Cited by 176GDF15 and Related BiomarkersAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

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Growth differentiation factor 15 predicts future insulin resistance and impaired glucose control in obese nondiabetic individuals: results from the XENDOS trial

Kempf, Tibor, Guba-Quint, Anja, Torgerson, Jarl, Magnone, Maria Chiara, Haefliger, Carolina, Bobadilla, Maria, Wollert, Kai C·2012·European Journal of Endocrinology

DOI 10.1530/eje-12-0466

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Abstract

OBJECTIVE: Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine that is increased in obesity and established type 2 diabetes. We assessed whether GDF-15 can predict future insulin resistance and impaired glucose control in obese nondiabetic individuals. DESIGN AND METHODS: Plasma GDF-15 concentrations were measured with an automated electrochemiluminescent immunoassay at baseline and after 4 years in 496 obese nondiabetic individuals (52% men, median age 48 years, median body mass index (BMI) 37.6 kg/m(2)) enrolled in the XENical in the prevention of Diabetes in Obese subjects (XENDOS) trial. RESULTS: The median GDF-15 concentration at baseline was 869 ng/l (interquartile range 723-1064 ng/l). GDF-15 was related to body weight, BMI, waist-to-hip ratio, and insulin resistance (homeostasis model assessment of insulin resistance (HOMA-IR)) (all P < 0.01). Changes in GDF-15 from baseline to 4 years were related to changes in body weight, BMI, waist-to-hip ratio, and HOMA-IR (all P < 0.05). Baseline GDF-15 was associated with the risk to have prediabetes or diabetes at 4 years by univariate analysis (odds ratio (OR) FOR 1 unit increase in ln GDF-15, 3.2; 95% confidence interval (CI): 1.7-6.1; P<0.001), and after multivariate adjustment for age, gender, treatment allocation (orlistat vs placebo), BMI, waist-to-hip ratio, and glucose control at baseline (OR 2.2; 95% CI: 1.1-4.7; P=0.026). Similarly, baseline GDF-15 was independently associated with HOMA-IR at 4 years (P=0.024). CONCLUSIONS: This first longitudinal study of GDF-15 in a large cohort of obese individuals indicates that GDF-15 is related to abdominal obesity and insulin resistance and independently associated with future insulin resistance and abnormal glucose control.

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Authors: Kempf, T., Guba-Quint, A., Torgerson, J., Magnone, M. C., Haefliger, C., Bobadilla, M., & Wollert, K. C.
Affiliations: Medizinische Hochschule Hannover (DE)
F. Hoffmann-La Roche AG (CH)
Corresponding author: Wollert, Kai C
ORCID: Kempf, Tibor
Magnone, Maria Chiara
Haefliger, Carolina
Wollert, Kai C
Venue: European Journal of Endocrinology
Publisher: Oxford University Press (OUP)
Published: 2012-11
Volume: 167
Issue: 5
Pages: 671-678
ISSN: 0804-4643 (ISSN-L)
1479-683X
DOI: 10.1530/eje-12-0466
OpenAlex: W2103530523
Cited by: 176
References: 34
Citations by year: 2026: 10 · 2025: 17 · 2024: 12 · 2023: 6 · 2022: 24 · 2021: 22 · 2020: 19 · 2019: 13 · 2018: 14 · 2017: 5 · 2016: 15 · 2015: 10 · 2014: 6 · 2013: 2 · 2012: 1
FWCI: 4.66
Type: journal article
Language: en
Open access: closed
Locations: European Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › GDF15 and Related Biomarkers
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: growth differentiation factor 15, insulin resistance, prediabetes, type 2 diabetes risk, obesity, abdominal obesity, orlistat, HOMA-IR, biomarkers
MeSH terms: Adult, Aged, Analysis of Variance, Blood Glucose, Cardiovascular Diseases, Diabetes Mellitus, Female, Glucose Tolerance Test, Humans, Insulin Resistance, Longitudinal Studies, Luminescent Measurements, Male, Middle Aged, Obesity, Predictive Value of Tests, Risk Factors, Time Factors, Biomarkers, Body Mass Index, Odds Ratio, Randomized Controlled Trials as Topic, Waist-Hip Ratio, Growth Differentiation Factor 15, Electrochemical Techniques

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Growth differentiation factor 15 predicts future insulin resistance and impaired glucose control in obese nondiabetic individuals: results from the XENDOS trial

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