CoChat
Sign Up
Cited by 377Thyroid Disorders and TreatmentsBone health and osteoporosis researchThyroid and Parathyroid Surgery

The DOI matches its Crossref record.

Changes in bone mass during prolonged subclinical hyperthyroidism due to l-thyroxine treatment: a meta-analysis

Faber, Jens, Galløe, Anders Michael·1994·European Journal of Endocrinology
DOI 10.1530/eje.0.1300350
Open this paper in CoChat — free account

Abstract

L-Thyroxine (L-T4) in the treatment of thyroid disease resulting in reduced serum thyrotropin (TSH) has been associated with reduced bone mass and thus the potential risk of premature development of osteoporosis. However, several recent studies have failed to show such a detrimental effect. These disagreements are probably due to only a small number of patients taking part in each study, decreasing the change of finding significant differences and increasing the risk of missing a real difference (type 1 and 2 errors, respectively). We therefore performed a meta-analysis on the available papers (N = 13), in which bone mass was measured in the distal forearm, femoral neck or lumbar spine in a cross-sectional manner in women with suppressed serum TSH due to L-T4 treatment and in a control group. The women were divided according to their pre- and postmenopausal state, because preserved estrogen production plays a protective role against irreversible bone loss. Based on the number of measurements performed on the different sites of the skeleton, a theoretical bone composed of 30.4% distal forearm, 28.8% femoral neck and 40.8% lumbar spine could be constructed in premenopausal women (441 measurements). A premenopausal woman at an average age of 39.6 years and treated with 164 micrograms L-T4/day for 8.5 years, leading to suppressed serum TSH, had 2.67% less bone mass than controls (NS), corresponding to an excess annual bone loss of 0.31% after 8.5 years of treatment (NS). The risk…

Overview

Integrity signals

Registry

Crossref · 10.1530/eje.0.1300350

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Still being checked.

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Faber, J., & Galløe, A. M.
Affiliations
Frederiksberg Hospital (DK)
Corresponding author
Faber, Jens
ORCID
Faber, Jens
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
1994-04
Volume
130
Issue
4
Pages
350-356
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje.0.1300350
OpenAlex
W2159860352
Cited by
377
References
0
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 12 · 2013: 10 · 2012: 18
FWCI
13.50
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
subclinical hyperthyroidism, levothyroxine, bone mass, bone loss, osteoporosis risk, TSH suppression, thyroid hormone replacement, postmenopausal women, premenopausal women, distal forearm, femoral neck, lumbar spine, type II error, power analysis
MeSH terms
Adult, Cross-Sectional Studies, Female, Femur, Humans, Hyperthyroidism, Hypothyroidism, Lumbar Vertebrae, Middle Aged, Osteoporosis, Radius, Thyroid Neoplasms, Thyrotropin, Thyroxine, Bone Density, Premenopause, Postmenopause

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review