novel Targeted Therapeutic Agents Against Adrenocortical Carcinomas
Subramanian, C., Zhang, H., Gallagher, R. J., Hammer, G. D., Timmermann, B. N., & Cohen, M. S. (2014) · World Journal of Surgery · doi:10.1007/s00268-014-2532-0 · Cited by 25 · see citing works
Lawson, E. A., Zhang, X., Crocker, J., Wang, W., & Klibanski, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0153 · Cited by 24 · see citing works
Pathophysiological Link between Insulin Resistance and Adrenal Incidentalomas
Higgs, J. A., Quinn, A. P., Seely, K. D., Richards, Z., Mortensen, S. P., Crandall, C. S., & Brooks, A. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084340 · Cited by 23 · see citing works
Abduch, R. H., Bueno, A. C., Leal, L. F., Cavalcanti, M. M., Gomes, D. C., Brandalise, S. R., Masterallo, M. J., Yunes, J. A., Martinelli, C. E., Tone, L. G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12382 · Cited by 23 · see citing works
The role of epithelial growth factors and insulin growth factors in the adrenal neoplasms
Angelousi, A. G., Kyriakopoulos, G., Ansari, N. N., Karageorgou, M., & Kassi, E. N. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.05.52 · Cited by 23 · see citing works
Insulin resistance and adrenal incidentalomas: A bidirectional relationship
Sydney, G. I., Ioakim, K. J., & Paschou, S. Α. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.12.002 · Cited by 23 · see citing works
Brito, L., Ribeiro, T. C., Almeida, M., Jorge, A. A. D. L., Soares, I., Latronico, A., Mendonça, B., Fragoso, M., & Lerário, A. (2012) · Endocrine-Related Cancer · doi:10.1530/erc-11-0231 · Cited by 21 · see citing works
The challenge of developmental therapeutics for adrenocortical carcinoma
da Costa, R. B., Carneiro, B. A., Tavora, F., Pai, S. G., Kaplan, J. B., Chae, Y. K., Chandra, S., Kopp, P. A., & Giles, F. J. (2016) · Oncotarget · doi:10.18632/oncotarget.8774 · Cited by 21 · see citing works
van Koetsveld, P. M., Vitale, G., Feelders, R. A., Waaijers, M., Sprij-Mooij, D. M., de Krijger, R. R., Speel, E. M., Hofland, J., Lamberts, S. W. J., de Herder, W. W., et al. (2013) · Endocrine Related Cancer · doi:10.1530/erc-12-0217 · Cited by 20 · see citing works
Co-inhibition of EGFR and IGF1R synergistically impacts therapeutically on adrenocortical carcinoma
Xu, L., Qi, Y., Xu, Y., Lian, J., Wang, X., Ning, G., Wang, W., & Zhu, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.8827 · Cited by 20 · see citing works
Molecular markers of adrenocortical tumors
Jain, M., Rechache, N. S., & Kebebew, E. (2012) · Journal of Surgical Oncology · doi:10.1002/jso.23119 · Cited by 17 · see citing works
Rak kory nadnercza (ACC) — przegląd piśmiennictwa i doświadczenia własne
Dorota Dworakowska, B., Drabarek, A., Wenzel, I., Babińska, A., Świątkowska−Stodulska, R., & Sworczak, K. (2015) · Endokrynologia Polska · doi:10.5603/ep.2014.0069 · Cited by 19 · see citing works
Preclinical Models of Adrenocortical Cancer
Sedlack, A. J. H., Hatfield, S. J., Kumar, S., Arakawa, Y., Roper, N., Sun, N.-Y., Nilubol, N., Kiseljak‐Vassiliades, K., Hoang, C. D., Bergsland, E. K., et al. (2023) · Cancers · doi:10.3390/cancers15112873 · Cited by 17 · see citing works
Xu, X., & Sergi, C. M. (2016) · Contemporary Clinical Trials · doi:10.1016/j.cct.2016.07.011 · Cited by 17 · see citing works
Germano, A., Rapa, I., Duregon, E., Votta, A., Giorcelli, J., Buttigliero, C., Scagliotti, G. V., Volante, M., Terzolo, M., & Papotti, M. (2017) · Endocrine Pathology · doi:10.1007/s12022-017-9473-8 · Cited by 17 · see citing works
Catalano, R., Giardino, E., Treppiedi, D., Mangili, F., Morelli, V., Elli, F. M., Serban, A. L., Luconi, M., Mannelli, M., Spada, A., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.10.022 · Cited by 16 · see citing works
Clinical and molecular aspects of a pediatric metachronous adrenocortical tumor
Lima, L. D. O., Lerário, A. M., Alencar, G. A., Brito, L. P., Almeida, M. Q., Domenice, S., Latronico, A. C., Mendonca, B. B., & Fragoso, M. C. B. V. (2011) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302011000100010 · Cited by 16 · see citing works
Antonini, S. R. R., Leal, L. F., & Cavalcanti, M. M. (2014) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2014.941813 · Cited by 16 · see citing works
Are we failing in treatment of adrenocortical carcinoma? Lights and shadows of molecular signatures
Grisanti, S., Cosentini, D., Laganà, M., Abate, A., Rossini, E., Sigala, S., & Berruti, A. (2019) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2019.07.007 · Cited by 15 · see citing works
MicroRNA dysregulation interplay with childhood abdominal tumors
Salomão, K. B., Pezuk, J. A., de Sousa, G. R., Chagas, P. S., Pereira, T. C., Valera, E. T., & Brassesco, M. S. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09829-x · Cited by 15 · see citing works
Riedmeier, M., Decarolis, B., Haubitz, I., Reibetanz, J., Wiegering, A., Härtel, C., Schlegel, P., Faßnacht, M., & Wiegering, V. A. (2022) · European Journal of Endocrinology · doi:10.1530/eje-22-0173 · Cited by 15 · see citing works
Silveira, E. R., Cavalcante, I. P., Kremer, J. L., de Mendonça, P. O. R., & Lotfi, C. F. P. (2018) · Cancer Cell International · doi:10.1186/s12935-018-0527-x · Cited by 15 · see citing works
The role of mTOR pathway as target for treatment in adrenocortical cancer
Martino, M. C. D., Feelders, R. A., Pivonello, C., Simeoli, C., Papa, F., Colao, A., Pivonello, R., & Hofland, L. J. (2019) · Endocrine Connections · doi:10.1530/ec-19-0224 · Cited by 14 · see citing works
SIRT1 is involved in adrenocortical cancer growth and motility
Chimento, A., Luca, A. D., Nocito, M. C., Sculco, S., Avena, P., Padula, D. L., Zavaglia, L., Sirianni, R., Casaburi, I., & Pezzi, V. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16317 · Cited by 14 · see citing works
Role of filamin A in the pathogenesis of neuroendocrine tumors and adrenal cancer
Treppiedi, D., Catalano, R., Mangili, F., Mantovani, G., & Peverelli, E. (2022) · Endocrine Oncology · doi:10.1530/eo-22-0055 · Cited by 13 · see citing works
Molecular markers and targeted therapies for adrenocortical carcinoma
Xu, Y., Qi, Y., Zhu, Y., Ning, G., & Huang, Y. (2013) · Clinical Endocrinology · doi:10.1111/cen.12358 · Cited by 12 · see citing works
Doghman, M., Axelson, M., & Lalli, E. (2011) · Europe PMC (PubMed Central) · Cited by 12 · see citing works
Ribeiro, T. C., Jorge, A. A. L., Almeida, M. Q., Mariani, B. M. P., Nishi, M. Y., Mendonca, B. B., Fragoso, M. C. B. V., & Latronico, A. C. (2014) · BioMed Research International · doi:10.1155/2014/936031 · Cited by 12 · see citing works
Balderrama-Brondani, V., Montenegro, L. R., Lacombe, A. M. F., Magalhães, B. M., Nishi, M. Y., Funari, M. F. A., Narcizo, A. D. M., Cardoso, L. C., Siqueira, S. A. C., Zerbini, M. C. N., et al. (2020) · Cancers · doi:10.3390/cancers12030621 · Cited by 11 · see citing works
Analysis of IGF and IGFBP as Prognostic Serum Biomarkers for Adrenocortical Carcinoma
Patel, D., Ellis, R. J., Howard, B., Boufraqech, M., Gara, S. K., Zhang, L., Quezado, M., Nilubol, N., & Kebebew, E. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-3768-5 · Cited by 12 · see citing works
Passaia, B. D. S., Lima, K., Kremer, J. L., da Conceição, B. B., Mariani, B. M. P., da Silva, J. C. L., Zerbini, M. C. N., Fragoso, M. C. B. V., Machado‐Neto, J. A., & Lotfi, C. F. P. (2019) · Investigational New Drugs · doi:10.1007/s10637-019-00846-9 · Cited by 11 · see citing works
Kool, M., Galac, S., van der Helm, N., Corradini, S., Kooistra, H., & Mol, J. A. (2015) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12528 · Cited by 8 · see citing works
Szyszka, P., Grossman, A. B., Díaz‐Cano, S. J., & Dorota Dworakowska, B. (2015) · Endokrynologia Polska · doi:10.5603/ep.a2016.0054 · Cited by 11 · see citing works
- Authors
- Almeida, M. Q., Fragoso, M. C. B. V., Lotfi, C. F. P., Santos, M. G., Nishi, M. Y., Costa, M. H. S., Lerario, A. M., Maciel, C. C., Mattos, G. E., Jorge, A. A. L., Mendonca, B. B., & Latronico, A. C.
- Affiliations
- Universidade de São Paulo (BR)
- Unidade de Endocrinologia do Desenvolvimento (M.Q.A., M.C.B.V.F., M.G.S., M.Y.N., M.H.S.C., A.M.L., A.A.L.J., B.B.M., A.C.L.), Departamento de Anatomia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05403-900 São Paulo, Brazil
- Corresponding author
- Almeida, Madson Q.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-09-01
- Volume
- 93
- Issue
- 9
- Pages
- 3524-3531
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2095417135
- Cited by
- 176
- References
- 49
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 13 · 2019: 6 · 2018: 11 · 2017: 5 · 2016: 10 · 2015: 12 · 2014: 17 · 2013: 7 · 2012: 17
- FWCI
- 16.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- insulin-like growth factor II, IGF-II receptor, adrenocortical tumors, pediatric adrenocortical carcinoma, adrenal adenoma, NVP-AEW541, metastasis biomarkers, cell proliferation, apoptosis, cancer therapy
- MeSH terms
- Adenoma, Adolescent, Adrenal Cortex Neoplasms, Adult, Aged, Carcinoma, Child, Child, Preschool, Female, Humans, Infant, Insulin-Like Growth Factor II, Male, Middle Aged, Neoplasm Metastasis, Tumor Cells, Cultured, Gene Expression Regulation, Neoplastic, Receptor, IGF Type 2
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