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Cited by 62Adrenal and Paraganglionic TumorsAdrenal Hormones and DisordersHormonal Regulation and Hypertension

Bilateral and unilateral adrenal incidentalomas: biochemical and clinical characteristics

Morelli, V, Palmieri, S, Salcuni, A S, Eller-Vainicher, C, Cairoli, E, Zhukouskaya, V, Scillitani, A, Beck-Peccoz, P +1 more·2013·European Journal of Endocrinology
DOI 10.1530/eje-12-0777
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Abstract

OBJECTIVE: The possible different prevalence of arterial hypertension (AH), type 2 diabetes mellitus (T2DM), dyslipidaemia (DL) and vertebral fractures (FX) between patients with bilateral and unilateral adrenal incidentalomas (BAI and UAI, respectively) with and without subclinical hypercortisolism (SH) is unknown. In this study we compared the prevalence of AH, T2DM, DL and FX in BAI and UAI patients in relation to SH. DESIGN: Prospective study. METHODS: In 175 UAI and 38 BAI patients, we evaluated BMI, spinal and femoral bone mineral density (LS and FN BMD, respectively) and the presence of AH, T2DM, DL and FX. SH was diagnosed in the presence of 2 of the following: urinary free cortisol levels >193 nmol/24 h, serum cortisol levels after 1 mg dexamethasone suppression test >83 nmol/l or ACTH levels <2.2 pmol/l. RESULTS: Age, BMI and cortisol secretion were comparable, while FN BMD was lower in BAI than in UAI patients (-0.45±0.86 vs 0.09±1.07, P=0.004). The prevalence of SH, AH, T2DM, and DL was comparable, while the prevalence of FX was higher in BAI than in UAI (52.6 vs 28%, P=0.007). The presence of FX was associated with BAI (odds ratio (OR) 2.6, 95% confidence interval (95% CI) 1.2-5.6, P=0.016), after adjusting for SH (OR 1.77, 95% CI 0.85-3.7, P=0.12), BMI (OR 1.06, 95% CI 0.98-1.13, P=0.1), age (OR 1.07, 95% CI 1.04-1.11, P=0.0001) and LS BMD (OR 1.31, 95% CI 1.03-1.67, P=0.03). CONCLUSION: BAI patients have an increased FX risk than UAI ones. Further studies should investigate the causes of bone involvement in BAI patients.

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Crossref · 10.1530/eje-12-0777

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  • ACS is more frequently encountered in patients with bilateral AI than in those with unilateral lesions.

    “ACS is more frequently encountered in patients with bilateral AI than in those with unilateral lesions (317-319).”

    From Adrenal incidentaloma (2020) · cites this paper as [318]

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Authors
Morelli, V, Palmieri, S., Salcuni, A. S., Eller-Vainicher, C., Cairoli, E., Zhukouskaya, V, Scillitani, A., Beck-Peccoz, P., & Chiodini, I.
Affiliations
  • University of Milan (IT)
  • Casa Sollievo della Sofferenza (IT)
Corresponding author
Morelli, V
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2013-02
Volume
168
Issue
2
Pages
235-241
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje-12-0777
OpenAlex
W2116660566
Cited by
62
References
27
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 10 · 2014: 7 · 2013: 2
FWCI
6.19
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
subclinical hypercortisolism, vertebral fractures, hypertension, type 2 diabetes, dyslipidemia, bone mineral density, dexamethasone suppression test, ACTH, urinary free cortisol, Cushing's disease
MeSH terms
Adrenal Gland Neoplasms, Adult, Aged, Aged, 80 and over, Cushing Syndrome, Diabetes Mellitus, Type 2, Female, Humans, Hypertension, Male, Middle Aged, Prospective Studies, Bone Density, Body Mass Index, Prevalence, Odds Ratio, Spinal Fractures, Dyslipidemias

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